Abstract Book Ipps 2023 Uips Uttaranchal University

IPPS 2023
TWO DAYS
INTERNATIONAL CONFERENCE
ON
INNOVATION IN PHARMACY AND
PHARMACEUTICAL SCIENCES
from Discovery to Practice
ABSTRACT BOOK
APRIL 21, 22 2023
ORGANIZED BY
UTTARANCHAL INSTITUTE OF PHARMACEUTICAL SCIENCES
UTTARANCHAL UNIVERSITY, DEHRADUN
UTTARAKHAND, INDIA
Chancellor’s Message
Dear esteemed delegates

It is my honour and pleasure to extend a warm welcome to all of you to the International Conference
on “Innovation in Pharmacy and Pharmaceutical Sciences: From Discovery to Practice” organized by
Uttaranchal Institute of Pharmaceutical Sciences (UIPS), Uttaranchal University. The conference is
scheduled to take place on 21-22 April, 2023 and we are excited to have you join us for this
imperative event.
Pharmacy and Pharmaceutical Sciences have been evolving rapidly in recent years, and this
conference is an opportunity for experts and researchers from the academia and industry to come
together and share their knowledge and experiences in the field. Through the conference, we hope to
foster collaboration and innovation and create a platform to pave a way to the upliftment of the Drug
Development and Discovery.
I would like to thank the School of UIPS, Uttaranchal University for organizing this conference and
for bring together such a distinguished congregation of National and International bent of scientific
minds on this session. I am confident that your participation in this event will contribute to making it
a successful and rewarding experience for everyone involved.
Once again, I extend a warm welcome to all the delegates and wish you a fruitful and enjoyable time
during the conference.
Best regards,
Shri. Jitender Joshi
Chancellor
Uttaranchal University
Vice President’s Message
Welcome to the International Conference on Innovation in Pharmacy and Pharmaceutical Sciences,

where Uttaranchal University bring together experts and leaders from across the world to discuss the
latest innovations and advancements in the field of pharmacy and pharmaceutical sciences.
As the world rapidly evolves, so do the challenges and opportunities in the pharmaceutical industry.
This conference is a unique opportunity for researchers, clinicians, industry professionals, and
students to exchange ideas, collaborate, and learn about the latest developments in drug discovery,
development, and delivery. With keynote speeches, panel discussions, and workshops led by
renowned experts, this event promises to be an engaging and productive experience.
This conference will cover a range of topics in the field of personalized medicine, drug delivery &
safety, nanotechnology, biotechnology, and much more. We extend our sincere thanks to all the
contributors, reviewers, and editors who made this conference proceeding possible.
The conference is taking place in a vibrant city of Dehradun, North India which provide a perfect
backdrop for networking, exploring, and enjoying the local culture. I look forward to welcoming
you to this conference and creating unforgettable experiences together.
Together, we can shape the future of pharmacy and pharmaceutical sciences.
Best Regards,
Prof. (Dr.) Satbir S Sehgal

Vice President
Vice Chancellor’s Message
I extend my warm welcome to all the National and International delegates on the two days
International Conference entitled as “Innovation in Pharmacy and Pharmaceutical Sciences”
organized by Uttaranchal Institute of Pharmaceutical Sciences (UIPS), Uttaranchal University
Dehradun on 21-22 April, 2023. It gives me an immense pleasure to invite the distinguished galaxy
of speakers who have honored us by giving their precious time and showed their knowledge to all
the participants.
In this time, drug discovery is the most important factor for a growing economy. During the
outbreak of COVID-19 virus, development of vaccine is an example of perfect amalgamation of
scientific knowledge, cutting edge technologies and worldwide networking system. Now a day
drug discovery is not limited to formulate tablet, capsule or other formations but to minimize their
production cost and deliver a panacea for mankind.
So, in this context this International Conference emerges as a boon for the society and scientific
minds.
I sincerely congratulate the Organizing Committee for planning such comprehensive program that
will provide a privileged forum for the discussions on advancements, innovations and also for
arranging the technical session, poster presentations, oral presentation, covering distinctive themes
of the conference.
I wish good luck to all the delegates and participants and look forward to having a fruitful outcome.
Prof. (Dr.) Dharam Buddhi

Vice Chancellor
Pro-Vice Chancellor’s Message
It’s my privilege to address the two days International Conference on “Innovation in

Pharmacy and Pharmaceutical Sciences: From Discovery to Practice” organized by
Uttaranchal Institute of Pharmaceutical Sciences (UIPS), Uttaranchal University on 21-22
April 2023. Pharmacy is an integral part of healthcare system. Innovation in Pharmacy
associated with the advanced technologies, equipment, devices, methods, and service. This is
the demand of present scenario to organize conference on such beneficial and relevant topic.
Through this conference participants interact with the scientific minds of their genre and
fulfill their scientific thrust.
I convey my best wishes to the organizing committee to organize such fruitful conference.
I admire all participating hands implicated in the endeavor.
Prof. (Dr.) Rajesh Bahuguna

Pro Vice Chancellor
Message
from the
Chief Guest
I am glad to know that Uttaranchal Institute of

Pharmaceutical Sciences, Uttaranchal University is organizing a two days International
Conference on “Innovation in Pharmacy and Pharmaceutical Sciences: From Discovery
to Practice” on 21-22 April, 2023.
In this rapidly changing environment, healthcare sector face a new challenge every day.
From the time of malaria to corona virus outbreak, every citizen depends on healthcare
system. Pharmaceutical science is the main pillar for the development of newer
generation medicines. Pharmacy professionals not only deliver medicines but they are
the minds behind the development of new medicines. In this connection, this
International Conference is of prime importance.
The union of scientific minds across the world uplift the knowledge bar of the
participants. This type of conference also helps to improve the scientific personality of
the state.
I sincerely congratulate the Organizing Committee for planning such a comprehensive
program that will provide a privileged forum for the discussions on advancements,
innovations and also for arranging the technical sessions, poster presentations, oral
presentations, covering distinctive themes of the conference.
With best wishes
Prof. Durgesh Pant

Director General
Uttarakhand Council for Science & Technology (UCOST).
Dehradun, Uttarakhand, INDIA.
Welcome Message
from the desk of
Convener
It is indeed gratifying to welcome all the delegates to the two days International Conference on
“Innovation in Pharmacy and Pharmaceutical Sciences: From Discovery to Practice” organized by
Uttaranchal Institute of Pharmaceutical Sciences (UIPS), Uttaranchal University on 21-22 April
2023. This conference will provide a platform for the participants to observe the amalgamation of
National and International scientific minds collaboratively working on the path of upliftment of
Drug Development and Discovery.
Innovation in Pharmacy and Pharmaceutical Sciences are important pillars of the economic growth
of a country. Innovation in technology, scientific and medical domains is the prima choice of a
growing nation. The conference will serve as a platform for sharing new ideas to the budding
scientists.
It will also allow all the participants to interact with various National and International experts
from both Academics and Industry and share their views towards the innovation in Pharmaceutical
Sciences. The expected outcome of this conference is availing the brief of innovation in pharmacy
and pharmaceutical sciences. I assure that the scientific session will offer an implausible occasion
to become skilled under the leading experts from both Academics and Industry.
I am delighted to convey my best wishes to the organizing committee for selecting such innovative
and needful topic in this international conference “Innovation in Pharmacy and Pharmaceutical
Sciences: From Discovery to Practice”.
Best regards
Prof. (Dr.) Vikash Jakhmola

Dean UIPS
Welcome Message
from the desk of
Organizing Secretary
It gives me the utmost pleasure to welcome you all to the International Conference being held on the
beautiful lush green campus of Uttaranchal University in the historic city of Dehradun,
Uttarakhand. I on behalf of the organizing committee welcome you all to the International
Conference on “Innovation in Pharmacy and Pharmaceutical Sciences: From Discovery to Practice.”
This conference will provide an opportunity to bring researchers of National and International
Institutions and industries to one platform. The scientific programme will cover a wide range of
topics, combined with oral and poster presentations, guest lectures, and keynote addresses. The
conference will discuss the research at the fore front of pharmaceutical science such as development
of new knowledge base, discovery of novel medicines, and other poly pharmacological approaches.
The emphasis will be on highlighting the role of pharmacy and allied sciences in academics,
industry, research, and society.
The Organising Committee has worked hard with the guidance of the Dean, UIPS to make the
conference a grand success. At the time when we were entrusted with the task of organising this
conference, we were very thrilled and excited. But down the road, we faced many difficulties and
challenges. However, with the support of our management, colleagues, and advisers we will be able
to sail through this journey and we are hopeful that we would be able to meet the expectations of our
esteemed guests.
I appeal to the research community to extend their continued support and cooperation to the future
activities of Uttaranchal University.
Best regards
Dr. Nidhi Nainwal

Associate Professor, UIPS
Welcome Message
from the desk of
Head of Department
It is my proud privilege and honour to Welcome all of you to the International Conference on
"Innovation in Pharmacy and Pharmaceutical Sciences: from discovery to practice "
organised by Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University which
will be held from April 21-22 ,2023.
This Conference will be an opportunity to share thoughts and exchange of innovative ideas,
recent trends, technical expertise in the field of Pharmaceutical Sciences for the benefits of
researchers, professionals, educators and students on how to chart the journey forward to reach
new heights.
I'm pretty sure- this Conference will be stimulating and productive, the research presentation
and deliberation made in the conference will be of immense useful to the participants and will
inspire them to strive excellence in their domain.
I extend my thanks to all invited speakers, organising committee, conference sponsors like
SERB India, Mankind Pharma, Nitin Life Sciences, Bank of Baroda, Cyborg- ERP,
Anurag Enterprises, CBS publications and supporters for their excellence assistance and
invaluable contribution in the success of conference.
Once again welcoming you all to a wonderful learning and collegial experience.
I add my best wishes for a successful and fruitful conference.
Regards
Dr. Tarun Parashar
Associate Professor
Head of Department, UIPS
SPONSORED BY
ABSTRACTS
Table of Contents
Abstract Title of the Abstract Name of the Author(s) Page
Number Number
A-1 Development of Nano emulsion for oral brain targeted Sukriti Vishwas, Sachin Kumar 1
delivery of Fisetin for the Singh, Monica Gulati, Thakur
treatment of Alzheimer’s disease. Gurjeet Singh, Kamal Dua
A-2 Natural Bioenhancer: A tool for better drug absorption Sunita Singh, Chandan Maurya 1
mechanism.
A-3 A stability research investigation on the effects of Jey Kumar Pachiyappan, 2
simulated microgravity on nanoparticle. Gowthamarajan Kuppusamy,
Jeyaprakash, Karri V V S
Narayana
Reddy, Jayakumar Venkatesan.
A-4 Preliminary investigation of Resveratrol informulation Swati K. Kurtkoti, Harshaben 2
development for treatment of V. Patel.
Non-Small Cell Lung Cancer.
A-5 Role of Cyclodextrins as solubility enhancers in Neha Chauhan, Amit A Patel 3
combination with solubilizing agents
A-6 Fabrication, characterization, and toxicity evaluation of Meghraj Suryawanshi, Birendra 3
chemically cross-linked polymeric material: A proof of Shrivastava
concept.
A-7 Advancement of Nanotechnology and Nanoparticle in Vidhi Upadhyaya 4
diagnosis and drug delivery system for Cancer Treatment.
A-8 Molecular docking analysis of phytochemicals as Shubhra, Presenjit, Vikas 5
antibacterial inhibitors. Anand
A-9 Current status of target proteins for Type 2 Diabetes Prerna Uniyal, Surbhi Panwar, 5
Mellitus drug design strategy. Saumitra Chattopadhyay
A-10 A review on PCOD and its management Deep Pathak, Anoop Singh 6
Negi,Ganesh Kumar.
A-11 Design and synthesis of 2- Satendra Kumar. 6
Chloro/NitrophenylBenzimidazole analogues targeting
melk for thetreatment of Triple Negative Breast Cancer.
A-12 Molecular docking approach to identify potential Himanshi Gupta, Satendra 7
anticancer compounds from plant- derived natural Kumar
products.
A-13 Development and Evaluation of novel formulation of BigulYogeshver Bhardwaj, 7
Chebulinic acid for colon specific drug delivery. Priyanka Vishwas, Poonam
Negi
A-14 RP-HPLC method development and validation for Sumit Kumar, Kiran Singh 8
simultaneous quantification of Diclofenac Sodium and Sharma
Caffeine.
A-15 Targeting FNB 1 Gene and inactivating Zinc Tushar Singhal, NV Satheesh 8
Metallopeptidase to prevent Nuclear Blebbing in Progeria. Madhav,Deepak Goel.
A-16 A review on formulation and evaluation of nanosponges Ajay Pant, Alka Singh. 9
for topical drug delivery.
A-17 Molecular Docking Studies of Cyclodextrin with Drugs. Vaishali, Debadri Banerjee, 9
Anupama Singh, Vikas Anand
Saharan.
A-18 Gender differences and Estrogen role in Surbhi Panwar, Prerna 10
managing Parkinson’s Disease Uniyal, Akanksha Bhatt,
Neelima Kukreti.
A-19 Ethnobotanical and pharmacological uses of Alternanthera Abhishek Chauhan, Arvind 10
Ficoidea (l.) P. Beauv Negi
A-20 Diabetic Retinopathy screening techniques: A review Neelima kukreti, Akanksha 11
Bhatt,, Surbhi Panwar.
A-21 Preparation and in vitro characterization of Diacerein Vaibhav Sisodia,Shaffi K. 11
microsponges loaded topical gels. Tangri
A-22 Artificial Intelligence: New era of Pharma Industries Urvashi Negi, Kapil Kalra, 12
Pragati Bailwal, Jyoti Maithani
Kalra
A-23 Needle- Free Injection Technology Aarti Sati, Mitali Arora 12
A-24 Formulation and development of compression coated Saumya Mishra, Kapil Kalra, 13
colon targeted tablets of Budesonide. Shalini kumari, Ankita Negi
A-25 Development and evaluation of co-surfactant activity of Pankaj Nainwal, Prerna Uniyal, 13
rosuvastatin with peg 400 in form of micro-emulsion. Manu Pant
A-26 Pharmacognosticalpreliminary phytochemical screening Neetu Singh,Arvind Negi 14

and biological evaluation on Embeliaribs burm.
A-27 Automation, robotics, and advances in Artificial Mukul Bhardwaj, Pranshu 14
Intelligence in Pharmacy Tangri, Yamini chandola
Semwal
A-28 Role of acid sensing ion channels in diseases Himani Dumka, Kapil Kalra, 15
Babita Negi, Jyoti Maithani
Kalra
A-29 Organoids: An alternative to animal studies Bhavya Gupta, Ashish Dimri 16
A-30 Gene Editing: The Future of Medicine Anuj Giri, Sarthak Rawat, Kapil 16
Kalra, Vandana Pokhriyal
A-31 Application of ChatGPT in the Queries Related to Surojit Banerjee, Debadri 17
Pharmacokinetics of Cannabidiol and Verification of Banerjee, Anupama Singh,
ChatGPT Answers through a Thorough Literature Vikas Anand Saharan
Searching
A-32 Role of medicinal plants in Traditional and Modern Ankit Kumar, Ganesh Kumar, 17
Medicine: Exploring the potential of purified extracts and Deepak Kumar Semwal
their bioactive.
A-33 Antioxidant and hepatoprotective effect of aerial parts of Alok Bhatt, Anupama Singh, 18
Desmostachya Bipinnata against CCl4 induced liver Pallavi Ghildiyal
damage.
A-34 Phytochemical and antioxidant activity of Asplenium Jaideep S. Rawat, Aadesh 19
Dalhousiae methanolic extract from Nainital district of Kumar*, MahendraRana, Amit
Uttarakhand. J.Rana, Arasana
A-35 General overview on: A Wild traditional medicinal Alka Tailwal, Arvind Negi, 19
plant: Angel's trumpet Vinita Chauhan
(Brugmansia Suaveolens:Solanaceae)
A-36 Molecular Docking: A Drug Design Method Krati, Neelam Painuly, 20
Amandeep Singh Baghla
A-37 Synergistic potential therapeutic effects of Medicago Sachin Kumar, Ashok Kumar, 20
Sativawith Panax Ginseng and comparison between their Suhasini Nayal
phytochemical and nutritional profiles
A-38 Curcuma caesiaroxb. as an herbal medicine: A review Vinita Chauhan, Arvind Negi, 21
Alka Tailwal, Kapil Kalra
A-39 An overview of Process Validation in Pharmaceutical Megha Shivani, Suman Yadav, 21
Industry Kapil Kalra, Arti Raturi
A-40 Automation, Robotics and Advances in Artificial Mukul Bhardwaj, 22
Intelligence in Pharmacy PranshuTangri, Yamini
Chandola Semwal
A-41 Modification of physicochemical properties of Chitosan to Khanwelkar C. C., Shete A. S, 23
improve its Shah N. V.
Pharmaceutical Applications
A-42 Hydroxyethyl Cellulose as a versatile viscosity modifier in Vijaya Kumar J, Ajay Kumar 23
the development of sugar-free, Elegant Oral Liquid Dantuluria, Yi Liu,Thomas
Formulations Durig
A-43 Phytosomes: A novel approach for the targeted drug Vineet Joshi 24
delivery system
A-44 Cedrus deodara (Roxb. ex D.Don) G.Don“Wood of The Harshita Chandra, Indu Tewari, 25
Gods”: an inclusive study Sanjay Singh
A-45 Asparagus: A Medicinal Genus with Promising Anoop Singh Negi, Veerma 25
Phytochemistry and Pharmacological Activities Ram and Ganesh Kumar
A-46 Cubosome: A suitable nanocarrier for pharmaceutical drug Pragati Bailwal, Ashutosh 26
delivery system Badola
A-47 An Overview on Nanocarriers for Skin Problems Mayuri Gupta 26
Nimisha, A. K. Rai
A-48 Evaluation of antidepressant activity of the ethanolic Shivani Verma, Aarti Sati 27
extract of Pongamia Pinnata bark in Albino Wistar rats
A-49 Application of Nanosponges for toxin elimination from Shalu Verma, Alka Singh 27
contaminated water
A-50 Formulation and characterization of Linezolid loaded Ashutosh Bandola, Vivek 28
microcapsule in capsule shell Chauhan
A-51 Tuberculosis Biosensors: An Overview Jyotsana Bhatt, Archana 28
Dhyani, Ashish Dhyani
A-52 Understanding the concentration variation in Serum Sristi Anupam, Simran, Rina 29
Alkaline Phosphatase in patients of Das
Type 2 Diabetes Mellitus with hypertension
A-53 Anogeissus Latifolia: A Spectral Tree Holding Copious Mansi singh, Siva Prasad Panda, 29
Medicinal Properties Sanjesh Kumar, Kundan kumar
Chaubey
A-54 Review of a novel method for Microsponges drug delivery Mohammad Khalid, Umesh 30
mechanism Kumar Sharma
A-55 Assessment of health-related Quality of Life among Type Simran, Sristi Anupam, Rina 30
2 Diabetes mellitus patients with hypertension Das
A-56 The creation of molecules containing Imidazoles and their Meenu Chaudhary, Ashutosh 31
potential for healing Badola
A-57 Understanding Tirzepatide's function in the treatment of Ansh Aggarwal, Mayank Joshi 31
Type-2 Diabetes
A-58 A better bioavailabity by Oro Trans Soft Palatal Drug Srishti Morris, Ashutosh Badola 32
Delivery
A-59 Metal Organic Frameworks: A Recent Trend In Drug Varnit Tyagi, Chandan 32
Delivery Bhogendra Jha, Rashi Mathur,
Rajesh Kumar
A-60 Role of phytoconstituents against premature skin ageing Amreen, Vaibhav Rastogi, 33
Anurag Verma
A-61 Review on nutritional value and health benefits of Setaria Hemlata Bhatt 34
italic Syn. Panicum italicum (Foxtail millet)
A-62 Artificial Intelligence: Artificial Neural Networks NishikaAmankar, Bhavya Gupta 34
A-63 Formulation, evaluation of scaffold and comparative Lovely Chaurasia, 35

studies with transferosome for topical delivery in the Gaurav,MojahidUl Islam
treatment of wound healing
A-64 Fabrication, characterization and toxicity evaluation of MeghrajSuryawanshi, Birendra 35
chemically cross-linked polymeric material: A proof of Shrivastava
concept
A-65 Anti-Parkinson activity of Acorus Calamus Linn. using Sarfraz Ahmad, Sudhir Kumar 36
Haloperidol catalepsy Model Mishra, Farah Deeba, Nishu
Gautam
A-66 Evaluation of bacterial asthmatic treatment strategies: Devesh Kumar, Dushyant 37
targeting toll like Receptor4-myeloid differentiation-2 Kumar Mishra, Nishu Gautam,
complex inhibition Nishikant Gaur
A-67 Molecular mechanism of polyphenols in skin aging Deepti Dwivedi, Nimisha, Satya 37
management Prakash Singh
A-68 Significance of Computer Aided Drug Design (CADD)in Sakshi Duklan, Kiran Dobhal 38
Modern Medicine
A-69 Butterfly pea: An ideal candidate for Nutraceutical Anuradha Rawat, Ashish Dimri 38
Applications
A-70 Development and applications of Micro and Archana Dhyani, Nardev Singh, 39
Nanorobotics in drug delivery Ashish Dhyani
A-71 Immunotherapy: A Revolution in Cancer Treatment Vandana Pokhriyal, Kapil 39
Kalra, Subodh Negi
A-72 Natural vs Synthetic hydrotropes D Vidya Aashiyana Rai, Mamta 40
Chauhan, Jyoti Joshi
A-73 Design, formulation, and characterization of microcapsules Ankita Negi, Ashutosh Badola 40
of NSAID drug
A-74 Innovative 4D Printing Approaches to Address Debadri Banerjee, Surojit 41
Customization and Delivery Challenges of Drugs to Hard- Banerjee, Anupama Singh,
to-Reach Body Orifices in Humans Vikas Anand Saharan
A-75 Hydroxychloroquine (HCQ): Uses and its following ADRs Gulfsha Parveen, Divya 42
Chauhan, Mamta Chettri,
Ayushi Parcha
A-76 Teratogenic effect on different stages of Pregnancy EkshaSunderka, Jhuma Samanta 42
A-77 Proteomics Aarti Sati , Vibhanshu Bansal 43
A-78 Microneedle Patches: A Novel Approach for Transdermal Vanadan Sahani 43

Drug Delivery
A-79 Ethosomal gel for topical delivery of Mefenamic acid in Sunayana Tyagi, Prabhakar 44
the treatment of Rheumatoid Arthritis Vishakarma
A-80 Biogenesis, isolation, and applications of Cow milk- Riya Mahar 44
derived Exosomes
A-81 Identification and Assessment of different types of toxicity Ravi Ranjan Kumar, Jhuma 45
Samanta
A-82 Exploration of Rutin and its formulation for the treatment Jyoti Vishnoi, Mamta F. Singh 45
of Alzheimer’s Disease
A-83 Formulation and evaluation of Panchchurna Gufran khan, Jyoti Joshi 46
A-84 Modeling of Pharmacophore QSAR developing and Sonika Rani, Neelam Painuly, 46
validation Amandeep Singh Baghla
A-85 In-silico molecular docking and ADME studies of Harsh Agarwal, 47
naturally derived polyphenols for Xanthine Oxidase Shami Ratra Chaddha
inhibitory activity
A-86 Controlled Drug Delivery System Jyoti Srivastava, Kajal Chauhan, 47
Vikas Jakhmola
A-87 Next Generation Pharma: Unlocking QbD Advantages Komal Soni, Surojit Banerjee, 48
with Commercial Software Debadri Banerjee, Anupama
Singh, Vikas Anand Saharan
A-88 A Mucoadhesive as a Gastroretentive Drug Delivery Harsh Upadhyay, Jyoti Joshi 48
System
A-89 Sleep and related disorders Mohit Varshney, Supriyo Saha, 49
TaruSaklani, Tarun Parashar,
Vikas Jakhmola
A-90 Self-Nano Emulsifying Drug Delivery System as a Novel Sanjeev Kumar, Naman Singh 50
Approach Rawat, Jyotsana Suyal
A-91 Monitoring of ADR department of neurology epilepsy of a Sakshi Saini, Jhuma Samanta 50
tertiary care hospital
A-92 Predictive Software Tools for ADME in Drug Discovery Mahalaxmi Muskan, Surojit 51
Banerjee, Debadri Banerjee,
Saharan
A-93 Role of product development and management on Aakash Bhanu Tiwari, Jhuma 51
manufacturing company Samanta, Jyoti Joshi
A-94 The Consumption Scenario of Nutraceuticals Globally Anand, Lokesh, 51
MahamedhaDeorari, Vikas
Jakhmola
A-95 Formulation and evaluation of herbal toothpowder Akash Samanta, Jyotsana Suyal, 52
Vikash Jakhmola
A-96 Polypharmacy &Social Economic Problems Anamika Kumari, Jyoti Joshi 53
A-97 Commercial Software of Optimization for Gagandeep Singh*, Surojit 53
Pharmaceutical Formulation: A Game-Changer in Drug Banerjee, Debadri Banerjee,
Development Anupama Singh, Vikas Anand
Saharan
A-98 Mouth Dissolving Drug Delivery System in Geriatric Ayush Mishra, Jyoti Joshi 54
Patient
A-99 Antimicrobial resistance: A serious complication of Zainab Parveen, Swati Kumari 54
Antibiotics Chhavi Chauhan, Kiran Dobhal
A-100 Insect repellent using natural agents Ankita, Jhuma Samanta 55
A-101 Formulation and evaluation of drug-loaded 3D-Printed Pallavi Joshi, Ashutosh Badola 55
filaments via hot-melt extrusion
A-102 Monitoring of ADR department of Cardiology Harshit Chaurasia, Jyoti Joshi 55
Hypertension of a Tertiary Care Hospital
A-103 Use of 3DPrinting technology for Customized Dosage Swati Kumari, Jyotsana Suyal 56
Forms and drug delivery systems
A-104 Paediatrics’ challenges with the Oral Drug Delivery Pankaj Singh Karki, Anil Rawat 57
System and current methods
A-105 Molecular Pharmacology Sanjana Katlaria, Mahamedha 57
Deorari
A-106 Prevalence of diabetes in India Kabita Sharma, Jhuma Samanta 58
A-107 Adverse Drug Reactions and Pharmacovigilance of herbal Jyoti Pandit, Tarun Parashar 58
medicine in India
A-108 Applications of CRISPR- Cas9 in Therapeutics Marhaba Rashid Mohammed, 59
Laxmi Singh
A-109 Navigating the Literature – Salient Features of Biomedical Avantika, Surojit Banerjee, 59
Sciences Databases Debadri Banerjee, Anupama
A-110 Evaluation & formulation of Sunscreen Stick: A novel Bhawana Bhatt, Sudhakar 60
innovative approach for photoprotection Kaushik, Anupriya Sundriyal
A-111 Overview of cosmeceutical Smriti, Chhoti Kumari, 60
MahamedhaDeorari,Vikas
Jakhmola
A-112 Application of Biosensors Abhishek Chauhan, Mahamedha 61
Deorari
A-113 Self-Emulsifying Drug Delivery System Sarvesh Tripathi, Jhuma 62
Samanta
A-114 Antibiotics Resistance Aman Bhatt,Shaheen 62
Anjum,Sachin Kumar
Verma,Joytsana Suyal
A-115 Optimizing Drug Formulations with Machine Learning Geetika Gupta, Surojit Banerjee, 63
Algorithms Debadri Banerjee, Anupama
A-116 Organoid Intelligence (O.I.) Aditya Kumar, Pranjal Bisht, 63
Pallavi Ghildiyal
A-117 Orally Disintegrating Films: A novel convenient dosage Diwas Adhikari, Meenakshi 64
form for rapid relief Kandwal, Shivanand Patil
A-118 A review of the phytochemical and pharmacological study Lalita Rawat 64
of Berberis Asiatica (Kilmoda)
A-119 Pharmaceutical Formulations Design and Development: Gaurav Chandra, Surojit 65
An Expert System Approach Banerjee, Debadri Banerjee,
Saharan
A-120 Application of Ofloxacin Nandini Chaturvedi 65
A-121 Preventive effects of Polyalthia Longifolia against Divya Bisht, Arvind Kumar 66
Gentamicin-induced nephrotoxicity in Wistar rats Shakya, Deena Prakash,
Ramesh Kumar, Sangeeta
Shukla
A-122 Formulation and Development of herbal Gel containing Kalash Mishra, Divya Rawat, 66
Cannabis Sativa and Neem leaves extract for Anti- Akshanda Chandel, Shiva Rana,
inflammatory and Anti-bacterial activity Deovrat Kumar
A-123 Preparation and characterization of Schiff base Metal Piyush Kumar Singhal, Arvind 67
complexes Kumar, Bhuwanendra Singh
A-124 Targeted Drug Delivery Systems Vani Chandravansi, Chinkey 67
Mittal
A-125 Uneasiness activity of inclusion complex of Mahima, Bhuwanendra Singh, 68
hydroxyPropyl β-cyclodextrin Arvind Kumar
with Acorus Calamus oil
A-126 Advancement of nanotechnology and nanoparticles in Anushree Sammal, Chinkey 68
diagnosis and drug delivery system for cancer treatment Mittal
A-127 Markov Modeling for Assessing Cost-Effective Analysis Ashutosh Bhandari, Surojit 69
of Pharmaceutical Drug Products Banerjee, Debadri Banerjee,
Saharan
A-128 Pharmacological investigation of Celtis Australis for Anuj Giri 69
castor oil induced diarrhea inAlbino mice
A-129 Brief insights on Digital Pills with Ingestible Sensors Shivani Bisht 70
A-130 Artificial Intelligence Algorithms for the Recognition of Meenakshi tyagi, Aarti Prajapati 70
Skin Diseases
A-131 In-Vitro Models for Studying Diabetes: Advances, Jyoti Sharma 71
Techniques, and Considerations
A-132 Key Development in the Area of Artificial Neural Network Aman Kumar, Debadri 71
for Pharmaceutical Optimization Banerjee, Surojit Banerjee,
Saharan
A-133 Neurological Activity of Pueraria montana (Aerial Part) Mohammad Shami, 72
Extract Bhuwanendra Singh, Arvind
Kumar
A-134 Advances in-vitro Models for Understanding Arthritis: Himanshi Rathaur 72
Techniquesand findings
A-135 Antibiotic resistance: A threat to mankind Abhit Kumar, Mansi Pal 73
A-136 Computationally establish new role of iridoid in the Sakshi Duklan, Samiya, Kiran 74
treatment of Zika and Influenza (H3N2) viruses Dobhal, Sarkar M. A. Kawsar,
Vikash Jakhmola, Prinsa,
Supriyo Saha.
A-137 A Review on Microsphere Arunava Biswas 74
A-138 Development, preparation and characterization of buccal Sudhir Priyadarshi, Shaffi K. 75
tablets of Ethamsylate Tangri
A-139 Robots for Aseptic Manufacturing of Parenteral Ruchika Rawat, Surojit 75
Saharan
A-140 Precision Medicine: Better frame of treatment Aarti Sati, Kritika Saini 76
A-141 Natural Products as Potential Therapeutic Agents for Vaishali Koul 76
Parkinson Disease
A-142 Formulation and Evaluation of Herbal Lipsticks Ashutosh Badola, Meenu 77
Chaudhary
A-143 The Impact of genomics in drug discovery and in Aarti Sati, Priya Joshi 77
Pharmacy
A-144 Drug repurposing in Tuberculosis: A hope for MDR Mansi Pal, Abhit Kumar 78
Tuberculosis
A-145 Streamlining Drug Development with in Silico Shubham Chauhan, Surojit 78
Pharmacokinetic Characterization of Pharmaceutical Banerjee, Debadri Banerjee,
Formulations Anupama Singh, Vikas Anand
Saharan
A-146 Innovation approach to control Hyperthyroidism Aarti Sati, Mansi Chaudhary 79
A-147 Pharmacology, morphology, and chemical constituent of Shahin saifi,Luxmi Yeasmin 79
Rosa Damanscenaand their role in Hypertension
A-148 Formulation and evaluation of ocular inserts of Ashutosh Badola, Nazim 80
Fexofenadine
A-149 Efficient Aerosol Delivery: Harnessing CFD for Himani Pant, Debadri Banerjee, 80
Pulmonary Drug Delivery Optimization Surojit Banerjee, Anupama
A-150 Exploration of Bioactive profile of Magnolia species Purabi Saha, Amit Semwal, 81
Vikash Jakhmola, Supriyo Saha
A-151 A Review on Gene Therapy Vidya Marwal 81
A-152 Neuroprotective effect of selected drug in rotenone Priya Kumari 82
induced Parkinsonismin Experimental rat
A-153 Orally disintegrating tablets: A boon and future of Sharada Pokhrel, Arti Kori, 82
ModernPharmaceutics Shivanand Patil
A-154 Robotic System for Precise Drug Delivery Sambhavi Mamgain, Surojit 83
Saharan
A-155 Strategies and new technologies in drug discovery and Khushi Tyagi 84
drugdevelopment
A-156 A new recent proteolytic enzyme: Serratiopeptidase. Payal Saxena 84
A-157 Herbal drug discovery: Challenges and perspectives Arpit Kumar 85
A-158 Comparison of Dissolution Profiles, Modeling of Aniket Sharma, Surojit 85
Dissolution and Banerjee, Debadri Banerjee,
Predicting Dissolution of Drug Formulations Anupama Singh, Vikas Anand
Saharan
A-159 A review on Flaxseed for the health and diseaseprevention M. Mamta, Farswan AS 86
perspectives
A-160 Recent trends and methods in antimicrobial drug discovery Tannu Chaudhary 86
from plant sources
A-161 A Comparison of Reference Management Softwares for Ram Prasad, Surojit Banerjee, 87
Research Debadri Banerjee, Anupama
A-162 Micellar nanoparticle based novel drug delivery strategy Aachal Patel, Swati Kurtkoti 87
for the treatment of Psoriasis-a preliminary investigation
A-163 Quality by design (QbD) in innovation in Pharmacy and Dixit Thakur 88
Pharmaceutical sciences: From discovery to practice
A-164 Formulation and evaluation of transdermal patch of Abdul Ahad, Chinkey Mittal 88
Aceclofenac
A-165 Formulation and evaluation of suspension nanoparticles Shubham Singh, Rahul Kumar, 89
delivery of Phoenix Dactylifera (Date fruit) for childbirth Gulafshan Parveen
pain reliever
A-166 Robots Take the Lead in 3D Printing of Dosage Forms: An Khushbu Arora, Surojit 89
Insight into Advancements Banerjee, Debadri Banerjee,
Saharan
A-167 Coumarin: A promising Pharmacophore in Medicinal Ritesh Rana, Priyanka 90
Chemistry Devi,Gauree Kukreti
A-168 Avaleha: An Herbal Formulation for Immunomodulation Tulsi Chauhan, Anupama Singh 90
A-169 A review on Self Nanoemulsifying Drug Delivery System Reetika Gupta, Gauree Kukreti 91
A-170 Bioelectric Medicines: A revolution in Modern Medicine Muskan Bhagat, Sayantan 91

Mukhopadhyay
A-171 Personalized Medicine- A need of future Soumya Singh, Sayantan 92
Mukhopadhyay
A-172 Formulation and evaluation of tablet of Areca nut for the Afshan Ansari, Nitish Kumar, 92
treatment of Helminthiasis disease Gulafshan Parveen
A-173 3DPrinting: A step towards Modernised Medicines Divyanshu, Sayantan 93
Mukhopadhyay
A-174 Determination of pesticides residues on fruits and Ashish, Sayantan 93
vegetables by non-destructive methods Mukhopadhyay
A-175 Preparation and in vitro of transdermal patches for Anzla Shirin, Shaffi K. Tangri 93
management of mental stress
A-176 A review on recent advancements in Aptamer based Komal, Sayantan 94
sensing techniques and its therapeutic application Mukhopadhyay
A-177 Exploratory studies using Molecular Docking Gauree Kukreti, Vijay Juyal, 94
Rajeshwar Kamal Kant Arya
A-178 Promising Nanotechnology based approaches in clinical Yamini Pant*, Surojit Banerjee, 95
trials for treating Glaucoma Anupama Singh, Vikas Anand
Saharan
A-179 Evaluation of medicinal plant Achyranthes Aspera Sarvesh Kumar, Vijay K. Jyoti, 95
Ranjit Singh
A-180 A Review on Nanoparticles Anuj Kumar, Sayantan 96
Mukhopadhyay
A-181 Formulation and evaluation of anti-acne herbal gel Ruchita Negi, Shaffi K. Tangri 96
A-182 Pharmacological activities of Mikania genus: A review H. Lalruatdiki, Rita Saini, 97
Shivanand M. Patel
A-183 Herbs for COVID-19 Varnika 97
A-184 Tissue Chips: Innovative Tools for Drug Development and Arbaz khan, Tarun Parashar, 98
Disease Modelling Jyotsana Suyal
A-185 An overview on recent advantages and future treatment of Ishika Chakraborty, Tarun 98
Polycystic Ovary Syndrome (PCOS) Parashar,Shalu Verma
A-186 Quantum Dots Neha Kandpal, Nidhi Nainwal, 99
Vikash Jakhmola
A-187 Gold compounds as anticancer agents Aarti Sati, Shagufta Jawaid 99
A-188 Pulsatile Drug Delivery System Latika Bisht, Tarun Parashar, 100
Vikash Jakhmola
A-189 Computational Prediction of Protein Structure Sapna Rana, Amandeep Singh 100
Baghla
A-190 Microneedle-based insulin transdermal delivery system: Shivam Tyagi, Nidhi Nainwal, 101
Current status and translation challenges Vikash Jakhmola
A-191 Process Validation of Rosuvastatin tablet(10mg): HMG- Tanya Sehgal 101
COA Reductase inhibitor
A-192 Gold Nanoparticles Shivansh Khaudiyal, Nidhi 102
Nainwal, Tarun Parashar,
Vikash Jakhmola
A-193 Colon Targeted Drug Delivery System Rishabh Mishra, Tarun 102
Parashar, Vikash Jakhmola
A-194 Pharmacological management of Non-Alcoholic Fatty Shalini Bohra 103
Liver Disease (NAFLD)
A-195 Dry Powder Inhaler Rakshanda, Nidhi Nainwal, 103
Yogita Ale, Vikash Jakhmola
A-196 Niosome Transdermal Patch of Ketoconazole Gaurav Joshi 104
A-197 Innovative Research: Determination of SPF of leaves Sneha Gupta, Sudhakar 104
extract of DovyalisCaffra Kaushik, Bhawana Bhatt
A-198 Big Data Analytics for Healthcare in the Future: A Vaibhav Adhikari, Nidhi 105
Comprehensive Review Nainwal, Vikash Jakhmola
A-199 In-vitro assessment of anti-inflammatory activity of Ayushi, Sudhakar Kaushik 105
ethanolic
stem bark extract ofHibiscus Rosa Sinensis Linn.
A-200 An Overview of Liposomes for Targeted Delivery Aakash Tripathi, Shalu Verma, 106
Vikash Jakhmola
A-201 A review: strategies for producing and developing Aman Rajput, Bhupendra 106
genetically engineered plants for viral resistance Kumar, Yogesh Tiwari, Smriti
Kumari, Sidra Wazir
A-202 Application of Nano-pore Sensors for Biomolecular Asif Ali, Nidhi Nainwal, Vikash 107
Interactions & Drug Discovery Jakhmola
A-203 Nanocarriers for effective management of pancreatic Nyanbeni, Nidhi Nainwal, 107
cancer Vikash Jakhmola
A-204 Protein derived biosensor for pharmacokinetic studies and Saurav Chamoli, Nidhi 108
drug screening Nainwal, Vikash Jakhmola
A-205 Pharmacist: A bridge between patient and physician Vishwajeet Anand, Amit 108
Semwal, Vikash Jakhmola,
Supriyo Saha
A-206 Gene therapy for inherited problems in neonates Bhawna 109
A-207 Role of Artificial Intelligence in disease management and Abhishek Bhatt, Lata Bisht 109
health care system
A-208 Innovative research: evaluation of sunscreen activity of Sudhakar Kaushik, Bhawana 110
cream containing leaves extract of Withania Somnifera for Bhatt, Payal Saxena
topical application
A-209 Automation and robotics for Sorting, Packaging, and Pranjal Bisht, Nandini 110
Dispensing Bhardwaj, KiranDobhal
A-210 Natural product-based nanomedicine in the treatment of Harshit Mishra, Rita Saini, 111
Inflammatory Bowel Disease: a concise review Shivanand Patil
A-211 Nanosponges: A potential approach for drug delivery Alka Singh, C.S. Chauhan 111
A-212 Current Use and Future Prospects of Nanoparticles Neeraj Kandpal, Tarun Gupta, 111
Containing Anticancer Drugs Vasu Sharma, Jyotsana Suyal
A-213 Novel approaches of polyherbal matrix tablet in term of Muskan Kumari Prasad, Jaya 112
better therapeutic efficacy Rautela, Vikash Jakhmola
A-214 Mucoadhesive agent in recent advancement of Nasal Drug ItikaGuleria, Jaya Rautela, 112
Delivery System Vikash Jakhmola
A-215 Drug products of Recombinant DNA technology Samiya, TaruSaklani, Vikash 113
Jakhmola
A-216 Review on roll of traditional herbal drugs in treatment of Parul Sharma, Rishi Pal, Irfan 114
Age-related CNS disorders. Ali, Hema Chaudhary
A-217 Formulation and evaluation of transdermal therapeutic Ashutosh Badola, Anjali 114
system for delivering nano size Itraconazole Gurung
A-218 An overview: Viral infection and their mode of entrance in Akanksha Bhatt,Neelima 114
host cells Kukreti,Surbhi Panwar, Prerna
Uniyal
A-219 Essential oil: New hope to overcome antimicrobial Surabhi Shakya, Amit Kumar 115
resistance Verma
A-220 Development and evaluation of oral dispersible film of Ruchi Sharma, Deepika Joshi 115
local anaesthetic agent
A-221 The newer skin model for Cosmeceuticals testing Aashta Gajjar 115
A-222 Nano Drug Delivery for Neurological Disorders Rimpal Kanyal 116
A-223 Precision Medicine Shivam Kumar 116
A-224 Medicinal Properties and Uses of Bryophyllum Pinnatum Taru Saklani, Janhvi Dubey, 117
(Pattharchata) Jasvinder Singh, Harsh
Chaudhry, Tanuja Vyas
A-225 Design expert based approach for statistical optimization Kapoor Bhawana, Bilandi Ajay, 117
of antihypertensive Losartan potassium Nanoparticles Bhatt Sarswati Prakash
using Box- Behnken Design
A-226 Polypharmacological and computational approaches to Pallavi Pandey, Samiya, Sakshi 118
establish HDAC inhibitors in the treatment of Alzheimer Duklan, Mohammad Asif,
Vikash Jakhmola, Prinsa,
Supriyo Saha
A-227 Dysfunction of Thyroid hormone during pregnancy Ahmed AyuvaDawa, Dipika 118
Rawat
A-228 Relationship of Blood Pressure on Type 2 Diabetes Okoro Chibuike Bonaventure, 119
Mellitus patient Dipika Rawat
A-229 In silico study of Tephrosia Purpurea phytocompounds as Shivani Rawat 119

Antidiabetic agent by targeting α-Glucosidase and α-
Amylase enzyme
A-230 Baicalein loaded solid lipid nanocarriers for Mansi Varshney, Poorvi 120
neurodegenerative disorders Varshney, Bhavna Kumar,
Neeraj Kumar Sethiya,
Manmohan Singhal
A-231 Nanocarriers: A potential tool for topical delivery of Archana Sharma, Rupa 120
Antihypertensive drugs Mazumder, Ganesh Kumar
A-232 Development of unnatural amino acids (UAA’s): A trendy Rupali Joshi, Gurjeet, Ajay 121
scaffold for innovative pharmaceutical research Singh Bisht
A-233 Interest towards versatility of Iridoids and its novel Monika, Neeraj Kumar 121
mechanistic approach
A-234 Therapeutic potential of Curcuma Caesia (black turmeric) Kushwaha Amit, Kapoor 122
for topical drug delivery Bhawana, Kala Shivani
A-235 Mishandling of pMDI and DPI inhalersin Asthma and Manish Kumar, Poonam Joshi 122
COPD
A-236 Artificial Intelligence: An achievement of modern Health Lakshaya Sharma, Abhishek 123
Care System Sharma
A-237 Monkey Pox Himanshu Pandey, 123

