Professional Documents
Culture Documents
Systematic Review
Management of Traumatic Nerve Palsies in Paediatric
Supracondylar Humerus Fractures: A Systematic Review
Christy Graff 1,2,3, *, George Dennis Dounas 1,2,3 , Maya Rani Louise Chandra Todd 2,3 , Jonghoo Sung 1
and Medhir Kumawat 2
1 The Women’s and Children’s Hospital, North Adelaide, SA 5006, Australia; jonghoo.sung@sa.gov.au (J.S.)
2 Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5005, Australia;
medhir.kumawat@student.adelaide.edu.au (M.K.)
3 The Royal Adelaide Hospital, Adelaide, SA 5000, Australia
* Correspondence: christy.graff@sa.gov.au
2. Methods
The review has been conducted in accordance with the Joanna Briggs Institute (JBI)
methodology for systematic reviews of effectiveness with reference to the a priori protocol
published in the same journal [7,8]. The review has been registered with the International
Prospective Register of Systematic Reviews PROSPERO (CRD42019121581).
A comprehensive search strategy was conducted on 7 June 2021 (Supplementary S1).
Randomised controlled trials, cohort studies, case series, and case studies published after
1950 were included. The databases searched were Ovid Medline, Embase, and Cochrane
Central, as well as a grey literature search using Google Scholar with the first 200 results
returned also reviewed. The bibliographies of the accepted manuscripts were reviewed to
identify other relevant published research. The search was re-executed on 23 May 2022,
due to the longevity of data curation.
The aim of the study was to compare the effectiveness of operative versus expectant
management on the recovery of nerve palsies in paediatric supracondylar fractures. The
inclusion criteria were papers that included:
- A paediatric patient with;
- An ipsilateral traumatic upper limb nerve palsy after a SCHF;
- With no pre-existing neurological impairment.
Studies were excluded if:
- They did not provide details regarding follow up or the outcome of the traumatic
nerve palsy;
- It was not possible from the reporting to separate individual outcomes from large
groups of nerve palsies.
Sequential screening of the manuscripts by title, abstract, and full text were performed
by two independent reviewers to determine suitability based on the inclusion and exclusion
criteria. The results of the final search were reported in accordance with the preferred
reporting items for the systematic reviews and meta-analysis (PRISMA) guidelines [9]
(Supplementary S2).
Data extraction was performed by two independent reviewers using a prescribed
extraction form. Each eligible manuscript underwent critical appraisal and assessment of
methodological quality by two independent reviewers using standardized critical appraisal
instruments from the Joanna Briggs Institute (JBI) for Systematic Reviews and Research
Synthesis (Supplementary S3–S6) [8]. Cohort studies with complete follow up were scored
out of eleven, case series out of ten, and case reports out of eight. Cohort studies without
confounding factors or incomplete follow up were scored out of ten, and cohort studies
without confounding factors and without incomplete follow up were scored out of nine.
Discrepancies between reviewers at all stages were resolved by a senior reviewer.
The primary outcome was nerve palsy recovery, ranging from “full recovery” to “no
recovery” as a descriptive measure. Secondary outcomes include time to recovery, modality
of treatment, use and timing of investigations, findings at operation, and duration of
follow up. Data were synthesised in narrative and tabular format. Due to considerable
clinical heterogeneity, a meta-analysis was not performed. Where appropriate, frequencies,
percentages, and summaries of data were included for analysis.
3. Results
A total of 7919 results were identified on initial search. All of the results were collated
and uploaded into EndNote version X.9 (Clarivate Analytics, Philadelphia, PA, USA) and
de-duplication occurred, with a final number of 2744 articles retrieved [10]. After title and
abstract screening, there were 218 manuscripts reviewed in full including bibliography
reviews, of which 51 met the inclusion criteria and were included in this systematic review
as demonstrated in the PRISMA flow diagram (Figure 1) [9]. From the final 51 manuscripts,
16 were case reports/series with the remainder being cohort studies. There were 509 nerve
Children 2023, 10, x FOR PEER REVIEW 3 of 11
reviews, of which 51 met the inclusion criteria and were included in this systematic review
Children 2023, 10, 1862 as demonstrated in the PRISMA flow diagram (Figure 1) [9]. From the final 51 manu- 3 of 11
scripts, 16 were case reports/series with the remainder being cohort studies. There were
509 nerve palsies described, with the median nerve most commonly affected and the most
common fracture type
palsies described, withreported as Gartland
the median type
nerve most 3. No studies
commonly wereand
affected excluded due
the most to bias
common
(Table 1).
fracture type reported as Gartland type 3. No studies were excluded due to bias (Table 1).
