Two French scientists, who theorized and

A mathematical and graphic function observed that radio sensitivity was a Factors that affect the radiobiologic The principal aim of the study of
that relates radiation dose to observed function of the metabolic state of the tissue response to tissue. radiobiology is to understand
response being irradiated.

Are considerably more sensitive to radiation States that radiosensitivity increases ___cells are radioresistant
exposure as are children compared with the ____ cells are radiosensitive. with the rate of proliferation and
mature adults differentiation of cells.

The standard radiation, by convention, is

LET Stands for? _____ in the range of ____ RBE stand for? Is a measure of the rate at which energy is
transferred from ionizing radiation to soft
tissue

This type of x-ray beam was used for many

LET is expressed in units of years in radiation oncology and in
The LET of diagnostic xrays is As the LET of radiation increases, the
essentially all early radiobiologic research
approximately ability to produce biologic damage

Diagnostic x-rays have an RBE of Radiations with lower LET than Dose protraction and fractionation cause If the dose is delivered continuously but
diagnostic x-rays have an RBE less effect because time is allowed for at a lower dose rate
intracellular repair and tissue recovery.
 If the total dose to be delivered is
divided into several sessions (fractions)
Used in radiation oncology in an attempt to
enhance the radiosensitivity of nodular,
avascular tumors, which are less
radiosensitive than tumors with an adequate
blood supply
Occurs when the cell dies before
replicating
Examples of sensitizing agents
Human responses to radiation exposure
fall into two types:
Dose fractionation is used routinely in
Humans are most sensitive
The combined processes of _______
and ________ contribute to recovery
from radiation damage
Become incorporated into the DNA of
the cell and amplify the effects of
radiation on that molecule.
Responses usually follow high-dose
radiation exposure and appear as an
early response.
Factors that affect Radiosensitivity
After birth , sensitivity decreases until
___ at which time humans are most
resistant to radiation effects.
Is attributable to a repair mechanism
inherent in the biochemistry of the cell
Radioprotective compounds
include molecules that contain a
sulfhydryl group (sulfur and
hydrogen bound together), such
as:
Responses are cancer, leukemia, or
genetic effects.
OER stands for?
Show that human cells can recover from
radiation damage.
Agents that enhance the effect of
radiation are called
Have not found human application
because, to be effective, they must be
administered at toxic levels.
Threshold dose-response relationship
 Non-threshold dose-response Incidence of response increases Severity of response increases with When the radiation dose is doubled, the
relationship with radiation dose radiation dose response to radiation is ____

Indicates that even without radiation

Skin effects resulting from very high
exposure, that type of response, such as
doses in fluoroscopy follow a _____
cancer, occurs
dose response relationship.

.
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