MahamedhaDeorari, Vikash
Jakhmola
A-238 Onychomycosis: Current Therapy and Future Provocation Ayushi, Nidhi Nainwal, Mansi 124
Butola,Vikash Jakhmola
A-239 Comprehensive review on the medicinal plant of northeast HimankoGogoi, Sanskriti Rai 125
region of INDIA
(Solanum torvum)
A-240 Formulation and Evaluation of Floating Microsponges for Rohit Sharma 125
ODDS
A-241 Development and in-vitro characterization of liposomal Mohini Rawat, Dr. G. 126
embedded in-situ ocular gel of Dorzolamide hydrochloride Gnanarajan
for the treatment of Glaucoma
A-242 Comparative HPTLC profile and Antimicrobial activity of Akriti Rawat, Akash Tyagi, 126
Leaves and Rhizomes of Acrous calamus Linn.” Ajay Singh Bisht
A-243 Formulation and Evaluation of Mucoadhesive tablets for Saheda Begam, Satyam sah 127
gastro-retentive drug delivery using natural polymers.
A-244 Awareness of Intellectual Property Rights among different Ritesh Jha, Pallavi Ghilidiyal 128
Universities of INDIA
A-245 Aerosol of Paracetamol Aman Kumar, Vikash Jakhmola 128
International Conference
on
“Innovation In Pharmacy & Pharmaceutical Sciences: From Discovery to Practice”
A-1
Development of Nano emulsion for oral brain targeted delivery of Fisetin for the
treatment of Alzheimer’s disease
Sukriti Vishwas1, Sachin Kumar Singh1,2*, Monica Gulati1,2, Thakur Gurjeet Singh3, Kamal Dua2,4
1
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India
2
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of
Technology Sydney, Ultimo, NSW, 2007, Australia
3
Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab 140401, India
4
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007,
Australia
sukritivns92@gmail.com
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that affects mainly aged patients.
Various pathogenic factors such as degeneration of cholinergic neurons, enhanced oxidative stress and
enhanced neuroinflammation are responsible for progression of AD. As per recent reports, more than 44
million people are affected by AD worldwide. The present study was designed to investigate the
neuroprotective properties of Fisetin nanoemulsion against the streptozotocin induced AD in Sprague
Dawley (SD) mice. Nanoemulsion of fisetin was prepared by using spontaneous emulsification method.
Box-Behnken design (BBD) was used to optimize the formulation. The mean droplet size, zeta potential,
polydispersity index and drug loading of the optimized fisetinnanoemulsion was found to be 32±1.21 nm, -
15.99±0.58 mV, 0.26±0.51 and 99.5±2.25%, respectively. AD was induced to the SD mice through
administering 3 mg/kg of streptozotocin through intracerebro ventricular injection and then supplemented
with the 5 mg/kg and 10 mg/kg of fisetinnanoemulsion orally from 4th day to 23rd day. The behavioural
changes were examined using step down passive avoidance and morris water maze test. Our findings
recommended that the treatment with fisetinnanoemulsion could ameliorate the cognitive impairment by
suppressing the neuroinflammation and oxidative stress in the rats induced by streptozotocin.
Keywords: Alzheimer’s disease, Fisetin, Nanoemulsion, Aluminium chloride, Neuroprotective effects.
A-2
Natural Bioenhancer: A tool for better drug absorption mechanism
Sunita Singh*, Chandan Maurya
Department of Chemistry, Navyug Kanya Mahavidyalaya, University of Lucknow, Lucknow-226004, UP. (India)
oceans.singh@gmail.com
The term bioenhancer was first coined by Indian scientist C.K. Atal, the Director of the Regional Research
laboratory, Jammu, who discovered and scientifically validated the world’s first bioavailability enhancer,
Piperine in 1979. Bioenhancers are the molecules, which do not possess drug activity of their own at the
dose used but promotes and augment the bioavailability or the uptake of drugs in combination therapy.
They got also mention in Ayurveda in which Sanskrit term “Yogvahi,” is referred for bioenhancers which
means “to rise in effect.” Theyreduce the dosage, cost, toxicity, and other side effects, as well as the amount
of time it takes to act. Piperine molecule acts as bioenhancer for the drugs namely Nevirapine, Rifampicin,
Propranolol, Nimesulide, Ciprofloxacin. Piperine appears to top in the list of bioenhancers as it has been
used as bioenhancer for Allopathic, Ayurvedic and Unani drugs. Piperine enhances Cmax of different drugs
significantly. Different bioenhancers may have the same or different mechanisms of action. Bioenhancers
are considered to enhance the bioavailability of companion drugs either by inhibiting the drug metabolizing
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enzyme, cytochrome P450 or by transepithelial electrical resistance factor (TER) in controlling the
permeability of intestinal mucosa.
Keywords: Bioenhancer, Bioavailability, Dosage, Piperine, Cytochrome P450.
A-3
A stability research investigation on the effects ofsimulated microgravity on nanoparticle
Jey Kumar Pachiyappan1,Gowthamarajan Kuppusamy1 *, Jeyaprakash2, Karri V V S Narayana
Reddy 1, Jayakumar Venkatesan 3
1
Department of Pharmaceutics, JSS College of Pharmacy, Ooty, The Nilgiris, Tamil Nadu.
2
Department of Pharmaceutical Analysis, JSS College of Pharmacy, Ooty, The Nilgiris, Tamil Nadu.
3
CEO, Valles Marineris International Private Limited, India.
jeyk984@gmail.com
During the space travel mission, astronauts' physiological and psychological behavior will alter, and
they will start consuming the terrestrial drug product. Despite microgravity, radiation exposure, rapid
changes in temperature and humidity, strong vibrations, dense vacuum, and other issues encountered, the
drug product undergoes physicochemical changes. It will ultimately impact the shelf life and diminish the
Pharmacokinetic and Pharmacodynamic profile of the drug product when API and inactive ingredient
(excipient) are exposed to the space environment, leading to changes in the structure of the compound.
Consequently, these changes in the physical and chemical properties will produce a loss of potency and the
formation of toxic degradation products. Similarly, it will affect the excipient, which reduces the activity of
the excipient, and the formation degradation product will influence the potential of the drug substance. In
these states, novel formulation strategies play a crucial role in preventing the formation of impurities,
degradant products, and potential loss of drug substances. Nano-sized drug delivery can control the drug
from hydrolytic and enzymatic degradation. Additionally, they provide the advantages of delivering the
drug to specific sites of the body at a predetermined time interval. It will also provide stability to the
photolabile drugs, exhibiting significantly less photodegradation over radiation exposure. The
pharmacokinetic and pharmacodynamic analogs of non-clinical studies can also be evaluated using rodent
hind limb suspension analog studies. Through these rodent suspension studies, we can understand the drug
plasma profile, altered PK/PD, usage and effectiveness, and drug stability during the space mission.
Keywords: Nanoparticle, Microgravity, Pharmacokinetic, Stability, Clinostat-3D,Pharmacodynamic.
A-4
Preliminary investigation of Resveratrol informulation development for treatment of
Non-Small Cell Lung Cancer
Swati K. Kurtkoti*, Harshaben V. Patel
IndukakaIpcowala College of Pharmacy, CVM University, New Vallabh Vidyanagar, Anand, Gujarat, India
swati.kurtkoti@cvmu.edu.in
Resveratrol (RSV) is a polyphenols’ stilbenoids group associated with several health benefits. It has been
reported in various cancer with wide spectrum of activity. However, RSV has limited clinical use due to its
low oral bioavailability and instability. The present investigation was carried out to study the effectiveness
of RSV in treatment of non-small cell lung cancer and development of formulation thereof. Analytical
method was developed using LC/MS/MS. The physicochemical properties of the drug were studied along
with stability. The MTT assay and Scratch assay was carried out using A549 cell lines to determine the
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IC50 value of the drug for treatment of NSCLC. The solution state pH stability of resveratrol was assessed
in various buffers ranging from pH 2 to 10 for 24 h at 37 °C and was found that RSV is Resveratrol is
relatively stable above pH 6 and has maximum degradation at pH 9. The MTT assay showed that RSV has
a IC 50 value of 40M. The scratch assay demonstrated that RSV is an effective anti-migrating agents in
A549 cell lines at a concentration greater than its IC 50 value. These results further showed that the anti-
migrating activity was both concentration and time dependent. From the present study, it can be concluded
that, RSV can effectively be used in treatment of NSCLC, however there is a need to formulate a drug
carrier, which can protect the drug in plasma and at the same time can deliver the drug in a controlled
manner.
Keywords: Resveratrol, Non-small cell lung cancer, Scratch Assay, anti-migrating activity.
A-5
Role of Cyclodextrins as solubility enhancers in combination with solubilizing agents
Neha Chauhan*, Amit A Patel
Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Charusat Campus, Changa-
388 421, Anand, Gujarat, India
nhrawat10@gmail.com
One of the most important qualities in pharmacy is solubility. A medicine's effectiveness is influenced by
how efficiently it dissolves in a particular media. Solubility is crucial in determining the concentration of
drug needed to generate the intended pharmacological effect as all pharmaceuticals ingested by the body
must be in the form of a solution. A drug's bioavailability is greatly affected by how well it dissolves in
water. Drugs have reduced bioavailability due to limited solubility. A medication's solubility may be
enhanced in many ways. Adding cyclodextrin to a medication can increase its solubility, among other
things. There is widespread interest and usage of cyclodextrins because of their functional excipient
properties. They are a kind of cyclic oligosaccharides characterised by an outer hydrophilic layer and an
inner lipophilic layer. Among naturally occurring cyclodextrins (CDs), γ-cyclodextrin (CD) stands out as
having the best water solubility, greatest cavity size and least toxicologically problematic profile. Aγ-CD
may form inclusion complexes with a wide variety of drugs. γ-CD molecules may improve therapeutic
bioavailability by enhancing both drug solubility and membrane permeability.Increasing a drug's solubility
is a topic we'll explore here. To increase the solubility of medications and thus their therapeutic efficacy,
this study is set out to examine how cyclodextrin in combination with different solubilizers could be
employed in this regard.
Keywords: Cyclodextrin, Solubility, Inclusion complex, Enhancement, Polymer.
A-6
Fabrication, characterization, and toxicity evaluation of chemically cross-linked polymeric
material: A proof of concept
Meghraj Suryawanshi*1, Birendra Shrivastava1
1
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India-302017
suryawanshimeghraj917@gmail.com
The current study required to determine the properties of a basil seed mucilage-based polymeric network as
well as its toxicity. By using potassium persulfate (KPS) as an initiator, microwave-assisted synthesis a
green approach was used to produce a graft copolymer of a polymeric blend of Basil seed mucilage (BSM)
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and acrylamide (AM). Variable amounts of AM and KPS were used to optimize the best grade based on the
highest percentage of grafting efficiency, and the results were investigated using intrinsic viscosity
measurement, FT-IR, DSC, H-NMR spectra, and X-ray diffraction. The degree of swelling is determined
by the concentration of mucilage, monomer, and the density of crosslinking in the polymeric network. The
microwave irradiation process with potassium persulfate as the redox initiator is a visible, green, and cost-
effective method. The BSM-4 batch showed 464% grafting and 107.23% grafting efficiency. FTIR, DSC,
H-NMR and XRD analysis showed result about completion of grafting process and changes in functional
groups. The BSM-4 batch proved that basil seed mucilage polymeric network is totally safe for oral drug
delivery of BCS class II and IV drugs. The findings of the toxicity study indicate that the developed
polymeric network is safe and non-toxic. As a conclusion, the Basil seed mucilage-based polymeric
network will be encouraging for long-term delivery of any BCS Class II or IV drug, and acute toxicity
testing proved that the mucilage-based network had been secure for oral drug delivery.
Keywords: Natural, Mucilage, Polymeric Network, Basil Seed Mucilage, Toxicity, Grating copolymer.
A-7
Advancement of Nanotechnology and Nanoparticle in diagnosis and drug delivery system for
Cancer Treatment
Vidhi Upadhyaya*
Department of Pharmaceutical Sciences Kumaun University Bhimtal, Nainital ,Uttarakhand
Vidhiupadhyaya123@gmail.com
From a few decades, Cancer has become one of the deadliest diseases, in comparison with other diseases
and with an increase in the risk of more cancer patients. Various formulation was invented by the research
to overcome the risk of cancer. Cancer is a broad term, which describes the disease that results, when
cellular changes cause the uncontrolled growth and division of cells. Cancerous tumours can be eradicated
by not only targeting a site but also simultaneously using a multiple target approach. One of the Novel
preparations which come in existence was nanoparticles over the years it was in progress and showed an
advancement for overcoming the complexities in the clinical treatment of cancerous tissues. Nanoparticles
are the ones which offer the opportunity to reformulate drug that have been discontinued due to poor
bioavailability, lack of selectivity to desired target or extreme toxicity. Drug loaded nanoparticles maintain
high concentration within tumour cells, it avoids the development of resistance.Nanoparticles are currently
in an early stage of development. They have potential and ability to selectively target cancer cells without
damaging healthy tissues. Effectively designed nanoparticle has the ability to accumulate in tumour either
active or passive targeting and enhances the cytotoxic effects of the anti-tumour agents. Several
Nanodevices for drug delivery are liposomes, micelles, nanorobots, nanotubes,cantilevers,These
preparation are most effective against cancer treatment. All the details regarding this topic have been
presented and list in my oral presentation. This not only gave the detail knowledge regarding the
advancement in the field of nanotechnology, but it also gives an approach how it is improving the cancer
treatment. Several studies are underway on ligand – Modified AuNPs the AuNP – targeting approach can
also be used in the future for cancer drug delivery.
Keywords: Tumour cell, Nanoparticles, Nanodevices, Nanorobots, Cantilever.
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A-8
Molecular docking analysis of phytochemicals as antibacterial inhibitors
Shubhra1, Presenjit2, Vikas Anand1
1
Department of pharmaceutical sciences, Sardar Bhagwan Singh University
2
Radiology nuclear allied imaging sciences, Institute of nuclear medicine and allied sciences, D.R.D.O
shubhrasingh890@gmail.com
Bioactive phytochemical substances are proving to be essential therapeutic agents in the face of the
development of antimicrobial resistance. The phytochemical compounds are typically safe for human
consumption and have been approved for use as food additives by the Food and Drug Administration
(FDA). Food-borne infections are a persistent public health problem that poses significant challenges to
global health and the economy as a result of globalization and active food commerce between
countries.Salmonella spp. and Escherichia coli are two enteric bacterial pathogens on the list of 'priority'
food borne pathogens. Non-typhoidal Salmonella (NTS) serovars and diarrhoeagenic E. coli (DEC)
pathotypes are the most common causes of gastrointestinal infections across the world. Moreover, DEC
pathotypes, particularly enteroaggregative E. coli (EAEC), have long been linked to food borne outbreaks
across the world, posing a threat to global food safety and public health. The prevalence of NTS and EAEC
has been frequently recorded from both industrialized and developing nations. Antimicrobials have lately
been used on a bigger scale as both prophylactic and therapeutic treatments to battle infections. In recent
years, the evolution and natural selection of bacteria, along with the unprecedented usage of antimicrobials,
have contributed to an alarming surge in antimicrobial resistance. Phytochemicals have emerged as one of
the most promising holistic alternative methods with very little adverse effects. Bioactive phytochemicals
and essential oils were discovered to have significant antibacterial action against Salmonella spp. and E.
coli. The Computer Aided Drug Design (CADD) might reduce research costs by saving time and money on
molecule manufacturing. In this regard, we have utilized molecular docking, a computational approach to
determine the binding affinity of known phytochemicals to the targeted bacteria, which will further validate
the resistance to bacterial growth.
Keywords: CADD, Docking, Bioactive, Phytochemicals.
A-9
Current status of target proteins for Type 2 Diabetes Mellitus drug design strategy
Prerna Uniyal1*, Surbhi Panwar1,Saumitra Chattopadhyay2
1
School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, India.
2
Department of Computer Science Engineering, Graphic Era Hill University, Dehradun, Uttarakhand, India.
prerana.uniyal@gmail.com
Even after a great advancement and development in the field of medical science it is a big task to achieve
victory over Type 2 Diabetes Mellitus (T2DM). Characterized by a high glucose level in the bloodstream,
T2DM can be a reason for fatal events like stroke, cardiac failure, nephropathy and retinopathy. Out of the
numerous new avenues that have been explored for the management of T2DM, drug–protein interaction is
one of the most promising candidates which can be taken as highly effective method for the formulation of
new antidiabetic drugs. With the discovery of sodium-glucose co-transporter-2 (SGLT-2) protein as a target
for antidiabetic drugs, many advanced antidiabetic drugs have introduced in market from past two decades;
which has led researchers to hunt for new target proteins along with their potential modulators that can help
in the development of newer antidiabetic drugs. This review article comprises a broad literature of the latest
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developments in the management of T2DM with respect to new target proteins for the successful
management of symptoms of T2DM using mono, dual or triple combination medication therapy.
Keywords:Diabetes Mellitus, Protein tyrosine phosphatase 1B, Glycogen synthase kinase 3.
A-10
A review on PCOD and its management
Deep Pathak1, Anoop Singh Negi 2 ,Ganesh Kumar3
1
Student B.Pharm, College of Pharmacy, Shivalik Campus, Dehradun
2
Assistant professor, College of Pharmacy, Shivalik Campus, Dehradun
3
Principal, College of Pharmacy, Shivalik Campus, Dehradun,
deeppathak804@gmail.com
Polycystic ovary Disease (PCOD) is a common endocrine disorder that affects reproductive-aged women. It
is characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. The
exact cause of PCOD is not fully understood, but it is believed to be related to a combination of genetic and
environmental factors. The management and treatment of PCOD vary depending on the individual's
symptoms and goals. Lifestyle modifications such as weight loss, exercise, and a healthy diet can be
effective in managing symptoms such as irregular menstrual cycles and insulin resistance. Medical
management of PCOD typically involves hormonal therapies such as oral contraceptives, antiandrogens,
and insulin-sensitizing agents. Fertility treatments such as ovulation induction and in vitro fertilization can
also be used for women who wish to conceive. In conclusion, PCOD is a common condition that can
significantly impact a woman's health and quality of life. Appropriate management and treatment can help
to alleviate symptoms and improve overall health outcomes. A multidisciplinary approach that includes
lifestyle modifications, medical management, and fertility treatments, when necessary, can provide optimal
care for women with PCOD.
Keywords:PCOD, Lifestyle, Ovulation, Health.
A-11
Design and synthesis of 2-Chloro/NitrophenylBenzimidazole analogues targeting melk for
the treatment of Triple Negative Breast Cancer
Satendra Kumar*
School of Pharmaceutical Education; Research, Jamia Hamdard University, Hamdard Nagar, New
Delhi, Delhi 110062, India
sch@jamiahamdard.ac.in
Breast cancer is one of the most prevalent form of cancer in women, and escalating resistance to
chemotherapy poses a significant challenge to the discovery of novel chemotherapeutic agent. The most
lethal form of cancer in women’s is breast cancer, although an extremely dangerous type of breast
carcinoma is triple negative breast carcinoma (TNBC) because of its high rates of proliferation and
metastasis with poor prognosis. It has been reported that derivatives of nitro benzimidazole with
different types of functional groups have remarkable anticancer efficacy. In accordance with earlier
research, certain synthetic 2-chloro/nitrophenylbenzimidazole analogs exhibited remarkably specific
inhibition against MCF-, MDA-MB-231 cell lines. The therapeutic target is a cell cycle-regulating kinase
recognized as Maternal Embryonic Leucine Zipper Kinase (MELK), which is excessively expressed in
TNBC and associated with the growth of cancer. The objective of this research is to design, synthesize and
biological evaluation of 2-chloro/nitrophenylbenzimidazole analogs. The molecular docking studies of
these designed and synthesized derivatives were performed against MELK (PDB ID: 5IH9) and compound
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3,4, and 6 shows better dockingscore. Synthesize compound 6 and 4 shows 45.56 μM for MCF-7 and 75.48
μM for MDA- MB-231 respectively.
Keywords: Breast cancer, Molecular docking, MDA-MB-231, MCF-7, MELK.
A-12
Molecular docking approach to identify potential anticancer compounds from plant- derived
natural products
Himanshi Gupta*, Mr. Satendra Kumar
Advance Institute of Biotech and Paramedical Sciences, Department of Medicinal chemistry,Kanpur,(U.P.), India
himanshigpt11@gmail.com
Numerous substances produced from plants have been claimed to have potent anticancer activities, although their
exact mechanisms of action are still unknown. The Schrodinger suit was used to conduct docking investigations on
specific plant-derived chemicals with anticancer potential. We employed a molecular docking method to find natural
product compounds that have anticancer activity in conjunction with a particular receptor protein and a selective
inhibitory mechanism from chemicals originating from specific plants. Finding promising anticancer chemicals is our
aim. Selected compounds were assessed as cytotoxic agents against MCF7 and HCT 116 cell lines using virtual
screening on the protein Vascular Endothelium Growth Factor Receptor VEGFR-2 as a model. Thisstudy's goal
is to compile data on the anticancer effects of various plant-derived chemicals on the MCF7 and HCT 116 cell lines
utilising PDB ID. (4ASD). According to the docking data, alkaloids, steroidal glycosides, triterpenoid glycosides, and
flavonoid glycosides (polyphenol) had better dock scores than other substances. The 4ASD protein was docked with
the chemicals to find appropriate inhibitors of the protein function.
Keywords: Cancer, Anticancer drug, Natural product, Molecular Docking, Protein data bank, VEGFR-2.
A-13
Development and Evaluation of novel formulation of Chebulinic acid for colon specific drug
delivery
BigulYogeshver Bhardwaj*, Priyanka Vishwas, Poonam Negi
School of Pharmaceutical Sciences, Shoolini University, Solan 173229, Himachal Pradesh, India
bybraw08@gmail.com
Terminalia chebula, is employed as major ingredient in Ayurvedic formulations. Chemical analysis of these
formulations have revealed a number of pharmacologically interesting components including chebulinic
acid. Chebulinic acid has shown to exhibit antiulcer activity since it possesses antisecretory, antioxidative
and anti-inflammatory action. In spite of huge potential of chebulinic acid in gastrointestinal problems, its
use in pharmaceutical field is limited because of its high hydrophobicity and poor aqueous solubility.The
present research work aimed to formulate chebulinic acid loaded alginate microspheres for local treatment
of ulcerative colitis. The best-optimized microsphere was compressed in the form of matrix-forming tablet
for the colon targeting. Chebulinic acid loaded microspheres was prepared employing emulsion cross
linking method and were evaluated for particle size and PDI by master sizer and Entrapmentefficiency by
ultra centrifugation, on the basis of them microsphere was selected. The entrapment of chebulinic acid
inside microsphere was confirmed by XRD, DSC and FT-IR. Further, chebulinic acid- loaded matrix tablets
were evaluated for in vitro release kinetics in colonic condition. Particle size of microspheres were with in
the range of 927.8 – 1439 nm, and PDI range within 0.168 – 0.764nm. Spherical shaped microspheres were
confirmed by scanning electron microscopy. In vitro release kinetic showed regression coefficient of
microsphere matrix tablet formulation was found to be 0.9552, it shows that drug release follows peppas
model for matrix tablets. Thus, study suggest that chebulinicacid-based microsphere loaded matrix tablet is
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appropriate for colon target. The present study proved that chebulinic acid microsphere loaded matrix
tablets can be the ideal delivery system for colonic delivery.
Keywords: Terminalia, Chebulinic acid, Ulcerative colitis, Matrix-forming tablet.
A-14
RP-HPLC method development and validation for simultaneous quantification of
Diclofenac Sodium and Caffeine
Sumit Kumar*, Kiran Singh Sharma
KIET School of Pharmacy, KIET Group of Institutions, Delhi NCR, Ghaziabad, Uttar Pradesh (201206)
sumitsharma08836@gmail.com
A simple, rapid, precise, sensitive and reproducible Reverse Phase High-Performance Liquid
Chromatography (RP-HPLC) method has been developed for the simultaneous estimation of Diclofenac
sodium (DS) and Caffeine (CAF) in bulk drug and formulation. Chromatographic separation of DS and
CAF was achieved on Waters alliance 2489, by using C18 (150 mm × 4.6 mm, 3.5 µm) column with a
mobile phase consisting of methanol: water (pH adjusted to 3 using o-phosphoric acid) in the ratio of 70:30
(v/v). The flow rate was 1.0 ml/min and detection were carried out at 279 nm using a UV detector. The
retention times of DS and CAF were 3.75 and 6.80 min, respectively. The linearity for DS and CAF were
found in the range of 5-50 and 2–20 µg/ml respectively. The proposed method was validated according to
ICH guidelines. The accuracy, specificity and robustness of the method were within the acceptable limit of
± 2%. Precision (%RSD) intra-day and intra-day for DS was found to be 0.36 and 0.31 and for CAF was
found to be 0.17 and 0.20 respectively, limit of detection for DS was found to be 0.07 and for CAF was
found to be 0.15, limit of quantification for DS was found to be 0.22 and for CAF was found to be 0.46.
The proposed method was validated and successfully applied for the simultaneous estimation of DS and
CAF in bulk drug and formulation.
Keywords: RP-HPLC, Diclofenac Sodium, Caffeine, Simultaneous, Validation.
A-15
Targeting FNB 1 Gene and inactivating Zinc Metallopeptidase to prevent Nuclear Blebbing
in Progeria
Tushar Singhal*, NV Satheesh Madhav,Deepak Goel
Faculty of Neuropharmacology, DIT University, Dehradun, Uttarakhand, India – 248001
tushar.singhaldehradun@outlook.com
Progeria is an autosomal dominant genetic disorder which is manifested by very early aging. Individuals
with progeria typically live to their mid-teens to early twenties and the trait is rarely inherited, as carriers
usually do not live to reproduce their offspring. The ailment develops during cell division in a newly
conceived zygote/gametes of one of the parents. Technically, the specific genes responsible for the cause
are the mutations in the LMNA, FBN1 and AKT1, the mutated forms are called progerins sharing identical
systemic involvements, hence closely correlated. The cysteine present at the C-terminus, farnesylates via
zinc metallopeptidase and allows cleavage of prelamin A to Lamin A, which inhibits the formation of
Lamin A, creates the prelamin A abundancy, this further inhibits DNA repair, causing nuclear blebbing,
which tends the nucleus to lose its shape and integrity. In the present study, we used the progeria mouse
model, and mutated the FBN 1 gene, as it possesses 8 distinct cysteine modules of which one is mutually
shared by the LMNA gene at the C-terminus, and thus altered the cysteine with serine, further we have
incorporated protease inhibitors as well, to inhibit ZMPSTE 24. The results evidently exhibit loss of
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premature greying and minimisation of hypogonadism, scleroderma, myotonic dystrophy and

lipodystrophy. Further, it was significantly comprehended that, by inhibiting farnesyltransferase on the
FBN 1 gene, and productive mutation of cysteine with the consecutive analogue, lobulation of nuclear
envelope, thickening of the nuclear lamina, loss of peripheral heterochromatin & clustering of nuclear
pores was prevented. This study has very effectively targeted on the abolishment of Nuclear Blebbing,
which was not focused till date in the present context. Also, the productive mutation distinctively
demonstrated the promotion of natural repair of DNA double strand breaks, by increasing Non-
Homologous End Joining, leading to natural Homologous Recombination. Auxiliary, this study may
progress vision of knowledge regarding risk factors, pathophysiology, and management of these conditions.
Keywords: Progeria, Mutation, Cysteine, Autosomal Dominant, Metallopeptidase.
A-16
A review on formulation and evaluation of nanosponges for topical drug delivery
Ajay Pant*, Alka Singh
School of Pharmaceutical Sciences and Research, Sardar Bhagwan Singh University, Balawala, Dehradun,
Uttarakhand, India
ajaypant1998@gmail.com
Nanosponges are a new and emerging technology that plays an important role in controlled drug delivery.
Nanosponge is a nano-sized drug carrier with a three-dimensional structure made by cross-linking
polymers. The advantage of nanosponges is that it can accommodate a variety of medications in a variety of
sizes. Nano sponges are small, virus-sized sponges that easily penetrate the skin. They reach a specific
target site, sticking to a surface andreleasing the drug in a controlled manner. They are more effective for
targeted drug deliverysystems because they increase solubility, permeability, bioavailability of drug. Drug
deliveryvia the topical route is generally preferred for topical dermatological action. The local actionof
drugs has certain limitations in terms of drug residence time, lipophilicity, solubility andpermeability, skin
irritation, and allergic reactions. Existing formulations such as creams andointments have disadvantages
such as stability problems, stickiness, and poor absorption andpenetration. Drug having large molecular
weight have permeability issue through topicalroute. The invention of nanosponges is an important step
towards overcoming the challengesassociated with traditional drug delivery. In the present review the
topical effects ofnanosponges via various topical dosage form like cream, ointment etc is studied to
overcomechallenges faced by conventional dosage forms.
Keywords: Nanosponges, Topical drug delivery, Permeability, Stability.
A-17
Molecular Docking Studies of Cyclodextrin with Drugs
Vaishali*, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
School of Pharmaceutical Science and Technology, Sardar Bhagwan Singh University, Balawala, Dehradun, 248001,
India
vvisu693@gmail.com
Cyclodextrins (CDs) and their derivatives (α-CDs, β-CDs, ϒ-CDS) have become increasingly popular in
the pharmaceutical industry due to their unique amphiphilic nature, which allows them to increase the
solubility of drugs and protect them from degradation also increase biocompatibility which make them an
ideal choice for drug delivery systems. Additionally, CDs have been used to mask the bitter taste of drugs,
thereby increasing the acceptability of oral medications. Docking studies predict drug-CD inclusion
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complex formation by calculating binding energy and confirming complexation. Docking studies at
molecular level are advantageous as it contributes to optimization of drug design, screening large number of
libraries and increasing accuracy. Software programs such as AutoDock Tools (ADT) version 1.5.6,
AutoDock Vina 1.1.2, AutoDock 4.2, PyRx etc. are frequently used to conduct molecular docking studies.
To visualize the docked moieties, researchers often use PyMol and Discovery Studio Visualizer version 4.0.
This literature survey was carried out on PubMed, Google Scholar and Scopus to find attempts on
molecular docking of CD and guest molecules for the application of taste masking. Docking studies of
cyclodextrin (CD) and ligands involve preparing a structure, generating grid points, calculating binding
energy, and analysing the best docked conformation. This technique has been used to mask the bitter taste
of drugs. Although docking studies of CD for enhancing bioavailability and modifying release are some of
the areas which can still be explored in depth.
Keywords: Inclusion complex, AutoDock, Discovery Studio Visualizer, Bitter taste, Binding energy.
A-18
Gender differences and Estrogen role in managing Parkinson’s Disease
Surbhi Panwar, Prerna Uniyal, Akanksha Bhatt, Neelima Kukreti
Assistant professor, School of Pharmacy, Graphic Era Hill University, Dehradun-248001, India
surbhipanwar@gehu.ac.in
Parkinson’s is a disorder in which dopaminergic neurons degenerate. It is also identified by occurrence of

α-synuclein in the substantia nigra. It is suggested that men are 1.5 times at greater risk than females.
Oxidative stress or free radicle stress, protein aggregation, defects in the ubiquitin-proteasome pathway,
and autophagy are some of the cell-autonomous mechanisms involved in pathogenesis of the disease
whereas spreading of α-synuclein, a continuous degeneration of dopaminergic and non-dopaminergic
neurons and inflammatory processes are the non-cell-autonomous mechanisms. Estrogen shows
neuroprotective activity via rapid signaling pathways utilizing both genomic and non-genomic
mechanisms. Other mechanisms include ligand-independent and estrogen response element (ERE) -
independent mechanism. Ligand-independent mechanism makes it possible for estrogen receptor to be
activated in the presence of low levels of estrogen. They also slow down the onset of age-related neuro-
disorder via targeting mitochondria.
Keywords: Gonadocorticoids, Neurodegeneration, Nigrostriatal, Neuroprotection, Dopamine.
A-19
Ethnobotanical and pharmacological uses of Alternanthera Ficoidea (l.) P. Beauv
Abhishek Chauhan*, Arvind Negi
GRD (PG) IMT, Department of Pharmacognosy, Dehradun-248018, Uttarakhand, India
abhishekchauhan2050@gmail.com
Alternanthera ficoidea (L.) P. Beauv is a vital medicinal plant and broadly used with inside the remedy of
kind of Diseases. The herbs have numerous spreading branches with simple leaves and small white
flowers.Present day examine become consequently completed to offer needful ethnobotanical and
pharmacological info of the complete plant. According to Ayurveda A.ficoidea is called as Mathsyakshi.
The morphological study reveals the leaves are simple, alternate; leaves lamina is rectangular, and the
bottom is wedge-shaped. The microscopy reveals the dorsiventral type of leaves, with diacytic stomata,
covering lower epidermis and presence of calciumoxalate crystals and bunch of spiral vessel ground tissue.
Phytochemically, the various extract showed the presence of diverse phytochemicals such as alkaloids,
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phenolic compounds, carbohydrates, saponin steroids and triterpenoids tannin, proteins flavanoids content
as compared to root and stem. The physicochemical analysis explored the loss on drying at 105 oC, water
soluble extractive value, alcohol soluble extractive value, Total ash value, acid insoluble ash value;
Phytochemicals were evaluated for the plant Alternanthera ficoidea(L.) P. Beauv. ex DC. Using HPTLC
fingerprinting. The results of the study could be useful in setting some diagnostic indices for the identity
and preparation of a monograph of the plant. A. ficoidea has anti-microbial, anti-oxidant, antipyretic,
nootropic, hepato-protective, hematinic, anti-ulcer, hypoglycemic, anti-diarrhoeal, anti- Inflammatory etc.
Activities. It also used in elimination of kidney stone and inflammation of uterus and ovary.
Keywords:Mathsyakshi, Physicochemical analysis, Macroscopy, HPTLC fingerprinting.
A-20
Diabetic Retinopathy screening techniques: A review
Neelima kukreti*, Akanksha Bhatt,, Surbhi Panwar
Assistant Professor, School of Pharmacy,Graphic Era Hill University
nkukreti@gehu.ac.in
Diabetes retinopathy becomes a long-term consequence of diabetes mellitus. Gradually there is a change in
the retinal microvasculature and affect the non- profusion area and raising vascular permeability. It is
estimated from 2010, there were 285 million diabetic people worldwide. Increase in number of diabetic
patients increases the need for professional to scan diabetic retinopathy but there is no best screening
method for India's diabetic population.It leads to a rise in diabetes patients because there aren't enough
trained personnel and retinal imaging experts with the rapid development of deep learning and deep neural
networks, artificial intelligence (AI) programs have been applied to find different photographs of many
diseases, including DR. The advancement of various screening methods for diabetic retinopathy and the
relevant limitation in artificial intelligence that have been made available in recent years are the two main
foci of the review we are conducting here.
Keywords: Diabetic Retinopathy, Artificial Intelligence, Screening Technique, Diabetes Mellitus.
A-21
Preparation and in vitro characterization of Diacerein microsponges loaded topical gels
Vaibhav Sisodia*,Shaffi K. Tangri
Shri Guru Ram Rai University, Dehradun
rajputvaibhav5560@gmail.com
Microsponge is a recent innovative technology for target-specific delivery systems with controlled release.
Microsponges are made up of tiny, pliable beads that are filled with an active ingredient and range in size
from 10 to 25 microns. Microsponges offer several advantages, making them a flexible drug delivery
mechanism. They are also very effective, stable, non-irritating, non-toxic, non-allergic, and non-mutagenic,
with fewer side effects and higher patient compliance. Microsponges delivery system (MDS) has recently
received attention for the controlled release of medications onto the epidermis with the assurance that the
medication will remain primarily localized and won't enter the systemic circulation in significant amounts.
MDS have a bright future in the pharmaceutical industry thanks to their special qualities like small size,
effective carrier characteristics, enhanced product performance and elegance, extended-release, reduced
irritation, and improved thermal, physical, and chemical stability that make them flexible to create new
product forms. Microsponges were prepared with Eudragit RS 100 by ‘Quasi Emulsion Solvent diffusion
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Method’. Formulation was prepared by using different concentration of polymer and evaluated for drug
content, drug release, entrapment efficiency, and particle size.
Keywords: Diacerein, Microsponges, Gels, Drug Release.
A-22
Artificial Intelligence: New era of Pharma Industries
Urvashi Negi1*, Kapil Kalra1, Pragati Bailwal2, Jyoti Maithani Kalra3
1
Department of Pharmacy, Alpine College of Management and Technology, Dehradun, Uttarakhand
2
Research Scholar, Department of Pharmaceutical Sciences, SGRR University, Dehradun, Uttarakhand
3
School of Pharmaceutical Sciences, Himgiri Zee University, Dehradun, Uttarakhand
urvashinegi5@gmail.com
In Pharma industries machine learning is commonly used for drug investigation, new drug delivery system,
drug imaging, clinical data collection etc. in phase of COVID-19 (Coronavirus) pandemic Artificial
intelligence (AI) is used for early detection and diagnosis of the infection by medical imaging technologies
like Computed tomography (CT), monitoring the treatment by creating an intelligent platform for automatic
monitoring, prediction. Artificial intelligence (AI) in Pharma industries and pharmaceutical technology has
grown with time, and it’s useful to understand the correlations between various formulations and process
factors. Artificial intelligence (AI) is described in the context of health as the application of algorithms and
software to complement human awareness or attention during the analysis of intricate medical data artificial
intelligence works with the solution of issues via symbolic programming by using machine learning
techniques. With numerous applications in business, medicine, and engineering, it has developed into a
science of problem solving. Healthcare industry requires the support of new technologies like Artificial
intelligence (AI), Internet of things etc. The main aim of Artificial intelligence (AI) is to analyze, prepare
for the prevention measures and fight with COVID-19 (Coronavirus) and other pandemics. The article
discusses about various application of AI in drug discovery, medical imaging, medical devices, Cancer
diagnostics and treatment decisions, telehealth and remote patient monitoring etc. it’s potential to generate
and analyses healthcare data to improve patient care and reduce costs and clinical risk while enhancing
administrative processes within organizations. Artificial intelligence (AI) which assists in the early
detection of emerging illnesses will eventually replace pharmacists.
Keywords: Health Care, Artificial Intelligence,Tomography, Telehealth,Algorithms.
A-23
Needle- Free Injection Technology
Aarti Sati, Mitali Arora*
Department of Pharmacology, School of Pharmaceutical Sciences,Shri Guru Ram Rai University, Dehradun,
Uttarakhand, India
mitaliarora35@gmail.com
Needle-free injection (NFI) systems are novel ways to introduce various medicines into patients without
piercing a conventional needle. The needle injection has many complications like anxiety, fever, avoidance,
disgust, and needle stick injuries. Therefore, NFI systems are used to overcome these complications. In
NFI's a jet of fluid is accelerated to high-speed providing it significant penetrating power through a fine
diameter nozzle when placed against the skin. Energy sources such as springs, gas cartridges, and electricity
can be used. The transmission of diseases is prevented. We can also deliver a solid dosage form through it,
which can be used to overcome the stability factor encountered in the liquid dosage form. Needle-free
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injection technology was developed to reduce the number of needle-stick accidents and associated
problems; easy to use, and disposable, and its use is expected to increase considerably. Self-administration
is feasible with these devices. This technology is used to deliver not only drugs but also proteins, peptides,
monoclonal antibodies, small molecules, and vaccines. Needle-free technology offers the obvious benefit of
reducing patient concern about the use of a needle. Needle-free injection gives highly effective injections
for a wide range of drugs and bioequivalent to syringes and needles, results in less pain, and is strongly
preferred by patients. Additional benefits include very fast injection compared with conventional needles
and no needle disposal issues. Not only it can benefit the pharmaceutical industry by increasing product
sales, but it also has the added potential to increase compliance with dosage regimens and improve
outcomes.
Keywords: Needle-free injection, novel, needle-free devices
A-24
Formulation and development of compression coated colon targeted tablets of Budesonide
Saumya Mishra*, Kapil Kalra, Shalini kumari, Ankita Negi
saumyamishra1988@gmail.com
Aim of the proposed research was the formulation and evaluation of a compressed coated colon targeted
tablet using Budesonide to be used for Crohn’s disease. For this purpose, different polymers like Eudragit L
100, Eudragit S 100, and Ethyl cellulose were used to prevent the contact of core tablet containing
Budesonide with 0.1N HCl for 2 hours and in phosphate buffer pH 6.8 for 1 hour. Compression coating of
core tablet was done by the powder mixture of polymers with different ratios and different amounts of
coating mass, and it was concluded that the outer coating for each batch was not stable for 2 hours in 0.1N
HCl. Hence, it was decided to prepare the granules of the coating polymer mixture. Different batches were
prepared by taking three variables and varying their ratios at three levels (low, medium, high) by using Box
Behnken Design. Two batches F10 and F14 were selected as optimized batches as they showed evaluation
parameters like hardness, friability, weight variation, disintegration test in 0.1N HCl and in phosphate
buffer of pH 6.8 within the standard limits in comparison to other batches. These batches also represented
acceptable results for all evaluation tests of tablets and their individual dissolution profiles indicated their
suitability to be used as colon targeted drug delivery systems.
Keywords: Budesonide, Eudragit L 100, Eudragit S 100, Compression.
A-25
Development and evaluation of co-surfactant activity of rosuvastatin with peg 400 in form of micro-emulsion
Pankaj Nainwal1, Prerna Uniyal1, Manu Pant2
1
School of Pharmacy, Graphic Era Hill University, Clement town, Dehradun, Uttarakhand
2
Department of Biotechnology, Graphic Era Deemed to be University, Clement town, Dehradun, Uttarakhand
drpankajnainwal@gmail.com
Micro-emulsions offer an innovative way to deliver insoluble medications, safeguard labile