Table 1. Cont.
There were 372 traumatic nerve palsies which had full recovery with no intervention
(such as nerve exploration) or investigation (such as imaging or nerve conduction studies)
undertaken (73.9%) (see Table S1 Supplementary S7). The mean duration of time to full
recovery at final follow up in these patients was 19.5 weeks (approximately 5 months)
(ranging from 3 days to 1 year). Eight nerve palsies had no intervention (such as nerve
exploration) or investigation (such as imaging or nerve conduction studies) and were
not fully recovered at last follow up. Davis et al. [21] described an ulnar nerve palsy
with sensory disturbance at the 4-year follow up, and two radial nerve palsies with wrist
extension weakness at the 4-year follow up. Van Vught et al. [58] reported one patient with
ulnar, median, and radial sensory loss after a patient presented to them after 5 days with
Children 2023, 10, 1862 6 of 11
Volkmann’s ischaemic contracture. Yaokreh et al. [60] reported on two nerves that ‘required
electrophysiological studies’ at final follow up but no other detail was given.
There were 26 traumatic nerve palsies which did not document full recovery by the
final follow up (5.3%) (see Table S2 Supplementary S7).
There were 92 (18%) nerve palsies which underwent exploration at the time of initial
operation (see Table S3 Supplementary S7) of which 89 were described as a secondary intention
whilst exploring the brachial artery or an open fracture or converting to open reduction. Three
were explored due to surgeon preference of treatment of nerve palsies at presentation [1,19,54].
Eighty-eight which were explored at the time of the initial operation had full recovery by the
final follow up, one incomplete recovery, and three were lost to follow up. The findings at
exploration in forty-six out of ninety-two nerves were tethered or entrapped in the fracture
site, thirty-seven were in continuity, three lacerated, and four contused.
A total of 37 nerves (7.3%) underwent delayed exploration with an average time of
4.4 months (0.5 to 11 months) (see Table S4 Supplementary S7). It was found that 27 were
recorded as entrapped in the fracture site/callous/scarring and 10 were found to be completely
transected. The radial nerve was involved in sixteen cases, while the median in twelve, and
the ulnar in nine. Full recovery at final follow up was reported in 26 nerves. One radial nerve
was lacerated, explored, and repaired primarily, but then did not recover, and went on to
have a delayed exploration [41]. The primary repair was found to have failed, and was then
managed with a nerve graft, and ultimately, tendon transfers.
A total of 13 nerves were found to be completely lacerated on exploration (see Table S5
Supplementary S7). Interestingly, 10 of these were radial nerves. Most of these occurred at
the time of the injury, prior to reduction (see Table S5 Supplementary S7).
4. Discussion
Our systematic review focused on traumatic nerve palsies in paediatric supracondylar
humerus fractures. Iatrogenic or K-wire-associated nerve palsies represent a different
spectrum of nerve trauma and have been described elsewhere [30,61]. This review rep-
resents the most current comprehensive description of outcomes after traumatic nerve
palsies in paediatric supracondylar humerus fractures in the literature, with a total of
510 nerve injuries identified. The characteristics of a Gartland type 3 fracture were consis-
tent with previously reported papers, supporting the opinion that neurological injury is
more prevalent amongst more severely displaced fractures [2,24,62]. A total of 18 of the
51 papers did not report the Gartland type, and therefore we did not think a percentage of
Gartland type would be accurate to report.
The previous literature reports that 86–100% of nerve injuries will recover sponta-
neously by 6 months, with a mean time of approximately 3 months [41,63]. Most nerves
in the current series were managed expectantly, and had full spontaneous recovery, in
keeping with this ‘watch and wait’ policy which is consistently advocated in the literature
for patients with anatomical reduction [17,58]. However, an adequate reduction does not
rule out the possibility of entrapment and does not account for lacerations [42,55].