pharmaceuticals, manage drug release, and boost bioavailability. To enhance the stability factor and
solubility status of rosuvastatin, they can be administered topically, orally, or intravenously. PEG-400 as
co-surface-active agent is used. To increase the solubility and possibly the stability of a hydrophobic drug
(rosuvastatin), this study aims to create and access oil in water type of micro-emulsion-based formulation
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that oil from natural source and polyethylene glycol 400 as co-surfactant. Using the aqua titration approach,
an oil in water micro-emulsion was created. For optimization, investigations for particle size, stability &
solubility and pH were conducted, and then in vitro release tests were conducted. A 1:1 ratio of Tween80 to
PEG-400 (S mix) was determined for the manufacture of the final micro-emulsion based on solubility-
component evaluation and pseudoternary phase diagrams. 9.79% oil, 41.58 % S mix, and 47.81% water
make up the optimal ME-4 recipe that was chosen. It was discovered that the average globule size was
found 57.7 nm, the pH value observed 6.96, the zeta value observed 27.67 mV, and the transmittance
percentage was 97.1. The final formulation is more stable, according to the results of the thermodynamic
stability research. The developed micro-emulsion formulation improved the drug's solubilisation effect,
confirming the micro-emulsion system's usefulness as source for (BCS) class II delivery.
Keywords: Rosuvastatin, Micro-emulsion, Polyethyleneglycol-400.
A-26
Pharmacognostical preliminary phytochemical screening and biological evaluation on
Embelia ribs burm.
Neetu Singh*,Arvind Negi
GRD (PG)IMT, Department of Pharmacognosy,214- Rajpur Road,Dehradun -248018, Uttarakhand, India
neetusingh248001@gmail.com
EmbeliaribesBurm is the large scandent shrub belongin from Family- Myrsinaceae. It is found in Assam,
Arunachal Pradesh, Bangal,Andhra Pradesh, Odisha and Madhya Pradesh lower and central Himalayas in
India. Embeliaribes grows in semi evergreen and deciduous forest at altitudes of 1500meters. The common
name of Embeliaribes are False black pepper or Vai Vidanga.EmbeliaribesBurm.are found in India’s. It
grows in semi-evergreen and deciduous forests at altitudes of 1,500 meters. The parts of plants are use in
pharmaceutical formulation-fruits(berries), leaves and roots .The phytochemical constituents present in
embeliaribes burm.is embelin, embeliol, vilangin, embeliaribyl ester, embelinol, alkaloids, steroids,
phenolic acid , resin and volatile oil, fatty acids and flavanoids. The therapeutic uses of Embeliaribes are
antibacterial, anti-fertility, anti-protozoal, stomach problems, lungs disorders,analgesic, intestinal problem
,indigestion, antifungal, mouth ulcers, sore throats, pneumonia, heart disease, and obesity, as well as
analgesic, anti-inflammatory, and antioxidant. The seed can be kept in gunny bags after harvesting in a dry,
low-moisture environment. The pharmaceutical preparations of Embelia ribs are tablets,capsules , powder,
cream , ointment and oils.
Keywords: Embeliaribes, Vedanga, Phytochemical constituents, Antifungal.
A-27
Automation, robotics, and advances in Artificial Intelligence in Pharmacy
Mukul Bhardwaj1*, Pranshu Tangri1, Yamini chandola Semwal1
GRD (PG)IMT, Department of Pharmacognosy,214- Rajpur Road,Dehradun -248018, Uttarakhand, India
mukulbhardwaj865@gmail.com
Artificial intelligence (AI) is a branch of computer science that deals with the problem–solving by the aid
of symbolic programming .it has greatly evolved into a science of problem- solving with huge application
in business, health care, engineering. The main objective of this artificial intelligence to identify useful
information processing problems and give an abstract account of how to solve them.AI pharmacy solutions
include an automated dispensing technology that uses automation features to understand prescriptions and
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dispense medications, with minimal involvement from a pharmacist. Artificial intelligence in Pharma refers
to the use of automated algorithms to perform tasks which traditionally rely on human intelligence. Over
the last five years, the use of artificial intelligence in the pharma and biotech industry has redefined how
scientists develop new drugs, tackle disease, and more Pharmacy automation involves the automation of
common tasks and processes performed in a pharmacy or other healthcare settings.For example, the
dispensing of medications has traditionally been a time consuming and tedious task performed by
pharmacists for several decades. Artificial intelligence helps pharma companies find patients for clinical
trials. While AI can be used to make sense of clinical trials data, another use of Artificial
Intelligence in the pharmaceutical industry is to find the patients to take them. The Massachusetts (MIT)
has found that only 13.8% of drugs successfully pass clinical trials. Furthermore, a company can expect to
pay between$161 million to $2 billion for any drug to complete the entire clinical trials process and get
FDA approval.
Key words: Automation, Artificial Intelligence, Computers, Robotics.
A-28
Role of acid sensing ion channels in diseases
Himani Dumka*1, Kapil Kalra1, Babita Negi1, Jyoti Maithani Kalra2
1
2
School of Pharmaceutical Sciences, Himgiri Zee University, Dehradun
himanidumka31051998@gmail.com
Neurons in neurodegenerative illnesses gradually become dysfunctional and die. Cognitive impairment,
speech impediments, and motor dysfunction are a few symptoms that represent neurodegeneration of
neurons. The common pathophysiological hallmark of neurodegenerative illnesses are loss of neuronal
populations in the brain and/or spinal cord. The two most prevalent neurodegenerative diseases,
Alzheimer's disease (AD) and Parkinson's disease (PD) are diagnosed in over 36 million people
globally.AD is characterized by neuritic plaques and neurofibrillary tangles as a result of amyloid-beta
peptide (Aβ) buildup in the brain's most severely afflicted region, the medial temporal lobe and neocortical
regions. A synucleinopathy, Parkinson's disease is a common neurological condition. Lewy bodies and cell
loss in the substantia nigra, especially in the ventral component of the pars compacta, are the pathological
hallmarks of Parkinson's disease. Amyotrophic lateral sclerosis (ALS) has originally been defined as a pure
motor neuron disease, but is now recognized as a multisystem neurodegenerative disorder, with disease
heterogeneity at the clinical, genetic and neuropathological level. A dominantly inherited CAG
trinucleotide repeatedthe increase in the huntingtin gene on chromosome 4 results in Huntington disease
(HD). ASICs are ligand-gated cation channels activated by extracellular H+ and are widely distributed in
mammalian central and peripheral nervous systems as members of the degenerin and epithelial Na+ channel
(DEG/ENaC). There are four different genes (ACCN1 to 4) encode at least six different subunits (ASIC1a,
ASIC1b, ASIC2a, ASIC2b, ASIC3, and ASIC4). ASICs have a crucial role in prevention of
neurodegenerative diseases.
Keywords: Cognitive impairment, Huntingtin gene, Lewy bodies, Synucleinopathy.
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A-29
Organoids: An alternative to animal studies
Bhavya Gupta*, Ashish Dimri
1
Department of Pharmacy, GRD PG Institute of Management and Technology, Dehradun-248009, UK, India
gupta06bhavya29@gmail.com
Mostly, animal models are used for toxicological assessment of novel medications. Although this
traditional method is effective in learning information from an in vivo model, there are a number
ofproblems with these studies, including uncertain outcomes, substantial financial investment, and ethical
dilemmas. Organoids, which are biological replicas of particular organs or tissues made of living
cells/biomaterials, are good substitutes for animal experimentation. Human organoids, by imitating
complex microenvironments and many of the in vivo physiological activities of critical tissues, are
expected to overcome the translational gap between humans and animals and increase our understanding of
the mechanisms behind illness and developmental processes. Human organoids are intended to be used in a
variety of research applications, including basic research areas in embryology, physiology, and evolution as
well as studies of disease conditions and therapeutic efficacy and toxicity. In this article, we collated the
most recent toxicological information on human organoids and reviewed their value, limits, and
possibilities, with an emphasis on prospective in vitro predictive tests for organ toxicities (gut, liver,
kidney, heart, and brain) caused by available commercial medications. The number of studies presenting
toxicity investigations utilizing human organoids is still relatively small, and there is currently no accepted
strategy for predicting organ toxicities induced by drug using human organoids. However, given the
impressive advancements in organoid research over the last ten years and the rise in human organoid
studies, additional research on the potential utility of organoids for toxicity assessments is anticipated in the
coming years.
Keywords: Toxicological, Organoids, Microenvironment, Predictive.
A-30
Gene Editing: The Future of Medicine
Anuj Giri*, Sarthak Rawat, Kapil Kalra, Vandana Pokhriyal
Department of Pharmacy, Alpine College of Management & Technology, Dehradun, Uttarakhand
anujgiri2520@gmail.com
Gene editing technology, such as CRISPR-Cas9, has revolutionized the field of medicine and opened new
possibilities for treating a wide range of diseases. The ability to edit the genetic code of living organisms
with precision and accuracy has the potential to cure genetic disorders, eradicate infectious diseases, and
even enhance human traits. Gene editing is a technology that allows scientists to modify the DNA sequence
of living organisms, including humans. The most widely used gene editing tool is CRISPR-Cas9, which
uses a protein called Cas9 and a guide RNA to cut the DNA at a specific location and replace it with a new
sequence. This technology has been compared to a “genetic scissors” that can cut and paste DNA with
precision and accuracy. Gene editing technology has already been used to treat genetic disorders such as
sickle cell anaemia and beta-thalassemia by correcting the defective gene responsible for these diseases. In
these cases, the gene editing tool is delivered into the patient’s cells using a virus, which then cuts and
replaces the defective gene with a healthy one. Gene editing technology has the potential to revolutionize
the field of medicine and create a world without genetic diseases and infectious diseases. However, it is
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important to proceed with caution and carefully consider the ethical implications of this technology.
Keywords: CRISPR-Cas9, Genetic, Gene, β-thalassemia, DNA sequence.
A-31
Application of ChatGPT in the Queries Related to Pharmacokinetics of Cannabidiol and
Verification of ChatGPT Answers through a Thorough Literature Searching
Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, Balawala, Dehradun 248001,
India
banerjeesurojit114@gmail.com
ChatGPT is an AI-powered chatbot that engages in human-like conversations. It is based onOpen AI& GPT
3.5 language model and is trained using supervised and reinforcement learning techniques. It is capable of
various tasks such as language generation, text completion,translation, summarization, question answering,
chatbot dialogue, text classification, andparaphrasing. CBD, an aromatic monoterpenoid found in Cannabis
sativa, is different fromtetrahydrocannabinol as it does not have psychoactive properties. CBD is used for
treatingseizures associated with Lennox-Gastaut syndrome, Dravet syndrome, or Tuberous
SclerosisComplex. This study aimed to assess the accuracy ofChatGPT in providing answers to questions
related to the pharmacokinetics of CBD, comparedto a systematic review and other scholarly literature. We
formulated qualitative, quantitative, andliterature retrieval questions as prompts for ChatGPT, totaling 33
questions.The answers provided by ChatGPT were compared with the systematic review and otherscholarly
literature, considering the cut-off date of ChatGPT. The accuracy of ChatGPT wascalculated in percentage.
All answers were saved in PDF format. Analysis of the responses toquantitative questions revealed that
82% of ChatGPT responses were incorrect, 18% werepartially correct, and 0% were correct. For qualitative
questions, the responses were 0%incorrect, 36% partially correct, and 64% correct. For questions based on
literature review, theresponses were 64% partially correct, 18% incorrect, and 18% correct. ChatGPT may
notprovide accurate quantitative values of parameters and should be used cautiously for
qualitativequestions. It may not be a suitable option for literature search in the field of
pharmaceuticalsciences at this time. Scientists should exercise caution when using ChatGPT for their
researchpurposes. Overall, the accuracy of ChatGPT answers may vary depending on the type ofquestions
and researchers should consider its limitations in their scientific work.
Keywords: ChatGPT, Artificial Intelligence, Chatbot. Natural Language.
A-32
Role of medicinal plants in Traditional and Modern Medicine: Exploring the potential of
purified extracts and their bioactive
Ankit Kumar1,2, Ganesh Kumar2, Deepak Kumar Semwal1
1
Faculty of Biomedical Sciences, Uttarakhand Ayurved University, Dehradun, India
2
College of Pharmacy, Shivalik Campus, Dehradun, India
ankitkumarkoli88@gmail.com
Medicinal plants have been used for centuries worldwide to treat various ailments and promote health and
well-being in various systems of medicine, including traditional, complementary, and alternative medicine.
The use of plants for medicinal purposes is deeply rooted in the history of human civilization and continues
to play a vital role in the management and treatment of various diseases. The traditional systems of
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medicine, such as Ayurveda, Traditional Chinese Medicine, and Unani Medicine, rely heavily on the use of
plant-based remedies. Plants are a rich source of bioactive compounds that possess therapeutic potential and
are used in the development of modern drugs and therapies. The role of plants in different systems of
medicine offers a valuable platform for the exploration and utilization of natural products for the benefit of
human health. According to estimates, there are around 300,000 species of plants on earth, of which only a
small percentage have been studied for their medicinal properties. However, the potential of medicinal
plants as a source of new drugs and therapies is enormous. Herbal-based products have gained increasing
popularity in recent years as a natural alternative to synthetic drugs. These products are derived from
medicinal plants and their extracts and have been used in traditional medicine for centuries. The use of
herbal-based products is not only driven by their perceived efficacy and safety but also by the growing
demand for natural and sustainable products. The global market for herbal-based products is estimated to be
around US$ 120 billion, and this figure is expected to grow in the coming years. The development and use
of herbal-based products offer great potential for the discovery of new drugs and therapies.
Keywords: Plant-based remedies, bioactive, traditional medicine, herbal-based.
A-33
Antioxidant and hepatoprotective effect of aerial parts of Desmostachya Bipinnata against
CCl4 induced liver damage
Alok Bhatt1*, Anupama Singh2, Pallavi Ghildiyal3
1
School of Pharmacy, Graphic Era Hill University, Bell Road, Clement Town, Dehradun 248002, Uttarakhand, India
2
Department of Pharmacognosy, School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh
University, Balawala, Dehradun 248001, Uttarakhand, India
3
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Premnagar, Dehradun, Uttarakhand, India
alokbhatt03@gmail.com
Liver is exposed to high concentrations of toxicants and toxic metabolites in the process of metabolic
detoxification, making it susceptible to injury. Liver damage is associated with cellular necrosis, increase in
tissue lipid peroxidation, and depletion in tissue GSH level, etc. In present study soxhlet and cloud point
extraction of Desmostachyabipinnata aerial parts was performed. Preliminary phytochemical identfication
was performed by chemical tests and TLC. After that validated the traditional claim i.e.; antioxidant and
hepatoprotective potential using CCl4 induced hepatotoxicity model. In soxhlation, maximum extractive
yield was found in alcoholic extract (20.00 ± 0.68 % w/w), phenols and flavonoids present in alcoholic
extract were found to be 10.92% w/w and 20.81 %w/w respectively. In cloud point extraction, CPE 8 was
found best among all eight extracts of cloud point extraction (Temperature 60oC, time 2 hours and triton x-
100 concentration 5%) having maximum extraction yield 11.2 ± 01.26 % w/w, flavonoids (13.44% w/w)
and phenols (43.63% w/w). In phytochemical screening of extracts phenolics, flavonoids, alkaloids and
steroids were present in different extracts of Desmostachyabipinnata. In CCl4 induced hepatotoxicity,
because of the tissue & serum analysis the order of hepatoprotective effect was found as alcohol extract <
chloroform extract < C.P.E < standard marketed formulation. The difference in activity of these extracts in
reducing hepatotoxicity may be due to the nature and quantity of phyto-constituents present in these
extracts. However, further studies are going on for isolation and characterization of the active constituent
responsible for this activity.
Key words: Desmostachyabipinnata, Hepatoprotective, Antioxidant, CCl4.
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A-34
Phytochemical and antioxidant activity of Asplenium Dalhousiaemethanolic extract from
Nainital district of Uttarakhand.
Jaideep S. Rawat, Aadesh Kumar*, MahendraRana, Amit J.Rana, Arasana
College of Pharmacy,Roorkee
aadesh@rceroorkee.in
Asplenium dalhousiae Hook (Aspleniaceae) is a fern (pteridophyte) found with a rosette of long, with 6 to
13 pairs of lobes. The lobes are 5-12 mm wide. They are found in shady, rocky and ravines in moist soil. It
has been generally distinguished by its allied species by its once pinnatifid leaves from Asplenium
Exiguumthathas bipinnatified leaves. It is a genus (Asplenium) of about 700 species of ferns found
worldwide extensively, mostly native to northern Mexico and disjunction to the Himalaya Mountains in
Asia. They generally habitat at IHR (Indian Himalayan Region) includes Kashmir, Himachal, Uttarakhand,
and many more in India. Plant was collected form Bhimtal and identified from BSI, Dehradun. Plant
material were air dries under shade and powdered manually processed for extraction. In successive hot
percolation the plant material was extracted with methanol. After completion of extraction, the solvent was
removed, and the extract was concentrated with the help of rot vapor. Extract was subjected for preliminary
phytochemical screening. Phytochemical screening tests were for tannins, saponins,carbohydrates, quinines,
alkaloids, flavonoids, triterpenoids, and steroids. It shows that alkaloids, triterpenoids and fixed oil were
absent whereas rests all are present. The totalflavonoids, phenolic, tannin was also determined. The total
flavonoids were found to be1.31%, the total tannin was found to be 1.18% and the total phenolic was found
to be 9.27%.Antioxidant activity was determined by DPPH method. In-vitro antibacterial activity wasdone
by using Pseudomonas aeruginosa (MTCC 424), Staphylococcus aureus (MTCC 737)Bacterial strains. In
which zone of inhibition was found 46.5% in respect to positive controlMTCC 424 and 81.66% in respect
to MTCC 737.
Keywords: Antioxidant activity, In-vitro antibacterial activity, Staphylococcus aureus.
A-35
General overview on: A Wild traditional medicinal plant: Angel's trumpet
(Brugmansia Suaveolens: Solanaceae)
Alka Tailwal*, Arvind Negi, Vinita Chauhan
Department of Pharmacognosy GRD(PG)IMT, Dehradun -248001, Uttarakhand, India.
alkatailwal99@gmail.com
Throughout life, ailments are a person's constant companion early humans were motivated to investigate the
natural world by their efforts to treat illnesses and their aspirations for long life. The herbs that pursued
eventually became the man's first medicines. Surprisingly, traditional medicines are still used by 80% of the
global population. The World Health Organization promotes traditional medicines because they are
affordable, accessible, and generally free of side effects. Brugmansiasuaveolens (Family-Solanaceae)
commonly known as “White angel's trumpet” is a flowering shrub native to the South America, Several
tropical and temperate regions of the world produce plants for traditional medicine and ornament. Angel’s
trumpets is a semi-woody evergreen shrub or small tree with many branched trunk and growing up to 3-5
metres(10-16 feet) in height. The oval shaped leaves can be toothed or entire and are alternately arranged
along the stems. The large pendulous flowers hanging almost straight down and can be white, cream,
yellow, orange, pink in colour. Often people confuse the plants with the annual herbaceous plants in the
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similar genus Datura. In various civilizations, this plant has been employed in traditional medicine. The
stems and leaves of the plant are used, and different chemical compounds such as alkaloids, volatile
compounds (mainly terpenes), flavonoids, steroids, glycosides, and carbohydrates were found to be present.
It has been used traditionally for the treatment of arthritis, pain, inflammation, fungal infections of the skin
and also used as analgesic, sleep inducer, antimicrobial, cytotoxic, nematocidal, antinociceptive, anticancer,
muscle relaxant and various other activities.
Keywords: Alkaloids, Volatile compounds, Analgesic, Inflammation activity.
A-36
Molecular Docking: A Drug Design Method
Krati*, Neelam Painuly, Amandeep Singh Baghla
Department of Pharmacology, School of Pharmacy and Research, Dev Bhoomi Uttarakhand University,
Dehradun.
kratisharma8979@gmail.com
Molecular docking plays a very important tool for drug discovery, provide lots of molecular docking
method and their development and in drug discovery. In molecular docking, several methods are available
for protein structure determination like high throughput protein purification, Crystallography and Nuclear
magnetic resonance. These methods also help to study the protein ligand complexes. Molecular docking
provides a computational design for drug discovery. Drug discovery mainly classified into 2 parts. (A)
Ligand based drug design (B) Structural based drug design. For ligand- based drug design, Pharmacophore
modelling and Quantitative structure activity relationship (QSAR) methods are used. In second hand, for
the structure-based drug design, Molecular docking is the most common method which was discovered in
1980’s. The Molecular docking can be used for the interaction between molecule and protein, Behaviour of
molecule at the binding site of protein. The molecular docking has involved in two steps – (1). Prediction of
ligand confirmation. (2.) Assessment of binding affinity. There are two types of molecular docking – Rigid
molecular docking which is also known as “Lock and key” method and other type is Flexible docking
which is also known as “Induced fit”. In Rigid docking both receptor and ligand are treated as rigid. In
flexible docking, molecule which is smaller than other rotates. The main advantage of molecular docking is
to analyse the conformation and provide a pose of molecule into binding site of macromolecular target.
Keywords: Molecular docking, Drug design, Lock, and key, Induced fitdocking method.
A-37
Synergistic potential therapeutic effects of Medicago Sativa with Panax Ginseng and
comparison between their phytochemical and nutritional profiles
Sachin Kumar*1, Ashok Kumar1, Suhasini Nayal2
1
Graphic era Hill University, Dehradun, India
2
SuhasiniNayal, JBIT College of Pharmacy, Dehradun, India
srai24304@gmail.com
Alfalfa which is ‘Father of all herbs’ or ‘King of Herbs’ and Ginseng which is ‘Man root’ or ‘Herb for all healings.
Individually, both has copious number of phytochemicals and nutrients like flavonoids, saponins,
ginsenosides, vitamins, minerals and protein etc and this has already been proved by many scientific
researches. This comprehensive review aims to provide an overview of the potential health benefits of
Medicago Sativa (alfalfa) and Panax ginseng as herbs for complete wellness. Medicago Sativa has been
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found to possess anti-inflammatory, antioxidant, and anti-diabetic properties etc., while Panax ginseng has
been shown to boost immunity, improve cognitive function, and reduce stress and fatigue etc. The review
also compares the nutritional profiles of these two herbs and discusses the potential synergistic effects of
combining them with some existing scientific evidence. The review highlights the need for further research
to validate the efficacy of these herbs as magical combination of herbs for complete wellness and
recommends precautions for potential side effects and dosage considerations. The findings of this review
may contribute to the further clinical trials and validation of these herbs for improved wellness.
Keywords:Medicago sativa, Panax ginseng, Synergistic effects, Compatibility, Potential side effects.
A-38
Curcuma caesia roxb. as an herbal medicine: A review
Vinita Chauhan*1, Arvind Negi1, Alka Tailwal1, Kapil Kalra2
1
Department Of Pharmaceutical Sciences, Guru Ram Das Institute of Management & technology
2
Department of Pharmacy, Alpine College of Management & Technology
vinni6218@gmail.com
Curcuma caesia Roxb. is a relatively little known and practically unexplored medication, even though
traditional healers employ the genus Curcuma to cure a variety of diseases in ethnomedical practices.
Leucoderma, asthma, tumours, piles, bronchitis, and other conditions have reportedly been treated with
Curcuma caesia for a very long period in traditional medical systems. Bruises, contusions, and rheumatic
discomfort are treated with the paste. The rhizomes of the plants are frequently used in the treatment of
pneumonia, cough, and cold in children & for fever and asthma in adults. The current review aims to
develop the essential ethnomedicinal utilities. The zingiberaceae family includes Curcuma caesia, also
referred to as “kali haldi”. This plant can be found in the northeast, central India, the Papi Hills of the East
and West Godavari, and Andhra Pradesh. A perennial herb with tall, erect rhizomatous herb with large
leaves is called Curcuma caesia Roxb. Fresh rhizomes have a potent camphoraceous odour and are grown
for their rhizomes, which are utilised in traditional medicine. Camphor, ar-turmerone, (Z)- ocimene,
curcumin, 1, 8-cineole, elemene, borneol, bornyl acetate, and curcumene are said to be the main
components of the plant. According to reports, the plant has antifungal, anti-asthmatic, antibacterial,
smooth muscle relaxant, antioxidant, analgesic, locomotor depressant, anticonvulsant, and muscle relaxant
actions as well as anti-inflammatory qualities. This review focuses on the medicinal applications,
phytochemistry, and pharmacological effects of the plant and shows how herbal products can be as safe as
synthetic products while yet being as effective as modern medicine.
Keywords: Curcuma caesia, Phytochemistry, Ethnomedicinal,Camphoraceous.
A-39
An overview of Process Validation in Pharmaceutical Industry
Megha Shivani*1, Suman Yadav1, Kapil Kalra1, Arti Raturi2
l
Department of Pharmacy, Alpine College of Management and Technology, Dehradun, Uttrakhand
2
Om Bio Science and Pharma College, Roorke, Haridwar
shivanimegha@gmail.com
Validation is one of the important steps in achieving and maintaining the quality of the final product. If
each step of production process is validated, we can assure that the final product is of the best quality.
Validation is the art of designing and practicing the designed steps alongside with the documentation.
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Validation and quality assurance will go hand in hand, ensuring the thorough quality for the products.
Process validation emphasize on process design elements and maintaining process control during
commercialization and communicate that it is an ongoing program and align process validation activities
with product lifecycle. The purpose of this review is to present an introduction and general overview on
process validation of pharmaceutical manufacturing with special reference to the requirements stipulated by
the US Food and Drug Administration (FDA). Quality is always an imperative prerequisite when we
consider any product. Therefore, drugs must be manufactured to the highest quality levels. End-product
testing by itself does not guarantee the quality of the product. Quality assurance techniques must be used to
build the quality into the product at every step and not just tested for at the end. In pharmaceutical industry,
Process Validation performs this task to build the quality into the product because according to ISO
9000:2000, it had proven to be an important tool for quality management of pharmaceuticals. Drug must be
manufactured to the highest quality level. Through this review article we want to have had the knowledge
of the process validation and want to put the basic outline over this process validation process. Drug must
be manufactured to the highest quality level. Through this review article we want to have had the
knowledge of the process validation and want to put the basic outline over this process validation process.
Keywords:Process, Pharmaceutical manufacture, Design, Quality.
A-40
Automation, Robotics and Advances in Artificial Intelligence in Pharmacy
Mukul Bhardwaj*, PranshuTangri, Yamini Chandola Semwal
Department of Pharmacognosy GRD(PG)IMT, Dehradun -248001, Uttarakhand, India.
mukulbhardwaj865@gmail.com
Artificial intelligence (AI) is a branch of computer science that deals with the problem–solving by the aid
of symbolic programming .it has greatly evolved into a science of problem- solving with huge application
in business, health care, engineering. The main objective of this artificial intelligence to identify useful
information processing problems and give an abstract account of how to solve them.AI pharmacy solutions
include an automated dispensing technology that uses automation features to understand prescriptions and
dispense medications, with minimal involvement from a pharmacist. This allows pharmacists to serve a
higher number of patients and enhance satisfaction levels. The pharmacists can, furthermore, offer patients
more time and address the wrongly perceived notion that pharmacy is a purely transaction-based business.
Artificial intelligence in Pharma refers to the use of automated algorithms to perform tasks which
traditionally rely on human intelligence. Over the last five years, the use of artificial intelligence in the
pharma and biotech industry has redefined how scientists develop new drugs, tackle disease, and more
Pharmacy automation involves the automation of common tasks and processes performed in a pharmacy or
other healthcare settings.For example, the dispensing of medications has traditionally been a time
consuming and tedious task performed by pharmacists for several decades. Artificial intelligence helps
pharma companies find patients for clinical trials.
Keywords:Artificial Intelligence, Automation, Pharmacy.
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A-41
Modification of physicochemical properties of Chitosan to improve its
Pharmaceutical Applications
Khanwelkar C. C1., Shete A. S2, Shah N. V.*3
1
Department of Pharmacology, Krishna Institute of Medical Sciences, KVV, Karad, Maharashtra, India.
2
Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth, Karad, Maharashtra, India.
3
Department of Pharmacology (Pharmaceutical Sciences), Krishna Vishwa Vidyapeeth, Karad, Maharashtra, India.
nutanu56@gmail.com
Chitosan has received much more attention as a functional biopolymer with applications in
pharmaceuticals, drug delivery systems and cosmetics. Nevertheless, chitosan application is limited by its
solubility in aqueous solution and this limitation is overcome by modification of its physicochemical
properties to become soluble in aqueous media. The main objective of present investigation was to modify
physicochemical properties of Chitosan to improve its aqueous solubility and it will be useful to improve
performance of active pharmaceutical ingredients and its pharmaceutical applications. The following were
supplied by Loba Chemicals, Mumbai: Chitosan, ascorbic acid, citric acid, glutaric acid, succinic acid,
oxalic acid, acetic acid, hydrochloric acid, sodium hydroxide, sodium chloride and Itraconazole supplied by
Glenmark, Mumbai. Here modified derivatives of chitosan increase degree of deacetylation with decrease
in viscosity and molecular weight. FTIR and XRD studies showed the interaction between chitosan and
coformers. Solubility study indicates improved water solubility of chitosan derivatives using coformersupto
75% at neutral pH. Itraconazole complex with these derivatives proved increased drug release as compared
to plain chitosan.Chitosan and its derivatives as a conformer in complexation with Itraconzole have shown
there are increasing 6 times more solubility and dissolution of Itraconazole. Hence, it is possible to obtain
water soluble chitosan with specified properties from oxalic acid, citric acid, glutaric acid, ascorbic acid,
succinic acid, and chitosan of varying degree of deacetylation, viscosity and average molecular weight.
Keywords: Chitosan, Deacetylation, Itraconazole, Conformers.
A-42
Hydroxyethyl Cellulose as a versatile viscosity modifier in the development of sugar-free,
Elegant Oral Liquid Formulations
Vijaya Kumar J1*, Ajay Kumar Dantuluria1, Yi Liu2,Thomas Durig3
1
Ashland Private Limited, India,
2
Ashland (China) Holdings Co., Ltd., China,
3
Ashland Specialty Ingredients, Wilmington, DE, USA.
vjujare@ashland.com
Pharmaceutical formulations in liquid form for oral administration are commonly utilized for geriatric and
pediatric patients who have difficulty swallowing solid dosage forms. Consistency and stability of the
liquid vehicle are critical for ensuring consistent drug delivery. Rheology, texture, and stability are among
the Critical Quality Attributes (CQAs) that must be addressed in the development of oral liquid and semi-
solid dosage forms. The distribution of pharmaceutical components relies on the manipulation of
rheological properties, texture, and stabilization within these forms. The utilization of thickening agents to
increase the viscosity of the liquid vehicle serves to reduce particle settling. Historically, sugars such as
sucrose were utilized for this purpose, as well as for masking the taste of active pharmaceutical ingredients
(API). However, alternative thickening agents such as Xanthan gum, Tragacanth, Carrageenan, and
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cellulose derivatives (such as sodium carboxymethylcellulose, methylcellulose, hydroxypropyl

methylcellulose, hydroxypropyl cellulose and hydroxyethyl cellulose etc.) are increasingly employed as
they do not possess the same risks of glycogenic and carcinogenicity as sugars. Cellulose derivatives, due to
their water binding and viscosity modifying properties, can be effectively utilized to enhance the
rheological properties and stability of oral liquid and semi-solid dosage forms, resulting in improved patient
satisfaction and product shelf-life. The use of hydroxyethyl cellulose, a highly water-soluble cellulose ether
polymer, as a viscosity modifying or rheology modifying agent within oral liquid dosage forms, as well as
its underlying polymer chemistry, is thoroughly examined in this literature review.
Keywords: Rheology, Hydroxyethyl cellulose,Natrosol™ 250 HEC, Syrup.
A-43
Phytosomes: A novel approach for the targeted drug delivery system
Vineet Joshi1,2
1
Adarsh Vijendra Institute of Pharmaceutical Science Shobhit University Gangoh Saharanpur, UP
2
College of Pharmacy, Shivalik Campus, Dehradun, Uttarakhand.
The word Phytosome is derived from the term “Phyto” which means to the plant, and “some” means to cell-
like. Phytosomes also known as Phyto-phospholipid complexes, are the vesicular drug delivery systems that
are generally formed either by the interaction between the hydrophilic portion of the phospholipids.
Phytosomes are structurally quite like liposomes, but the difference is that the active ingredient in
liposomes is present inside the hydrophilic cavity or within the layers of the membrane while in
Phytosomes the drug/plant constituents are part of the membrane itself. Various methods have been
proposed for formulating Phytosomes such as freeze-drying co-solvency technique, rotary evaporator
method, anti-solvent precipitation method, and salting out method. Phytosomes have received tremendous
attention for phytochemical delivery as a fast-growing class of nanovesicles. The main characteristics of
Phytosomes are size and shape, surface charge, chemical composition, lamellarity and stability,
encapsulation efficiency, and release behavior. Recently various researchers worked on Phytosomes based
drug delivery systems such as the effect of Phytosomes on Nervous systems, Phytosome effect in the
Genitourinary system, Phytosomes as Modulators of the Immune System, Phytosomes’ Role in the
Respiratory System Diseases, Phytosomes Efficacy in Metabolic Syndrome, Phytosomes in the
Gastrointestinal system, etc. various drugs incorporated with Phytosomes to produce targeted drug delivery
as well as enhance the activity of the drugs such as doxorubicin Phytosomes effectively inhibit the growth
of breast cancer cell, silibinin-loaded Phytosomes for the treatment of prostate cancer, curcumin
Phytosomes as anti-inflammatory activity, etc. According to the facts provided above, it can be concluded
that the potential of Phytosomes with the effort of researchers and clinicians has a bright future for
applications in the pharmaceutical field.
Keywords:Phytosome, Vesicular, Co-solvency, Genitourinary system.
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A-44
Cedrus deodara (Roxb. ex D.Don) G.Don “Wood of The Gods”: An inclusive study
Harshita Chandra, Indu Tewari*, Sanjay Singh
Siddhartha Institute of Pharmacy, Dehradun
Indu.tewari12@gmail.com
Cedrus Deodara, belongs to the family pinaceae it is use in the treatment of skin conditions, microbial
infections, joint disorders, asthma, kidney stones, ulcers, and other conditions diseases of the immune
system and brain, the medicinal tree Cedrus deodara has historically been important and well-mentioned in
traditional medical systems of India, Pakistan, China, Korea, and others. In order to assess the potential for
the development of novel therapeutic agents, this review provides an overview of the knowledge that is
currently available regarding the biological activity, pharmacological profile, and traditional uses of Cedrus
deodara crude extract, as well as details on its isolated compounds and oil which can be obtained from
Cedrus deodara. The databases used to compile all the relevant information from previously published
literature for this species included Scopus, Google Scholar, Science Direct, Web of Science, Springer Link,
and PubMed. The Northern Regional Centre, the Plant Survey of India, theplantlist.org, and relevant book
chapters and volumes were also investigated, along with other official internet resources. Preliminary
pharmacological study on different Crude extracts, essential oils, fractions, and isolated compounds from
Cedrus deodara showed a variety of notable pharmacological and biological activities, such as anticancer,
antibacterial, antifungal, analgesic, anti-inflammatory, neuroprotective, antiurolithiatic, antiarthritic, and
antiasthmatic. Therefore, further research must be done to ascertain its method of action, efficacy, dose
range, and safety in treating a variety of pathological disorders.
Keywords:Cedrus deodara, Ethnomedicine, Toxicity, Antiurolithiatic.
A-45
Asparagus: A Medicinal Genus with Promising Phytochemistry and Pharmacological
Activities
Anoop Singh Negi1,2, Veerma Ram1 and Ganesh Kumar2
1
Sardar Bhagwan Singh University, Dehradun, India
2
College of Pharmacy, Shivalik Campus, Dehradun, India
anoopnegi.oct@gmail.com
Medicinal plants are of great importance in traditional medicine, as they have been used for centuries to
treat various ailments and promote health and well-being. Many modern drugs have been developed from
medicinal plants, and these plants continue to play a vital role in the development of new drugs and
therapies. In modern drug discovery, plant families and genera can serve as a valuable source of lead
compounds for the development of new drugs. It is a widely distributed genus comprising over 300 species,
many of which are known for their medicinal properties. Asparagus species have been traditionally used in
various medicinal systems, including Ayurveda, traditional Chinese medicine, and Unani medicine, to treat
various ailments such as inflammation, cancer, diabetes, and various gastrointestinal disorders. The
phytochemical analysis of Asparagus has revealed the presence of several bioactive compounds, such as
saponins, flavonoids, and phenolic acids, which are responsible for their medicinal properties. These
bioactive compounds have been found to possess various pharmacological activities, including anti-
inflammatory, antioxidant, antimicrobial, and anticancer activities, among others. Asparagus species also
have potential applications in the food and cosmetic industries due to their nutritional and cosmetic
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benefits. Further studies are needed to explore the full potential of the Asparagus genus and to develop new
drugs and products based on these species.
Keywords: Drug discovery, bioactive compounds, food & cosmetic industry.
A-46
Cubosome: A suitable nanocarrier for pharmaceutical drug delivery system
Pragati Bailwal, Ashutosh Badola
Department of Pharmaceutical sciences, SGRR University, Dehradun Uttarakhand, India
pragatibailwal90@gmail.com
Cubosomes are nanostructured liquid crystalline particles with specific amphiphilic lipid compositions that
are used as biocompatible drug delivery vehicles. Curved bicontinuous lipid bilayers are arranged in three
dimensions as a honeycomb structure with two internal aqueous channels that can accommodate drugs of
different polar characteristics. Because of their unique characteristics, such as thermodynamic stability,
bioadhesion, the ability to encapsulate hydrophilic, hydrophobic, and amphiphilic substances, and the
potential for controlled release through functionalization, cubosomes are seen as promising vehicles for a
various routes of administration The cubic shape offers a enormous membrane surface area for loading
membrane proteins and medicinal compounds when compared to liposomes. The self-assembling
properties of cubosomes make their production simple and uncomplicated. By using intense shearing
action, such as that produced by sonication and homogenization, amphiphilic lipids such monoolein,
monolinolein, phytantriol, etc. self-assemble into non-lamellar bicontinuous cubic phases. Using stabilising
agents is an important step in the preparation of cubosomes to prevent re-coalescence of the dispersed
particles into the parent bulk cubic structure when dispersed in water. Commonly used stabilizing agents
are Pluronics, especially F127 (Poloxamer 407) are used as stabilizing agent. The drug release from
cubosomal dispersions has demonstrated improvement in bioavailability by solubilizing drugs that are
poorly water soluble, decrease in adverse effects, enhancement of intracellular penetration, protection
against degradation, possibility of sustained drug release, and the biodegradable nature of lipids is an
additional advantage, making cubosomes a suitable carrier for oral, parenteral, topical, transdermal, and
pulmonary drug delivery.
Keywords: Nanoparticles, Cubosomes, amphiphilic, bio adhesive, solubility.
A-47
An Overview on Nanocarriers for Skin Problems
Mayuri Gupta1, Nimisha1*1, A. K. Rai2
1
Amity Institute of Pharmacy, Lucknow, Amity University Uttar Pradesh, Sector 125, Noida, 201313, India.
2
Department of Pharmacy, PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur
nsrivastava3@lko.amity.edu
Nanotechnology offers promising applications in medicine, especially pharmaceuticals to deliver drugs

safely and specifically. In comparison to current technologies, nanosized carrier systems pose the least
damage to the skin's natural barrier function. Transdermal delivery of drugs using nanocarriers has emerged
as a valuable alternative to increasing the range of available drugs. The delivery of lipophilic and
hydrophilic drugs through the stratum corneum is possible via an array of nanocarriers, and treatment is
possible on a local or systemic level. In addition to their biocompatibility and low cytotoxicity, these
carriers enhance a drug's stability and have many applications (oral, intravenous, pulmonary, ocular and
dermal). Although various methods have been developed to improve skin penetration and permeation of
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therapeutics, they are usually aggressive and could lead to irreversible damage to the stratum corneum.
Nanocarriers are made up of a mixture of solid and liquid lipids (oils) diffused in an aqueous solution
containing a surfactant. The use of nanocarriers for delivery of targeted drugs to the skin, in order to ensure
sustained release and localized effects, has enabled the penetration of therapeutics across the skin, a highly
complex biological barrier, leading to a successful treatment of various life-threatening dermatological
conditions.
Keywords: Nano Carriers; Transdermal; Dermatological Disorders; Cytotoxicity.
A-48
Evaluation of antidepressant activity of the ethanolic extract of Pongamia Pinnata bark in
Albino Wistar rats
Shivani Verma1, Aarti Sati2
1
School of Pharmacy, Graphic Era Hill University, Bell Road, Clement Town, Dehradun 248002,
Uttarakhand, India.
2
Department of Pharmacology, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel
Nagar, Dehradun, Uttarakhand, India.
shivaniverma.123ktw@gmail.com
The two most common and severe psychiatric disorders are anxiety and depression. These disorders are
treated with a variety of drugs, but many of them have harmful side effects. Alternative treatments,
including herbal medicines, have been proven to be effective in reducing depression. The objective of the
current research was to assess the antidepressant efficacy of pongamia pinnata bark ethanolic extract
(PPBE) in albino wistar rats. There were six different animal groups, and each consisted of six animals per
group. Animals were subjected to different stress paradigms daily for a period of 21 days to induce
depressive like behavior. As a standard drug (fluxoteine (10mg/kg i.p.) was used. An ethanolic extract of
pongamia pinnata bark at a dose of (100, 200, 400 mg/kg) was used for 28 days, after that behavioral
parameters were performed (forced swim test, tail suspension test, locomotor activity test). An ethanolic
extract of Pongamia pinnata bark possesses an antidepressant effect when compared with the standard drug
fluoxetine. Chronic treatment with PPBE significantly reversed the unpredictable chronic stress-induced
behavioral (increased immobility period, ambulatory movement and biochemical (increased catalase
activity and decreased lipid peroxidation) in stressed rats. All the three doses (100, 200, 400 mg/kg) showed
significant results. Among all the three doses, the highest dose (PPBE 400 mg/kg p.o.) showed the most
significant results comparatively. Thus, it can be concluded that PPBE could be an attractive neuro-
pharmacological agent for the treatment of depression.
Keywords: Immobility, Pongamia pinnata, Antidepressant activity, PPPBE, Depression.
A-49
Application of Nanosponges for toxin elimination from contaminated water
Shalu Verma*1,2, Alka Singh3
1
Research Scholar,School of Pharmaceutical Sciences, SGRRS, Dehradun, Uttarakhand, India-248007
2
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India
3
School of Pharmaceutical Sciences, SBS University, Balawala, Dehradun, Uttarakhand, India
Vermashalu339@gmail.com
With advances in nanoscience and technology, a wide range of materials and better goods may be available
with altered physical qualities as a result of their size reduction. It is incorrect to think about
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nanotechnology as a solitary approach that only affects certain fields. It serves more as a generalised term
for science that has positive effects on a variety of fields, including healthcare, the environment, and
hundreds of commercial products. The nanoparticles with porous structures are known as nanosponges.
Initially, nanosponges were created to administer medications topically. They can also be utilized in
environmental applications to purify water or remove metal stains, which help to clean up ecosystems.
They have dimensions of 1µ m or less and cavities with tuneable polarity. By altering the crosslinker to
polymer ratio, nanosponges of various specific sizes can be created. High cross-linking typically results in
low-swelling polymers that are better suitable for the treatment of water because water won't occupy the
area designated for metal trash and can be more easily filtered from the water after cleaning. The
elimination of toxins from the contaminated water is emphasised in this study. Moreover, a comprehensive
review of the nanotoxicity and biosafety of these nanosponge-based water treatment technologies is
necessary. The design and implementation of nanosponge-based systems for removing toxins from water
are discussed with a focus on constraints and future trends.
Keywords: Nanotechnology, Nanosponges,Water, Contamination, Nanomaterials.
A-50
Formulation and characterization of Linezolid loaded microcapsule in capsule shell
Ashutosh Bandola*, Vivek Chauhan
SGRR University, Dehradun, Uttarakhand
ashutosh.badolam.pharma@gmail.com
The main purpose of this study is to formulate linezolid-loaded microcapsule linezolid is an oxazolidinone
antibacterial agent effective against most strains of aerobic grampositive bacteria and mycobacteria.
Microencapsulation is an advanced technology, using which a compound can be encapsulated inside a
particular material, making a tiny sphere of diameter ranging from 1 μm to several 100 μm.
Microencapsulation is done for protecting the sensitive compounds and to ensure their safe delivery. The
compound or active material which is encapsulated is called the core and the material which is used for
encapsulating is called the encapsulant. Encapsulants can be either polymeric or nonpolymeric materials
like cellulose, ethylene glycol, and gelatin. There are several techniques used for microencapsulation. The
characterization and optimization of efficient and successful encapsulation can be done by studying the
encapsulation efficiency and various properties of the capsules like morphology, size, hydrophobicity,
hygroscopicity, solubility, surface tension, thermal behavior, and mechanical properties.
Keywords: Linezolid, Microencapsulation, Mycobacteria, Encapsulant.
A-51
Tuberculosis Biosensors: An Overview
Jyotsana Bhatt1*, Archana Dhyani1, Ashish Dhyani2
1
School of Pharmacy, Graphic Era Hill University, Dehradun
2
Department of Hotel Management and Hospitality, Graphic Era (Deemed to be University), Dehradun
bhattjigyasha94@gmail.com
Tuberculosis is the most common infectious disease of bacterial origin. It is one of the major global health
issues of 21st century due to number of factors including non-precise diagnostic techniques, uneconomical
first- & second-line treatment and constantly emerging multidrug resistance cases. Even after a decade of
its first detection, no precise detection technique has been developed which is fast, sensitive, accurate and
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inexpensive. Only detection techniques available are microscopy and culture techniques which take a long
time in detection causing a delay in administering the right dose in right time. To overcome the limitations
of the conventional diagnostic techniques, several microbiological, clinical and imaging diagnostic
techniques are studied. Biosensors are among the newly studied diagnostic techniques for the early and
accurate detection of tuberculosis. Different types of biosensors working on different principle utilizing
various recognizing biomolecules are studied including magneto-elastic biosensors, piezoelectric
biosensors. This article provides a review on different types of biosensors utilized and studied for the
diagnosis of tuberculosis along with their specifications.
Keywords:Tuberculosis, Biosensors, Magnetic Biosensors, Breathalyzer, Aptamers.
A-52
Understanding the concentration variation in Serum Alkaline Phosphatase in patients of
Type 2 Diabetes Mellitus with hypertension
Sristi Anupam*, Simran, Rina Das
M.M College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, Haryana
srist.anupam149@gmail.com
Assessment of alkaline phosphatase (ALP) among patients of Type 2 diabetes mellitus (T2DM) with
hypertension (HTN) is an essential parameter. The liver plays an important role in keeping glycemic control
in check. Increased ALP levels are associated with poor glycemic control, increased insulin resistance, and
a higher risk of type II diabetes. Several processes including insulin resistance and elevated oxidative stress
can affect serum ALP activity and diabetes. This cross-sectional study includes a total of 60 participants
(30-60 years). The study was conducted for a period of 3 months. The Serum ALP concentrations of the
participants were analysed. Patients suffering from already known hepatic disease and other comorbid
conditions like kidney diseases, pregnant or lactating women were excluded from the study. Among a total
of 60 patients (30 male, 30 females) with T2DM and HTN. Males had a mean age of 50.6 years, while
females had a mean age of 48.28 years. Males and females have mean serum ALP concentrations of 200
U/L and 223.47 U/L respectively. Elevated serum ALP was shown to be more prevalent in males as
compared to females. It has been found that elevated serum ALP is more common in males with T2DM
with HTN than in females. This finding may help in early detecting hepatic disturbance in diabetic with
hypertensive individuals.
Keywords: Oxidative Stress, Insulin Resistance, Comorbid.
A-53
Anogeissus Latifolia: A Spectral Tree Holding Copious Medicinal Properties
Mansi singh 1, Siva Prasad Panda*1, Sanjesh Kumar1, Kundan kumar Chaubey2
1
Institute of Pharmaceutical Research, GLA University, Mathura, UP-281406 India
2
Division of Research and Innovation, School of Applied and Life Sciences, Uttaranchal University, Dehradun,
Uttarakhand-248007, India
sivaprasad.panda@gla.ac.in
Herbal medications have a significant place in the treatment of a wide variety of illnesses and disorders
since they have high therapeutic effectiveness and either no adverse effects at all or very few negative
effects. The current situation demonstrates that herbal plants and the extracts of those plants are used
extensively due to the spectrum of pharmacological and medical benefits that they provide. Reviewing
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previous research on the pharmacological activity, phytoconstituents, ethnobotanical qualities, and

biotechnological investigations of Anogeissus latifolia was the purpose of the current study, which proved
enlightening. Because it contains a variety of chemicals, including terpenoids and flavonoids, Anogeissus
latifolia possesses antioxidant activity. This is due to the presence of these chemicals in the plant. This plant
is also being investigated for its potential antiulcer, antimicrobial, anthelmintic, and wound-healing
properties in pharmacological and medicinal studies. The Anogeissus Latifolia plant also generates a sort of
gum exudate that is also known as "ghatti gum," and this ghatti gum is commonly employed as a polymer
that is used in the production of several types of medications. This article is a review of a study that
discusses the numerous medicinal applications and pharmacological activities of the plant known as
Anogeissus Latifolia.
Keywords: Anogeissus Latifolia, pharmacological activity, biotechnological studies, Phytoconstituents,
biotechnological studies.
A-54
Review of a novel method for Microsponges drug delivery mechanism
Mohammad Khalid1, Umesh Kumar Sharma2
1
Research Scholar, College of Medical Sciences, IIMT University, Meerut (UP) India
2
Dean, College of Medical Sciences, IIMT University, Meerut (UP) India
Due to their advantages and the fact that this subject is still in its infancy, researchers from all over the
world are now looking into using microsponges as drug carriers. Microsponges are porous microsphere-
based polymeric drug delivery systems. These tiny, spherical particles have a broad porous surface and
resemble microscopic sponges. The distribution of oral and biopharmaceutical drugs also uses this
innovative technology for topical controlled release agents. To increase their effectiveness, microsponges
are dependable delivery systems that incorporate both water-insoluble and water-sparing agents. Many
kinds of medications can be captured by microsponges, which are used in formulations like cream, gel,
lotion, and powder. Cerac, Ultra guard, and retinol cream are just a few examples of commercially
accessible formulations. One of the best aspects of this technology is that it is self-sterilizing. It also offers
improved formulation flexibility and increases the effectiveness of topically active medicines. Many studies
have shown that microsponges are non-mutagenic, non-irritant, and non-allergic in nature. The current
review describes in detail the release mechanism, preparation techniques, characterization, assessment
criteria, and uses of the microsponges technology.
Keywords: Microsponges, Drug Delivery, Preparation, Topical, Oral.
A-55
Assessment of health-related Quality of Life among Type 2 Diabetes mellitus patients with
hypertension
Simran*, Sristi Anupam, Rina Das
M.M College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University. Mullana, Ambala, Haryana
Assessment of health-related quality of life (HRQOL) in patients suffering from type 2 diabetes mellitus
(T2DM) with hypertension (HTN). Mostpeople with diabetes and hypertension have a low Quality of Life
due to their treatment plan and way of living. Numerous bodily organs, including the kidneys, feet, eyes,
heart, and even the nerves can suffer harm from high blood sugar. Blood vessel hardening and elevated
blood pressure are additional effects of diabetes. Long term of these conditions can also affect mental
health by quick changes in mood, also managing such conditions can be stressful which may affect their
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day-to-day life. The above cross-sectional study was done with a sample size of 60 diabetic- hypertensive
individuals for 3 months. A health-related quality of life questionnaire for physical and psychological
domain was filled by these patients. Patients who are unwilling to participate in the study were
excluded.Almost 60% of the patients reported that their daily work is affected to a large extent, whereas
only 15% felt no problem at all in performing daily work. Assessment of the psychological domain of
HRQOL revealed that only 5% of patients were normal, without any symptoms of depression, anxiety or
stress, whereas the majority,i.e., 75% of the patients developed symptoms of anxiety and stress. Physical
and psychological health altered in diabetic patients with hypertension. Their daily work is affected to a
larger extent.
Keywords:Psychological, Hypertensive, Type 2 Diabetes Mellitus, HRQOL.
A-56
The creation of molecules containing Imidazoles and their potential for healing
Meenu Chaudhary, Ashutosh Badola
Shri Guru Ram University, Patel Nagar, Dehradun
1979mchaudhary@gmail.com
Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen
atoms, and two double bonds. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one
nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. It is a white or colorless solid
that is highly soluble in water and other polar solvents. Due to the presence of a positive charge on either of
two nitrogen atoms, it shows two equivalent tautomeric forms. It is the basic core of some natural products
such as histidine, purine, histamine and DNA based structures, etc. Imidazole has become an important
synthon in the development of new drugs. The derivatives of 1, 3-diazole show different biological
activities such as antibacterial, antimycobacterial, anti-inflammatory, antitumor, antidiabetic, anti-allergic,
antipyretic, antiviral, antioxidant, anti-amoebic, anthelmintic, antifungal and ulcerogenic activities, etc. as
reported in the literature. In present study we tried an enhancement procedure to the process for producing
imidazole by dehydrogenating imidazolines olivine, which involves reacting the imidazoline with the
olivine catalyst in combination with 30% by weight of a copper, chromium, or a combination of both
catalysts at temperatures between 180 and 240 degrees Celsius and pressures ranging from atmospheric to
400 psig.
Keywords:Imidazole, Heterocyclic Compounds, Dehydrogenation, Antimycobacterial, Anti-Inflammatory.
A-57
Understanding Tirzepatide's function in the treatment of Type-2 Diabetes
Ansh Aggarwal, Mayank Joshi*
M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana,
133207, India.
ansh2001aggarwal@gmail.com
Two of the most prevalent diseases, type 2 diabetes and obesity, have a significant cost impact on the
healthcare system. Insulin resistance decreased insulin secretion, obesity, a diminished incretin action, an
increase in glucagon production, and dyslipidemia are a few of the pathophysiological components that
make up type 2 diabetes. This study aims to provide evidence for the use of tirzepatide in the management
of type 2 diabetes. For the past ten years, literature that was relevant to this study was gathered from a
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variety of search engines, including Pubmed, Scopus, Google Scholar, and science direct. A wide range of
type 2 diabetics were assessed in the Phase 3 SURPASS clinical trial programme who received a once-
weekly subcutaneous injection of tirzepatide (5, 10 and 15 mg), either alone or in combination with other
drugs. When administered without insulin, tirzepatide was well tolerated and carried a low risk of
hypoglycemia. The results of these trials suggest that tirzepatide offers a fresh opportunity for the rapid and
effective reduction of body weight and glycated haemoglobin in type 2 diabetics.
Keywords: Glucagon, Insulinotropic, Peptide, Glycemia, Metabolism.
A-58
A better bioavailabity by Oro Trans Soft Palatal Drug Delivery
Srishti Morris1,2, Ashutosh Badola1
1
Shri Guru Ram Rai University, Patel Nagar, Dehradun
2
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Premnagar, Dehradun, 248001,
Uttarakhand
srishtimorris23@gmail.com
The absorption of drugs through the oro trans soft palatal delivery improves bioavailability of drugs Drug
absorption is mainly via passive diffusion through the lipoidal membrane. Thus, oro trans soft palatal drug
delivery has attracted the attention worldwide for optimizing the drug delivery. Oro trans soft palatal
delivery possibly bypass first-pass metabolism of drugs, avoidance of pre-systemic elimination within the
GI tract This route is easily accessible by patients, the mucosa is relatively permeable with a rich blood
supply, it is robust and shows short recovery times after stress or damage, and the virtual lack of
Langerhans cells makes the oral mucosa tolerant to potential. Buccal and sublingual dosage forms are
typically short acting because of limited contact time between the dosage form and the oral mucosa. Since
administration of drugs through these routes interferes with eating, drinking and talking therefore, these
routes are generally considered unsuitable for prolonged administration, whereas soft palatal medication
delivers steady infusion of drugs over an extended period of time, because of the function of the soft palate
to cover the glottis while swallowing, it is more fitted for sustained and controlled drug delivery also due to
the presence of immobile mucosa. The site is not affected by salivary secretion and tongue activity and can
be used as an ideal route for drug delivery and the pH is more nearer to blood as compared to buccal and
sublingual route.It can also serve as a smart route for the targeting of drugs to the brain
Keywords:Bioavailability, Membrane, Langerhans cells, Soft palatal, Permeable.
A-59
Metal Organic Frameworks: A Recent Trend In Drug Delivery
Varnit Tyagi1*, Chandan Bhogendra Jha2, Rashi Mathur2, Rajesh Kumar1
1
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India
2
Division of Radiological Nuclear & Imaging Sciences,Institute of Nuclear Medicine & Allied Sciences, DRDO, New
Delhi, India.
varnit.tyagi21@gmail.com
Metal organic frameworks (MOFs) are a novel class of nano-porous materials that have rapidly gained
popularity in recent years. Metal-organic frameworks are crystalline porous substances composed of metal
ions or clusters that are chemically linked together by organic linkers. The development of MOFs with
tunable structures, properties, and their potential applications in the fields of gas adsorption/separation,
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catalysis, sensors, drug delivery, magnetic materials, and optical devices, have received tremendous
interest. The most commonly used techniques for the synthesis of MOFs are non-solvothermal,
solvothermal, microwave assisted, and sonochemical. These MOFs can be changed into Nano-MOFs when
the size of MOFs is decreased to the nanoscale. Nano-MOFs, or nanoscale MOFs, can be fabricated as drug
carriers, and their size can be tuned according to intended applications. These nano-MOFs are flexible in
terms of of biocompatibility, biodegradability and can be easily functionalized to satisfy the necessary
degree of host-guest interaction while retaining a larger and completely changeable pore window. They
have been utilised to deliver a range of drug, including hormones, metabolic labelling molecules, anticancer
drugs, and antibacterial agents. Recentstudies highlighted these MOFs can also be used for improved
cellular uptake, controlled drug release, and drug targeted therapy. The loading of drugs into the MOFs can
be done by in situ encapsulation and post-synthetic modification. These diverse advantages may open up
new possibilities for multifunctional drug delivery and for the targeted therapy to overcome the problems
associated with traditional drug carriers. The short existence of MOFs in biomedicine poses a significant
long term toxicity concern, which is expected may be leaching of metal ion and its degraded product, must
be addressed before reaching to clinics. In conclusion, fabrication of biocompatible, adaptable, and
effective drug delivery systems based on MOFs is a potential research topic that has yet to be explored and
investigated.
Keywords: Biomedical, drug delivery, MOFs, porous.
A-60
Role of phytoconstituents against premature skin ageing
Amreen*, Vaibhav Rastogi, Anurag Verma
Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Utter Pradesh
amreenansari2345@gmail.com
Ageing is a process of phenotypic changes in cutaneous cells as well as anatomical and functional alterations in
extracellular matrix components such as collagens and elastin. There are two major processes that govern skin ageing:
intrinsic and extrinsic. Extrinsic ageing is caused by environmental factors like air pollution, smoking, alcohol abuse,
poor nutrition and sun exposure. Intrinsic ageing is dependent on time and genetic background. Fairness creams are
popularly used to reduce skin problems such as hyperpigmentation, sun spots and assures to slow down the signs of
skin ageing. However, these claims are based on the presence of synthetic agents like bleaching agent and other
chemicals which are not good for skin. Chemicals like mercury, nickel, chromium, hydroquinone and steroids present
in the fairness creams can cause a lot of skin problems like thinning of skin, discoloration of face, capillaries become
prominently visible, severe acne, hypersensitivity to sun, rebound paradoxical pigmentation, facial hair growth, skin
allergy and sometimes skin cancer. Thus, to fight premature ageing, it is beneficial to use herbs and plant extracts. For
the prevention of skin ageing, phytoconstituents such as resveratrol, epicatechin, epigenin, retinol, quercetin, lutin,
ferulic acid, gallic acid, ellagic acid, punicallagin, etc can be utilised in herbal cosmetic formulations. These
phytoconstituents are present in various plants such as ginseng, oregano, rosemary, horsetail, sage, ashwagandha,
guduchi, cinnamon and calendula. Thus, by using herbs various cosmeceuticals can be prepared to reduce the signs of
premature ageing effectively.
Keywords: Skin Care, Phytoconstituents, Skin Ageing, Free Radicals, Antioxidants.
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A-61
Review on nutritional value and health benefits of Setaria italic Syn. Panicum italicum
(Foxtail millet)
Hemlata Bhatt*
1
H.N.B Garhwal University, Uttarakhand
visithemlata@yahoo.co.in
Foxtail millet is a member of the Paniceae tribe (subfamily Panicoideae of the Poaceae) and came from
green millet domestication in northern China about for 8000 years ago. Foxtail millet is extensively
cultivated in the developing countries in semiarid and arid regions of Africa, Americas, Asia because of its
health benefits, good yield with minimal agricultural inputs, and adaptation to different biotic and abiotic
stresses such as salinity, drought and fungal diseases. A healthy and environmentally friendly small crop of
foxtail is an increasingly attractive alternative for crop production. Foxtail millet has a sweet, bitter taste. It
contain niacin B3 (0.7mg), riboflavin B2 (0.11mg), thiamine B1 (0.59 mg), carotene (32µg), iron (6.3mg),
calcium (0.03g), phosphorus (0.29g), protein (12.3g), minerals (3.3g), carbohydrates (60.6g) and fiber
(8gm) in per 100gm of dry grains. Foxtail millets are an excellent source of iron and calcium which play a
pivotal role in maintaining the health of bones and muscles. Nutritionists strongly recommend the intake the
Foxtail millet for keeping various neurological disorders like Alzheimer’s, Parkinson’s and convulsions.
Eat it daily to protect heart from various ailments. The glycemic index of Foxtail millet is at 50.8 making it
an ultimate choice of low-glycemic foods. Include it in daily diet to witness a healthy dip in levels of blood
sugars, glycosylated hemoglobin and lipid profile. Foxtail millet contains a good source of amino acids
including Lecithin and Methionine which play a crucial level in decreasing cholesterol by reducing excess
fat in the liver. The presence of Threonine prevents fatty liver, further decreasing the levels of bad
cholesterol. Tryptophan, an amino acid present in Foxtail millet in ample amounts is crucial for preventing
hunger pangs. Eat it with loads of vegetables to regulate bowel movements and to lose weight. A rich
source of vitamins, minerals and other nutrients, Rich in protein, dietary fiber, an array of vitamins and
minerals, include these millets to control blood sugar, lose weight, boost immunity and protect heart health.
Unlike popular opinion that millets are not a delight to eat, one can whip up amazing recipes with these,
enjoy and lead a healthy lifestyle.
Key words: Foxtail Millet, SetariaItalic, Poaceae.
A-62
Artificial Intelligence: Artificial Neural Networks
Nishika Amankar, Bhavya Gupta*
Department of Pharmacy, GRD PG Institute of Management and Technology, Dehradun – 248009, UK, India
gupta06bhavya29@gmail.com
The branch of computer science which allows machines to work efficiently, can analyze complex data. In
artificial intelligence computational models’ algorithms or set of rules are used which supports the machine
to mimic the cognitive functions of human such as learning, problem solving. In the field of pharmaceutical
and healthcare research AI plays various roles to investigate in enormous data from various modalities. In
drug discovery, AI can be used in both drug screening and drug design. Various artificial neural networks
(ANNs) like deep neural networks (DNNs) or recurrent neural networks (RNNs) are being employed in
rational drug design and drug delivery formulation development. An important useful application of AI is
development of expert system in which fuzzy logics is highly used since it has ability to solve problems like
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human being and same related with decision making, self-organization feature maps, propagation and
activation functions vary from common neural network system in neuro fizzy networks. The ability of
artificial neural networks for sensational information processing features like non- success tolerance,
parallelism, learning, non- linearity robustness, skill to drive imprecise and fuzzy information, allow its use
in rational drug design. The ability of ANNs to discover, optimize, pattern classification, clustering and
solve complicated problems in real life, is beneficiary for future prospective. This review article
characterizes various roles and features of ANNs for healthcare organization, also applications of artificial
intelligence and machine learning in rational drug design process. It defines a promising future of this
technology for students, researchers, and pharmaceutical industries.
Keywords: ANNs, DNNs, RNNs, FUZZY LOGICS, CLUSTERING.
A-63
Formulation, evaluation of scaffold and comparative studies with transferosome for topical
delivery in the treatment of wound healing
Lovely Chaurasia *1, Gaurav 1,MojahidUl Islam 2
1
Department in pharmacy, IIMT College of medical sciences, IIMT University,Meerut 250001, Uttar Pradesh, India
2
Department of Pharmacy, Vishveshwarya Group of Institution, Greater Noida
Formulation, evaluation of scaffold and comparative studies with transferosome for topical Delivery in the
treatment of wound healing. The scaffold and transferosome comprising of differing level of Synthetic and
natural polymer, scaffold and transferosome were ready by vortex blending strategy. Different boundaries
like solubility considers, drug content, self-emulsification appraisal, precipitation appraisal, thickness, pH,
in-vitro disintegration was assessed for hydrogel and emulgel. Distinguish of medication was finished by
liquefying point, Infrared Spectroscopy, and TLC. Adjustment bend of LawoniaInermiscorrosive was ready
in 0.1 N phosphate buffer (Ph 7.0) at λ max 352 nm. The solubility investigation of LawsoniaInermiswas
performed by utilizing phosphate buffer (pH7.0) for 72 hrs at 37± 0.5℃ by orbital shaker strategies. A rate
drug content worth of all plans of was inside LawsoniaInermis 93.54-99.95%., Formulation F3, F08 and
F10 was clear, slightly bluish appearance which was graded I. A percentage drug content value of all
formulation of LawsoniaInermiswas within 93.54- 99.95%. The diluted nano showed no visible signs of
phase separation or drug precipitation after storage for 24 hrs, which implies formation of stable hydrogel
Dissolution study was performed by the dissolution apparatus at 37 in phosphate buffer pH 7.0.
Formulation F3 shows maximum drug release (98.09±0.74). Comparison of % CDR of pure drug and F3
revealed maximum cumulative drug releaseof F3 was found to be 98.09±0.74 at 60 minutes while that of
pure drug was 21.14±0.33 shows improved drug release of F3 due to enhanced solubility.
Keywords: Poly Dispersity Index, Zeta Potential, Fourier Transform Infrared Spectroscopy.
A-64
Fabrication, characterization and toxicity evaluation of chemically cross-linked polymeric
material: A proof of concept
MeghrajSuryawanshi*, Birendra Shrivastava
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India-302017
suryawanshimeghraj917@gmail.com
The current study required to determine the properties of a basil seed mucilage-based polymeric network as
well as its toxicity. By using potassium persulfate (KPS) as an initiator, microwave-assisted synthesis a
green approach was used to produce a graft copolymer of a polymeric blend of Basil seed mucilage (BSM)
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and acrylamide (AM). Variable amounts of AM and KPS were used to optimize the best grade based on the
highest percentage of grafting efficiency, and the results were investigated using intrinsic viscosity
measurement, Fourier Transformation infrared spectroscopy (FTIR), DSC, H-NMR spectra, and X-ray
diffraction. The degree of swelling is determined by the concentration of mucilage, monomer, and the
density of crosslinking in the polymeric network. The microwave irradiation processwith potassium
persulfate as the redox initiator is a visible, green, and cost-effective method. The BSM-4 batch showed
464% grafting and 107.23% grafting efficiency. FTIR, DSC, H-NMR and XRD analysis showed result
about completion of grafting process and changes in functional groups. The BSM-4 batch proved that basil
seed mucilage polymeric network is totally safe for oral drug delivery of BCS class II and IV drugs. The
findings of the toxicitystudy indicate that the developed polymeric network is safe and non-toxic. As a
conclusion, the Basil seed mucilage-based polymeric network will be encouraging for long-term delivery of
any BCS Class II or IV drug, and acute toxicity testing proved that the mucilage-based network had been
secure for oral drug delivery.
Keywords: Green Synthesis, Polymeric Network, Basil Seed Mucilage, Toxicity, Grating copolymer.
A-65
Anti-Parkinson activity of Acorus Calamus Linn. using Haloperidol catalepsy Model
Mr. Sarfraz Ahmad1 Mr. Sudhir Kumar Mishra2, , Dr. Farah Deeba3, Ms. Nishu Gautam4
1
K.R. Mangalam University, Sohna road, Gurugram, Haryana- 122103
2, 3
Assistant Professor –SGT University, Chandu Budhera, Bdli Road Gurugram, Haryana-122505
4
Assistant Professor -United College of Engg. And Research (Pharmacy) KP-III, Greater Noida,Uttar Pradesh-201310
Khansafaraz786.sk@gmail.com
The most common neurodegenerative movement disorder is Parkinson's disease (PD), which are the most prevalent
motion disorders and the second most common central nervous system degenerative disease. As we know the
prevalence and incidence rates in Europe are estimated around 108–257/100,000 annually. Swiss albino mice were
taken and divided into the five group (n=6). Group-I received normal saline (3ml/kg p.o.). Group-II received
haloperidol (1mg/kg, i.p) along with NS (3ml/kg p.o.). Group-III received Acorus Calamus (200mg/kg, p.o) with
haloperidol (1mg/kg, i.p). Group-IV received Acorus Calamus (400 mg/kg, p.o) with haloperidol (1mg/kg,i.p). Group-
V received Levodopa (30mg/kg i.p, once per day for one week) with haloperidol (1 mg/kg i.p.). After that we perform
the antioxidant activity with the help of the determining the serum SOD level, serum TBARs and DPPH assay.
According the results of biochemical tests of our study are in accordance with previous studies as well. The oxidative
stress parameters (MDA) are also positively modulated by A. Calamus so as to decrease the oxidative damage to
neurons. And ascorbic acid being well antioxidant and exhibit a very good antioxidant activity with IC50 value 24.84.
Significant antioxidant activity was also observed with Acorus Calamus when compared with the standard (IC50)
54.05. As well as AC200 & AC400 is significant versus haloperidol & Levodopa (***p < 0.001, ***p < 0.001).
Acorus Calamus is an important medicinal plant that plays a significant role in protection from oxidative stress. With
respect to this study, the findings showed that the methanolic extract treatment could maintain the normal range of
natural antioxidant enzymes in brain tissue. This has given us knowledge of the possible role of antioxidant enzyme in
protecting the mitochondrial activities and reduces in-vivo oxidative stress in neurons.
Keywords: MDA, Acorus Calamus, SOD, TBARs, DPPH, Levodopa, haloperidol.
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A-66
Evaluation of bacterial asthmatic treatment strategies: targeting toll like Receptor4-myeloid
differentiation-2 complex inhibition
Devesh Kumar1, Dushyant Kumar Mishra1, Nishu Gautam1, Nishikant Gaur2
1
United College of Engg. And Research (Pharmacy) KP-III,GreaterNoida,Uttar Pradesh-201310
2
swIEC College of Engg. And Technology KP-III, Greater Noida, UttarPradesh -201310
rdev3322@gmail.com
Bacterial asthma exacerbation evaluated on Ovalbumin murine model induced by lipopolysaccharide and evaluated by
TLR/MD2 complex antagonist. Asthma is a bronchial disorder that causes by shortens also; expand as well as creating
additional bodily fluid in the airway tube. The model was performed on rats given ovalbumin, LPS and antagonist
compound curcumin and study protocol results were confirmed by leukocyte level, body mass measurement and
oxidative stress biomarkers level in blood serum. Results & discussion: The curcumin has shown positive
treatment results over animal samples such as leukocyte infiltration rate reduced, improvement in body weight as well
as significant reduction in oxidative stress markers in treatment groups. According to results curcumin has shown
therapeutic potential in the treatment of bacterial asthma management in ovalbumin asthma murine model. This
compound can be a best treatment option for airways inflammation.
Keywords: Asthma, Exacerbation, TLRs, TLR-4, PAMP, LP.
A-67
Molecular mechanism of polyphenols in skin aging management
Deepti Dwivedi1, Nimisha1*, Satya Prakash Singh2
1
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, India
2
Dr. Ram Manohar Lohia Avadh University Ayodhya Uttar Pradesh
deeptidwivedi303@gmail.com
Skin aging is an inevitable progression, and several factors are behind this process, and the chief conducive
factor is UV radiation including further factors being dry skin, absence of nutrition, hormonal imbalance,
smoking, etc. Skin aging is classified into two types: Intrinsic aging and extrinsic aging which is also a
synonym of photoaging. Crow eyes, wrinkles, spots, elasticity loss, sagging, and unstrengthens of the skin
are commonly found in aged skin. Various tactics are existing to prevent skin aging. As per the literature,
several antioxidants are preferred in cosmetics for skin aging. Natural polyphenols are significant
phytoconstituents that carry scavenging phenomena and prepare complexes with proteins. This
phenomenon of polyphenols gives it an exciting perception in the handling of skin aging. Polyphenols
absent longer duration stability, have less bioavailability rate, are too delicate to light and temperature, have
less solubility, and have an acrimonious and caustic taste. This phenomenon bounds its custom in edible
items. To exclude these limitations, we focus on new delivery tactics and nano-formulations, which are,
nanocarriers measured as a promising technique. With plant-obtained polyphenols and their bioavailability,
several forms of nano-formulations can be used for therapeutic and cosmetics purposes, and nano-
formulations can be a promising technology for skin aging treatment. Ultimately, in the long
run, herbal purified polyphenols or polyphenol-wealthy plant extracts (semi-artificial or artificial) would
possibly supplement the pores and skin chemotherapeutics, our solar protection armamentarium, and in
addition enhance the advantage of aesthetic strategies (e.g., microdermabrasion). Thereby, polyphenols are
also gaining recognition as elements in cosmetic formulations (cosmeceuticals).
Keywords: Polyphenols, Skin Aging, Photoaging, Nano-Carriers.
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A-68
Significance of Computer Aided Drug Design (CADD) in Modern Medicine
Sakshi Duklan*, Kiran Dobhal
1
Uttranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, 248007, India
duklansakshi4@gmail.com
Medical drug design and evolution is a vital push of cutting-edge research. therefore, it is miles important
that scholars seeking tiers in an expansion of synthetic and organic bailiwick emerge as uncovered to the
research and improvement machine prior in their modules. The natural synthetic testing ground direction,
indispensable for masses health expert gradation applications in organic and associated discipline, is
properly suitable for a first creation to techniques crucial to the improvement of prescription drugs. at the
same time as altogether additives of investigation and improvement may surround a large number of
assignments, engaging on components of ligand format, an essential facet of medical drug studies and
evolution, led by way of infinitesimal design (laptop-abet medical drug drawing), is good for a multiweek
assignment at some point of the second one session organic testing ground path. Along the means of the use
of the usage of free, on hand online software program like PatchDock, Chimera, and SwissADME, college
scholars are guide thru a potential medical drug layout challenge centered on giving rise to ionic prohibitors
of AChE (pain) derived from appeared therapeutics.Besides being handiest college scholars dock one self’s
personal specific prohibitors, however additionally they're guide via amassing crucial toxicological records
locus via designing amidst SwissADME. standard, college scholars are designated the possibility to peer
attributes of the medical drug modeling procedure past the coalescence of multiplex organic molecules
inside a testing ground-like domain.
Keywords: Ligand-format, inhibitors, therapeutics, toxicological, software, modelling.
A-69
Butterfly pea: An ideal candidate for Nutraceutical Applications
Anuradha Rawat, Ashish Dimri
Department of Pharmacy, GRD IMT, Rajpur road, Dehradun, Uttarakhand, India
annurawat8475@gmail.com
Neutraceuticals are substances that are regarded as foods, components of foods, or dietary supplements
utilized in the treatment and prevention of various diseases. Potential uses for ClitoriaTernatea L. include
food, medicine, and nutraceuticals. An array of bioactive metabolites, such as carbohydrates, fatty acids,
anthocynins, cyclotides, triterpenoides, flavanol glycoside, kaempferol, quercetin, taraxerol, and lactons,
can be produced from the genetic material of Clitoriaternatea L. It is also known as shankupushpam,
aparajita, girikarnika, Peigeon wings etc. In addition to its primary function as a colourant, it might be said
that microencapsulated butterfly pea anthocyanins work as a slip-modifying neutralizing agent. These
flowers are said to have aphrodisiac properties. Clitoriaternatea L. extracts have diuretic, nootropic, anti-
inflammatory, analgesic, antipyretic, antidiabetic, antilipidemic, anti-arthritic, antioxidant, and wound
healing effects. Nothing is known regarding the differences in seed and blossom colour, which range from
white to purple color. The butterfly pea is a native plant of Indonesia. They are a cool-season crop farmed
all over the world, with planting times varying from early January to late spring.The viabilities of this
butterfly pea genotype ranged from 56% to 99%, the weight of 100 seeds ranged from 2.57 to 5.88g, and
the total seed weight ranged from 34.07 to 226-26 g. To logical drug design for future investigations, we
covered a wide range of pharmacological properties derived from C. Ternatea L.
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Keywords: Butterfly pea, Neutraceuticals, Bioactive metabolite, Microencapsulated, Aphrodisiac.
A-70
Development and applications of Micro and Nanorobotics in Drug Delivery
Archana Dhyani1*, Nardev Singh1 Ashish Dhyani 2
1*
School of Pharmacy, Graphic Era Hill University,Dehradun
2
Department of Hotel Management and Hospitality, Graphic Era (Deemed to be) University,Dehradun
archana.dhyani89@ gmail.com
Micro and nanorobotics is a brand-new field of research that emerged from the fusion of
micro/nanotechnology and robotics and has since acquired enormous importance. The advantages of micro-
and nanorobots include their small dimension, light weight, high flexibility, and high sensitivity. Micro-
and nanorobots have sparked the scientific community's interest in research and opened up a broad variety
of application areas, including medication delivery and disease diagnostics, due to their differences from
macroscopic robots. Over the past 30 years, research on micro- and nanorobots has made major strides.
This essay provides a detailed explanation of the development of these robots. Then, each of the primary
robot components including their actuation, design, production, and control is discussed separately.
Additionally, potential challenges in developing such robots are explored from the perspectives of
intelligence and sensing, therapeutic applications, materials, and performance.
Keywords: Microrobots, Nanorobots, Targeted Delivery, Actuation, Design.
A-71
Immunotherapy: A Revolution in Cancer Treatment
Vandana Pokhriyal*, Kapil Kalra, Subodh Negi
Department of Pharmacy, Alpine College of Management & Technology, Dehradun
pvandu95@gmail.com
Immunotherapy has emerged as a promising treatment modality for cancer. It aims to boost the body’s own
immune system to recognize and attack cancer cells. Unlike traditional treatments, such as chemotherapy
and radiation, which can harm healthy cells, immunotherapy targets cancer cells specifically. This review
discusses the various types of immunotherapies, including checkpoint inhibitors, CAR T-cell therapy, and
cancer vaccines. Cancer vaccines are designed to stimulate the immune system to recognize and attack
cancer cells. These vaccines can be made from cancer cells or specific proteins expressed by cancer cells.
They can also be combined with other immunotherapy, such as checkpoint inhibitors, to enhance their
efficacy. Immunotherapy has revolutionized cancer treatment and has the potential to cure many types of
cancer. However, there are still challenges that need to be addressed, such as resistance and toxicity. We
also highlight the challenges associated with immunotherapy, such as resistance and toxicity, and the
ongoing efforts to overcome these hurdles. Finally, we discuss the potential future directions of
immunotherapy, including combination therapies and personalized medicine. It is made up of white blood
cells and organs and tissues of the lymph system. Immunotherapy is a type of biological therapy.
Immunotherapy, on the other hand, is a novel approach that harnesses the power of the immune System to
fight cancer.
Keywords: Chimeric antigen receptor, Radiation, Chemotherapy.
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A-72
Natural vs Synthetic hydrotropes
D Vidya Aashiyana Rai*, Mamta Chauhan, Jyoti Joshi
Department of Pharmacy, Kingston Imperial Institute of Technology & Sciences, Doonga, Dehradun, India-248007.
raiaash274@gmail.com
A hydrotrope is a compound that solubilises hydrophobic compounds in aqueous solutions. Hydrotropes