A comparison of time frame to full recovery between no exploration, exploration at
initial operation, and delayed exploration was unable to be calculated in this review as the
majority of papers reported recovery ‘at time of final follow up’ or provided a broad range,
such as 1 day to 10 months or 1 to 4 years [17,43]. It is important to recognize that the ‘time
to full recovery’ for nerve palsies is the time of final follow up. The literature is not robust
enough to determine how long it took for the nerve palsies to fully recover.
It was found that 7.4% of nerve palsies required delayed exploration due to persistent
deficits or stagnated recovery at an average of 4 months. Exploration has been advocated
for if there is no clinical recovery from 6 weeks to 3 months [30,41,64]. If the nerve is found
in continuity at 3 months and is neurolysed, there is a trend to complete recovery [20,58].
Incomplete recovery was more common after complete nerve transection, or if exploration
occurred after 4 months. There were 13 reports of nerve laceration secondary to paediatric
SCHFs, of which 10 were the radial nerve, and had poorer outcomes.
Children 2023, 10, x FOR PEER REVIEW 7 of 11
Figure 2. Algorithm for the management of traumatic nerve palsies after paediatric supracondylar
Figure 2. Algorithm for the management of traumatic nerve palsies after paediatric supracondylar
humerus fractures.
humerus fractures.
The majority of included papers did not have a primary objective of nerve palsy out-
The majority of included papers did not have a primary objective of nerve palsy
comes; they were commonly reported on only as a complication in part of a wider review
outcomes; they were commonly
of SCHF management techniques.reported on described
Those that only as anerve
complication in part
palsy in detail of aoften
were wider
review
case studies and thus have impacts of selection bias confounding the results. The 5% were
of SCHF management techniques. Those that described nerve palsy in detail of
often case studies and thus have impacts of selection bias confounding the results. The 5%
of nerves that did not fully recover in this series is likely overinflated due to the selection
bias of persistent deficits being reported in case series. Our review included eight case
reports, focusing only on nerves that were lacerated or entrapped, and so were not typical
of the normal pathway of nerve palsies after paediatric supracondylar humerus fractures.
Children 2023, 10, 1862 8 of 11
There is unfortunately very limited literature dedicated to the management of these injuries
from injury to full recovery, which is surprising considering the importance of the topic.
Retrospective or prospective data from large centres or multicentre trials on the recovery of
nerve palsies in this population is required for improved confidence in recommendations
for management.
Another limitation is that two of the largest series describing 425 nerve palsies were
excluded by full text; a report of the interventions and outcomes was unclear for the
purposes of this review. The authors were contacted for further details which were not able
to be obtained at the time of submission [63,66].
The incidence of complete lacerations of nerves after paediatric SCHFs has never
been reported before. This systematic review suggests that the radial nerve is more often
lacerated than other nerves, which is a new finding to our knowledge. This needs further
investigation, and a radial nerve that is not recovering after a paediatric SCHF may need
earlier investigation or exploration.
Supplementary Materials: The following supporting information can be downloaded at: https://
www.mdpi.com/article/10.3390/children10121862/s1, Supplementary S1: Search Strategies.
Supplementary S2: PRISMA 2020 Checklist. Supplementary S3: JBI Critical Appraisal Checklist
for Case Control studies. Supplementary S4: JBI Critical Appraisal Checklist for Cohort Studies.
Supplementary S5: JBI Critical Appraisal Checklist for Case Series. Supplementary S6: JBI Critical
Appraisal Checklist for Case Reports. Supplementary S7: Tables S1–S5. References [67–74] are cited
in the supplementary materials.
Author Contributions: C.G.: writing of protocol, data collection, data extraction, results interpreta-
tion, writing of paper, supervision of authors. M.R.L.C.T.: writing of protocol, data collection, data
extraction, results interpretation, writing of paper. G.D.D.: writing of protocol, data collection, data
extraction, results interpretation, writing of paper. J.S.: data extraction, assessment of papers. M.K.:
data extraction, assessment of papers. All authors have read and agreed to the published version of
the manuscript.
Funding: This research received no external funding.
Institutional Review Board Statement: Not applicable due to the nature of the study.
Informed Consent Statement: Not applicable due to the nature of the study.
Data Availability Statement: Raw data is available on request to the primary author.
Conflicts of Interest: The authors declare no conflict of interest.
Children 2023, 10, 1862 9 of 11
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