are used industrially and commercially in cleaning and personal care products like laundry detergents,
surface cleaners, dishwashing detergents, liquid soaps, shampoos and conditioners. The choice of
hydrotrope is based on the builder levels and requirements for each specific application.Hydrotropy is an
important tool to other solubilization methods, such as micellar solubilization, salting, and miscibility
because of the independent character of solvent. It does not require any chemical modification of drugs. It
only requires mixing the drug with the hydrotrope in water. The use of a high amount of synthetic
hydrotropes is very dangerous for human administration. However natural hydrotropes can be used in
combination with synthetic hydrotropes. While using in a combination of natural and synthetic hydrotropes,
it has been reported that due to their intermolecular complex formation it helps in enhancing the solubility
of drugs and reduces the concentration of individual hydrotropes using mixed hydrotropy approach. Natural
hydrotropes such as caffeine, tannic acid, epigallate, piperazine, and coconut derivatives have been used in
few studies. The use of natural hydrotropes is beneficial over synthetic hydrotropes as it is safe for human
use. The hydrotropy increases the solubility of solutes by the addition of high concentration of alkali metal
salts of different organic acids. According to Neuberg, there are several concentrated aqueous hydrotropic
agents available synthetically or naturally. Some of the hydrotropic agents are sodium benzoate,
niacinamide, citric acid, tannic acid, piperazine, and caffeine. They have been observed to enhance the
aqueous solubility of poorly water-soluble drugs. This article gives insight of the use and differences
between natural and synthetic hydrotropes in various fields
Keywords: Hydrotropes, Builder, Congregations, Miscibility.
A-73
Design, formulation, and characterization of microcapsules of NSAID drug
Ankita Negi*, Ashutosh Badola
School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun (Uttarakhand) 248001.
negiankita665@gmail.com
Microencapsulation is a technology that involves the production of small, spherical particles called
microcapsules that are designed to enclose a material or substance within a protective shell. This
technology has gained popularity in recent years due to its numerous applications in different fields.
Pharmaceutical, cosmetic, agriculture and other fields are using microencapsulation as new approach to
improve the stability, shelf-life, and bioavailability of different substances. This paper showed formulation
of microencapsulation, their advantages and disadvantages, and the various applications of
microencapsulation. Beside conventional microcapsules, it also encompasses self-assembling structure and
other particulate requiring preparative manipulation. This paper provides an overview of encapsulation
materials, the mechanism of release through the capsule wall and preparation techniques, and the numerous
applications to which microcapsules can be applied. NSAIDs are pain relieving drugs which are used to
treat arthritis pain and also for body aches, swelling, stiffness. When core materials are surrounded by
Microcapsules of Etoricoxib were prepared by solvent evaporation method by using different drug-polymer
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ratio with different solvent. Prepared microcapsules were evaluated for the particle size, percentage yield,
incorporation efficiency, flow property and in vitro drug release. From the result we can conclude that as
the concentration of polymer increases, it affects the particle size, percentage yield and drug release of
microcapsules. And different shape of microcapsules had seen with different solvent (Chloroform, Acetone)
and polymer (HPMC, 2-Hydroxypropyle-beta cyclodextrin). The excellent flow properties, particle size,
percentage yield (93.24%), incorporation efficiency (95.69%) and percentage drug release (96.88%)
showed by F3 for a period of 15 hrs. Results of the present study indicate that Etoricoxib microcapsules can
be successfully designed to offer protection and enhance the bioavailability.
Key words: Microencapsulation, NSAIDs, Core material, Coating material, Chloroform.
A-74
Innovative 4D Printing Approaches to Address Customization and Delivery Challenges of
Drugs to Hard-to-Reach Body Orifices in Humans
Debadri Banerjee, Surojit Banerjee, Anupama Singh, Vikas Anand Saharan
School of Pharmaceutical Sciences and Technology, SBS University, Balawala, Dehradun 248001, India
debban96@gmail.com
4D printing involves use of 3D printing techniques to fabricate shapes which can reversibly or irreversibly
transform when triggered by any external stimulus like temperature, pH, radiation, hydration, magnetic
force, electricity, heat. This shape transformation ability is conferred with smart materials like shape
memory alloys, shape memory polymers, and hydrogels. 4D printing brings numerous customization
possibilities based on shape and functionality. Since the publication of the first scientific article on 4D
printing in 2013, this technology has rapidly advanced and expanded its applications to various fields like
aerospace, automotive technology, fashion, medical devices, tissue engineering and fabricating drug
delivery systems. In 2016, Li et al developed a fusion of 3D printing and shape-changing hydrogel-based
micro-robots was developed for the delivery of anti-cancer drugs. This development has attracted attention
of various drug delivery scientists to exploit the potential of 4D printing for the development of drug
delivery systems (DDS) or devices. Conventional drug delivery approaches have restricted accessibility for
hard-to-reach body orifices like stomach, urinary bladder, eustachian tube, vagina, and others leading to
reduced bioavailability and limited local action. A thorough literature survey was conducted on databases
such as PubMed, Google Scholar, and Scopus to find such research attempts. This oral presentation
illustrates all such customised DDS or devices developed to deliver drugs to eustachian tube, oesophagus,
stomach and urinary bladder. Some orifices like nostrils, rectal, vaginal and meibomian gland orifice are
potential areas where research is to be observed in future. These innovations are evident that 4D printing
has increased the accessibility, improved drug delivery efficiency and increased patient compliance.
Additionally, 4D printed DDS have offered personalized treatments for specific medical conditions like
sudden hearing loss, tissue regeneration, healing wounds and prolonged release of drug into urinary
bladder. This represents a breakthrough in the field of drug delivery, marking a significant advancement.
Keywords: SMM, 4D printing, Drug Delivery, Advancement.
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A-75
Hydroxychloroquine (HCQ): Uses and its following ADRs
Gulfsha Parveen, Divya Chauhan*, Mamta Chettri, Ayushi Parcha
Gyani Inder Singh Institute Of Professional Studies, Dehradun
Hydroxychloroquine is the derivative of Cholroquine which comes under the class of disease modifying
antirheumatic drug (DMARDs) and under the class of 4-Aminoquinolines.The aim of the present study has
been undertaken with the main focus to unriddle the use of HCQ in various autoimmune diseases other than
rheumatoid arthritis like lupus erythematosus, antiphospholipid syndrome, serositis, sjogren’s syndrome,
ankylosing spondylitis, psoriatic arthropathy, gout arthritis neurosarcoidosis, sarcoidosis, juvenile
idiopathic arthritis, atopic dermatitis, photodermatitis, covid patients. And other than autoimmune disease
HCQ is used in malaria and in cancers it is used with the combination of trametinib.The optimal dose in
adult is between 200mg/day and 400mg/day (BD) twice a day, whereas in children it is between
6.5mg/kg/day.Contraindications are in liver disease, allergy, eye or vision problems, psoriasis, glucose-6-
phosphate dehydrogenase deficiency (G6PD), heart disease, kidney disease.The short term ADRS of HCQ
are nausea, vomiting, loss of appetite, dizziness or headache and diarrhea.ADRs when used for longer
period of time are complication in eyes that is retinopathy, cardio toxicity like abnormalities in conduction
system while pumping of blood and cutaneous complications like bleaching of hairs, psoriasis, alopecia,
pigmentation in skin. Combination therapy of HCQ is methotrexate, omeprazole (PPI), sulfasalazine.
Keywords: Serositis, Ankylosing spondylitis, ADR,Hydroxychloroquine.
A-76
Teratogenic effect on different stages of Pregnancy
Eksha Sunderka*, Jhuma Samanta
Department of pharmacy, Kingston Imperial Institute Of Technology and Sciences, Doonga, Dehradun, India, 248007.
str.eksha@gmail.com
Teratogenic effects can occur when a developing fetus is exposed to harmful environmental factors during
pregnancy. These effects can occur at different stages of pregnancy, including the pre-implantation stage,
the embryonic period, and the fetal period. During the pre-implantation stage, teratogens can cause
chromosomal abnormalities or death of the embryo. In the embryonic period, exposure to teratogens can
result in major structural abnormalities, such as neural tube defects, cleft palate, and heart defects. In the
fetal period, exposure to teratogens can lead to functional abnormalities, growth restriction, and cognitive
and behavioural deficits. Teratogens can come from various sources, including drugs, alcohol, tobacco,
radiation, and infectious agents. The effects of teratogens on fetal development depend on factors such as
the type and dose of the agent, the duration and timing of exposure, and genetic susceptibility. Preventing
exposure to teratogens is critical in reducing the incidence of congenital malformations. Health care
providers should educate women about the risks of teratogens and provide counselling to minimize
exposure. Pregnant women should avoid known teratogens and follow recommended guidelines for
prenatal care. Early detection and management of congenital malformations can improve outcomes for
affected individuals and their families. Overall, understanding the teratogenic effects on different stages of
pregnancy can help prevent congenital malformations and promote better outcomes for both mother and
child.
Keywords: Teratogenic Effects, Pregnancy, Fetal Development, Malformations.
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A-77
Proteomics
Aarti Sati *, Vibhanshu Bansal
Department of Pharmacology, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun,
Uttarakhand, India
vibhanshubansal108@gmail.com
Proteomics is the large-scale investigation of proteins, their structure, and function in various biological
samples, such as cells, organs, or organisms. Proteins are important effectors of cell functions and
phenotypes because they can better capture a cell functional state and dynamic features. Proteomics data
processing and analysis is a complex process that might lead to the discovery of new disease biomarkers for
clinical and diagnostic applications. Whole saliva molecular content reflects current physiological or
disease circumstances and can be indicative of systemic disease conditions at distant anatomical sites.
According to the research, entire saliva can be a valuable source of information for detecting pathologies
such as genetic, autoimmune, cardiovascular, and metabolic illnesses, malignancies, and viral/bacterial
infections. As a result, saliva opens new avenues for the discovery of novel clinical biomarkers that are
simple, accurate, inexpensive, and non-invasive to collect. Salivary proteomics is vital for understanding
illness pathophysiology, developing non-invasive diagnostic markers, and offering important insights for
targeted therapy and therapeutic management of many diseases. As a result, saliva opens new avenues for
the discovery of novel clinical biomarkers that are simple, accurate, inexpensive, and non-invasive to
collect. Salivary proteomics is vital for understanding illness pathophysiology, developing non-invasive
diagnostic markers, and offering important insights for targeted therapy and therapeutic management of many
diseases.
Keywords: Biomarkers, whole saliva, Proteomics, Diseases.
A-78
Microneedle Patches: A Novel Approach for Transdermal Drug Delivery
Vanadan Sahani
Shree Dev Bhoomi Institute of Education Science and Technology, Dehradun, Uttarakhand
sahanivandana15@gmail.com
Microneedle patches are an innovative and disruptive technology for transdermal drug delivery. They are
designed to overcome the limitations of traditional drug delivery systems by providing a non-invasive and
painless method for drug delivery through the skin. Microneedle patches consist of arrays of microneedles
that penetrate the stratum corneum, the outermost layer of the skin, to deliver drugs to the underlying
layers. Microneedle patches are versatile and can be designed to deliver a wide range of drugs, including
small molecules, peptides, proteins, and vaccines. This technology has several advantages over traditional
drug delivery methods, such as improved patient compliance, reduced side effects, and enhanced efficacy.
Furthermore, microneedle patches can be self-administered, reducing the need for healthcare professionals,
and providing a more convenient and cost-effective alternative. Microneedle patches have shown promising
results in preclinical and clinical trials and have been successfully used in a variety of biomedical
applications, including diabetes management, vaccination, pain management, and cosmetic treatments.
However, there are still several challenges and limitations to be addressed, such as improving the design
and fabrication techniques of microneedle patches, ensuring their safety and regulatory compliance, and
scaling up the manufacturing process to make them more accessible and cost-effective. Overall,
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microneedle patches represent a transformative technology for drug delivery and hold great potential for
revolutionizing the way drugs are delivered in the future.
Keywords: Microneedles, Skin, Diabetes,Delivery.
A-79
Ethosomal gel for topical delivery of Mefenamic acid in the treatment
of Rheumatoid Arthritis
Sunayana Tyagi *, Prabhakar Vishakarma
IIMT college of medical sciences, IIMT university
tyaginayana@gmail.com
Molecules with poor aqueous solubility are difficult to formulate using conventional approaches and are
associated with many formulation delivery issues. To overcome these obstacles, nano vesicle technology
can be one of the promising approaches. Hence, in this study, the feasibility of mefenamic acid (MA) is
examined in ethosomal gel in the treatment of RA. This method is the most often used for producing
ethosomal formulations. In this method, phospholipid, medication, and other lipid components are
dissolved in ethanol in a covered jar at room temperature by aggressively whirling with a mixer. Propylene
glycol or similar polyol is added while stirring. This mixture is cooked to 300ºC in a water bath. To shrink
the vesicle size of an ethosomal formulation to the required level, sonication or extrusion procedures may
be utilized. The goal of the current study was to formulate and assess mefenamic acid ethosomes for topical
medication administration. Several ethanol (20–60%) and soya lecithin (1–5%) concentrations were used to
create the ethosomal formulations. The formulation with 30% ethanol and 3% soya lecithin demonstrated
the maximum drug release (82.66%) and highest transdermal flux in in-vitro release trials. The improved
formulation & drug content and entrapment effectiveness were determined to be 85.32% and 99.5%,
respectively. It was discovered that the drug release from the developed vesicles followed first order
kinetics with a higuchi diffusion mechanism. Mefenamic might perhaps be delivered more effectively via
the skin if it were made into ethosomes.
Keywords: Zeta Potential, transdermal delivery, ethosomes, mefenamic acid, and scanning.
A-80
Biogenesis, isolation, and applications of Cow milk- derived Exosomes
Riya Mahar*
School of Pharmaceutical Sciences, Himgiri zee university, Dehradun
Exosomes (EXOs) are naturally occurring endosome-derived nanoparticles that are released by several
biological cells. Earlier exosomes were thought to be merely the waste products from maturing red blood
cells therefore they did not receive much attention at that time. Exosomes are now found in all body fluids
including plasma, urine, tears, cerebral spinal fluid, semen, bronchial fluid, saliva, serum, amniotic fluid,
synovial fluid, lymph, gastric acid, bile, and breast milk. The only biological liquid with EXOs that is
produced commercially is milk. Exosomes have their beginnings in endosomes, and the ultimate content of
the exosomes is produced as a result of interactions with various intracellular vesicles and organelles during
the biogenesis process. They have the same traits as their parents and can be derived from several sources.
Size exclusion chromatography, density gradient centrifugation, or (ultra) centrifugation can be used to
separate EXOs from milk; however, because of the complex makeup of milk, which includes casein
micelles and milk fat globules, there are additional considerations that must be made when using the
aforementioned methods on milk. In addition to these benefits, exosomes prolong their usefulness as
delivery vehicles by preventing undesired buildup or by homing to the liver, which avoids metabolic
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problems. These organic carriers have extended circulation times and can transport therapeutic loads that
can even breach the blood-brain barrier, posing some serious therapeutic problems.
Keywords: Exosomes, cow milk, biogenesis, isolation techniques, applications
A-81
Identification and Assesment of different types of toxicity
Ravi Ranjan Kumar*, Jhuma Samanta
Department of pharmacy, Kingston Imperial Institute of Technology and Sciences, Dehradun India, 248007
ravimth086@gmail.com
The U.S. National Academy of Sciences sparked a significant shift in toxicity testing practises in 2007 with
the publication of the seminal paper Toxicity Testing in the 21st Century: A Vision and a Strategy. It plans
to make toxicity testing more effective and reduce. By switching from existing expensive and time-
consuming in vivo testing with qualitative endpoints to in vitro toxicity pathway studies using robotic high
throughput screening and mechanistic quantitative metrics on human cells or cell lines. Avoiding major
disruptions in these toxicity pathways would be the main goal of risk assessment in the exposed human
population. The implementation of computational systems biology models to ascertain the dose-response
models of route function alterations. Extrapolation of in vitro findings to human in vivo pharmacokinetic
models for the specific exposure would be used to determine blood and tissue concentrations. This
procedure would improve test results' relevance people, and it would cover several compared to
conventional toxicological testing methods, test agents. As with all available tool the resources required to
realise the vision are either already in existence or are in an advanced stage of development. commitment to
change in the scientific community, which may be assisted by a thorough discus sion of the vision, and
securing the required resources to improve present Understanding of pathway perturbations and pathway
assays in are the primary conditions to achieve this paradigm shift. Biological models are implemented in
computing systems and with people. By putting these tactics into practise, a new toxicity testing paradigm
that is solidly founded on human biology would emerge.
Keywords: Lead Toxicity, Lead Poisoning, Environmental, Health, Heavy Metals.
A-82
Exploration of Rutin and its formulation for the treatment of Alzheimer’s Disease
Jyoti Vishnoi*, Mamta F. Singh
Department of Pharmaceutical Sciences & Technology, Sardar Bhagwan Singh University, Balawala, Dehradun, India
Flavanoids have dominated the hunt for new therapeutic agents to treat a variety of human diseases over the
years. One such important flavonoid, rutin, has gained recent recognition for its crucial role in the treatment
of a number of diseases, including cancer, diabetes mellitus, insulin resistance, neurodegenerative diseases,
etc with a high degree of safety and few side effects. Ras/Raf and PI3K/Akt, MAPK, TGF-
2/Smad2/3Akt/PTEN, and other signalling pathways in cancer have all been shown to be controlled by
rutin. Rutin appears to be successful in treating several neurodegenerative diseases, including Alzheimer's
disease, according to several studies. Rutin decreases tau hyperphosphorylation by increasing PP2A level,
suppresses gliosis and neuroinflammation by downregulating NF-kB pathway, prevents microglial synapse
engulfment, and restores synapse loss in the brain by decreasing the level of oxidative stress and
proinflammatory cytokines and by increasing the level of antioxidant enzymes.However, several issues,
including poor solubility, low permeability, and subsequently low bioavailability, restrict the utility of rutin
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and its efficacy in the treatment of these diseases. As a result, numerous innovative delivery mechanisms
and administration approaches have proven that they can avoid nearly all of the issues mentioned above,
which has increased rutin's pharmacological potency.As a result of its improved therapeutic effects in
treating a variety of neurodegenerative diseases, new rutin delivery carriers and various route of
administration (including lipidic, vesicular, polymeric, inorganic, and protein nanoparticles, as well as
complexes) are being studied to surmount its pharmaceutical challenges.
Keywords: Nanotechnology, Bioavailability, Pharmacokinetics, Rutin.
A-83
Formulation and evaluation of Panchchurna
Gufran khan* Jyoti Joshi
Department of Pharmacy Kingston Imperial Institute of Technology and Sciences, Dunga, Dehradun, India, 248007
guffu726@gmail.com
Panchchurna consists of simple, routine procedures for treating conditions such as constipation,
haemorrhoids, flatulence, and pain in the abdomen. All formulation and ingredients, physical constant
values were determined and compared with the standard values of the ingredients.Constipation is defined in
Ayurvedic texts as a beginning of many sicknesses. One advertised formulation suggests presence of
cadmium, while Cr and Pb each are found in in house and marketed formulations. The excessive ranges of
Ca, Cu, k, Na and Mg are present in all the formulations of Panchakarmachurna. This observe suggests the
presence of essential and doubtlessly toxic elements are in the restrict and components may be used on
ordinary foundation without any harmful effect. PanchChuruna aids to control constipation, haemorrhoids,
and conditions like abdomen, flatulence, assimilatory like situations. on this, PPT an effort is made to
provide an explanation for the pharmacological homes of PANCH CHURUNA and its position in
constipation Ayurvedic formulary of India provided the formula to be used in the preparation of two
batches of samples obtained from the market and two batches of fermented in the laboratory. It is safe and
effective for gastrointestinal problems to use Ayurvedic medicines. Organoleptic, microscopic, flow
properties, and preliminary phytochemical screening were performed on all four batches. Many people
suffer from Mala baddhata, or constipation, due to their eating habits and lifestyles.
Key words: Panchsakar, Standardization, Pharmacognostical, Ash values.
A-84
Modeling of Pharmacophore QSAR developing and validation
Sonika Rani*, Neelam Painuly, Amandeep Singh Baghla
Department of Pharmacology, School of Pharmacy and Research, Dev Bhoomi Uttarakhand University, Dehradun
chaudharysonika04@gmail.com
A very Important part of drug design is prediction of small Molecule binding to a target macromolecule. A
Reasonable qualitative prediction of binding can be made by specifying spatial Arrangement of a small
number of atom or functional group such arrangement is called pharmacophore search finds molecule with
different overall chemistries but have a functional group in correct geometry. A common use of
pharmacophore is to search 3D databases for molecules that are contained in pharmacophore. A
pharmacophore describes framework of molecular features that are vital biological Activity of a compound
pharmacophore model are used to structural Information about active ligand target. The pharmacophore
model developed are used to Identify novel compound that process is challenging task that Requires
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contribution of multidisciplinary Approaches pharmacophore modeling has been used in various stage of
drug discovery Process. The major Application are VSD, DTFLP and ADMET process. Pharmacophore
modeling decided by Ligand based and structure based can be defined as in Ligand based are virtual
screening and land optimization and its describe as a 3D structure of multiple known ligands which are
excreted through ligand alignment have chemical characteristics common represent the importance
interaction between ligand and potential macromolecule target. And structure based can be defined as De
No Vo drug designing and target identification create a relationship from 3D structure of macro molecular
target and macromolecular ligand .3D QSAR pharmacophore generation module of DS was used to create
Quantitative pharmacophore to find important characteristics in training set compound feature mapping
module in DS was exploited. 3D QSAR Method used the information of dimensional molecular structure of
ligands.
Keywords: ADMET, VSD, DTFLP, 3D QSAR.
A-85
In-silico molecular docking and ADME studies of naturally derived
polyphenols for Xanthine Oxidase inhibitory activity
Harsh Agarwal1*, Shami Ratra Chaddha2
1
Himalayan Institute of Pharmacy and Research, Rajawala road Selakui, Uttarakhand-248007
2
Smt. Tarawati Institute of Biomedical and Allied Sciences, Roorkee, Haridwar, India-247667
Xanthine oxidase (XO) is an enzyme that generates reactive oxygen species and cause the oxidation of
hypoxanthine into uric acid. Its over activity can lead to the gout-causing hyperuricemia and oxidative
damage to the tissues. The prototypical xanthine oxidase (XO) inhibitors have been used in the clinical
management of gout and conditions associated with hyperuricemia, but they suffer from many side effects.
Natural products are excellent sources of lead compounds in the search for new medications in certain
clinical disorders. This study includes in-silico molecular docking of naturally derived polyphenols with
antioxidant action on xanthine oxidase receptor. The results of molecular docking were analyzed for
binding affinity and various types of interactions with the receptor. The findings showed that the certain
compounds under investigation had better binding affinity with XO receptor than the standard drug. Further
all the compounds after evaluation with ADME Descriptors were also seen to show drug likeness and did
not violate Lipinski rule of five. Based on these studies, certain compounds were selected for further
research. This research will help us to search better xanthine oxidase inhibitor alternatives which can be
used in conditions like oxidative stress, inflammation, and gout.
Keywords: Xanthine Oxidase, Hyperuricemia, Polyphenols, Molecular Docking, ADME.
A-86
Controlled Drug Delivery System
Jyoti Srivastava*, Kajal Chauhan, Vikas Jakmola
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun,248007
Controlled drug delivery systems maintained suitable and desired drug release over and extended period or
for a longer time. Conventional drug delivery system (tablets, capsule, syrups, ointment etc). Deteriorate
from low bioavailability and alteration in plasma drug level and are not able to attain sustain release of
pharmaceuticals. In this oral route of administration plays a vital role for controlled delivery of drug.
Controlled release product provides advantage over standard doses form by better acute pharmacological
reponse, therapeutic response and movement of drug inside the body. In such a way that it minimizes
dosing regularity to an amount that once daily doses are acceptable. Curative management through systemic
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plasma concentration gives utmost profitability of drug with deduction in limited and systemic unwanted
secondary effect and restore to health. Various factors that affect oral control release drug delivery system
such as solubility, absorption, distribution, half-life, metabolism. There are different mechanical
characteristics for planning of oral control release drug delivery system such as matrix, reservoir, osmotic
pressure, ion exchange resins etc.
Keyword: Controlled Release, Oral, Drug Delivery System, Dosing Regularity, Sustain Release.
A-87
Next Generation Pharma: Unlocking QbD Advantages with Commercial Software
Komal Soni*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
Department of Pharmaceutical Sciences & Technology, Sardar Bhagwan Singh University, Balawala, Dehradun, India
School of Pharmaceutical Sciences & Technology, Sardar Bhagwan Singh University, Balawala, Dehradun, India
The traditional approaches to research and development in analytics, which rely on trial and error and
inspection of finished products, may not efficiently meet the quality requirements of modern analytics
processes. Quality by Design (QbD) is a proactive and systematic approach to product and process
development that aims to maintain a predefined quality level throughout the entire development cycle.
Integration of QbD concepts with technology has resulted in the development of various QbD software,
which offer several benefits in pharmaceutical product design. Several literature sources on QbD software,
such as Fusion QbD, JMP QbD, Master Control QbD software, and Lean QbD, were found through
literature indexed in PubMed and Google Scholar. For example, Fusion QbD (S-matrix, version Fusion
Pro) is used in Ultrahigh Performance Liquid Chromatography methods for the development of glucose-
responsive insulin therapeutics in pharmaceutical R&D. JMP QbD software (SAS, version JMP Pro), also
known as JMP Statistical Discovery, has been utilized in pharmaceutical R&D for the development of
chitosan-coated nanoliposomes. Lean QbD software (QbD Works, version Knowledge Management
Pharma 4.0) has been employed in QbD for Abbreviated New Drug Applications (ANDAs) in
pharmaceutical R&D, specifically for immediate-release dosage forms. The aim of these applications is to
ensure good drug product quality profiles and minimize deviations and costly investigations. Incorporating
statistical multivariate analysis in the design of experiments can provide a more reliable and comprehensive
understanding of the relationship between multiple factors and the desired outcome, leading to the
development of robust methods and homogeneous products.
Keywords: QbD, SAS, Dosage, R&D.
A-88
A Mucoadhesive as a Gastroretentive Drug Delivery System
Harsh Upadhyay*, Jyoti Joshi
Department of Pharmacy, Kingston Imperial Institute of Technical Sciences, Doonga, Dehradun, India-248007
harshupadhyaya05@gmail.com
Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive
dosage form the adhesion between two materials, at least one of which is a mucosal surface, is generally
referred to as mucoadhesion. The mucoadhesive ability of a dosage form is dependent upon a variety of
factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric
formulation. This review article aims to provide an overview of the various aspects of mucoadhesion,
mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various
mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal). mucoadhesive
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substances In the past 20 years, mucoadhesion has attracted fresh interest in drug delivery applications that
involve extending the residence time of mucoadhesive dose forms through various mucosal channels.
Topical and local systems based on mucoadhesives have demonstrated improved absorption.Since
mucoadhesive drug administration has a large surface area and a strong blood flow, it provides quick
absorption and good bioavailability. The first-pass hepatic metabolism and gastrointestinal degradation are
avoided by drug administration over the mucosa. could be designed to give a controlled rate of medication
release for a better therapeutic outcome while allowing for prolonged retention at the application location.
The delivery of dosage forms to mucosal surfaces may be advantageous for drug molecules that are not
suited for oral administration, such as those that experience acid degradation or significant first-pass
metabolism. internal enzymes.
Keywords:Mucoadhesion, Enzyme, Buccal.
A-89
Sleep and related disorders
Mohit Varshney*, Supriyo Saha, TaruSaklani, Tarun Parashar, Vikas Jakhmola
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University-Dehradun, Uttarakhand, India. Pin-248007
mohitvarshney606@gmail.com
Sleep has a crucial role in how the brain functions work in basic physiological processes including
digestion, appetite regulation, and the operation of the immune, hormonal, and cardiovascular systems.
Generally speaking, the various stages of sleep are commonly split into two categories: one phase of quick
eye development/rapid eye development (REM) sleep and four stages (1-4 stages) of non-fast eye
development/non-rapid eye development (NREM) that are explained on the basis of depth of sleep. Sleep
disorder may be discussed or elucidate as the condition in which the individual is suffering from the
disturbed sleep cycle due to the various factors like excess workload, health condition, tobacco smoking,
alcohol consumption, taking excessive energy drink, uneven sleep timings, diet, wrong sleeping position,
sleeping environment, irregular sleep, genetics history, emotional stress, phycological factor, fatigue,
circadian rhythm, hypersomnia, parasomnia, obesity and under weightlessness, age, sexual relationship,
mental health, anxiety level, irregular menstrual cycle, status in the society, lifestyle etc. It is common for
people to experience sleep disturbances, which can have a negative impact on their health and quality of
life. Insomnia, circadian rhythm disorders, sleep apnea, hypersomnia/narcolepsy, parasomnias, and restless
legs syndrome/periodic limb movement disorder are the six main sleep disorders. Most of the sleep disorder
are easy to treat while some of the major disorders are difficult to manage or treat. Genetic sleep disorders
are Fatal Familial Insomnia (FFI),Familial Advanced Sleep Phase Syndrome (FASPS), Obstructive Sleep
Apnea/Hypopnea Syndrome (OSAHS), Sleep Walking (Somnambulism), Nocturnal Enuresis etc. This
review also concerned with the diseases associated to the existing sleep disorders and the ayurvedic
preparations as well as the allopathic medicines available for treating sleep disorders.
Keywords: Sleep, Genetic Sleep Disorders, Ayurvedic Preparation, Allopathic Preparation.
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A-90
Self-Nano Emulsifying Drug Delivery System as a Novel Approach
Sanjeev Kumar*, Naman Singh Rawat, Jyotsana Suyal
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, 248007
The majority of recently discovered medications are not well soluble in water, which poses a serious
challenge for oral administration. Poor gastrointestinal permeability is another major issue that influences
oral bioavailability; as a result, lipid formulations have been very helpful in enhancing solubility and oral
bioavailability. It is intended to intensify the effects of lipophilic medications that are poorly soluble in
water by using lipid-based formulations like SNEDDS (Self Nano Emulsifying Drug Delivery System).
Drug delivery research now heavily relies on nanotechnology, which has a significant impact on the
therapeutic performance of hydrophobic medicines. Several advantages of SNEDDS include improved
mobility, improved drug stability, and improved oral bioavailability of a restricted number of water-soluble
pharmacological components. Droplet size determines how SNEDDS are categorized. Self-Nano
Emulsifying Drug Delivery System, or SNEDDS, refers to droplets with a size of less than 100 nm. A co-
solvent, co-surfactant, and oil combination are all components of nano emulsion. SNEDDS to raise the
clinical efficacy of oral medication administration and to improve the better & desired in vitro drug release
bioavailability. A summary of SNEDDS's process, composition, and need in India's youth is shown in this
poster. The bioavailability of drugs that aren't very water soluble may be increased by SNEDDS. By using
processes for solidification, such as spray drying, lyophilization, pour moulding, and physical adsorption,
among others, the stability of SNEDDS is further strengthened.
Key words: SNEDDS, Nano emulsion, Bioavailability, Lipophilic.
A-91
Monitoring of ADR department of neurology epilepsy of a tertiary care hospital
Sakshi Saini*, Jhuma Samanta
Department of Pharmacy, Kingston Imperial Institute of Technology and Sciences, Doonga, Dehradun, India-248007
The research and practises involved in the identification, evaluation, comprehension, and avoidance of side
effects or any other drug-related issue are referred to as pharmacovigilance (PV). WHO promotes PV at the
national level in collaboration with the WHO Collaborating Centre for International Drug Monitoring,
Uppsala. The WHO PV Program included 134 nations as of the end of 2010. The objectives of PV are to
improve patient care and patient safety when it comes to the use of medications, as well as to promote
public health initiatives by offering trustworthy, impartial information for a thorough evaluation of the risk-
benefit profile of medications. Unprovoked, repeated seizures caused by the neurological disorder epilepsy
are called seizures.According to the World Health Organization, 50 million Trusted Source people
worldwide suffer from epilepsy, and the Centers for Disease Control and Prevention estimates that there are
close to 3.5 million Trusted Source individuals suffering from it in the United States. The World Health
Organization describes an adverse drug reaction (ADR) as "any response by a substance which is
unpleasant, unanticipated and occurs at dosages typically employed in man for prevention, diagnosis, or
dangerous effect for a fatal life." The patient's given to identifying the patient demographics most at risk,
the pharmaceuticals most frequently to blame, and the likely causes of ADRs. It occurs virtually daily in
healthcare settings.
Keywords:Epilepsy, Drug Monitoring, Prophylaxis, Pharmacovigilance.
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A-92
Predictive Software Tools for ADME in Drug Discovery
Mahalaxmi Muskan*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
The poor pharmacokinetics of drug molecules is a significant factor that leads to their high failure rates in
drug discovery and development. To address this issue, predictive software tools for absorption,
distribution, metabolism, and excretion (ADME) are now widely used by pharmaceutical companies and
research institutions to screen drug candidates for their therapeutic potential. By improving the safety and
efficacy of pharmaceutical drug products, pharmacokinetic studies can also increase the success rates of
clinical trials. These software tools utilize advanced technologies such as machine learning, artificial
intelligence, and computational modeling to predict the ADME properties of drug candidates. Examples of
such software tools include ADMET Predictor, Derek Nexus, SwissADME, GastroPlus, and K-ADME.
With the help of these software tools, researchers can screen many molecules efficiently and prioritize
compounds for further testing and formulation development. This accelerates the drug discovery process
and helps bring new drugs to the market more quickly and efficiently. This paper provides an overview of
some of these software tools and their applications in predicting ADME.
Keywords: ADME, Derek Nexus, SwissADME, GastroPlus, K-ADME.
A-93
Role of product development and management on manufacturing company
Aakash Bhanu Tiwari*, Jhuma Samanta, Jyoti Joshi
Kingston Imperial Institute of Technology Doonga, Dehradun. Uttarakhand, India-248007
aakashtiwari.smarty@gmail.com
The process of developing an existing product or bringing a new one to market is known as product
management. It begins with the conception of a product that customers will use and finishes with an
assessment of the product's performance. There have been numerous innovative ideas, methodologies,
procedures, and software tools created for the production of various products. The establishment of
computer-based concepts and procedures is the foundation of modern innovation research, which supports
several product development initiatives. Identifying key product development processes and understanding
how they relate to the organizational competency that has been built are crucial for the manufacturing
company's long-term success. The acceptance, use, and total activity of the product in the target market are
all impacted by the procedures used in the production of financial services.
Keywords: Product, Innovation, Market, Customer.
A-94
The Consumption Scenario of Nutraceuticals Globally
Anand, Lokesh, Mahamedha Deorari, Vikas Jakhmola
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, 248007.
Nutrition supplements and herbal drugs have gained significant popularity as alternative or complementary
therapies for various health conditions. While proper nutrition is essential for maintaining good health, the
use of dietary supplements and herbal drugs is increasing due to their potential health benefits. These
products are readily available over the counter, and many people turn to them to improve their health and
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well-being. Nutrition supplements are products designed to supplement the diet with nutrients that may be
lacking or deficient. They may contain vitamins, minerals, amino acids, or other nutrients, and they are
available in various forms, such as tablets, capsules, powders, and liquids. Many people use nutrition
supplements to support their overall health, enhance athletic performance, or manage specific health
conditions. Herbal drugs, also known as botanicals, are plant-based products that contain one or more active
ingredients that may have medicinal properties. Herbal drugs have been used for centuries in traditional
medicine and are now gaining recognition in modern medicine. Examples of commonly used herbal drugs
include ginseng, echinacea, and St. John's wort. While herbal drugs are generally considered safe, they can
interact with prescription medications, so it is important to consult with a healthcare provider before using
them. The use of nutrition supplements and herbal drugs has both benefits and risks. Proper use of these
products can provide essential nutrients, support overall health, and complement conventional medical
treatment. However, improper use can lead to adverse effects, including toxicity, drug interactions, and
adverse effects on health. Therefore, it is essential to use these products under the guidance of a healthcare
provider and to choose reputable brands that have been independently tested for safety and efficacy.
Keywords: Nutritional supplements, Herbal medicine, Dietary supplements, Phytochemicals.
A-95
Formulation and evaluation of herbal toothpowder
Akash Samanta, Jyotsana Suyal, Vikash Jakhmola
akashxisci@gmail.com
There are 10 billion bacteria in the mouth cavity, some of which are harmful to the oral cavity's cleanliness.
Traditional herbal tooth powders are used to clean teeth and to treat a variety of oral diseases, including
tooth decay, disintegration, irritation, and toothaches.The three main dental issues are gingivitis, plaque,
and periodontal disorders. These serious problems are the result of improper oral hygiene practices and
disregard for proper teeth care. By resulting in gum tissue irritation, this carelessness promotes plaque
accumulation on teeth and eventually resulted in periodontitis and tooth loss.Due to the use of ingredients,
most artificial dentifrice products, including toothpaste and toothpowder, have adverse effects that include
mouth inflammation, mouth sores, stinging, and inflammation. By the formulation of herbal toothpowder
utilizing Tulsi, Neem, Arjuna, Clove, Cinnamon, Amla, Catechu, Liquorice, Black Pepper, Camphor,
Charcoal, Rock Salt, and Mentha, an endeavour is developed to provide an alternate to the consumers. The
produced tooth powder was assessed for its organoleptic and physical qualities, including color, odour,
flavor, stability, rheology, and abrasiveness, to make sure it has all the necessary components to combat
inflamed gums.To avoid the negative effects of traditional tooth powder made from synthetic substances,
research was done to create a tooth powder that can be used as a tool for good oral hygiene. Many herbal
substances with antimicrobial, antiseptic, and cooling characteristics were used to make the tooth powder.
Keywords:Tooth Decay, Plaque, Artificial Dentifrice, Arjuna, Neem, Liquorice.
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A-96
Polypharmacy & Social Economic Problems
Anamika Kumari, Jyoti Joshi
When at least five medications are taken at once, this is referred to as polypharmacy, which raises the
possibility of drug-drug and drug-disease interactions as well as non-adherence to drug therapy. Due to age-
related pharmacokinetic and pharmacodynamic changes, this may have detrimental health effects,
especially in older persons. Additionally, older persons who have several chronic diseases frequently
encounter a multidisciplinary approach to their care. In these situations, professional communication is
crucial to ensuring the quality of healthcare delivery, including the right prescription of medications.
Reduced cognitive abilities, mortality, and an increased risk of hospitalisation were discovered in older
persons who use many medications. Morbidities serving as the primary justification for pharmaceutical use
may contribute to poor health outcomes in those who use many medications. The adverse effects of
polypharmacy include mortality declines, unfavourable medication responses, prolonged hospital stays, and
return to the hospital soon after discharge. Due to lowered renal and hepatic function, older people are
significantly more at risk of negative consequences. Global health issues are being brought on by
polypharmacy. Concurrent usage of various drugs by people with multimorbidity may increase their quality
of life and length of life. The increased risk of hazardous drug reactions, numerous unanticipated bad
effects brought on by undiscovered drug. Pharmacies are an important part of society, and this is especially
true for low-income patients. Pharmacies are often the only way to access needed medications, and patients
need to make sure that they have proper insurance coverage to ensure the quality of their health care. This
article will discuss the many problems that low-income patients face and the need for pharmacies to be
accessible to all.
Keywords: Polypharmacy, Pharmacokinetics, Global Health, Multimorbidity.
A-97
Commercial Software of Optimization for
Pharmaceutical Formulation: A Game-Changer in Drug Development
Gagandeep Singh*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
Optimization is a crucial process in the pharmaceutical field, as it ensures that safety, efficacy quality of
pharmaceutical products. Studying the impact of multiple formulation variables on the quality parameters
of a pharmaceutical formulation using traditional methods like OFAT (one factor at a time) can be a time-
consuming and resource-intensive process, requiring many formulation variables to be physically tested.
Testing all possible combinations of variables at different levels, sometimes in combination, can be a
burdensome task. However, advancements in computational science have given rise to the development of
commercial software that can optimize formulations and predict optimal formulations, saving time and
costs for formulation scientists. Design of Experiments (DoE) is a valuable feature of these software tools,
allowing for the creation and prediction of optimal formulation combinations. A literature search was
conducted on PubMed and Google Scholar for the last 5 years, revealing the use of several optimization
software including Design-Expert®, MiniTab, JMP, XLSTAT, etc. This software are capable to perform
DoE, screening of factors, optimization through classical statistical designs, response surfaces, contour plot,
modelling of formulation variables and predication of formulations. Software differs in their interfaces and
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underlying computing programs. This paper aims to present an overview on some of these software and
how these can be helpful in optimizing and predicting pharmaceutical formulations.
Keywords: Optimization, PubMed, Software, Programs.
A-98
Mouth Dissolving Drug Delivery system in Geriatric patient
Ayush Mishra*, Jyoti Joshi
Kingston Imperial Institute of Technology and Sciences Dehradun
mishraayush580@gmail.com
Among the different novel drug delivery systems, the fast-dissolving drug delivery system is rapidly
gaining interest in pharmaceutical Industry. Fast dissolving drug delivery systems have been gaining
popularity and acceptance because they are easy to administer and achieve better patient compliance
Dissolving tablets are commonly used as a well – liked and widely accepted dosage form, especially for
paediatrics because of the partial development of the muscular and nervous system, as well as for geriatric
patients suffering from Parkinson’s disease or hand tremors. Capsules and tablets are among the solid
dosage forms that face problems nowadays such as difficulty swallowing There is no doubt that the oral
route of administration is the most convenient route of administration, but there is a major disadvantage:
dysphagia (difficult swallowing). Novel drug delivery systems have developed mouth dissolving tablets
that have improved pet compliance and are much more convenient.
Keywords: Dysphagia, NDDS, Geriatric, Capsules.
A-99
Antimicrobial resistance: A serious complication of Antibiotics
Zainab Parveen*, Swati Kumari1 Chhavi Chauhan, Kiran Dobhal
Antimicrobial resistance (AMR) is an ever-evolving global danger driven by the misuse and abuse of
antitoxins. AMR occurs when the microbe-stimulating ingredient counteracts the effects of an anti-infective
drug, rendering it insufficient to treat a bacterial disease. This results in longer stays in medical clinics,
higher medical costs, and higher death rates. Development of new antimicrobial agents has also been slow,
further compounding the problem. AMR is caused by multiple variables, looking at the misuse of
antimicrobial agents by hu man and biological organisms, lack of cleaning and disinfection, and the global
spread of safe microorganisms. Addressing this problem will require several approaches, including
promoting the conscious us use of antitoxins, improving new antimicrobial agents and selective treatments,
and additional observation and monitoring in the fight against antitoxin blockages. infection. Several AMR
actions have been fully launched, including the Global AMR Action Plan sent by the World Health
Organization (WHO). The arrangement aims to promote the responsible use of antitoxins, continue the
exploration and monitoring of antimicrobial resistance, and increase awareness of this issue. Additionally,
experts are looking for selective drugs f or bacterial diseases, such as bacteriophages and probiotics, to
reduce reliance on anti-infective drugs. In conclusion, antimicrobial resistance is a serious threat to general
global wellbeing and requires planned and sustained efforts to address it. Proper infection control
management, promotion of cleaning and sterilization, and allocation of resources to further infection
control improvements are key components of a comprehensive AMR program.
Keywords:Infection, Monitoring, Misuse, Treatment, Disease, Cleaning.
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A-100
Insect repellent using natural agents
Ankita*, Jhuma Samanta
Department of pharmacy, Kingston Imperial Institute of Technology Science, Dehradun India 248007
Plant based repellent have been used for generations in traditional practice as a personal protection Measure
against host-seeking mosquitoes. Mosquito repellent is a revolutionary innovation to protect human from
the bites of mosquito borne Disease such as dengue. These active ingredients show promise for further
development into formulation that may serve as Alternatives to DEET or possibly be used as natural bio-
pesticides to kill mosquitoes. Natural products are an ideal source of chemicals for topical application to
human skin. In order to document the insecticidal/ repellent plant which can use as source for development
of new As source for development of new plant based insecticides repellent. In this study, Neem plant1
from Bandar Abbas city was used to assess its repellence effect. Therefore, after drying and powdering
using maceration method, final Neem extract concentration of 5%, 10% and 20% was provided.
Mittler&Dadd methodology was hired to assess this effect. In this method, the antifeedant effect of the
Neem plant extract was evaluated on cabbage-feeding aphid (BrevicoryneBrassicae). After 24 and 48
hours, the reduced numbers of faeces spot of aphids showed that the Ingestion of the provided food mixture
contained Neem plant extract was significantly decreased. Here It was shown that the Neem plant extract
could be used as an efficient repellent.
Keywords: Neem, Insect Repellent Composition, Anopheles Stepheni.
A-101
Formulation and evaluation of drug-loaded 3D-Printed filaments via hot-melt extrusion
Pallavi Joshi*, Ashutosh Badola
Department of Pharmaceutics, School of Pharmaceutical Sciences, SGRR University, Patel Nagar, Dehradun
Febpharm@gmail.com
3D printing is quickly becoming a major manufacturing process in recent years, with fused deposition
modelling (FDM) being the most popular method. Three dimensional (3D)- printing via fused deposition
modelling (FDM) allows the production of individualized solid dosage forms. This study presents a
development of 3D-printable filaments produced via hot-melt extrusion. PVA was chosen as a sustained
release polymer, TEC were evaluated as suitable plasticizers for producing 3D-printable filaments
containing model drug. The formulation was printed into filaments and analyzed regarding their dissolution
profiles and other evaluation parameters. The produced filaments were thus considered potentially suitable
for printing dosage form for immediate or modified release, when loaded with active ingredients for any
type of dosage forms.
Keywords: 3D Printing, Hot Melt Extrusion, Modified release dosage form, FDM, Printability
A-102
Monitoring of ADR department of Cardiology Hypertension of a Tertiary Care Hospital
Harshit Chaurasia*, Jyoti Joshi
Department of pharmacy, Kingston Imperial Institute of Technology and Sciences
Doonga, Dehradun,India-248007
Due to their potential for use in medicine and pharmaceuticals, herbs are now used all over the world and
the herbs are also useful for project of people from several different types of illnesses. The produced herbal
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handwash formulation with the help of different herbal ingredients had no negative side effects and the
results were within acceptable ranges. Hand hygiene is an important principle and practice to control and
reduce the health care acquired infection. As a result, the need of healthcare services is increasing on a
global scale. Basically, the hands are the primary mode to transfer infections. Due to this the hand hygiene
is very important to avoid the spreading of infections and to control the transfer of harmful gems. Infected
hands can act as a carrier for spreading harmful microorganisms. An effort has been performed to create a
polyherbal hand wash gel combining eucalyptus extract shows antibacterial activity and Tulsi shows
purifying activity, to fight germs and responsible for controlling diseases and keep your skin safe. As
compared to antiseptic soaps and other antiseptic products which are used in cleaning this designed poly
herbal handwash gel was more effective at removing bacterial germs from human's hand. As a result, it can
be used as an antiseptic with little to no negative effects.
Keywords:Eucalyptus, Hand hygiene, Herbal handwash gel, Antiseptic property, Herbal product .
A-103
Use of 3D Printing technology for Customized Dosage Forms and drug delivery systems
Swati Kumari*, Jyotsana Suyal
Recently, more and more people are considering the use of 3D printing innovations in thepharmaceutical
industry. The ability to use 3D printing innovations to create modified measurement structures and drug
delivery frameworks offers several advantages over traditional assembly techniques. This innovation could
disrupt the way drugs are made and delivered to patients, allowing f or more feasible and efficient
personalized drug arrangements. Innovations in 3D printing offer several advantages over traditional
assembly strategies. A significant benefit is the ability to create chaotic, personalized drug delivery
frameworks and tailor precise dosages to each patient. Innovation also provides faster time to creation,
reducing opportunities to demonstrate new drugs and enabling pharmaceutical organizations to respond
quickly to changing industry needs. Another major benefit of 3D printing innovation in the pharmaceutical
industry is the ability to create drug delivery frameworks that are better suited to patient needs. These
include personalized delivery structures such as tablets and casings that can be tailored to individual patient
needs, as well as implantable devices that can deliver drugs over long periods of time. The use of 3D
printing technology also offers a huge cost reserve for pharmaceutical manufacturing. By eliminating the
need for different stages of creation and reducing material waste, 3D printing innovations could radically
reduce the overall cost of manufacturing drugs. All things considered, the use of 3D printing innovations in
the pharmaceutical industry offers gr eat potential for creating custom measurement structures and drug
delivery frameworks that meet individual patient needs. Although there are still challenges to overcome,
this innovation could change the way drugs are manufactured and delivered, providing more robust and
effective personalized drug arrangements.
Keywords:Drug, Printing, Innovation, Framework, Delivery, Needs, Industry.
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A-104
Paediatrics’ challenges with the Oral Drug Delivery System and current methods
Pankaj Singh Karki*, Anil Rawat
karkip988@gmail.com
Most drugs cannot be given to paediatric patients in proper dosage forms. The current study's goal is to
demonstrate novel approaches to paediatric oral medication administration. To address issues with drug
administration, toxicity, and taste preference, the drug is designed to best suit a child's age (neonatal-3
years), need for diagnosis, size, and physiological condition. Pharmacotherapy in paediatrics differs from
that in adult medicine in many ways. In terms of palatability, the formulation for paediatric use presents the
greatest challenge. Because of the many constraints in the solid formulation, in paediatrics, the drug
formulation should be designed with flexible doses, improved palatability, and ease of administration in
mind. The current study's goal is to demonstrate novel approaches to paediatric oral drug delivery. To
overcome issues with drug administration, toxicity, and taste preference, the drug is designed to best suit a
child's age, need for treatment, size, and physiological condition. Neonatal dosage forms should ideally be
safe, enjoyable, dose-adequate, and free of pharmaceutical errors. One of the most common reasons for
poor patient adherence, particularly in children and the elderly, is difficulty swallowing tablets and/or pills.
Patients who are paralysed or immobile and unable to take traditional dosage forms require an alternative
method of medication administration. The medicated straw is a novel delivery method that allows
medication to be consumed with non-viscous liquids such as water, tea, juice, or any other beverage. It is a
simple and effective method of accurately delivering medications to young children and the elderly. Since
inorganic particle delivery systems support an appropriate emulsifier security and suitability profile in these
delicate clinical groups, they can be used as multifunctional active ingredients to meet the special
healthcare needs of kids and babies.
Keywords:Paediatrics, Novel drug delivery, Neonatal, Medicated Straw
A-105
Molecular Pharmacology
Sanjana Katlaria*, Mahamedha Deorari
sanjanakatlaria2000@gmail.com
Due to its focus on determining how medications work at the molecular level using techniques like genetic
and molecular biology, molecular pharmacology is one of the areas of pharmacology that is growing the
fastest. It oversees the teaching of students in biophysics and molecular biology, along with the
pharmacology of cell signalling, transmitters, molecular toxicology, receptors, protein release and
synthesis, protein binding and interaction, drug design, drug discovery and identification, developmental
genetics, pharmacodynamics, and therapeutic strategy studies. To comprehend the molecular underlying
principles of disease in human and the method of medication action, systems biology has expanded
tremendously in the recent past and is now frequently used in the biomedical field. The only method to
understand how drugs function in biological systems is through the study of molecular pathways. Through
the drug-ligand interactions, drug-target prediction, the use of proteomics and genomics, the drugs activity
at the molecular and cellular level, and their application methods, molecular pharmacology today is of vital
importance in the enhancement of drug discovery. This provides an excellent platform for the development
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of new therapeutic compounds and the advancement of existing drugs. Network analysis and dynamic
modelling are the foundations of molecular pharmacology. Also, the receptor concept has been extremely
helpful in the evolution of molecular pharmacology. The study of molecular pharmacology allows for the
discovery of new compounds that may be more effective or have fewer side effects. The twentieth century
marks the beginning of rational drug design based on pharmacological explanation, which additionally
allows researchers to do molecular level work.
Keywords: Molecular, Pharmacology, Drug, Discovery.
A-106
Prevalence of diabetes in India
Kabita Sharma*, Jhuma Samanta
Department of Pharmacy, Kingston Imperial Institute of Technology and Sciences, Doonga, Dehradun, India-
Diabetes prevalence is spreading fast, particularly in emerging nations such as India. According to current
World Health Organization data, India has the world's highest number of diabetes subjects. Diabetes
incidence in India is increasing, according to the Chennai Urban Population Study (CUPS), the Chennai
Urban Rural Epidemiology Study (CURES), and the National Urban Diabetes Survey (NUDS). Some of the
major risk factors for diabetes are universal, although their severity varies between races, regions, and
nations. Diabetes prevalence in India might be due to a mix of genetic and environmental factors caused by
urbanization and industrialization, which has resulted in inactive lifestyles, physical inactivity, stress, and
obesity caused by energy and fat heavy foods. Diabetes problems that arise during the most productive
years of their life result in a major burden of disease and death, creating an economic and social burden at
both the individual and national levels.Diabetics are more than twice as expensive to treat as non-diabetics,
due to the high expenditures involved with the care of associated problems. Prevention appears to be the
most efficient method of fighting this disease. This article discusses the social and economic consequences
of diabetes in India, as well as the preventive actions that must be taken.
Keywords:Indians, Diabetes, CURES CUPS; Health economics.
A-107
Adverse Drug Reactions and pharmacovigilance of herbal medicine in India
Jyoti Pandit, Tarun Parashar
In health food stores, natural products are readily available without a prescription and are generally
perceived as being risk-free. The main objective was to determine how using natural remedies would affect
individuals receiving antiretroviral therapy who had negative pharmaceutical reactions (Craftsmanship).
The ability to progress Indian traditional medicine is increasing globally as a result of the homegrown
medication/items' increasing availability over the past few years, both as a component of general medical
care and of ordinary treatment systems.Antagonistic medication response (ADRs) is characterized as
potentially negative results thought to relate to the utilization of restorative items, including natural
prescriptions (WHO 1995). Unconstrained detailing frameworks, for example, the Canada Watchfulness
Program are involved by numerous nations as an approach to checking thought ADRs. In Canada, doctors,
drug specialists, other medical services suppliers and buyers can submit reports for appraisal to recognize
item wellbeing worries that require activity, for example, changes to item naming or dosing, or expulsion
from the market.Considering this, this study examined the opinions of food shop employees on concerns
about the security of locally produced goods. The information above shows how business considerations
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affect product selection and the disclosure of adverse event data in health food storage, as well as how
product exchanges may be related to a store's staff's ability to respond to Health Canada's efforts to collect
ADR data regarding domestically produced goods. Homegrown products were specifically chosen due to
the increased risks associated with them when compared to other NHPs.
Keywords: ADR, Pharmacovigilance, Medicine.
A-108
Applications of CRISPR- Cas9 in Therapeutics
Marhaba Rashid Mohammed, Laxmi Singh
marhaba.rashid123@gmail.com
The use of genetic manipulation in pharmacy dates as far back as the 1980s with the discovery of rDNA
technology. Since past few years, CRISPR- Cas9 has been in the limelight as a powerful and revolutionary
gene editing tool which can be used to turn genes on and off, and cause deletions or insertions in genes.
CRISPR was originally identified as an adaptive immune system of bacteria against viral pathogens. Cas 9
is a part of CRISPR acting as a restriction enzyme to cut specific parts of DNA when it complexes with an
RNA molecule to help it recognize the target site. This is a more efficient and precise way of genetic
modification by cleaving, so far, up to 20 bp long genomes and can has made possible the editing of larger
animal and human genome as well. The pharmacy field is also beginning to apply CRISPR to develop new
ways to cure genetic diseases, such as sickle cell anaemia and beta- thalassemia. Additionally, drug target
identification process needed for drug discovery is also utilizing CRISPR- Cas9 for in vivo studies to find
the link between particular genes and diseases and creating animal models to more accurately mimic human
diseases. CRISPR achieves this by making it possible to precisely modify the animal's genome to introduce
specific human disease mutations, hence developing large animal models for various diseases. CRISPR-
Cas9 tool seems to hold a potential for creating innovative solutions to treatment and it is crucial for
pharmacists to capitalize on this novel technology.
Keywords: CRISPR, Cas9, Gene Editing, Drug, Discovery, Target.
A-109
Navigating the Literature – Salient Features of Biomedical Sciences Databases
Avantika*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
A literature search is a systematic and organized process of searching for all the relevant literature, such as
journal articles, books, conference proceedings, and other published materials, related to a specific topic or
research question.Navigating the vast amount of scientific literature in biomedical sciences can be a tough
task for researchers. To overcome this challenge biomedical sciences databases have been developed.
Biomedical literature databases such as PubMed, Web of Science, Scopus and Google Scholar are
specifically created to store, organize, and facilitate access to scientific literature for researchers. Exploring
the literature needs the effective use of database searching techniques and a clear understanding of the
features and functionalities of these databases. A comparative analysis was conducted to explore the
features of these databases. All these databases have their unique features and advantages. PubMed is
specifically focused on biomedical literature and is curated by the National Library of Medicine, which
ensures high-quality and reliable content. It also provides advanced search options and filters specific to
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biomedical research. Google Scholar, on the other hand, has a broader coverage across multiple disciplines
and is known for its user-friendly interface and ease of use. Web of Science and Scopus are bibliographic
databases. Google Scholar, Web of Science and Scopus also provide citation metrics and allow users to
track the citations of their publications.Allthese databases provide access to a diverse range of literature
searches, making them valuable resources for comprehensive literature reviews and evidence-based
practice. This paper aims to highlight a comparison of these databases and the potential improvements in
the literature search.
Keywords: Literature, Scopus, Web of Science, Google Scholar.
A-110
Evaluation & formulation of Sunscreen Stick: A novel innovative approach for
photoprotection
Bhawana Bhatt*, Sudhakar Kaushik, Anupriya Sundriyal
School of Pharmaceutical Sciences, SGRR University, Dehradun, Uttarakhand, India
bhawanabhatt729@gmail.com
Plants are considered as one of the most important sources of medicines. Sunscreens are more prevalent for
the protection of the human skin from harmful UV rays of the sun. Medicinal plant can be used in the
preparation of effective sunscreens which are helpful for the protection of our skin as they do not have any
side effects and can be used for any skin type. Due to its capacity to only cover a very limited surface area
with each application, sunscreen in the stick form is currently gaining notice. It has a high-water resistance,
is simple to use, and creates a cohesive, durable protective film. This study is based on studying the SPF of
PyrostegiaVenustaplant and to develop a formulation for photoprotection. The physical characteristics of
the leaf were studied. Extraction of the leaf was performed. To determine the phytoconstituents, the
ethanolic extract& phytochemical composition was screened. From this ethanolic extract the SPF was
studied by In vitro method from Mansur equation. A formulation was developed from the extract which
was a sunscreen stick. The results showed presence of alkaloids, tannins, and flavonoids in the ethanolic
extract. The SPF of the leaf was reported to be 10.84075 ± 0.02. The sunscreen stickformulation also
showed satisfactory photoprotective activity. The study findings lead us to the conclusion that
the formulation could shield the skin from the damaging effects of ultraviolet radiation.
Keywords:Pyrostegiavenusta, UV rays, Phytochemical screening, Sunscreen Stick.
A-111
Overview of cosmeceutical
Smriti, Chhoti Kumari, MahamedhaDeorari,Vikas Jakhmola
Cosmeceuticals is a word that helps people to know about the cosmetics and herbal cosmetics, it was
invented by Raymond Reed and concept was popularised by Dr. Albert Klingman in late 1970s. The
Federal food, Drug, and Cosmetics Act does not recognise it, but the beauty industry uses this word to refer
to cosmetic products that uses in medicinal or drug benefits. Cosmeceuticals help to minimise cosmetic
problems like wrinkles, or dull complexion etc. Cosmeceuticals can help to maintain our healthy skin,
without needing any prescription. There are many ingredients which are involved in the composition of
cosmeceuticals are vitamins, minerals, protein and active ingredients like sunscreens, antioxidants,
retinoids, botanicals, peptides, proteins, hydroxy acids, and skin brightening agents. It also act as both
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cosmetics and medicines and combine cosmetic products with pharmaceutical products. It contains active
ingredients like vitamins and hyaluronic acid. The growth and future prospective of cosmeceuticals market
size valued at USD 51.04 billion in 2021 and is projected to grow from USD 54.58 billion in 2022 to USD
97.62 billion in almost 2029. There are many scopes of cosmeceuticals that almost exponentially
expanding, for example with the discovery of alpha acid for exfoliation, different formulation of topical
vitamin C, and skin rejuvenation and many more. Also, cosmeceuticals have many benefits like to improve
skin tone, oiliness, pore sizes, dry skin, pigmentation etc. In the increasement or rising of dermatologist
practices in recent years has been the high demand for cosmetics services. These are topical cosmetic
pharmaceutical hybrids intended to enhance the beauty. It plays an important role in management of
common dermatologist conditions both as a first line treatment for mild or moderate disorder and clinical
therapy.
Keywords: Cosmeceuticals, Herbal Cosmetics, Growth, Topical preparation
A-112
Application of Biosensors
Abhishek Chauhan*, Mahamedha Deorari
Biosensors are nowadays ubiquitous in biomedical diagnosis as well as a wide range of other areas such as
point-of-care monitoring of treatment and disease progression, environmental monitoring, food control,
drug discovery, forensics, and biomedical research. A wide range of techniques can be used for the
development of biosensors. Their coupling with high-affinity biomolecules allows the sensitive and
selective detection of a range of analytes. We give a general introduction to biosensors and biosensing
technologies, including a brief historical overview, introducing key developments in the field and
illustrating the breadth of biomolecular sensing strategies and the expansion of nano technological
approaches that are now available. Electrochemical sensors and biosensors have received enormous
attention because of their low cost, rapid response, high sensitivity, good detection limit, and excellent
selectivity. The development of biosensors and sensors is of great significance and is urgently required for
the detection of various biomolecules such as glucose, ascorbic acid, serotonin, tryptophan, uric acid,
cholesterol, and so on. Biosensors are analytical tools or systems consisting of an immobilized biological
sensing material in close contact with a suitable transducer that convert the biochemical signals to a
quantifiable electrical signal. Biosensors are now used in variety of disciplines, including medicine, food
industry and environmental science. This review discusses the basic features of biosensors, types of
biological materials used and details of most important types of biosensors currently used specifically in
food industry.
Keywords: Affinity Reagents, Biosensors, Glucose Sensor, Nano Materials, Pregnancy.
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A-113
Self-Emulsifying Drug Delivery System
Sarvesh Tripathi*, Jhuma Samanta
The pharmaceutical industry faces a major challenge with orally administered drugs' low aqueous
solubility, which results in poor dissolution and low bioavailability, high intra- and inter-subject variability,
and a lack of dose proportionality. Approximately 35 to 40% of recently launched drugs have this problem.
Several processes, such as salt production, solid dispersion, and complex creation, might increase this.
SEDDS are characterized as isotropic mixtures of one or more hydrophilic solvents and
cosolvents/surfactants that have the extraordinary capacity to produce fine oil-in-water (o/w) micro
emulsions under gentle agitation followed by dilution in aqueous media, such as GI fluids. The current
review offers an up-to-date overview of SEDDS developments about its composition, assessment, various
dosage forms, newer methods of solidifying liquid SEDDS, as well as a variety of applications. It may be a
viable strategy for lipophilic medicines with dissolution rate-limited absorption if these formulations and
procedures can create microemulsions or fine oil-in-water (o/w) emulsions following modest stirring and
dilution by water phase along the GI tract. The evaluation of SEDDS and its uses are also covered, with an
emphasis on the improvements made to the dosage form and solid self-emulsifying delivery mechanism of
SEDDS. SEDDS may be researched for the development of a formulation with sustained drug release by
incorporating a suitable polymer into the formulation. The development of this technology may result in a
novel use for the delivery of medicines.
Keywords: SEDDS, Microemulsions, Lipophilic, Bioavailability, Cosolvent.
A-114
Antibiotics Resistance
Aman Bhatt,Shaheen Anjum,Sachin Kumar Verma, Joytsana Suyal
amanbhatt483@gmail.com
Antibiotic resistance poses serious challenges to health and national security, and policy changes will be
required to mitigate the consequences of antibiotic resistance. Resistance can arise in disease-causing
bacteria naturally, or it can be deliberately introduced to a biological weapon. In either case, life-saving
drugs are rendered ineffective. Resistant bacterial infections are difficult to treat, and there are few new
antibiotics in the drug development pipeline. This article describes how antibiotic resistance affects health
and national security, how bacteria become antibiotic resistant, and what should be done now so antibiotics
will be available to save lives in the future. Antibiotics resistance is among the leading global health till
date. The antibiotics are misused in different fields such as inappropriate prescribing of antibiotics, their
overuse in the livestock sector, etc. Antibiotics are the wonder drugs to combat microbes. Antibiotics
resistant infections correlate with the level of antibiotics consumption. Non – judicial use of antibiotics is
mostly responsible for making the microbes resistant.
Keywords: Antibiotics, Resistance, Infections.
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A-115
Optimizing Drug Formulations with Machine Learning Algorithms
Geetika Gupta*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
Machine learning (ML) is a subfield of artificial intelligence that focuses on creating algorithms capable of
making predictions or decisions based on input data. In the pharmaceutical industry, ML algorithms have
proven to be useful for various applications such as the optimization of drug formulations, drug discovery,
and pharmacokinetic predictions. Due to the numerous variables and factors involved in these processes,
ML techniques are valuable for their ability to analyze vast amounts of data. An extensive literature survey
revealed various designs of supervised, unsupervised, and semi supervised ML can be utilized for
optimizing drug formulations. Some of these designs include, K-nearest neighbour, support vector machine,
decision tree, and principal component analysis which use solubility, stability, and bioavailability data to
predict the properties of new formulations. SVMs are another type of ML algorithm that can predict the
properties of new formulations based on their similarity to known data points. Random forests can be
utilized to determine the most crucial excipients and dosage forms for enhancing drug stability, solubility,
and bioavailability. Moreover, Bayesian optimization can be utilized to identify the most suitable
combination of excipients and dosage forms for a given drug based on previous formulations. The
utilization of Artificial Neural Networks can significantly contribute to the optimization of pharmaceutical
products. The purpose of this paper is to showcase how these designs can enhance optimization by
explaining their fundamental concepts. However, use of ML in the pharmaceutical industry not only speeds
up the process of drug development and enables the discovery of new materials and innovative
formulations, but also leads to the generation of novel findings in the realm of drug formulation research.
Keywords: Machine learning, Pharmaceutical,Industry, Optimization.
A-116
Organoid Intelligence (O.I.)
Aditya Kumar*, Pranjal Bisht, Pallavi Ghildiyal
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun
Organoid Intelligence in Biocomputing is an Artificial Intelligence (AI) based technology in which the
applications of Biocomputing are applied to develop an artificial organ known as organoid to replace the
processing unit, i.e., CPU in the computer system to enhance the efficiency of processor. Organoid is a
miniature version of any organ produced by stem cells in vitro. The application of the OI is to study the
development of human brain and the pharmacological responses of various drugs on the brain. It also
emphasises the drug discovery, biomedical research, and regenerative medicine. However, there are some
challenges in this field of interest including technological changes such as scaling up, microfluidic systems,
new model and algorithms and some ethical challenges too. According to the findings, human brain
organoids might be used to better understand brain development and diseases. Because research copies of
human mind organoids are so diverse, artificial intelligencetechniques are used to study the evolution of the
human brain. But the advantages are more than the challenges. So, this is an upcoming approach in the field
of pharmacy.
Keywords: Organoid, Intelligence, Biocomputing,Artificial Intelligence, Human Brain.
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A-117
Orally Disintegrating Films: A novel convenient dosage form for rapid relief
Diwas Adhikari‫٭‬, Meenakshi Kandwal, Shivanand Patil
Department of Pharmacy, Shree Dev Bhoomi Institute of Science and Technology, Uttarakhand Technical University,
Dehradun-248007, India
adhikaridiwas51@gmail.com, pharmameenakshi23@gmail.com
With advancement in the therapeutic evolution, novel drug delivery system has been growing immensely,
developing the new dosage forms called as Mouth Dissolving films, also known as Orally Disintegrating
films. They are specially designed for dissolving locally inside the mouth, does not require water for
disintegration and exerts its therapeutic effect immediately due to easy accessibility to oral mucosa. It also
leads to the higher bioavailability as the first pass metabolism is bypassed. Pediatric, Geriatric and
Dysphagic patients are highly benefitted through these dosage forms who have difficulty in swallowing
thus promoting a patient compliance. Mouth dissolving films can be specially prepared using Solvent
Casting Method. Materials such as Active Pharmaceuticals Ingredients, Saliva Stimulating agents,
Plasticizers, Surfactants, Artificial Sweeteners, Film forming Polymers, Super disintegrants and desired
solvent can be employed for the preparation. Prepared Mouth Dissolving films can be evaluated by
different attributes such as Folding Endurance, Thickness, Mouth Dissolving Time, Content Uniformity,
Disintegration time, In-vitro Dissolution test, Assay %, Tack Test, Tensile Strength, Surface pH,
Percentage elongation, Swelling Properties, Contact Angle Measurement, Percentage Moisture Absorption,
Percentage Moisture Loss etc. This article provides an overview regarding Mouth dissolving films, its
preparation and evaluation.
Keywords: Solvent Casting, Pediatric, Geriatric, Dysphagic, Pharmaceutical Ingredients.
A-118
A review of the phytochemical and pharmacological study of Berberis Asiatica (Kilmoda)
Lalita Rawat*
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun,Uttarakhand
Indian barberry, or Berberis Aristata (Kilmoda), is a deciduous evergreen shrub. Which are found in the
temperate and sub-tropical regions and the Himalayas in India and Nepal. Berberis aristata is commonly
known as Daruhaldi, Kingoda, tree turmeric, and Citra. Kilmora is a woody plant with yellow and brown-
coloured bark. It has teeth that are rough in texture and deep green in colour. This plant produces yellow
flowers and aconite violet colour edible fruit. Kilmora fruit is juicy, contains plenty of sugar, and is a rich
source of vitamin C and other nutrition. Alkaloid content 4% in root and in stem 1.95% of which berberine
form 2.09% and 1.29% polyphe, carotenoid and vitamin c, triterpenes, phenolic, compound, tannis. Many
deciduous species, such as Berberis thunbergi and Berberis vulgaris, indicate a pink or red colour. B.
landidula and B. varruculosa have dark red and violet foliage found in horticulture. Kilmora plant has
many medical uses, such as antioxidants, antibiotics, anticancer, and antimicrobials. This review aims to
highlight a comprehensive account of phytochemical and pharmacological activities along with traditional
uses considering many recent findings and the potential for future research.
Keywords: Berberine, Phytochemical, Pharmacological Himalayas, Antioxidant.
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A-119
Pharmaceutical Formulations Design and Development: An Expert System Approach
Gaurav Chandra*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
Pharmaceutical formulation is a complicated process that need a vast knowledge and years of experience.
To assist this process, Expert system (ES) came into scenario to guide the researcher in formulating and
developing new drug. An ES for pharmaceutical formulations is a computer-based program designed to
assist formulation experts in developing a new drug product. This fusion of pharmaceutical technology and
artificial intelligence works by acquiring knowledge from various source like literature, experimental data
and expert opinions that result in development of more efficient and cost-effective drug. The acquisition
system collect data from various sources and integrates it into knowledge base. Afterwards the inference
engine employs this knowledge to produce solutions for the specified issue. Explanation facility describes
the solution that is produced by the inference engine and is directly communicated with users through user
interface. An extensive exploration of literature was carried out on PubMed, Google scholar, and Scopus
with the objective of obtaining knowledge about different expert system (ES) utilized in the pharmaceutical
field. Notably, certain well-known ES such as CAPEX, SeDeM, and ESFppop are commonly employed by
pharmaceutical companies. These techniques find specific application in the production of hard gelatin
capsule, push-pull osmotic tablet and orally disintegrating tablet. The aim of this paper is to discuss the role
of expert system in pharmaceutical formulation development and their application in reducing the time and
cost required to bring new drug formulations to the market.
Keywords: Expert system, CAPEX, SeDeM, ESFppop.
A-120
Application of Ofloxacin
Nandini Chaturvedi1*
School of Pharmacy and Research, Dev Bhoomi Uttarakhand University, Dehradun
Ofloxacin is a newly licensed fluoroquinolone with an antimicrobial spectrum like ciprofloxacin. Compared
with ciprofloxacin, the MIC90 values for ofloxacin are lower for S aureus, C trachomatis, and
Ureaplasmaurealyticum, but somewhat higher against gram-negative bacteria (especially P aeruginosa).
Ofloxacin has favourable pharmacokinetics with almost 100% bioavailability; peak serum concentrations
obtained one to two hours following oral dosing are higher than those achieved with ciprofloxacin. The oral
bioavailability is decreased by the coadministration of antacids, but ofloxacin does not alter serum
theophylline concentrations. Ofloxacin has demonstrated bacteriologic and clinical efficacy in the treatment
of urinary tract infections, respiratory tract infections, prostatitis, and skin and soft tissue infections caused
by susceptible organisms, although there are little data to recommend ofloxacin over ciprofloxacin for these
indications. Ofloxacin should not be used alone to treat anaerobic or mixed aerobic/anaerobic infections,
and a penicillin or cephalosporin is preferred for known or suspected streptococcal or pneumococcal
infection. Ofloxacin is the only quinolone currently approved for the treatment of uncomplicated
gonorrhoea.
Keywords: Ofloxacin, Bacteria, Quinolone.
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A-121
Preventive effects of Polyalthia Longifolia against Gentamicin-induced
nephrotoxicity in Wistar rats
Divya Bisht 1 *, Arvind Kumar Shakya1, Deena Prakash 1 , Ramesh Kumar 2 , Sangeeta Shukla 3
1
Biochemistry Discipline, School of Sciences, IGNOU, NewDelhi-110068, India.
2
Department of Biochemistry, Bundelkhand University, Jhansi- 284 128 (U.P.), India.
3
School of Studies in Zoology, Jiwaji University, Gwalior, Madhya Pradesh-474001, India.
divyabisht489@gmail.com
Drug-induced nephrotoxicity is currently a global health concern. Traditional medicinal plantsoffer a wide
range of therapeutic effects for the treatment of various kidney diseases. The aim ofthe present study was to
evaluate the preventive and curative effects of Polyalthia longifolia (PL)leaf extract against gentamicin-
induced nephrotoxicity in male Wistar albino rats. Animals weredivided into six groups (n=6/group), PL
extract was given at three doses (150 mg/kg, 300 mg/kgand 600 mg/kg of body weight, p.o.) for 11 days,
and gentamicin (80 mg/kg of body weight, i.p.)toxicity was induced from days 4 to 11 along with PL
therapy. Blood and kidney tissue sampleswere collected after 24 hours of the last administration. The
results showed that PL extractsignificantly prevented the alteration in the level of key renal markers,
including urea, uric acid,albumin, creatinine, triglyceride and cholesterol, along with remarkable
prophylactic effect onthe oxidative stress markers, namely superoxide dismutase, catalase, lipid
peroxidation, reducedglutathione, glutathione peroxidase and glutathione reductase. Results obtained in
biochemicalassays were well supported by histological observations of intact cellular architecture of
kidneyagainst gentamicin-induced toxicity. PL extract showed significant nephroprotective
activity(p<0.05) in dose-dependent manner, and maximum protection was found to be at 600
mg/kg.These results revealed that Polyalthia longifolia leaves exhibit preventive and curative
propertiesagainst gentamicin-induced nephrotoxicity and can be studied further to utilize its
therapeuticproperties against drug-induced nephrotoxicity.
Keywords:Polyalthia longifolia, Gentamicin, Drug-toxicity, Nephroprotection.
A-122
Formulation and Development of herbal Gel containing Cannabis Sativa and
Neem leaves extract for Anti-inflammatory and Anti-bacterial activity
Kalash Mishra, Divya Rawat, Akshanda Chandel, Shiva Rana* , Deovrat Kumar
College of Pharmacy, Roorkee
ranashivarajput@gmail.com
Bacteria are everywhere and play a crucial part in the maintenance of germs that cause illness and disease.
Skin infections are anticipated to occur at a rate of 24.6 per 1000 person yearly. The treatment of any skin
infections primarily consists of any necessary surgical debridement; nevertheless, injecting an antibiotic
directly into a wound has several potential benefits. Topical antibiotic treatment and wound care are
recommended. The administration of a therapy may allow treatment with medicines that are not yet
available (or safe) for systemic therapy. Gels are semi-solid systems having qualities intermediate between
solids and liquids, in which the movement of the dispersing medium is constrained by an interlacing three-
dimensional network of particles or solvated macromolecules of thedispersed phase. This study aimed to
explore the potential of Cannabis sativa, neem leaves extract as anti-inflammatory and antibacterial agents.
The formulation has been developed by solvent casting method. The experiment was conducted using
various techniques to measure the effectiveness of each substance individually and in combination. Results
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showed that Cannabis sativa and neem leaves extract both had strong anti-inflammatory properties, while
glycerol demonstrated significant antibacterial activity. When combined, these substances exhibited
enhanced anti-inflammatory and antibacterial effects, indicating potential for their use in pharmaceutical
and medical applications. Overall, this study highlights the importance of exploring natural products for
their therapeutic potential andprovides insight into the potential of these substances as novel anti-
inflammatory and antibacterial agents.
Keywords: Anti-inflammatory, Novel gel, Cannabis sativa, Neem extract, Anti-bacterial agent.
A-123
Preparation and characterization of Schiff base Metal complexes
Piyush Kumar Singhal 1 *, Arvind Kumar 1, Bhuwanendra Singh 2
1. Department of Pharmaceutical Chemistry, SD College of Pharmacy & Vocational Studies, Muzaffarnagar,
U.P.
2. Department of Pharmacognosy, SD College of Pharmacy & Vocational Studies, Muzaffarnagar, U.P
psinghal680@gmail.com
A complex of metals with Schiff bases are prepared by using with different ligands that’s 0.01 mole of
aldehyde and amines respectively by help of classical method which is reflux contestation for 5-6 hrs at 30-
40°C with an ethanol as a solvent in synthesis. Schiff base is a complex of N = C compounds derived by
condensation reaction of aldehyde ketone and amino groups. Schiff bases contain aryl or alkyl group. after
the preparation of ligand, 4-{(E)-[(4-chlorophenyl) methylidene] amino} benzoic acid, 4-{[(4-nitrophenyl)
imino] methyl} phenol that reaction was made with transition metals by using this Schiff base. For the
evaluation of the complexes several methods have been performed such as TLC was done to check purity
and confirmation of reaction, after that NMR, IR and ICPMS was performed for structure confirmation and
acid digestion method is used for sample preparation the methods adopted to prepare the metal complex
was suitable without any drawback. Anticonvulsant activity is confirmed using Swiss albino mice with a
comparative study with a standard by i.p. route at 30 mg/kg.
Keywords: Complex, ICPMS, coordination, Schiff base.
A-124
Targeted Drug Delivery Systems
Vani Chandravansi*, Chinkey Mittal
Department of Pharmacy, GRD (PG) IMT, Dehradun, Uttarakhand-248001
Drug targeting is an advanced version of concept of ‘Magic Bullets’given by Paul Ehlrich.Targeted Drug
Delivery systems are the specialized systems for delivering the drug moiety tothe body part of interest i.e.,
organ, tissue, cell. Targeted drug delivery, additionally referredto as Intelligent Drug Delivery. Various
strategies are used to target drug to the targetedorgan/tissue, in which passive targeting and active targeting
are widely used. Carriers orvehicles for drug delivery transport the drug either at intervals or within the
locality of target.Different carriers are being used and investigated, which include nanocarriers
(nanocapsules,nanospheres), colloidal (vesicles) system, polymer (multifunctional dendritic
polymer),Micelles and liquid crystals also. The inherent advantage of this advanced technology is
thereduced dose required to administer and thus leading to its reduced side effects. Drugtargeting preferably
avoid Hepatic first pass metabolism and hence, beneficial overconventional drug delivery system. During
the emergence of new disease and/or disorder, thedemand for new and more effective medicaments is
particularly strong. Lifestyle relatedissues like cardiovascular disorders and Diabetes can be effectively to
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treat targeted deliverysystems. Drug targeting systems like nanoparticles can be employed for the treatment
ofcancer and tumors which is the leading cause of death in developed countries. The goal of thetargeted
drug delivery system is to prolong, localize, target, and have a protected druginteraction with the targeted
tissue.
Keywords: Drug Targeting, Prolong, Nanoparticles, Active targeting, passive targeting
A-125
Uneasiness activity of inclusion complex of hydroxyPropyl β-cyclodextrin
with Acorus Calamus oil
Mahima 1*, Bhuwanendra Singh 1, Arvind Kumar2
1
Department of Pharmacognosy, SD College of Pharmacy & Vocational Studies, Muzaffarnagar, U.P
2.
Department of Pharmaceutical Chemistry, SD College of Pharmacy & Vocational Studies,Muzaffarnagar, U.P
mahimarana863@gmail.com
Acorus calamus Linn. is an ayurvedic plant also known as vach, sweet flag etc belonging to the
familyAcoraceae and amphibiotic, amphibious in nature. The essential oil has broad spectrum activity, to
increase the stability of oil, the inclusion complex is prepared with cyclodextrin by different methods like
coprecipitation.Initially collected fresh leaves of Acorus calamus, extract the oil by using Clevenger
apparatus for 8hr. Theinclusion complex made by coprecipitation method and then dried in desiccator for
24hr: Anxiety studies areconfirmed in this research work because of the Acorus calamus chemical
Constituent α-Asarone majorly and many more. Structure confirmation studies are done by TGA, SEM,
TEM analysis and for confirmation ofcomplex of oil with cyclodextrin. Cyclodextrin is basically used for
the enhancement of stability and bioavailability of the oil. The above-mentioned information and medicinal
properties of Acorus calamus is also reported in many diseases and disorder this research confirm that after
in vivo studies on Swiss albino mice, cyclodextrin complex with essential oil have anti-anxiety properties
with better stability with a Diazepam (Standard Dose) at 1.0 mg/kg by i.p. route.
Keywords:Acorus calamus, Cyclodextrin, Anxiety, α-Asarone, coprecipitation.
A-126
Advancement of nanotechnology and nanoparticles in diagnosis and drug delivery system for
cancer treatment
Anushree Sammal*, Chinkey Mittal
Cancer is a disease characterised by uncontrollable growth of some body's cell which can spread by
nearby tissue or invade distant places in body leading to tumor formation causing a range of cancer like
breast cancer, lung cancer, prostate cancer etc. It is also one of the leading causes of deaths globally.
Traditional methods like surgery, radiation therapy, chemotherapy etc are currently available for cancer
treatment in the market but they also carry risk along with it like it can cause damage to normal tissue or
incomplete eradication of cancer. By overcoming theshortages of the traditional cancer treatments or by
enhancing the overall treatment along current methods nanotechnology can bring a new direction in the
cancer therapy.It is the science of modifying matter at nano scale. Nanotechnology with better
biocompatibility, increased stability, better permeability, and reduced toxicity can help in selective
targeting to neoplasms and tumours by active targeting or passive targeting. Nanoparticles are smaller in
size than cell but large enough to encapsulate many small molecules and allow modification in size, shape,
chemical and physical properties. The properties of nanoparticles also enable in a better
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therapeutic action. Nanotechnology not only helps in drug delivery but also be used in development of new
therapeutics by using nanomaterial characteristics. In past few years efforts have been made in the
development of nanomedicines and nanodevices like micelles, dendrites, nanorobots. So nanotechnology
for cancer in long run can be safer and more effective.
Keywords:Cancer, tumor, nanotechnology, nanoparticles, radiation, chemotherapy, nanomedicines
A-127
Markov Modeling for Assessing Cost-Effective Analysis of Pharmaceutical Drug Products
Ashutosh Bhandari*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
Markov models have become an essential tool in healthcare economics, particularly in the evaluation of the
cost-effectiveness of healthcare interventions. These models are used to analyze the potential outcomes of a
particular intervention by illustrating disease states and tracking transitions between them. To support cost-
effectiveness analyses, several tasks are involved, such as developing decision trees, creating mathematical
spreadsheets, developing simulation models, and performing cost enumeration. Markov models play a
crucial role in developing patient education models, pharmaceutical sales tools, and aiding shared decision-
making between patients and healthcare providers. The Markov decision tree is commonly used to compare
the cost-effectiveness of different treatment options by integrating information related to natural history,
clinical efficacy, health-related quality of life, resource use, and costs into a lifetime cost estimate. Several
software tools are used in Markov modeling, including Microsoft Excel, TreeAge Health Pro, etc. These
software tools can help generate cost-effectiveness analyses and aid in the development of patient education
models and pharmaceutical sales tools. Numerous studies have been conducted using Markov models to
evaluate the cost-effectiveness of various treatments. For example, a Markov decision tree was constructed
using the TreeAge Pro program to perform a cost-effectiveness analysis of chemotherapy versus
chemotherapy plus bevacizumab for the treatment of cervical cancer. Overall, Markov models are a critical
analytical tool for estimating the cost-effectiveness of treatment programs and can aid in market analysis of
pharmaceutical products. Their importance in healthcare economics cannot be overemphasized, and they
will continue to be widely utilized in decision analyses in the future. The aim of this paper is to describe a
specific application of Markov modeling in the pharmaceutical industry, which involves evaluating the
cost-effectiveness of different drug products over time. This analysis can help stakeholders make informed
decisions about the allocation of resources and identify the most effective strategies for improving patient
outcomes.
Keywords: Markov modelling, TreeAge, Market.
A-128
Pharmacological investigation of Celtis Australis for
castor oil induced diarrhea inAlbino mice
Anuj Giri*
Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand
girianuj31@gmail.com
Celtis australis is a traditionally used plant for treating variety of human ailments including intestinal
disorders, neurological deficits, pain, inflammatory conditions, gout, chicken pox and measles. Aim: The
aim of present study was to investigate the pharmacological properties of Celtis australis in curing castor oil
induced diarrhea. Materials and methods: Fresh Celtis australis leaves were plucked during morning hours
from 8:00 a.m. to 10:00 a.m. which were then verified by correct identification. Freshly bought leaves were
cut into small bits and air- dried at room temperature for a week. Dried leaves were ground into powdered
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form and extracted using reflux apparatus. Both Wister Albino rats (n=20) of both genders were housed
inside plastic cages for 2 weeks period for acclimatization before experiment. Institutional clearance was
obtained from Institutional Animal study review board and Ethical committee. Mice were fed castor oil till
development of diarrhea. They were then fed prepared aqueous extract of Celtis australis byoral route in
different doses amounting to total of 3000 mg/kg dose. Rats were divided into four groups (250 mg/kg; 500
mg/kg and 750 mg/kg) and control. All data was recorded as mean and standard deviation values. One-way
ANOVA was applied, and statistical significance was derived. Result: Celtis australis leaf extract at dose of
750 mg/kg was found to statistically significant in controlling diarrhea induced by castor oil. Celtis Autralis
can be used as a medicinal agent for treatment of diarrhea.
Keywords:Diarrhea, Castor Oil, Pharmacological.
A-129
Brief insights on Digital Pills with Ingestible Sensors
Shivani Bisht*
Sardar Bhagwan Singh University, Balawala, Dehradun:248161, Uttarakhand.
shvni311299@gmail.com
Digital pills, also known as smart pills or connected pills, are medications that are equipped with a tiny
sensor that can be ingested and then tracked remotely. The sensor is usually no larger than a grain of sand
and is activated when it encounters stomach acid. Once activated, the sensor sends a signal to a patch worn
on the patient& skin, which in turn sends the data to a mobile app or web-based portal that can be accessed
by the patient, their doctor, or other authorized individuals. The purpose of digital pills is to improve
medication adherence and to help doctors and caregivers monitor a patient&medication usage more closely.
The technology can be especially useful for patients with chronic conditions or for those who need to take
multiple medications on a regular basis. By tracking when a patient takes their medication, doctors can
better tailor treatment plans and ensure that patients are receiving the appropriate dosage. These pills claim
to enhance cognitive skills such as memory, concentration, creativity, and motivation, also known as
cognitive enhancers or nootropics. Some smart pills are promoted as prescription drugs, while others are
sold as dietary supplements over the counter. There is some scientific evidence that certain smart pill
ingredients, such as caffeine, B vitamins, and herbal extracts, can improve cognitive function to some
extent. While digital pills are still a relatively new technology, there are already several on the market.
Digital pills have a significant potential for savings in healthcare costs by reducing the need for emergency
medical care and the hospitalization of patients. The efficacy and safety of smart pills, on the other hand,
are still being debated in the scientific community.
Keywords: Digital, Sensors, Patients, Pills.
A-130
Artificial Intelligence Algorithms for the Recognition of Skin Diseases
Meenakshi tyagi1, Aarti Prajapati2
1
Department of Pharmaceutical Sciences, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University,
Gangoh, Saharanpur, UP 247341
2
Department of Pharmacy, Quantum School of Health & Science, Quantum University, Dehradun Highway,
Mandawar, Roorkee, Uttarakhand 247167
Artificial Intelligence (AI) algorithms for automatic skin disease are available on the consumer market. The
accuracy of diagnostics is rare. We evaluated the diagnostic accuracy of open-access AI applications to
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recognize skin diseases. The AI algorithm classified images that gave five different diagnoses, which were
compared to clinical diagnosis by dermatologists and/or histologists. In the diagnostic groups, the level of
diagnostic accuracy varied considerably. The online application has shown allow diagnostic accuracy
compared to dermatological evaluation and needs further development. Input signs have been developed to
classify disorder. With the help of experts in this area, we received symptoms of 10 skin diseases. Symptom
data are trained by different classifications. We observed that high-quality AI-based support for clinical
decision-making improves the accurate diagnosis of AI or doctors and better serves less qualified doctors.
Keywords: Artificial, Intelligence, Classification, Skin Disease, Nearest.
A-131
In-Vitro Models for Studying Diabetes: Advances, Techniques, and Considerations
Jyoti Sharma
College of pharmacy, Shivalik Campus, Dehradun
jyotisharma11801@gmail.com
Diabetes is a global health challenge, and in-vitro models have emerged asvaluable tools for studying the
pathophysiology and potential therapeutic interventions for thiscomplex disease. The present study an
overview of the importance of in-vitro models in diabetesresearch, highlighting the need for precise and
controlled experimental conditions to elucidatethe underlying mechanisms.This review discussed the
different types of in-vitro models used indiabetes research, including cell culture models and organoid
models. Cell culture models, suchas pancreatic beta cell lines, allow for controlled manipulation of
experimental conditions andgene expression to study specific mechanisms. Organoid models, derived from
pluripotent stemcells or primary tissues, mimic the complex architecture and function of organs, such as
thePancreas. The methods used for culturing and maintaining these models, as well as theexperimental
techniques and assays commonly employed, are discussed in this review.Results and Discussion: The
present study highlights the offerings of in-vitro models to ourunderstanding of diabetes. The findings
obtained from in-vitro studies have shed light on themolecular and cellular mechanisms underlying beta cell
dysfunction, insulin secretion, and otheraspects of diabetes pathogenesis. The advantages and limitations of
in-vitro models, includingtheir ability to recapitulate key aspects of diabetes patho-physiology while also
posing certainlimitations in terms of physiological relevance, are discussed in this study.In-vitro models
have proven to be invaluable tools in diabetes research, providinginsights into the molecular and cellular
mechanisms underlying the disease. They offercontrolled experimental conditions and allow for precise
manipulation of gene expression,providing a platform for studying specific mechanisms in a controlled
environment. However, itis important to interpret the results obtained from in-vitro models with caution,
considering theirlimitations in recapitulating the complex in-vivo environment. Overall, in-vitro models
havesignificantly contributed to our understanding of diabetes and hold promise for furtheradvancements in
diabetes research and drug development.
Keywords: Cell culture, Organoids, Insulin Secretion, Controlled Experimental Conditions.
A-132
Key Development in the Area of Artificial Neural Network for Pharmaceutical Optimization
Aman Kumar*, Debadri Banerjee, Surojit Banerjee, Anupama Singh, Vikas Anand Saharan
School of Pharmaceutical Sciences & Technology, Sardar Bhagwan Singh University, Balawala, Dehradun
Artificial Neural Networks (ANNs) are simulation of the information processing ability of the human brain.
ANNs are being increasingly recognized as a highly effective tool not just for predicting drug discovery and
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pharmacokinetics, but also for achieving significant advancements in optimizing pharmaceutical products.
ANNs consists of an input layer, an output layer and numbers of hidden layer depending on the complexity
of the problem. A variety of ANNs such as feed forward neural network, recurrent neural network,
convolutional neural network, and auto encoder are utilized for optimizing pharmaceutical products. The
selection of a specific technique is dependent on various factors such as the nature of the task, data
accessibility, and desired results. An exhaustive review of existing literature was performed on PubMed and
Google Scholar to explore research efforts on the integration of ANNs for optimizing pharmaceutical
products. The analysis revealed that ANNs aid in feature extraction, black-box optimization, and online
optimization. Their ability to learn from data and adapt to changing conditions makes them powerful tools
for solving a wide range of optimization problems. This paper aims at providing a comprehensive overview
of the developments in pharmaceutical optimization with assistance of ANN. Moreover, ANNs have
undergone significant advancement in recent years. These advancements have improved accuracy,
reliability, interpretability, and scalability of ANN models in pharmaceutical optimization.
Keywords: Artificial, Neural, Networks, Optimization.
A-133
Neurological Activity of Pueraria montana (Aerial Part) Extract
Mohammad Shami 1*,Bhuwanendra Singh 1 , Arvind Kumar 2 ,
1 Department of Pharmacognosy, SD College of Pharmacy & Vocational Studies, Muzaffarnagar,
U.P. 251001.
2 Department of Pharmaceutical Chemistry, SD College of Pharmacy & Vocational Studies,
Muzaffarnagar, U.P. 251001
mohdshami028@gmail.com
A perennial herb known as Pueraria montana, sometimes known as Indian kudzu, is found throughout
south-east Asia. It has been advocated for the treatment of menopausal syndrome, infertility issues, and
cardiovascular disease. It has been utilized in a variety of ayurvedic formulations as a restorative tonic,
antiaging, and immunological booster. Many photochemical, primarily iso-flavonoids like puerarin,
genistein, daidzein, and tube rosin, as well as other types of phytoconstituents such alkaloids,
carbohydrates, steroids, glycosides, and tannins, have been found in the tuber of Pueraria montana. Popular
plant P. montana is classified as a “Rasayna” medicine in ayurveda. The fresh leaves and stem of Pueraria
montana was collected from the Rishikesh (Uttarakhand). The leaves and stem dried under shade at room
temperature and made fine powder by using mechanical grinder. Then the powder was extracted using
ethanol as a solvent. Twenty-five gram of dried powder was weight and subjected to extract with 250 ml
ethanol in Soxhlet extractor. The Condensed extract was kept in a refrigerator-safe bottle.
Keywords:Pueraria montana, Puerarin, Immunological, Booster.
A-134
Advances in-vitro Models for Understanding Arthritis: Techniques and findings
Himanshi Rathaur
College of Pharmacy,Shivalik Campus,Dehradun,Uttarakhand
himanshiritarathaur@gmail.com
Arthritis is a debilitating joint disease affecting millions of people worldwide, and in-vitro models have
emerged as valuable tools for studying its pathophysiology and potential therapeutic interventions. This
study describes the different types of in-vitro models used in arthritis research, including cell culture
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models and tissue explant models. Cell culture models, such as chondrocyte cultures, synoviocyte cultures
and osteoblast cultures, allow for controlled manipulation of experimental conditions and gene expression
to study specific mechanisms. Tissue explant models, where small pieces of joint tissues are cultured ex-
vivo, provide a more physiological environment to study the interactions between different joint tissues.
The methods used for culturing and maintaining these models, as well as the experimental techniques
andassays commonly employed, are discussed in this study. The study highlights the contributions of in-
vitro models in evaluation of anti-arthritis potential of drug or medicaments. The findings obtained from in-
vitro studies have provided insights into the cellular and molecular mechanisms underlying cartilage
degradation, synovial inflammation, and bone remodelling in arthritis. The advantages and limitations of in-
vitro models, including their ability to mimic specific aspects of arthritis pathology while also posing
certain limitations in terms of complexity and variability, are discussed in this section. In-vitro models have
proven to be valuable tools in arthritis research, providing insights into the cellular and molecular
mechanisms underlying the disease. They offer controlled experimental conditions and allow for precise
manipulation of gene expression, providing a platform for studying specific mechanisms in a controlled
environment. However, it is important to interpret the results obtained from in-vitro models with caution,
considering their limitations in recapitulating the complexity of the in-vivo joint environment. Overall, in-
vitro models have significantly contributed to our understanding of arthritis and hold promise for further
advancements in arthritis research and drug development.
Keywords: Cell culture, tissue explant, cartilage degradation, synovial inflammation.
A-135
Antibiotic resistance: A threat to mankind
Abhit Kumar, Mansi Pal*
Department of Pharmacology, Sardar Bhagwan Singh University, Balawala Dehradun, Uttarakhand
Antibiotic resistance is an important concern for the public health authorities at global level as these are the
medication that combat and slow down the growth of bacteria. Antibiotics now days play a key role in any
treatment as they are used in various kind of diseases and infections. Resistance is development of the
ability to withstand the previously destructive effect of a drug. Antibiotic-resistant infections correlate with
the level of antibiotic consumption. The main causes of resistivity is regular use of antibiotics even in a
small illness, self- medication and also the practice done in hospital and clinics to increase the profit from
it. One major cause of resistivity is incomplete dosage when symptoms were vanished. Proper vaccination
in childhood, & also having the complete knowledge of antibiotics, its duration of use, dose of
administration as per the patient’s age group, regulations, surveillance of antibacterial resistance and proper
diagnosis of disease can lead to minimization of antibiotic resistance. Our purpose is to explore the origin,
development, and the current state of antibiotic resistance, regulation, and challenges by examining
available data & the optimal use of antibiotics medicines in human and animal health to reduce
antibiotic resistance.
Keywords: Antibiotics, Antibiotics resistance, bacteria, diagnosis, Usage technique.
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A-136
Computationally establish new role of iridoid in the treatment
of Zika and Influenza (H3N2) viruses
Sakshi Duklan1, Samiya1, Kiran Dobhal1, Sarkar M. A. Kawsar2, Vikash Jakhmola1, Prinsa3, Supriyo Saha1*
1
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Premnagar, Dehradun-248007,
Uttarakhand, India
2
Laboratory of Carbohydrate and Nucleoside Chemistry, Department of Chemistry, Faculty of Science, University of
Chittagong, Chittagong-4331, Bangladesh.
3
Siddhartha Institute of Pharmacy, Saharastradhara Road Near IT-Park Dehradun 248001.
supriyo9@gmail.com
Iridoids showed anticancer, antiproliferative, cardioprotective, hepatoprotective, antihyperglycemic, and

immune stimulatory activities. The prominence of iridoids has been recognized in recent years because of
improvements in methods for the extraction, storage, and isolation of natural components. Zika and H3N2
viruses belong to the RNA virus causing the reoccurrence of epidemics and pandemics in the last decades.
Both infections are the type of zoonotic diseases; that transmit very fast. In this manuscript, we selected 59
iridoids (Iridoid glycosides, Secoiridoids, Bis-iridoids and non-glycosidic iridoids) and performed
molecular docking interaction studies against 7VLG (Zika virus receptor) and 6EUY (H3N2 influenza virus
receptor). Molecular docking interaction revealed that 2'-O-(4-methoxycinnamoyl) mussaenosidic acid and
6-O-trans-p-Coumaroylshanzhiside methyl ester showed maximum dock score of (-) 8.6 kcal/mol and (-)
9.2 kcal/mol against 7VLG and 6EUY, respectively. Further confirmation of docking interaction was done
by MD simulation and MMPBSA analysis. MD simulation data showed that RMSD, RMSF were within
limit. MM/PBSA analysis data showed that free binding energy of (-) 21.398 kJ/mol and (-) 127.169 kJ/mol
was observed with 2'-O-(4-methoxycinnamoyl) mussaenosidic acid-7VLG and 6-O-trans-p-
Coumaroylshanzhiside methyl ester-6EUY, respectively. These data confirmed that if we are rerouting
these iridoids towards zika virus and influenza (H3N2) strains then it might be beneficial for mankind.
Keywords: Iridoids, Zika virus, Influenza H3N2, Molecular docking, MD simulation, MMPBSA.
A-137
A Review on Microsphere
Arunava Biswas*
GRD(PG) Institute of Management and Technology
arunavabiswas14@gmail.com
The microsphere is having free-flowing powder properties that are incorporate proteins and synthetic or
natural polymer. This polymer is biodegradable in nature and particle size having less than 200 µm.
Advanced drug delivery system has various advantages over the mainstream multi dose therapy. The
microsphere drug delivery systems are acceptable for attained delay or sustained release formulation with
minimum risk of dose repeatability and small gastric habitation time. The present review provides a
complete discussion of therapeutic aspects of the microsphere drug delivery system into deliberation of the
required area for microparticulate, types of polymers used, method of preparation, type of microspheres in
detail, parameters & targeting of microspheres & practical aspects of microspheres.
Keywords: Microspheres. Polymer,Biodegradable.
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A-138
Development, preparation and characterization of buccal tablets of Ethamsylate
Sudhir Priyadarshi*, Shaffi K. Tangri
School of Pharmaceutical Sciences, SGRR University, Dehradun, Uttarakhand, India
sudhirpriyadarshi98@gmail.com
A New drug delivery, such as a Mucoadhesive System, can enhance the effectiveness of drugs by
eliminating First pass Metabolism and Enzymatic Degradation caused by Gastro-intestinal tract, Oral
Mucoadhesive Drug Delivery System are Frequently used as a Novel site for Administration of drugs for
Controlled and immediate release. The objective is to formulate Mucoadhesive Buccal Tablets of
Ethamsylate by using compatible Biodegradable Polymers through Direct Compression Method. Buccal
Tablets were Evaluated through different parameters such as Thickness, Weight Uniformity, Hardness,
Friability and Content Uniformity Studies. Also, the Formulation were Evaluated for In-Vitro Drug
Release, Bioadhesive Strength, Moisture Absorption, Residence Time, and Drug Permeation. These gather
results make a Formula to Reduce its dosing Frequency leading to decrease its side effects, can be
administered to unconscious or uncooperative individuals, and increase Compliance of Patient.
Keywords: Buccal, Oral Mucoadhesive Drug Delivery System, Mucoadhesive.
A-139
Robots for Aseptic Manufacturing of Parenteral
Ruchika Rawat*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
In the past, pharmaceutical aseptic processing operations relied on manual interventions for tasks such as
filling, stoppering, capping, and heat-sealing of vials and ampoules, leading to personnel-related
contamination, especially during the filling of syringes. To enhance aseptic process control, advanced
technologies like isolators, automatic inspection systems, automated filling systems, and robotics were
introduced, providing benefits such as positive container handling, visual systems for inspection, and
verification of proper labelling information. Robotics are computer-controlled and offer flexibility, speed,
accuracy, and durability for industrial processes. Stericlean robots fully resistant to hydrogen peroxide are
used to meet pharmaceutical application requirements. Cleanroom robots, such as the CR/SCR series,
maintain cleanroom classifications, typically ISO class 5 or 6. BlueBotics mini, a compact autonomous
mobile robot, is ideal for cleanrooms, laboratories, light material handling, and small industrial robot
integration. At UCD, autonomous robots are being developed for environmental monitoring activities in
pharmaceutical facilities, including sampling and viable air and particulate air sampling. During the
COVID-19 pandemic, collaborative robots like YuMi have helped to analyze serological tests by
automating up to 77% of the testing actions and analyzing up to 450 samples per hour. The goal of
implementing robotic technology in cleanroom processes like aseptic filling is to reduce particle generation
and maintain ISO class 5 or 6 standards.
Keywords: Robots, Parenteral, Automatic, ISO.
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A-140
Precision Medicine: Better frame of treatment
Aarti Sati*, Kritika Saini
Uttarakhand, India
sainikittu13@gmail.com
Precision medicine is a new approach to illness prevention and treatment that considers the genetic,
environmental, and lifestyle variations of everyone. This initiative fosters evidence-based, or data-driven,
decision making by spanning a wide variety of scientific disciplines, including medicationdevelopment,
genomics, health communication, and causal inference. The heterogeneity of various illnesses is what
drives the need for precision medicine. Refined disease categorization is made possible by new diagnostic
techniques, and this may have significant prognostic consequences. Clinical trials can evaluate efficacy,
safety, and cost-effectiveness when targeted medicines are available, resulting in updated clinical
recommendations. Adoption of clinical implementation by regulatory bodies, payers, clinicians, and
patients is necessary. When it comes to clinical implementation, each of these groups has a unique
viewpoint, responsibility, and motivation. Health systems will need to offer diagnostics, informatics, and
decision assistance to healthcare practitioners due to the complexity of the data enabling precision
medicine. Due to their genetic composition and exposure to environmental risk factors, all patients have
unique demands. The implementation of individualised diagnostic tests and therapies that are based on a
patient particular genetic predisposition and history, along with generalised screening and preventative
efforts, results in the provision of the most effective healthcare for a patient group. By determining the
requirements of each patient and enhancing their results, precision medicine should be considered as a way
to provide the finest healthcare possible for a community.
Keywords: Precision Medicine, Disease, Genetic, Healthcare.
A-141
Natural Products as Potential Therapeutic Agents for Parkinson Disease
Vaishali Koul*
College of Pharmacy,Shivalik Campus,Dehradun, Uttarakhand
vaishali.koul@copdoon.org
Parkinson disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as tremors,
rigidity, and bradykinesia. Despite extensive research, there is no cure for PD, and the currently available
medications have limitations in terms of efficacy and side effects. As a result, there is growing interest in
exploring natural products as potential therapeutics for PD due to their safety, accessibility, and potential
neuro-protective properties. In this article, we provide a comprehensive review of the current literature on
natural products used in PD, including their mechanisms of action and potential benefits. Materials and
Methods: Present study conducted an extensive literature search using databases such as PubMed, Scopus,
and Web of Science, and reviewed relevant articles regarding in vitro, in vivo, and clinical reports on
natural products between 2000 and 2023. The mechanisms of action of these natural products were also
analyzed, including antioxidant, anti-inflammatory, and neuro-protective properties.Results and Discussion:
This review revealed that a wide range of natural products, including phytochemicals, herbal extracts, and
dietary supplements, have shown potential benefits in PD. Many of these natural products exert their effects
through multiple mechanisms, including antioxidant and anti-inflammatory actions, modulation of
signalling pathways and enhancement of neuronal survival. Some of the natural products studied include
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curcumin, resveratrol, green tea catechins, ginsenosides, and omega-3 fatty acids. Additionally, natural
products such as coenzyme Q10, vitamin D, and creatine have also been investigated for their potential
neuroprotective effects in PD. However, the results of these studies are not always consistent, and further
research is needed to determine their safety, optimal dosages, and long-term effects. Natural products have
emerged as promising candidates for the development of novel therapeutics for PD. Their diverse
mechanisms of action and potential neuro-protective properties make them attractive for further
investigation. However, more rigorous preclinical and clinical studies are needed to fully understand their
effectiveness, safety, and optimal use in themanagement of PD. Natural products have the potential to
complement existing treatmentoptions for PD and may offer new hope for patients with this debilitating
neurodegenerativedisorder.
Keywords: Curcumin, Ginsenosides, Neurodegenerative disorder, Clinical studies.
A-142
Formulation and Evaluation of Herbal Lipsticks
Ashutosh Badola, Meenu Chaudhary
Shri Guru Ram Rai University, Patel Nagar, Dehradun
Ashutosh.badolam.pharma@gmail.com
Synthetic colouring compounds have been discovered to be naturally carcinogenic and may induce allergic
reactions. Various natural ingredients, including concentrated juice of carrot, beetroot, and pomegranate
seeds (Punica granatum), were used to create herbal lipstick, along with beeswax, carnauba wax, vanilla
essence, castor oil, soft paraffin, strawberry essence, vitamin E, and lemon juice. A variety of assessment
tests, including those for color, melting point, breaking point, force of application, surface anomalies, pH,
skin irritancy test, and ageing stability, were performed on the prepared herbal lipstick. The results are
described here and compared to commercial standard formulations. The findings demonstrated that several
assessment parameters of manufactured herbal lipstick matched standard values and commercial
formulations. According to a study, natural edible colouring agents may be the best choice for making
herbal lipsticks.
Keywords: Herbal lipstick, Natural ingredients, paraffin, Bee wax, olive oil, coconut oil.
A-143
The Impact of genomics in drug discovery and in Pharmacy
Aarti Sati, Priya Joshi
Uttarakhand, India
piajoshi2001@gmail.com
The field of genomics, particularly high-throughput sequencing and characterization of expressed human
genes and their role enable the development of effective preventive measures as well as alter drug research
strategies and drug discovery methods. Pharmacogenomics uses broad systematic methods of genomics to
hasten the identification of drug response indicators. The possible application of genomics and
pharmacogenomics in drug discovery process is the possibility of treating disease in accordance with
genetic and particular patient markers, choosing drugs and dosages that are most effective for a certain
patient. The impact of DNA microarray technology (gene chips), approaches for gene therapy protocols, the
development of new detection assays for high-throughput screening (HTS), gene mapping, and proteomics
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are few parameters of how biotechnology is influencing pharmaceutical research. In aspect of

pharmacogenomics and pharmacy, to anticipate how a drug would affect a certain person, functional
polymorphisms in genes implicated in drug response or ADRs are increasingly utilised as markers. The
advent of pharmacogenomics as a primary topic in pharmaceutical and health care has created new potential
for the application of genetic information in personalised medication therapy and clinical practise. It is
predicted that genomics will start to have a significant impact on clinical medicine within the very short
time frame of 7–10 years. The most prevalent diseases including osteoporosis, diabetes, schizophrenia,
asthma, AD, arthritis, obesity and atherosclerosis are the main focuses of industrial concentration on R& D
and will remain such.
Keywords:Genomics, Pharmacogenomics, Gene Mapping, HTS.
A-144
Drug repurposing in Tuberculosis: A hope for MDR Tuberculosis
Mansi Pal, Abhit Kumar*
Department of Pharmacology, Sardar Bhagwan Singh University, Balawala, Dehradun, Uttarakhand
Mycobacterium tuberculosis is a deadly pathogen, which infects a large cluster of the population globally
and is the cause of the maximum number of deaths due to single infectious agent. Current therapy of TB,
Directly Observed Treatment Short - course (DOTS) comprises multiple antibiotics administered in
combination for 6 months, which eliminates the bacteria and prevents the emergence of drug - resistance in
patient. However, due to various limitations like severe toxicity, low efficacy and long duration, patient
struggle to comply with the prescribed therapy, which leads to the development of drug resistance (DR).
Drug repurposing is a cost-effective emerging strategy, which aims to treat resistant infectious diseases by
identifying known drugs with predicted efficacy for disease other than the target disease. The repurposed
drugs moxifloxacin, linezolid and clofazimine are used to treat extensively drug resistant TB when first- or
second-line drugs fail. Like clofazimine originally used to treat leprosy, it has not traditionally been used
against TB, because it has little bactericidal activity. However recent studies have shown that it has
sterilizing and treatment shortening potential. The list of other repurposed drugs includes sulphonamides,
sulphanilamide, sulfadiazine, clofazimine, linezolid, amoxicillin/ clavulanic acid, carbapenems, metformin,
verapamil, fluoroquinolones, statins and NSAIDs.
Keywords: Antibiotics, Drug repurposing, Drug resistance, Mycobacterium tuberculosis, Tuberculosis.
A-145
Streamlining Drug Development with in Silico Pharmacokinetic
Characterization of Pharmaceutical Formulations
Shubham Chauhan*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
Pharmaceutical formulations must meet high standards of quality, safety, and efficacy. The United States
Food and Drug Administration (FDA) and the International Conference on Harmonization (ICH) guidelines
for the manufacturing industry have focused on Quality by Design (QbD) as a way to ensure the quality of
pharmaceutical products. Traditional methods of evaluating pharmacokinetics, such as in vitro experiments,
have limitations in research and statistical data analysis. In contrast, in silico characterization provides
opportunities for researchers to advance their methods. However, developing new drug compounds can be
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challenging due to the lack of sufficient reasonable chemicals and biological properties for optimization. To
overcome this limitation, the ultimate goal is to replace in vitro experiments within silico ADME
(absorption, distribution, metabolism, and excretion) models. In silico pharmaceutical characterization
includes data interpretation, processing of logP and logD, Pka, solubility data, and assessment of ADME,
among other drug properties data. In recent years, in silico pharmacokinetic characterization has grown
significantly due to advancements in pharmacokinetic data analysis. Several important in silico tools
include Gastroplus, WinNonlin, PK Analix, XlSimEst and PK Solver. These tools offer researchers a
timesaving and easily operable method for fundamental analysis of pharmacokinetic data. This paper
describes in brief this software and some applications of these software for characterizing pharmaceutical
formulations for their pharmacokinetic parameters.
Keywords: ADME, Gastroplus, WinNonlin, PK Analix, XlSimEst.
A-146
Innovation approach to control Hyperthyroidism
Aarti Sati, Mansi Chaudhary
Uttarakhand,India
Mansichaudhary435@gmail.com
The parathyroid hormone is secreted from parathyroid gland (PTG) cells. PTG cells can sense small change
in plasma Ca 2+ levels by the presence of a cell surface Ca 2+ receptor (CaR) that belongs to the family of G
protein-coupled receptors (GPCR). Compounds that activate the CaR and inhibit PTH secretion are termed
‘calcimimetics’ because they mimic or potentiate the effects of extracellular Ca 2+ on PTG cell
function. Preclinical studies with NPS R-568, a first generation calcimimetic compound that acts as
a positive allosteric modulator of the CaR, have demonstrated that oral administration decreases serum
levels of PTH and calcium, with a leftward shift in the set-point for calcium-regulated PTH secretion in
normal rats. NPS R-568 also suppresses the elevation of serum PTH levels and PTG hyperplasia
and can improve bone mineral density (BMD) and strength in rats with chronic renal insufficiency (CRI).
Clinical trials with cinacalcethydrochloride (cinacalcet), a compound with an improved metabolic profile,
have shown that long-term treatment can suppress the inc calcium levels and PTH in patients with primary
hyperparathyroidism (1HPT).
Keywords: Calcimimetics, Calcium Receptor, PTG Hyperplasia, Clinical Trials.
A-147
Pharmacology, morphology, and chemical constituent of Rosa Damanscenaand their role in
Hypertension
Shahin saifi *,Luxmi Yeasmin
Department of Pharmacology, School of Pharmacy and Research, DevBhoomi Uttarakhand University Dehradun
shahinsaifi890@gmail.com
Rosa damanscena is Iranian flower plant. This is known as the king of flower and commonly known as
Damask rose and it is also known as the Golemohammadi in Iran. The Iranian are called flower of “Prophet
mohmmad” Rosa damanscena family is Rosaceae. it is traditional plant which have a different
pharmacological activity to treat the disease for example – anti microbial, anti-inflammatory. anticancer,
anti-depressant, anti-hiv, analgesic, antidiabetic, anti-ulcer, anti-lipase, cardiovascular effect, respiratory
effect, bronchodilator, neurotic atrophy, hypnotic effect, constipation, dementia, alpha glucosidase
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inhibitory, anti-aging. It consists of the active chemical constituent which responsible for the
pharmacological and therapeutic effects. The chemical constituents of arephenyl ethyl alcohol,
citronellylformate, β-citronellol, β-citronellol, trimethyl silyl ether,nerol,geraniol,etc.The Rosa
Damanscenahave aanti-hypertensive effect by their hydroalcoholic extract which useful in hypertension
because is decrease the heart rate and also decrease the systolic blood pressure its shows the this therapeutic
activity at higher dose (500mg/kg -1000mg/kg) of hydro alcoholic extract of rosa damnscena..
Keywords: Rosa Damanscena, Pharmacological, Iranian, Activity.
A-148
Formulation and evaluation of ocular inserts of Fexofenadine
Ashutosh Badola, Nazim
School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun, Uttarakhand, India
nazimansari149152@gmail.com
The main purpose of this study is to formulate ocular inserts of fexofenadine hydrochloride an
antihistamine used to treat allergic conjunctivitis, allergic rhinitis, uveitis and urticaria. The ocular insert
represents a significant advancement in the therapy of eye disease. Ocular inserts are defined as sterile, thin,
multilayered, drug-impregnated, solid or semisolid consistency devices placed into the cul-de-sac or
conjunctival sac, whose size and shape are especially designed for ophthalmic application. They are
composed of a polymeric support that may or may not contain a drug. The drug can later be incorporated as
dispersion or a solution in the polymeric support. They offer several advantages such as increased ocular
residence and sustained release of medication into the eye. The insert includes a body portion sized to
position within a lachrymal canaliculus of the eyelid. The inserts are classified according to their solubility
as insoluble, soluble, or bio erodible inserts. The release of drug from the insert depends upon the diffusion,
osmosis, and bioerosion of the drug, and this article is an attempt to present a brief about this newer drug
delivery system.
Keywords: Bioerosion, Diffusion, Membrane, Ocular inserts, Conjunctivitis.
A-149
Efficient Aerosol Delivery: Harnessing CFD for Pulmonary Drug Delivery Optimization
Himani Pant*, Debadri Banerjee, Surojit Banerjee, Anupama Singh, Vikas Anand Saharan
Efficient delivery of aerosolized drugs to the lungs is crucial for the successful treatment of respiratory
diseases. Computational fluid dynamics (CFD) has emerged as a powerful tool for optimizing pulmonary
drug delivery under various aerosol conditions. CFD simulations can be used to analyze key factors such as
aerosol particle size, inhaler design, and integration techniques to enhance drug deposition and distribution
within the lungs. Spray drying is a versatile approach widely used for delivering approved small molecule
oral products, as well as emerging applications for specific biologics and non-oral dry powder delivery.
Magnetic targeting technology is another area of study to stimulate magnetic particle transport and
deposition in specific regions of lung modeling. CFD simulations have been used to investigate marketed
formulations for pulmonary drug delivery, including Advair diskus, Respimat, ProAir HFA, and Pulmicort
Respules. To optimize pulmonary drug delivery systems, software tools such as ANSYS Fluent,
OpenFOAM, and STAR-CCM+ are commonly used software for CFD simulations. However, there are
challenges to overcome to ensure accurate and reliable results. For instance, incorporating realistic
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physiological conditions such as breathing patterns, lung geometry, and tissue deformation in CFD models
is essential for accurate predictions. There is also a need to validate CFD simulations using in-vitro and in-
vivo studies to increase confidence in the predictions. Despite these challenges, CFD simulations offer the
potential to improve patient outcomes, reduce healthcare costs, and enhance the treatment of respiratory
diseases.
Keywords: Advair diskus, Respimat, ProAir HFA, Pulmicort Respules.
A-150
Exploration of Bioactive profile of Magnolia species
Purabi Saha1, Amit Semwal2, Vikash Jakhmola1, Supriyo Saha1
1
2
College of pharmacy Shivalik Campus dehradun INDIA
purabisaha2000@gmail.com
Many Asian countries employ the bark of the Magnolia tree for medicinal purposes. Magnolia has a wide
range of medical uses, including regulating GI motility, treating cough and asthma symptoms, preventing
cardiovascular disease, treating mental illness, and treating brain disorders. 118 magnolia species were still
being researched as of this year as well. However, the International Union for Conservation of Nature has
designated 231 species as "vulnerable" or "critically endangered." These changes are very certainly caused
by new species. Magnolia leaves yielded 20 isolated chemicals, including 16 lignans with 6 distinct
structural types. The next compounds are 2,5′-dien-2′,8′-epoxy-5′-methoxy-8-methyl-4′-oxo-3,4-
methylenedioxy-spiro-5,5-undecane, veraguensin (16), sitosterol, and magliflonenone (7R, 8S, and
1′S)(20). α-pinene (29.7%), elemol (10.2%), α-pinene (8.5%), α-caryophyllene (7.2%), α-terpineol (7.0%),
guaiol (5.4%), and bulnesol (4.9%) were the main components of the essential oil, according to an analysis.
It has been hypothesized that Honokiol and Propofol's polyphenolic structural similarities account for their
similar hypnotic pharmacologic effects. This species can be found in the coastal lowlands of the United
States and Mexico from eastern Texas to North Carolina. Magnolia species shows some pharmacological
activities like neuroprotective, anticancer, anti-microbial, anti-platelets, anti-asthmatic, gastrointestinal,
hormone regulation. This plant has gained broad use in traditional medicine and as a beautiful tree due to its
huge, alluring flowers. Among the diseases that this plant may help are high blood pressure, cardiac issues,
dyspnea, stomach pain, muscular spasms, infertility, and epilepsy.
Keywords:Magnolia, Neuroprotective, Cancer, Antimicrobial, Antiplatelets, Hormonal Regulation.
A-151
A Review on Gene Therapy
Vidya Marwal*
Department of Pharmacy, Shree Dev Bhoomi Institute of Science and technology, Uttarakhand Technical University,
Dehradun-248007, India
vidyamarwal62@gmail.com
Gene Therapy approach has the potential to provide a single therapy with along lasting and potentially
curative clinical benefit. It is a new idea that offers hope to thosewho have extremely deadly illness. The
main idea behind this process to redesign the deliveryvehicles, which are typically nanostructured, plasmid
and viruses. Many diseases have beentreated or made better using genetic techniques. Gene therapy can be
using a variety of geneticmaterials, including DNA, RNA, shRNA, siRNA. ZNF, TALEN, and CRISPR are
the threeprimary gene editing methods utilized for in vitro and in vivo gene changes. Numerous
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newmedicine applications for FDA clearance have been promoted by recent research. the approachentails
mapping illness genes by connecting markers to family history of the disease and diseaseoccurrence, then
separating the gene from DNA clones that cover the region of interest. Thelatter has raised expectations for
more accurate and effective gene targeting because it calls fortwo distinct recognitions sites, which it more
specific. It can also result in quick and sufficientcleavage within the target sequence. Genes must be carried
to the target tissue via carriers. Theanalysis of fresh data and information is ongoing to develop gene
treatments forvarious ailments.
Keywords: Gene Therapy, Gene editing, Genetic material, CRISPR.
A-152
Neuroprotective effect of selected drug in rotenone induced Parkinsonism
in Experimental rat
Priya Kumari
Meerut Institute of Engineering and Technology, Meerut
priyakumarimrt555@gmail.com
The main objective of the study was to evaluate the In-vivo Pharmacological Studies on Selected drug.
Validated experimental animal model. The present work deals with the “Neuroprotective effect of selected
drug in rotenone induced Parkinsonism in Experimental rats. Parkinson was induced in wistar rats by oral
route administration of Iron (3 mg/kg) for 28 days. The animals were divided into 2 groups: first group of 5
rats received in control group, and another group are treatment groups. Animals were divided into 4 groups
of Second group of 5 rats received Rotenone (3 mg/ kg I.P.), Third group of standard groups in 5rats
received Bromocriptine (10 mg/kg; p.o.) and fourth group 5 rats and fifth group 5 rats ofParkinson rats
received selected drug at doses of 100 and 200 mg/ kg respectively. On the firstday, seventh day, fourteenth
day, all behavioural measures were assessed. Animals wereslaughtered on the 15th day for biochemical’s
parameter, neurotransmitter and histopathological(Cortex, striatum) studies in accordance with the
experimental methodology.The results showed that administration of selected drug at the respective doses
of 100mg /kg and 200 mg /kg along with Bromocriptine (10 mg/kg P.o.) resulted in a significantlylower
ofdopamine,GABA, MDA and SOD as comparing to Parkinson rats . Therewas also significant increase in
catalase activity in the middle brain, at the dose of 100 mg/kg and 200 mg/ kg as compared to Parkinson
(PD). PD is a chronic, progressive neurodegenerative disorder, characterized by thedepletion of
dopaminergic neurons due to oxidative stress and inflammation in the substantianigra. Getting started, in
this study, we found that direct administration of rotenone caused behavioural, biochemical,
neuroinflammation, neurotransmitter, and histopathological alterationswhich were confirmed by the poor
open field activity, reduced rot rod performance and low gripstrength, activity.
Keywords: Parkinson, Neuroprotective, Rat.
A-153
Orally disintegrating tablets: A boon and future of Modern Pharmaceutics
Sharada Pokhrel‫٭‬, Arti Kori, Shivanand Patil
Department of Pharmacy, Shree Dev Bhoomi Institute of Education, Science, and technology, Uttarakhand Technical
University dehradun-248007, India
sharadapokhrel001@gmail.com, aartikori76@gmail.com
Oral route is the most preferred route for drug administration. Orally Disintegrating tablets or
Orodispersible Tablets disintegrate in the mouth within a matter of seconds and these formulations are not
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to be swallowed. Orodispersible tablets are the part of novel drug delivery system which are most
commonly and widely used. They are composed of super disintegrants that differ them from other
conventional tablets. Use of super disintegrants make the tablets disintegrate within few seconds without
the need of water. Geriatric, Pediatric, travellers and those patients who have difficulty in swallowing are
highly benefitted through these dosage forms. They offer improved solubility, dissolution, bioavailability,
and better patient compliance. Orally Disintegrating tablets are formulated by various methods such as
Direct compression, Freeze drying or Lyophilisation, Spray drying, Sublimation, Mass extrusion, Wet
granulation etc. Today, Orodispersible tablets are easily available for the treatment of different diseases.
This review article includes advantages, limitations, ideal characteristics of super disintegrants, different
techniques for preparation, patented technologies, challenges in the formulation, mechanism of super
disintegrants and different evaluation parameters.
Keywords: Orodispersible, Lyophilisation, Geriatric, Pediatric, Super disintegrants.
A-154
Robotic System for Precise Drug Delivery
Sambhavi Mamgain*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
The field of medicine has relied on various traditional routes of drug administration, such as oral, rectal,
intranasal, and subcutaneous, for centuries. However, these methods have certain limitations, including
poor bioavailability, which refers to the amount of a drug that reaches the systemic circulation and produces
a therapeutic effect. Conventional drug delivery systems, such as tablets, capsules, and ointments, also
suffer from this issue. Recent advancements in technology have led to the development of robotic drug
delivery systems, which can precisely and consistently administer multiple doses of a drug at a pre-
established rate. These systems can also be programmed to adjust the dosage and rate of drug delivery
based on a patient's response or changes in their condition, offering personalized treatment and minimizing
the risk of adverse effects. Soft robots, made of flexible and biocompatible materials, have shown great
potential in drug delivery applications due to their ability to navigate complex biological environments and
deliver drugs precisely to target sites. Examples of soft robots include origami robots, which are made by
folding sheets of material into specific shapes to perform tasks like walking or grabbing objects, and sperm
robots, which move through fluids and navigate complex environments like the human body. Robotic
patches, wearable soft robots made of stretchable materials, can provide various functions such as sensing,
monitoring, and drug delivery, while robotic capsules are designed to be swallowed like pills for medical
applications such as endoscopy, diagnosis, or drug delivery. Finally, nanorobots are extremely small soft
robots designed to operate at the cellular or molecular level, performing tasks such as drug delivery or
targeted tissue repair. The development of these robotic drug delivery systems offers exciting possibilities
for the future of medicine.
Keywords: Robotics, Biocompatible, Drug, Delivery.
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A-155
Strategies and new technologies in drug discovery and drugdevelopment
Khushi Tyagi
Quantum School of Health Science, Quantum University, Roorkee
khushity44@gmail.com
New technologies in pharmaceutical sciences include innovative manufacturing processes, control, testing
strategies, and product technologies. Artificial intelligence (AI), machine learning (ML), and cloud
computing,exponentially accelerate drug discovery and drug development. The industry also focuses on
novel ways toenhance medication properties such as 3D cell culture or 3D organ printing and synthetic
biology. Over the lastten years, breakthrough technologies in pharmaceutical research and development
(R&D) have includedAI and ML. Every step of the drug-design process involves theapplication of AI,
which significantly lowers the cost and lowers the health risks associated with preclinicalstudies. The
Pharmaceutical industries can gain from cloud computing by promoting data sharing, teamwork,and
innovation, which helps hasten medication discovery and research. The development of three-
dimensional(3D) printing technology has the potential to transform the production of drugs and improve
life quality. Byadding layers of material to a product, 3D printing technology produces intricate geometric
forms under digitalcontrol. New cures for life-threatening diseases have been developed through gene
editing and biomedicalplatforms. These technologies have also benefited from improvements in computing
hardware and software.The development of innovative treatments for diseases that have been challenging to
treat with traditional methods up until now is made possible by these new technologies.
Keywords: Artificial Intelligence, Machine learning, Cloud computing, 3D organ printing.
A-156
A new recent proteolytic enzyme: Serratiopeptidase.
Payal Saxena*
Dev Bhoomi Uttarakhand university, Manduwala, Dehradun-248007
payalsaxena281997@gmail.com
In the human body, the normal functioning and metabolic process are forwarded by the enzymes. The
enzyme is used as catalyst to accelerate the biological reaction that occurs in body. Most of the enzyme are
present in the liver that function in many physiological functions such as neuronal functioning,
reproduction, digestion, and metabolising of food. Now-a-days the most focused medication as enzyme-
based medications for knowing its safety profile and effectiveness. The proven enzyme with its therapeutic
effects is Papain that is obtained from Papaya, Bromalin obtained from pineapple. Serra peptidase is also a
enzyme that is obtained from the intestine of the Silkworm Bombyx mori L. It is a proteolytic enzyme i.e.,
breakdown of protein. Serra peptidase enzyme shows many significant uses i.e., analgesic effect, anti-
inflammatory and anti- endemic effect.
Keywords: Serratiopeptidase, Enzyme, Pineapple.
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A-157
Herbal drug discovery: Challenges and perspectives
Arpit Kumar
Quantum School of Health Science,Quantum University, Roorkee
arpitdhiman123456@gmail.com
Herbal drug discovery has gained major attention in the pharmaceutical research field in recent decades.
The use of traditional herbal medicine has shifted towards modern approaches to drug design and therapy.
The World Health Organization recommends the practice of traditional systems of medicine as it is
affordable, safe, and culturally acceptable. Developing new possibilities for drug development by using
compounds from nature is a challenging method. Historically, natural products have played a significant
role in drug discovery, particularly for cancer and infectious diseases. Natural products and their derivatives
represent more than 50% of all the drugs in modern therapeutics. There is ongoing research into the
immunomodulatory properties of herbal medicines. The development and evaluation of herbs and herbals
are controlled and implemented through various agencies in different countries. One of the main challenges
is the low success rate and huge capital investment needed for the discovery of synthetic drugs, which has
led to a renewed interest in the research and development of traditional herbal medicine. Another challenge
is the need to continuously improve the quality and quantity of compounds that enter drug discovery
programs from plants. The prospects of herbal drug technology are promising, and the global knowledge
about Ayurveda and Indian herbals will hopefully be enhanced by information on the evidence base of
these plants, which will yield rich dividends in the coming years.
Keywords: Herbal drug discovery, infectious diseases, immunomodulatory, Ayurveda.
A-158
Comparison of Dissolution Profiles, Modeling of Dissolution and
Predicting Dissolution of Drug Formulations
Aniket Sharma*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
In the field of pharmaceuticals, determining the dissolution properties of drugs is critical for understanding
their behavior in the body and ensuring their effectiveness. In the past, this has been achieved through in
vivo and in vitro studies, but these methods have limitations, such as high cost and potential inaccuracies.
Therefore, there has been an increasing interest in using in silico methods to predict dissolution. In silico
methods involve the use of computer simulations to model and predict the behavior of drugs in the body.
One of the advantages of using in silico methods for dissolution studies is the precision they provide, as
they can be highly controlled and standardized. To address the challenge of predicting dissolution using in
silico methods, various tools and software have been developed. DD Solver and DDDPlus™ are two such
tools. DD Solver is a freely available program that can perform a range of techniques for comparing drug
release data, including exploratory data analysis, univariate ANOVA, and the difference and similarity
factors. The results of DD Solver have been shown to be satisfactory, making it a useful tool for dissolution
data analysis. DDDPlus™, on the other hand, is a leading commercial software that can simulate in vitro
dissolution of active pharmaceutical ingredients and excipients under various experimental conditions.
While there is limited published data validating its performance, it is widely used in the industry. The aim
of this paper is to highlight the use of software for simulating dissolution and modeling, and to emphasize
the advantages of using in silico methods for predicting drug behavior. By providing a more accurate
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understanding of dissolution properties, these tools can help ensure the safety and effectiveness of
pharmaceutical products.
Keywords: Dissolution, DDDPlus, Software.
A-159
A review on Flaxseed for the health and diseaseprevention perspectives
M. Mamta, Farswan AS*
Shree Dev Bhoomi Institute of Education Science Technology, Dehradun, Uttarakhand, India.
meghamarwal4621@gmail.com
Flaxseed, also known as linseed, is a popular plant-based food that has been consumed for thousands of
years. It is rich in fiber, protein, lignans and healthy fats, such as omega-3 fatty acids, making it a nutritious
addition to any diet. In recent years, there has been growing interest in the potential health benefits of
flaxseed, particularly in disease prevention. This review article aims to summarize the current state of
knowledge on the health benefits of flaxseed, with a focus on disease prevention. The article covers the
potential effects of flaxseed on various health conditions, including cardiovascular disease, cancer, diabetes,
and obesity. Studies have shown that flaxseed consumption can lower blood pressure, reduce inflammation,
improve lipid profiles, and reduce the risk of cardiovascular disease. Flaxseed has also been shown to have
anti-cancer properties, with potential benefits in reducing the risk of breast, prostate, and colon cancer.
Additionally, flaxseed may improve glycaemic control in individual with diabetes and aid in weight loss
efforts. However, there are some potential risks associated with consuming flaxseed, particularly in high
doses. In conclusion, flaxseed is a nutritious food that may offer a range of health benefits, particularly in
disease prevention. However, further research is needed to fully understand the potential benefits and risks
of consuming flaxseed, as well as the optimal doses and methods of consumption. Incorporating flaxseed
into a healthy and balanced diet may be a simple effective way to improve overall health and wellbeing.
Keywords: Flaxseed, Omega-3 Fatty Acids, Cardiovascular Disease, Disease, Balanced Diet.
A-160
Recent trends and methods in antimicrobial drug discovery from plant sources
Tannu Chaudhary*
Health Science, Quantum University, Haridwar, India
chaudharytannu86@gmail.com
The increasing incidence of drug- resistant pathogens raises an urgent need to identify and isolate new
bioactive compounds from medicinal plants using standardized modern analytical procedures. Medicinal
plant-derived compounds could provide novel straightforward approaches against pathogenic bacteria. The
focus is put the current challenges and future perspectives surrounding medicinal plants antimicrobial
activity. There are some inherent challenges regarding medicinal plant extracts and their antimicrobial
efficacy. Antimicrobial susceptibility tests for the determination of the antimicrobial activity of plant
extracts may show variations in obtained results. Research on the mechanisms of action, interplay with
other substances, and the pharmacokinetic and/or pharmacodynamic profile of the medicinal plant extracts
should be given high priority to characterize them as potential antimicrobial agents. Natural products
especially plants represent an inexhaustible reservoir of novel molecules for new drug discovery. Plant
derived crude extracts and pure compounds have a long history of management and cure of various
ailments. The resurgence of resistant microbial strains and emergence of newer and more lethal infections
has called for the need to acquire unique antimicrobials. The variations and modifications reported by
different researchers in the existing protocols along with their contributions in bioprospecting of
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pharmacologically active moieties have also been documented. In vitro antimicrobial assessment
methodologies are well established and have quite extensively served the purpose but to exploit the true
potential of plants as a source of antimicrobial compounds, the need of establishing standardized in vivo
testing protocols and determining valid correlation with in vitro efficacy result is mandatory.
Keywords: Medicinal, Bioactive, Antimicrobial.
A-161
A Comparison of Reference Management Softwares for Research
Ram Prasad*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
In today's digital age, the importance of proper citation cannot be overstated. Reference management
software has become a vital tool for professionals, students, and researchers seeking to streamline the
citation process. Nowadays manual referencing approach is not viable because of challenges like
duplication, as well as lack of harmonization of reference style and failure of keeping the record of citations
are matter of concern. One of the key advantages of reference management software is that it eliminates the
need for manual referencing, saving users significant amounts of time and effort. Additionally, these
software programs offer a range of benefits, including saving time and providing a secure database for
managing and storing citations, also these programs offer a variety of reference styles to accommodate the
requirements of different publications. Several commercially available reference management software
programs, such as Endnote, Mendeley, and Zotero, are designed to manage complex references in research
articles and other literature. However, there are differences in features, with Zotero offering open access
while the others require payment. Customer satisfaction is also a crucial factor that can influence user
preference. The aim of this paper is to provide viewers with a clear comparison of reference management
software programs and help them determine which one is best suited for their needs. This can be achieved
by comparing the pros and cons of each program and evaluating the company's approach to future updates.
By doing so, viewers can make an informed decision and choose the software that is most suitable for their
research requirements. Ultimately, the use of reference management software can help ensure accurate and
consistent citation, saving researchers valuable time and effort.
Keywords: Management, Software, Customer.
A-162
Micellar nanoparticle based novel drug delivery strategy for the treatment of Psoriasis-a
preliminary investigation
Aachal Patel, Swati Kurtkoti
IndukakaIpcowala College Of Pharmacy, New V.V.Nagar, Anand Gujarat, India-388121.
patelaachal11@gmail.com
Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to
treat many types of diseases, such as cancer, inflammation, hyperlipidaemias and psoriasis. However, its
effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and
systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery
systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. The
present work aims to increase permeability and bioavailability of curcumin by incorporating in a novel
emulsion- based formulation for better activity. Micellar nanoparticles were formed by emulsification
technique using high shear homogenizer. The formulation was characterized for different parameters such
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as particle size, zeta potential, viscosity, and drug content. The in-vitro drug release studies were conducted
using Franz Diffusion cell apparatus. The formulated MNP was found to have smooth, lotion like
consistency. The particle size analysis showed two characteristic sizes around 8nm, and 85 nm belong to
micellar structure and dispersed globule respectively. The formulation was observed to follow Higuchi
model and non-Fickian type of drug release indicating routes other than transcellular route. As compared to
marketed preparation, the MNP showed faster but stead drug release showing increased permeation
compared to the topical preparation. The formulation is cosmetically appealing with maximum therapeutic
benefits; however, the potential of system developed in the current investigation may be fully realized after
subjecting the formulation extensive in-vivo, pre-clinical, toxicological, and clinical evaluation.
Keywords: Psoriasis, Micellar, Nanoparticle, Curcumin.
A-163
Quality by design (QbD) in innovation in Pharmacy and Pharmaceutical sciences: From
discovery to practice
Dixit Thakur
Department of Pharmaceutics, GRD Institute of Management and Technology, Dehradun, Uttarakhand, India.
dixitthakurrohru@gmail.com
Recently the concept of “Quality by Design” (QbD) gaining much attention among pharmaceutical
industries for maintaining Quality. It serves as a bridge between industry and drug regulatory authorities to
move towards a scientific, risk based, holistic and proactive approach for development of pharmaceutical
product. It mainly covers designing and developing formulations and manufacturing processes to ensure
predefined product quality. Some of the QbD elements include defining target product quality profile,
designing product and manufacturing processes, identifying critical quality attributes, process parameters,
and sources of variability & controlling manufacturing processes to produce consistent quality over time
The purpose of this article is to discuss the concept of pharmaceutical Quality by Design and describe how
it can be helping to ensure pharmaceutical quality & drug development.
Keywords: Quality, Design, Drug, Pharmaceutical.
A-164
Formulation and evaluation of transdermal patch of Aceclofenac
Abdul Ahad*, Chinkey Mittal
ahad.abdul251003@gmail.com
The purpose of this research was to develop a transdermal patch by using solvent evaporationmethod
containing drug Aceclofenac with different ratios of hydrophilic (Polyethylene glycol)and hydrophobic
(propylene glycol) polymeric systems by using 15 % w/w of pectin to thepolymer weight, incorporated as
plasticizer. The physicochemical compatibility of the drug andthe polymers studied by differential scanning
calorimetry suggested absence of anyincompatibility. Formulated transdermal films were physically
evaluated aboutthickness, weight variation, drug content, flatness, tensile strength, folding endurance,
percentageof moisture content and water vapour transmission rate. All prepared formulations indicatedgood
physical stability. Formulation prepared with hydrophilic polymer containing permeationenhancer showed
best in vitro skin permeation as compared to all other formulations. The resultsfollowed the release profile
of Aceclofenac followed mixed zero-order and first-order kinetics indifferent formulation. However, the
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release profile of the optimized formulation F2 (r2 = 0.9935for Higuchi) indicated that the permeation of the
drug from the patches was governed by adiffusion mechanism. Formulation F2 showed highest flux among
all the formulations and 1.369-fold enhancements in drug permeation. These results indicate that the
formulation containing 10% propylene glycol give better penetration of Aceclofenac.
Keywords: Aceclofenac, Transdermal Patches, Polyethylene Glycol, Pectin, Solvent Evaporation.
A-165
Formulation and evaluation of suspension nanoparticles delivery of Phoenix Dactylifera
(Date fruit) for childbirth pain reliever
Shubham Singh*, Rahul Kumar, Gulafshan Parveen
Guru Nanak College of Pharmaceutical Sciences, Jhajra, Dehradun, Uttarakhand.
singhshu55@gmail.com, gulafshanmirza12345@gmail.com
This study to formulation and evaluation of Exosomal delivery of Phoenix Dactylifera (date fruit) for
relieving the childbirth pain. The date fruit has been shown several health benefits. Date fruit contains
different vitamins (riboflavin, biotin, thiamine, folic acid, and ascorbic acid), higher percentage of sugar
and carbohydrates, proteins, fatty acids, salt and minerals such as potassium and magnesium. The
components of phytoestrogen in the date fruit can regulate reproductive hormones. During of the delivery
process, pregnant women need a lot of energy to push foetus out. This process will go for the conditions
like fatigue,and lethargy. Dates fruit contain high sugar content glucose, sucrose and fructose for the source
of energy to maintain the energy in the body during the childbirth the sugar which is involve in the Phoenix
Dactylifera easily absorbed to the body, so it is safe and decreases the risk of gestational diabetes. Drinking
of date fruit syrup during labour may prevent prolonged labour. Dates contain the oxytocin which can help
stimulate contractions in the uterine muscles. Dates (Phoenix Dactylifera) contain carbohydrate can be
directly absorbed by the body. Also, date can accelerate labour process, increase cervix dilatation, and
reducethe need for induction. Moreover, date in Traditional Persian Medicine (TPM) has been mentioned as
a facilitator medicinal food for labour. "Date fruit also influences estrogen and progesterone hormones,
which are effective in preparing the uterus and cervical ripening". This study revealed the Phoenix
Dactylifera fruit help to reduce the pain before the childbirth.
Keywords: Childbirth, Phoenix Dactylifera, Hormones, Ripening, Blood glucose level.
A-166
Robots Take the Lead in 3D Printing of Dosage Forms: An Insight into Advancements
Khushbu Arora*, Surojit Banerjee, Debadri Banerjee, Anupama Singh, Vikas Anand Saharan
The utilization of 3D printing (3DP) technology has brought about numerous advantages for both the
pharmaceutical industry and patients. This technology has the potential to customize and tailor
pharmaceutical dosage forms according to specific needs and is more adaptable and flexible than traditional
manufacturing techniques. With 3DP, it is possible to print intricate structures and modify drug release
characteristics of dosage forms. Various 3D printing techniques such as Fused Deposition Modelling
(FDM), Fused Filament Fabrication (FFF), Stereolithography (SLA), and pressure-assisted microsyringe
(PAM) techniques are currently being used in the pharmaceutical industry. The FDA's approval of the first
3D-printed tablet of levetiracetam (SPRITAM®) in 2015 sparked a surge of interest in the 3D printing of
pharmaceutical components. Robotic technology is now being incorporated with 3D printing to achieve
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higher accuracy and personalized treatments. A thorough literature survey was conducted with the aim to
find attempts where 3DP is integrated with robots. Multiply Labs and Arcelis platform technology (Argos
Therapeutics now acquired by SCM Life Science) came up with a novel idea for the application of robotics
for manufacturing personalized medicines. This paper aims to highlight such attempts where 3DP and
robotics are integrated for the preparation of dosage forms. However, the combination of 3DP and robotic
technology have the potential to break through in the field of pharmaceutical sciences and technology.
Keywords: 3D Printing, FDM, FFF, SLA, PAM.
A-167
Coumarin: A promising Pharmacophore in Medicinal Chemistry
Ritesh Rana1*, Priyanka Devi1 ,Gauree Kukreti2
1
Himachal Institute of Pharmaceutical Education and Research Nadaun (H.P.)
2
Sardar Bhagwan Singh University, Balawala-Dehradun 248161, Uttarakhand, India
rvritesh1719@gmail.com
Coumarins are naturally occurring plants products having benzopyran-2-one nucleus. It was first isolated
from Tonka beans in1820.Over 1300 coumarins have been identified, principally as secondary metabolites
in green plants, fungi, and bacteria. Furthermore, several synthetic coumarins with a variety of
pharmacophoric groups at C-3, C-4 and C-7 positions have been intensively screened for various biological
properties. Over the past two decades there has been considerable amount of work with coumarins being
tested for anti-microbial, anti- HIV, anti-cancer, anti-tumour , anti-oxidant ,anti-coagulation activities , anti-
retroviral , anti-pyretic, anti-tuberculosis, acetyl choline inhibitors, anti-inflammatory and DNA gyrase
inhibitors. The presented work summaries the different synthetic approaches for synthesis of different
biologically active coumarin derivatives.
Keywords: Coumarin, Pharmacophoric, Anti-tumor, Anti-inflammatory.
A-168
Avaleha: An Herbal Formulation for Immunomodulation
Tulsi Chauhan*,Anupama Singh
Avaleha is a traditional Ayurvedic formulation has been used for centuries for its various health benefits. It
is a semi-solid, jam-like preparation made from natural herbs, fruits, and other ingredients, and is processed
with jaggery or honey. In recent years, Avaleha has gained significant attention for its immunomodulatory
properties, which have been extensively studied in both in vitro and in vivo models i.e., hematological
parameters and delayed-type hypersensitivity. In this paper, we have focused on the plants of the liliaceae,
verbenaceae, fabaceae, rosaceae and lamiaceae families, which are commonly used in immunomodulation.
Some of the plants from these families includes Allium sativum, Prunus domestica, Prunus armeniaca, Vitex
negundo, Mallotusphilipensisetc. This literature review is conducted through an extensive literature search
in pubmed, official books, ayurvedic pharmacopoeias, google scholar, magazine, articles and traditional
healers. The consumption of certain drugs is challenging due to their fibrous texture and bitter taste even
though they have good pharmacological actions can be incorporated by such formulation by certain pre-
processing. Therefore, the formulation of these drugs into a more palatable form, such as an ayurvedic
avaleha, is necessary. Furthermore, plants which have immunomodulatory properties were identified
through literature search and we are using these plants in formulation of immunomodulatory
Alukhubaninirgundikumkumadiavaleha in our laboratory. This formulation will be evaluated as per
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Ayurvedic pharmacopoeia and WHO guidelines and for its efficacy we will perform its immunomodulatory
activity.
Keywords: Ayaleha, Immunomodulation, in vivo.
A-169
A review on Self Nanoemulsifying Drug Delivery System
Reetika Gupta*, Gauree Kukreti
School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, Balawala, Dehradun,
Uttarakhand, India-248001
Self-nanoemulsifying drug delivery system is a new and emerging technology that plays an important role
in novel drug delivery system. In the present time, people take drugs orally most of the time. Because of
their low bioavailability, it makes difficulty to oral administration because 40% of them are poorly soluble.
Developing oral formulations, the water solubility, oral bioavailability and physical stability are the
challenging points to the pharmaceutical scientists. If we have to avoid this problem, we do the
encapsulation of hydrophobic drugs in lipid system like liposomes and micelles which have hydrophilic
surface bilayer that interacts with the aqueous medium and a hydrophobic core that matches the
hydrophobic drug. Doing the development of self nanomulsifying drug delivery system (SNEDDS) is
focused for poorly water-soluble drugs. For the development of self-nanoemulsifying drug delivery systems
(SNEDDS), surfactants, co-surfactants, and solubility in the oil phase are considered important keys to
prevent phase separation and precipitation after dilution and for improved solubility and oral
bioavailability. When taken orally, SNEDDS forms an oil/water emulsion directly with gastric juice. The
main benefit of SNEDDS is, It decreases the particle size by which the medicine is made smaller is size!
Bioavailability is increased which helps medicine to make its good effect on body. It increases the bio-
stability and reduces the chances of reaction/side effects. Using SNEDDS products in dry powder form will
help overcome the limitations of liquid. SNEDDS are administered by different routes such as oral route,
ocular, transdermal, vaginal route.
Keywords: Self-nanoemulsifying drug delivery system, Solubility, Poor oral Bioavailability.
A-170
Bioelectric Medicines: A revolution in Modern Medicine
Muskan Bhagat *, Sayantan Mukhopadhyay
School Of Pharmacy & Research, Dev Bhoomi Uttarakhand University, Manduwala, Dehradun,Uttarakhand, 248007
muskanpriya2000@gmail.com
Bioelectric medicine is a rapidly evolving field that explores the use of electrical signalling to modulate
cellular and tissue behaviour, with the potential to revolutionize modern medicine. The human body relies
on very complicated electrical signalling to coordinate physiological processes, and recent advancements in
bioelectric medicine have shown that targeted manipulation of these electrical signals can be used to treat a
wide range of disease and conditions. The therapeutic potential of bioelectric medicine is vast,
withpromising applications in area such as pain management, wound healing, neurological disorders,
cancer treatment. Furthermore, bioelectric devices offer several advantages over traditional
pharmacological treatments, including fewer side effects and the ability to provide real-time feedback and
control. Overall, bioelectric medicine represents a promising new frontier in the field of medicine, with the
potential to significantly improve patient outcomes and quality of life. This study report comes up with an
outline of the current state of bioelectric medicine, including various types of bioelectric medicines and
componentsused in these devices along with its clinical applications. The report also covers the challenges
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and limitations faced in this field and future expectations that required for more advanced and effective
bioelectronic therapies.
Keywords:Bioelectric, Medicine, Cellular, Tissue, Physiological, Processes.
A-171
Personalized Medicine- A need of future
Soumya Singh *, Sayantan Mukhopadhyay
School of Pharmacy & Research, Dev Bhoomi Uttarakhand University, Manduwala, Dehradun, Uttarakhand
In recent years, there is a great deal of boosting in surrounding the concept ofpersonalized medicine.
Personalized medicine is a concept that has the capability to transformmedical treatment to provide an
effective and customized therapeutic strategy based on thegenomic, epigenomic profile of an individual.
The use of genetic information via biomarkers hasplayed a major role in certain aspects of personalized
medicine (e.g., pharmacogenomic). Thegoal of personalized medicine is to maximize the therapeutic
efficacy and to attenuate the threatof drug toxicity for an individual person as it focuses on individual drug
treatment according toeach patientgenetic markup as well as molecular diagnosis. This is the best
opportunity to take one size fit all; approach to diagnostic, drug therapy, prevention and turn it into an
individualapproach. Currently, we consider the motivation of personalized medicine, innovative techniques
that facilitate future advancement, some recent experiments with success and complicationsincluding
potential ways to treat the individual with fertility and sterility issues and considersome current limitations
of that concept. Although, personalized medicine canfulfil all the requirements to improve health outcomes
by reducing health hazards.
Keywords: Personalized,Medicine, Pharmacogenomic, Biomarkers, Targeted.
A-172
Formulation and evaluation of tablet of Areca nut for the treatment of Helminthiasis disease
Afshan Ansari *, Nitish Kumar, Gulafshan Parveen
Guru Nanak College of Pharmaceutical Sciences, Jhajra, Dehradun, Uttarakhand.
afshanansari918113@gmail.com, gulafshanmirza12345@gmail.com
This is the study about the formulation and evaluation of tablet of Areca Nut for the treatment ofhelminthic
disease. Areca Nut is a natural drug is belonging to the family: Arecaceae. FromAncient time plants used
for the treatment of diseases due to their pharmacological activity.Areca nuts contain most of the active
compounds in its every part: seed/nut, leaves, root, and fruit.It is full of medicinal property, and it has major
bioactive molecule tannins, resins, flavonoids,alkaloids etc. Helminthiasis disease is soil transmitted
infections are caused by the differentspecies of parasitic worms. It is very common in children are suffer
from the helminthicinfections like roundworm, ascaris, tapeworm which are live in the GIT
(gastrointestinal tract)of the hosts. Areca nut is the most important drug act as anti-helminthic. Tablet is the
mostaffordable dosage form,and it increases the patient compliance. With the help of Areca Nutpowder, it
can be easy to formulate and evaluate. The method involve to formulation of tablet is wetgranulation
method. The powder having 1.5-2 mm particle size. The formulation contains thediluent: Starch,
disintegrant: microcrystalline cellulose, vehicle: water, glidant: talc, binder:acacia, coating agent: titanium
dioxide. The powder of all ingredients is compact by the directcompression method. Tablet were evaluated
by some physical parameters: Friability test,Disintegration test, Dissolution test, Hardness test. Study was
revealed that areca work on againstparasitic disease.
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Keywords: Areca Nut, Helminthic, Tablet, Powder, Binder, Glidant, Vehicle, Diluent,Disintegrant.
A-173
3DPrinting: A step towards Modernised Medicines
Divyanshu *, Sayantan Mukhopadhyay
3D Printing was first developed by Charles Haul in 1984. 3D-printing oradditive manufacturing is a process
of making three dimensional solid objects from a digital file.3D Printing can play a significant role in
multiple active ingredient dosage forms, where theformulation can be as a single blend or multilayer printed
tablets with sustained releaseproperties. It is a process of creating an object using a machine that put down
the material layer-by-layer in three dimensions until the desired object is formed. It is also called as
rapidprototyping. The advantages of drug delivery in 3D Printing are the high drug loading abilitywhen
compared to the conventional dosage form and they accurate and precise dosing of potentdrug which are
administered at small doses. The current advancement in 3D Printing is ApreciaZip dose. This technology
uses an aqueous fluid to bind together multiple layers of powder usinga unique, patient- protected process
to create a wide range of products. The industrial growth of3D-printing will change the nature of commerce
because end users will be able to do much oftheir own manufacturing rather than engaging in trade to buy
products from other people andcorporations. Finally, the prospects of 3D Printing are achieved optimized
drug releaseprofiles and drug dosage form supporting delivery.
Keywords: 3DPrinting, Inkjet Printing, Selective laser sintering, Fused deposition modelling, Zip dose.
A-174
Determination of pesticides residues on fruits and vegetables by non-destructive methods
Ashish*, Sayantan Mukhopadhyay
Fruits and Vegetables Consumption is very important for a healthy lifestyle. So, theirdemand in the market
is always high. Tofulfil the demand of the fruits andvegetables for the increasing population various type of
fertilizers and pesticides areused during the cultivation. Some Pesticides are also used even after the
cultivationfor increasing the storage duration and for altering the ripening duration. According toUNEP
Reports about 385 million cases of non-fatal unintentional pesticide poisoninghave been estimated to occur
every year with approximately 11,000 deaths. Thisstudy includes overview of the advanced techniques like
IoT-Deep Learning basedtechnique, D-SERS Substrate, Sensor integration method, Nano-SERS Chip for
thedetection of pesticides on fruits and vegetables and some most foundpesticides residues such as
Methamidophos, Ethoprophos, Dichlorovos, Omethoate,Pirimicarb are also discussed in this Paper.
Keywords: Pesticides, Fertilizers, Deep Learning, D-SERS, Sensor.
A-175
Preparation and in vitro of transdermal patches for management of mental stress
Anzla Shirin*, Shaffi K. Tangri
School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun, Uttarakhand, India
nehapadiyar6@gmail.com
Stress is a response to external challenges, pressures, or events. This includes things like looming deadlines,
difficult decisions or health scares. It can also be said as a state of worry or mental tension caused by a
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difficult situation. It is a natural human response that prompts us to address challenges and threats in our
lives. Herbal ingredients used as a soothing agent to treat stress includes – Brahmi, ashwagandha and
chamomile. Brahmi is used as an anti-anxiety medication. It is said to reduce symptoms of anxiety, level of
disability and mental fatigue and increase in memory span. Ashwagandha helps calm the brain, reduce
swelling, lower blood pressure, and alter the immune system. Chamomile is a well-known stress soothing
tea. Long term use of chamomile extract significantly reduce moderate to severe symptoms of generalized
anxiety disorder. Excipients used in preparation of patch includes gums(xanthum), humectant (glycerine,
PEG, panthenol), penetration enhancer (oil, DMSO, ethanol or decanol), and cooling agent (menthol) .
Transdermal patch was evaluated on parameters like - thickness, weight uniformity, drug content, content
uniformity, moisture content, flatness, thumb tack test, roller ball test, folding endurance and probe tack
test.
Keywords: Transdermal, Patch, Herbal, Mental.
A-176
A review on recent advancements in Aptamer based sensing techniques and its therapeutic
application
Komal*, Sayantan Mukhopadhyay
Aptamers are single-stranded oligonucleotide sequence with high specificity to bind tothe target molecule.
They have various merits such as prolonged storage life, highaffinity, low immunogenicity, and excellent
specificity towards the target. Aptamerscan bind to multiple targets with high specificity and affinity to
their special screeningprocess and tertiary structure. It is used in biosensors for target detection due to
theirsimple preparation and stable modification. Aptamer technologies in developing advance techniques
for producing aptamer with high performance and efficiently aswell as less cost. The Paper based sensor is
a product with a low price, short detectiontime, simple detection and is widely used as a rapid detection
method. This studyfocused on the screening method of Aptamer and applicable sensing techniques.
Modification of Aptamer for therapeutic application including therapeutic agent,Aptamer-Drug conjugates
and target delivery materials are discussed.
Keywords: Oligonucleotide, Biosensors, Aptamer, Conjugates.
A-177
Exploratory studies using Molecular Docking
Gauree Kukreti *, Vijay Juyal, Rajeshwar Kamal Kant Arya
Department of Pharmaceutical Sciences, Faculty of Technology, Sir J.C. Bose Technical Campus, Bhimtal,
Kumaun University, Nainital-263136, Uttarakhand, India
gauree25@gmail.com
Dasatinib is a medication that is used to treat certain types of cancer, such as chronic myeloid leukemia
(CML) and acute lymphoblastic leukemia. It belongs to the class of medication called kinase inhibitors. It
works by blocking the action of abnormal protein that signals cancer cells to multiply.Dasatinib (DAS),
belonging to biopharmaceutical classification system (BCS) II has a poor bioavailability of about 14-34%
because of poor solubility (less than 1 mg/mL). It also demonstrates pH-dependent solubility change.
Several attempts have been made to improve solubility and dissolution rate of dasatinib, these include the
use of cyclodextrins to form inclusion complexes, particle size reduction including drug nanoparticles.
Drug phospholipid complexes are a unique way of enhancing the oral bioavailability of poorly bioavailable
drug. A drug phospholipid complex will be prepared for the drug dasatinib. Before the formulation an
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exploratory molecular docking is done between the drug (dasitinib) and phospholipid to confirm the
possibility of interaction between the two for further formulation development.
Keywords: Dasatinib, Docking, Phospholipid, Interactions, Bonds, Bioavailability.
A-178
Promising Nanotechnology based approaches in clinical trials for treating Glaucoma
Yamini Pant*, Surojit Banerjee, Anupama Singh, Vikas Anand Saharan
School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, Balawala, Dehradun, 248001,
India
Glaucoma is a chronic eye disease that damages the optic nerve responsible for transmitting visual signals
from the eye to the brain and can lead to irreversible blindness. The condition is often associated with
increased intraocular pressure (IOP), and currently, 80 million people worldwide are affected by it. By
2040, this number is expected to increase to over 111 million. To address the challenges associated with
eye drop formulations, nanotechnology offers a potential solution to improve patient comfort and reduce
eye drop administration frequency. Nanoparticles can be engineered to encapsulate glaucoma drugs and
allow for controlled and sustained release of the medication over an extended period. In the past ten years,
clinical trials were conducted and chosen from clinicaltrials.gov, PubMed, and other databases to highlight
the importance of nanotechnology in translating clinical benefits to humans. The innovative approaches
include nanoparticle-based drug delivery, nanofabrication of implantable devices, and nanotechnology-
based neuroprotective strategies. These approaches have the potential to improve glaucoma management by
enhancing drug delivery, providing precise monitoring and therapeutic interventions, and protecting the
optic nerve from damage. Although no marketed nano-based products were found after an extensive
literature search. Ongoing research and clinical trials on several nano formulations, such as nanocrystals,
dendrimers, and nanogels, offer promising results. This emerging area holds great promise and scope of
nano formulation-based drug products, in near future, for the treatment of glaucoma.
Keywords: Intra-Ocular Pressure, Nanofabrication, Drug Delivery, Nanocrystals, Sustained Release.
A-179
Evaluation of medicinal plant Achyranthes Aspera
Sarvesh Kumar*1, Vijay K. Jyoti2, Ranjit Singh3
1
Krishna Pharmacy College,* Bijnor, Uttar Pradesh
2
Department of Pharmaceutical Science, H. N. B. Garhwal University (A Central University), Srinagar Garhwal
246174, Uttarakhand, India
3
AVIPS, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh
sarveshlohan@gmail.com
The aim of this research was to evaluate moisture content, ash value, different solubility test (acid, base and
water) successive value, thin layer chromatography and phytochemical screening of A. aspera.A. aspera
also known as the Chirchira and Latjirabelongs to the Amaranthaceaefamily and used as boils, asthma,
cough, cold, colic, skin disease and used to cure dropsy. The phytochemical screening of plant presence of
alkaloids, flavonoids, carbohydrate and saponin etc were present respectively. It can be concluded that the
different extract of the plant of A. asperapossess potent bleeding,antioxidant, snake bite, dog bite, scorpion
bite, leucoderma, renal complication and dysentery. Result showed that A. aspera root was found Total ash
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(17.90 mg/gm), Acid insoluble ash (39.00 mg/gm), water soluble ash (48.4 mg/gm), swelling index (1.2),
methanolic extractive value 7.80% was found. The present study was attempted for the first time to
investigate the moisture content, ash value, different solubility test (acid, base and water) successive value,
thin layer chromatography and phytochemical screening of A. asperato search for newer, safer and more
potent analgesic, antibacterial, anti-inflammatory, antioxidant agent and we herein delineate the results of
our study.
Keywords- Chirchira, Latjirabelongs, Amaranthaceae, Analgesic, Antioxidant, Bleeding.
A-180
A Review on Nanoparticles
Anuj Kumar *, Sayantan Mukhopadhyay
Particulate systems such as nanoparticles have recently been used as a physicalapproach to modify and
improve pharmacokinetics and pharmacodynamics. properties ofdifferent types of drug molecules. They
were used in life to protect the drug complex in thesystemic circulation to limit drug access to the drug
substance to selected locations and deliverthe drug to the site of action at a controlled and uniform rate.
Drug dosing studies are clearlymoving to the micro-nanoscale in scale. Nanotechnology is therefore
emerging as a field ofmedicine that is expected to have significant therapeutic benefits. Effective
development nanodelivery systems that can transport the drug specifically and safely to the desired site of
action isone of the most challenging tasks in the pharmaceutical industry. formulation researchers. They
seek to reformulate and add new indications to existing blockbusters to maintain positivescientific results
and therapeutic successes. Nano delivery systems mainly contain Nanoemulsions, lipids or polymer
nanoparticles and liposomes. During the last few years considerableresearch has been done on a new drug
delivery system using particulate vesicle systems as drugcarriers for small and large molecules.
Nanoparticles improved the therapeutic effect of drugsand minimized side effects. Basically, nanoparticles
were produced using different Techniquesfor dispersing preformed polymers as such, polymerization of
monomers, and gelation orcoacervation of hydrophilic polymer ions.
Keywords: Nanoparticles, Nanotechnology, Polymeric nanoparticles, Particle system, nano delivery.
A-181
Formulation and evaluation of anti-acne herbal gel
Ruchita Negi* Shaffi K. Tangri
School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun, India.
Acne is a localized skin condition that is due to clogged hair follicles with dead skin cells and oil released
by sebaceous gland. Acne can be present as inflammatory, non-inflammatory lesions or a mixture of both
affecting not only face but on chest and back too. Most common acne condition is Acne vulgaris it is an
inflammatory disorder of pilosebaceous unit (hair follicle, hair shaft and sebaceous gland) It is mainly
caused by Cutibacterium acnes. The chemical agent used for treatment of acne are - Salicylic acid, Benzoyl
peroxide, Oral Antibiotics (tetracycline, doxycycline, minocycline, and sulfamethoxazole / trimethoprim)
and Topical Retinoids besides there are many herbal ingredients that show antiacne property such as
Withaniacoagulans, Lithuania somniferous, Curcuma longa, Terminalia arjuna and Eucalyptus globule.
The objective of this work was to utilize Withaniacoagulans extract to formulate a gel for treatment of
acne. Withaniacoagulans has anti-microbial, antifungal, and anti-inflammatory action. The prepared gel was
evaluated on various parameters such as- pH, viscosity, stability, irritancy, and homogeneity thus the result
indicate that the developed gel formulation has potential for the treatment of acne.
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Keywords: Acne Vulgaris, Withaniacoagulans, Anti-microbial, Anti-acne.
A-182
Pharmacological activities of Mikania genus: A review
H. Lalruatdiki*, Rita Saini and Shivanand M. Patel
Department of Pharmacy, Shree Dev Bhoomi Institute of Education, Science and Technology,Dehradun.
hmardiktei01@gmail.com
Asteraceae is one of the largest family of angiosperms and contain the Mikania Genus. Most species of
Asteraceae are annual, biennial, or perennial herbaceous plants, but there are also shrubs, vines, and trees.
Members of the family have flower heads composed of many small flowers, called florets, that are
surrounded of bracts (leaf like structure). Several species of this family contain polyethylenic and
thiophenic compounds which are used as taxonomic markers. Also, their phytotoxic acts as a plant defence
mechanism. This study highlights the ability of Mikania micranta as an antibacterial, anti-fungal, anti-
parasitic, anti-inflammatory, cytotoxic and anti-cancer, anti-diabetic, and antioxidant by reading several
research articles and through my finding coined the mentioned pharmacological activities of Mikania
micrantha. There are approximately 430 species of this genus and only 12% have been studied, highlighting
their chemical and pharmacological diversity. This review concluded that Mikania Micranthahave huge
pharmacological activities and noted that it is safe to use as a medicinal plant.
Keywords: Pharmacological activities, Chemical composition, Mikania, consumption, cytotoxic.
A-183
Herbs for COVID-19
Varnika*
Department of Pharmaceutical Sciences, Sardar Bhagwan Singh University, Balawala, Dehradun, Uttarakhand
Varnika941165@gmail.com
For a few decades, COVID-19, a disease caused by the SARS-CoV-2 (severe acute respiratory syndrome
coronavirus2) virus, has been responsible for a pandemic since March 2020 and it had no cure. Therefore,
now to overcome the risk of COVID-19, different theoretical methods were used to obtain potential
candidates from herbal compounds to inhibit the SARS-CoV-2 main protease. COVID-19 can be eradicated
by not only targeting a site but also simultaneously using a multiple-target approach. Generally, there are
three routes for the transmission of covid-19 are aerosol transmission, droplet transmission, contact
transmission. A study of many infected patients found that the main transmission route of SARS-CoV-2 is
person-person contact. Some of the antiviral medicinal plant species are citrus Spp., orange (C. Sinensia)
Allium Sativum, Allium Cepa, Mentha Pipertia, and Nigella Sativaare the most desirable herbal drink or
fruit that can introduce effective adjuvant components in COVID-19 management. On top of exhibiting
direct antiviral effect, Herbal drugs with reported Anti-inflammatory activity may have significant roles in
COVID-19 treatment as the elevation of inflammatory indicators such as interleukin (IL)-6, erythrocytes
sedimentation rate (ESR) and C reactive protein (CRP) has been related to severe disease with worse
outcomes, most likely related to cytokine storm. This not only gave detailed knowledge regarding the
advancement in the field of herbal drugs but also gave an approach to how it is improving the COVID-19
treatment.
Keywords: COVID-19, Herbal Medicines, Uncontrolled Disaster, Narrative.
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A-184
Tissue Chips: Innovative Tools for Drug Development and Disease Modelling
Arbaz khan, Tarun Parashar, Jyotsana Suyal
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Premnagar, Dehradun,248007, Uttarakhand
Despite the well-known high incidence of failure in drug development, new developments in tissue
engineering and microfabrication have helped to create "organs-on-chips" or "microphysiological systems"
(MPS) that mimic the function of human. These "tissue chips" could be used for the safety and drug
screening tests, which could revolutionise the early stages of drug development. Additionally, they can be
utilised to simulate illness states, supplying new tools for deciphering disease pathologies and causes as
well as evaluating the efficacy of novel treatments. Future clinical trials-on-chips could be utilised to test
novel medicines in both populations and individuals, opening the door for precision medicine. Here, we'll
talk about tissue chips' diverse potential as well as the difficulties in developing them. In the future, they
may even serve as substitute human testing systems for new therapeutics, which would be especially
helpful for populations of people with rare diseases. They also have the potential to replace and improve the
use of animals in testing new medications and clinical treatments. The current state of tissue chip research
and its difficulties will be covered in this chapter. We will also go over how these devices are being used to
model the fundamental cell and molecular characteristics of rare disease, which has the potential to offer
new tools for comprehending disease pathologies as well as screening and efficacy testing of potential
therapeutics for drug discovery.
Keywords: Drug Toxicity, Safety, Cell Culture, Organson Chips, Tissue Chips.
A-185
An overview on recent advantages and future treatment of Polycystic Ovary Syndrome
(PCOS)
Ishika Chakraborty*, Tarun Parashar,Shalu Verma
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Premnagar, Dehradun, 248001, Uttarakhand
PCOS (Polycystic Ovarian Syndrome), be a multifaceted disorder that has an impact on a woman's
hormone levels, is distinguished by chronic ovulation and excessive ovarian activity. Ovarian dormancy or
primary insufficiency is other causes of ovulation. PCOS symptoms include polycystic ovaries syndrome,
hyperandrogenism, and infertility. It will increase the likelihood of developing diabetes mellitus type 2,
insulin resistance, and obesity, cardiovascular diseases. PCOS is associated withchronic low-grade
inflammation, and women with PCOS syndrome are more likely to developing non-alcoholic fatty liver
disease. Women with PCOS syndrome have higher levels of male hormones than usual. Because of this
hormonal imbalance, it is more difficult for them to become pregnant, and their bodies miss menstruation
cycles. The treatment plan must be tailored to the patient. Letrozole appears to be beneficial and more
effective than the standard treatment, clomiphene citrate, and may help patients recover through lifestyle
changes and herbal drugs.
Keyword: PCOS, Infertility, Diet, Diagnosis, Future.
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A-186
Quantum Dots
Neha Kandpal*, Nidhi Nainwal, Vikash Jakhmola
Kandpalneha20@gmail.com
Quantum dots are nano scale semiconducting materials that exhibit unique optical and electronic properties
due to their quantum confinement effects. They have attracted significant attention due to their potential
applications in a wide range of fields, including electronics, energy, biomedicines and photonics. Quantum
dots can be synthesized with precise control over their size, shape and composition, allowing them to be
tailored for specific application. They exhibit size dependent fluorescence and can be used as fluorescent
probes for biological imaging and sensing. In addition, they can be used as efficient light emitters in display
technologies and lighting, Quantum dots have also shown promising potential for improving efficiency of
solar cell by enhancing the absorption of light. The abstract provides a brief overview of the properties and
potential applications of quantum dots, highlighting their significant impact on various fields. Quantum
dots are tiny semiconductor crystals with dimensions on order of nanometres, which exhibit unique optical
and electronic properties. They are fabricated using a variety of methods such as colloidal synthesis
epitaxial growth, and lithography and can be made from different materials such as CdSe, Cds and andInp.
Due to their small size quantum dots have discrete energy levels, which give rise to size dependent
electronic and optical properties. This quantum confinement effects leads to unique properties such as light
extinction coefficient, high quantum yield and broad absorption spectrum. Quantum dots are used in a wide
range of applications such as optoelectronics, photonics, biomedicines, and energy. Despite some
limitations, quantum dots have significant potential for future technological advancements.
Keywords: Quantum dots, Electronics, Fluorescence, Biomedicines.
A-187
Gold compounds as anticancer agents
Aarti Sati, Shagufta Jawaid
Uttarakhand, India
shaguftajawaid19@gmail.com
Gold compounds are a class of metallodrugs with great potential for cancer treatment. During the last two
decades, a large variety of gold(I) and gold (III) compounds are reported to possess relevant
antiproliferative properties in vitro against selected human tumour cell lines, qualifying themselves as
excellent candidates for further pharmacological evaluation. The unique chemical properties of the gold
centre confer very interesting and innovative pharmacological profiles to gold-based metallodrugs. The
present review highlights our findings in the field of antitumor gold complexes bearing biologically
relevant molecules, such as DNA bases, amino acids, or peptide derivatives. The results show that very
active complexes are achieved with this sort of ligands in several cancer cells. Gold(I) thiolates employed
clinically in the treatment of rheumatoid arthritis display some potency against various tumours, but a
greater potential is found in their analogues. Gold (III) compounds featuring square-planar geometries, as
found in cisplatin, may target DNA, and may provide new anti-tumour agents.
Keywords: Gold compounds, Metallodrugs, Antiproliferative, Cancer.
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A-188
Pulsatile Drug Delivery System
Latika Bisht*, Tarun Parashar, Vikash Jakhmola
Pulsatile drug delivery system works technology has gained much attention in recent years and has become
a popular area of research in pharmaceutical industry. Pulsatile drug delivery system (PDDS) is a novel
drug delivery system designed to release drugs at predetermined time or intervals. These systems are
particularly useful for drugs that require specific dosing regimen or for drugs that are most effective when
administered at a particular time of day. This system works by releasing the drug in pulsatile manner where
the drug is released in bursts at specific intervals. This system typically consists of a drug reservoir and a
triggering mechanism can be controlled by various mechanism that release drug at predetermined intervals.
The triggering mechanism can be controlled by various stimuli such as temperature, PH, enzyme, and
magnetic field. PDDS has several advantages over conventional drug delivery system. Pulsatile drug
delivery system has been extensively studied in various therapeutic areas such as cardiovascular,
respiratory, and central nervous system disorder. PDDS technology has several challenges that need to be
addressed such as ensuring accurate and consistent drug release, long term stability of the system and
scalability of production. PDDS offers a unique approach for drug delivery by providing Targeted drug
release at specific intervals. The technology has many potential applications, particularly in therapeutic
areas where drug require a specific dosing regimen.
Keywords:Pulsatile, Predetermined, Drug, Therapeutic.
A-189
Computational Prediction of Protein Structure
Sapna Rana*, Amandeep Singh Baghla
sapnarana25200@gmail.com
Peptide bonds hold the amino acid sequence that makes up proteins together. Since drug receptors are
protein-based, it is possible to predict the structure and function of a drug by learning about proteins using
computers. Several techniques have developed in the last few years for designing and predicting protein
structures. Due to the rapid expansion of protein structure databases (PDB) or numerous software, protein
structure prediction technology is constantly evolving. To generate new types of drugs with improved
properties such as greater affinity between the drug and the receptor, improved effectiveness and
performance of the drug, and the drug exhibiting advanced therapeutic activities, new ideas have been used
to map out protein-protein inter-connections. Template-based modelling and template-free modelling are
the two primary methods implemented to design a desired protein's structure. In template-based modelling,
the target protein's undefined structure is created using previously identified drugs whose structures are
already known. Additionally, without using protein structure databases, template-free modelling allows for
the creation of new targets with sophisticated features. Template free modelling does not depend on the
previously determined structure of proteins. Protein structure prediction can also be done by using X-ray
crystallography and nuclear magnetic resonance (NMR). Hence it was concluded that the protein structure
prediction by using these techniques had found beneficial for the determination of functions of a protein so
that desired drug may be developed.
Keywords: Proteins, Protein structure prediction, protein structure database.
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A-190
Microneedle-based insulin transdermal delivery system: Current status and translation
challenges
Shivam Tyagi*, Nidhi Nainwal, Vikash Jakhmola
Diabetes mellitus is a symptom of the diabetic diabetes mellitus. Insulin therapy is crucial for people with
type 1 and severe type 2 diabetes mellitus. Injection under the skin is still the most used delivery route.
Techniques for non-invasive insulin delivery are being developed because they can help patients feel less
pain, anxiety, and tension. Due to their simplicity of use and lack of hepatic first-pass metabolism,
cutaneous delivery methods have attracted a lot of attention. One of the most promising methods is find that
it is easier (MN) nanotechnology, which may efficiently inject insulin through the cytoplasm of the skin in
a painless and less invasive manner. The study on MNs for cutaneous delivery of insulin, including empty
MNs, MNs that dissolve, MNs made of hydrogel, and MN patches that respond to blood sugar, will be
discussed in this article. According to the study phase, a summary and grouping of the clinical trials on the
use of MN devices for the delivery of insulin have also been made. The successful translation of MNs-
based insulin therapy still faces various obstacles. These difficulties safety, efficiency, patients and
prescriber acceptability, manufacturing, and scale-up, and regulatory authority acceptability.
Keywords: Challenges Insulin, Microneedle, Transdermal, Translation.
A-191
Process Validation of Rosuvastatin tablet (10mg): HMG-COA Reductase inhibitor
Tanya Sehgal*
Uttarakhand, India
sehgaltanya20@gmail.com
The main aim of the present research work was to study process validation of Rosuvastatin tablet. It can
really be ensured that the final end product is of the highest quality, if each step of the manufacturing
process is validated. Validation is best considered as an essential component of cGMP. As a result,
validation is indeed one of the elements of quality assurance programmes linked with a particular specified
process. Quality is not achieved simply through finished product testing and in-process monitoring, it must
be integrated throughout the manufacturing process. So, focusing on building the quality necessitates
particular focus to a few variables such as material selection, process design, control variables, in-process
control, and finished product testing. In this study, three consecutive batches (A, B, and C) of Rosuvastatin
tablets with the same batch size were used. The critical parameters that are involved in “sifting, dry mixing,
granulation, drying, lubrication, and compression stages” were discovered and analyzed. The results of this
process validation data provide a higher level of confidence that the manufacturing process delivers
products that meets its specified standards and quality attributes. This also offers documentary evidence for
the operational sequence of the manufacturing process and determining the critical parameters and variables
in the tablet production process. The result of process validation could be utilized to boost the efficiency,
ensure consistency in overall quality, and thus eliminating market complaints.
Keywords: Rosuvastatin, Validation, Quality Assurance, CGMP.
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A-192
Gold Nanoparticles
Shivansh Khaudiyal*, Nidhi Nainwal, Tarun Parashar, Vikash Jakhmola
Shivanshkhaudiyal19@gmail.com
Gold nanoparticles are a type of nanomaterials composed of gold atoms with sizes ranging from 1 to 100
nanometres in diameter. Due to their unique properties such as surface plasmon resonance, high surface
area to volume ratio, and easy functionalization, gold nanoparticles have gained much attention from
various fields including biomedical sciences, electronics, catalysis, and material sciences. One of the most
significant applications of gold nanoparticles is in the biomedical field. Gold nanoparticle have been
extensively investigated for their potential in drug delivery, imaging, and cancer therapy. the small size and
ability to functionalize the surface of gold nanoparticle make them suitable for targeted drug delivery to
cancer cells, reducing the side effects associated with traditional chemotherapy. Gold nanoparticles can also
be used as contrast agents in imaging techniques such as computed tomography and magnetic resonance
imaging due to their high X-ray absorption and magnetic properties respectively. In cancer therapy, gold
nanoparticle can be used as photothermal agents, where they absorb light and convert it into heat, which
can selectively destroy cancer cells. Dur to their unique optical properties’ gold nanoparticle can be used as
labels in immunoassays, allowing for the detection of low level of biomolecules. Gold nanoparticle can be
synthesised using various methods including chemical reduction, electrochemical methods and green
synthesis using plant extracts. The choice of synthesis method affects the size, shape and surface properties
of gold nanoparticles. In conclusion they have unique properties that make them suitable for various
applications in biomedical sciences, electronics, and material sciences. Their potential applications are vast,
and research in this field is ongoing.
KEYWORD: Gold,Nanoparticles, Cancer, Drug, Delivery.
A-193
Colon Targeted Drug Delivery System
Rishabh Mishra*, Tarun Parashar, Vikash Jakhmola
Drugs can be delivered locally as well as systemically through the colon. Inflammatory bowel disease can
be treated topically with local delivery.However, drugs that are directed directly into the colon can reduce
systemic side effects and make treatment more effective.Applying thicker layers of conventional enteric
coatings or extremely slow-releasing matrices to achieve slower release rates or longer release periods is the
easiest way to target drugs to the colon.Colon-specific drug delivery systems are beneficial for the
treatment of a number of local diseases like ulcerative colitis, Cohn’s disease, irritable bowel syndrome,
chronic pancreatitis, and colonic cancer. These methods include the utilization of detailing parts that
cooperate with at least one part of gastrointestinal physiology, like the variation in pH along the GI lot, the
event of colonic micro flora, and compounds, to accomplish colon focusing. Colon designated drug
conveyance framework can be used to convey protein and peptide drugs as they are known to debase in the
super gastric pH. This article discusses the advantages, disadvantages, and influences of colon-specific drug
delivery. The review also discusses several different older and newer formulation strategies that are
currently being used to improve Colon-specific drug delivery systems.The targeted drug delivery system for
the colon is especially important for the systemic delivery of protein and peptide drugs. It is also crucial for
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the therapeutic treatment of nocturnal asthma, angina, and other conditions that require a delay in drug
absorption.
Keywords: Site Specific, Colon, Drug, Delivery.
A-194
Pharmacological management of Non-Alcoholic Fatty Liver Disease (NAFLD)
Shalini Bohra*
Non-alcoholic fatty liver infection (NAFLD) is the most well-known long-term liver disease. NAFLD is
like increased liver-related morbidity and mortality, but it also includes CVS disease, diabetes, and non-
liver-related risk. A severe form of NAFLD called non-alcoholic steatohepatitis (NASH) is to blame for
most negative effects. Living style Change and weight loss can help with NASH, but they don't happen
often enough, and it's difficult to get results that can be proven. There is hence a real need for
(pharmacological) care. In this overview, we look at some of the suggestions and challenges for enhancing
pharmaceutical consideration. In fact, briefly summarise how some of the medications that are currently
available for a variety of yet have demonstrated assurance in the management of NASH side effects.
Finally, we briefly outline the key drugs/types of pharmaceuticals, mostly based on their component of
activity, that are currently being developed specifically to treat NASH and that may eventually lead to the
availability of medications approved for non-alcoholic fatty liver steatohepatitis.
Keywords: Clinical, CVS, Diabetes, Pharmacological, Steatohepatitis.
A-195
Dry Powder Inhaler
Rakshanda*, Nidhi Nainwal, Yogita Ale, Vikash Jakhmola
A device that delivers medication to the lungs in the form of a dry powder is known as a dry powder inhaler
(DPI). DPIs are frequently used to treat respiratory conditions like COPD, asthma, and bronchitis. Interest
in DPI as a productive and harmless to the ecosystem approach to conveying medications to the lung has
advanced rapidly lately. A dry powder inhaler can only accomplish these objectives if the powder
formulation is appropriate, the metering system is effective, and the device is carefully chosen. It is
essentially grouped into three classes: Nebulizer, pMDI, DPI. DPIs are an option in contrast to pMDI that
conveys prescription to the lungs as a dry powder. The API's particle size must be between 1 and 10
micrometres to ensure that the patient receives the same dose at different airflow rates every time. There are
four distinct formulation strategies for DPI, including: Drug carrier, drug additive, drug carrier, and drug
carrier free "Twin Stage Impingner" completed the lung deposition study. The internal breath device is
basic in achieving good transport of taken in medicine to lung which essentially assembled considering
estimations sort into single-unit and multi-measurements stores. A few techniques can be utilized to decide
if adequate item has been set into every holder. The tared cans that have been positioned on the filling line
are weighed once more, and the weight difference is equal to the net contents. The other approach is
destructive and involves dispersing the contents of a full container after weighing it.
Keywords: Pulmonary, Dry Powder, Carrier, Inhalation, Device.
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A-196
NiosomeTransdermal Patch of Ketoconazole
Gaurav Joshi
A drug used to treat fungal infections is ketoconazole. An antifungal medication called ketoconazole has
poor solubility, causes gastrointestinal discomfort, and has a first-pass impact. It is employed to treat fungal
skin infections (yeast). Also, it can keep them from returning. It addresses a variety of fungus infections,
including athlete's foot. Ketoconazole is no longer advised as a first-line antifungal agent since it is a well-
documented cause of clinically obvious acute drug-induced liver impairment. As an alternative to
traditional oral or injectable routes, the utilization of the transdermal delivery system has lately received
widespread recognition due to its capacity to transfer drug molecules over the skin membrane.So, in the
current work, it was originally created as nanoparticles to aid in absorption, and later on, promising
nanoparticles were used to construct nanoparticle-loaded transdermal patches.So, in the current study, it
was first manufactured as nanoparticles to aid in absorption, and later, promising nanoparticles were used to
construct nanoparticle-loaded transdermal patches Transdermal methods also have the advantage of
avoiding the first-pass hepatic metabolism that occurs when medicines are taken orally. There is less need
for repeated doses or applications of medication when drug formulations and concentrations are adjusted to
regulate drug release into the body over extended periods. Drugs may be effectively made available
throughout the body with TDDS. Transdermal patches are cutting-edge medication delivery methods that
are applied to the skin to produce systemic effects. The use of the TDDS system has various clinical
advantages over alternative methods. It offers a reliable medication release, keeps blood levels stable,
which might lessen systemic adverse effects, is easy, user-friendly, and helps to increase patient acceptance.
A drug's steady absorption over an extended length of time removes the need for frequent dosage, which
improves patient compliance. Ketoconazole transdermal patch formulated with nanoparticle loading can be
utilized effectively as a carrier to improve transdermal penetration and absorption.
Keywords: Ketoconazole, Nanoparticle, Transdermal Patch.
A-197
Innovative Research: Determination of SPF of leaves extract of DovyalisCaffra
Sneha Gupta*, Sudhakar Kaushik, Bhawana Bhatt
School of Pharmaceutical Sciences, SGRRU, Dehradun, Uttarakhand, India
griya1946@gmail.com
The objective of the current study was to investigate the sun protection factor (SPF) number based
Ultraviolet (UV) absorption capabilities of an ethanol herbal extract of Dovyaliscaffra leaves. Botanical and
herbal medicines are well-known for being secure and are well-liked by consumers. It also functions in a
number of other ways, including by enhancing the immune system, causing gene silencing, eradicating
carcinogens, and averting oxidative damage to DNA, kicking off particular pathways or through other
means. The freshly washed leaves were grinded and taken in beaker and soaked for 3 days covered with
aluminum foil for maceration with 50 ml ethanol. Then, filter with Whatman filter paper. The filtrate is
evaporated.0.2 gm was taken from the residue and diluted with 100ml of ethanol (200ppm). The sample
was sonification for 5 minutes. After dilutions, the absorbance was measured between 290-325 using UV-
visible spectrophotometer.Sample’s absorbance and SPF value were determined using the UV-
Spectrophotometric technique. The SPF value of the ethanol extract varies in range 5.39 in leaves of
Dovyaliscaffra. The result obtained from the study showed that Dovyaliscaffraleaves do contain some SPF
activity and whose further usage can be utilized for making various sun block formulation.
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Keywords: UV, Radiation, Sun burn, Skin aging, DovyalisCaffra.
A-198
Big Data Analytics for Healthcare in the Future: A Comprehensive Review
Vaibhav Adhikari, Nidhi Nainwal, Vikash Jakhmola
nidhi.nainwal87@gmail.com
The use of big data in the healthcare sector is a fast-growing topic that offers a new method of study,
moving away from small-scale case studies to more comprehensive data-driven analysis. Big data
effectiveness depends on developments in data standards, technology, and research. As a result, given its
potential to completely transform the sector, big data's future in healthcare holds out a lot of hope. Due to
the enormous amount of data available, big data analytics has revolutionized the healthcare sector.
Numerous benefits are presented by this change, including the chance to identify, anticipate, and prevent
health problems before they worsen, which will enhance the quality of life. To guarantee that big data
continues to have a beneficial impact on healthcare in the future, researchers and physicians are working
together. The healthcare system has access to a wide range of resources that can produce valuable data for
various applications, such as randomized controlled clinical trials, wearable gadgets that monitor vital signs
like blood pressure and physical activity, video-based monitoring systems for spotting falls in elderly
people living alone, personal genomic services, imaging gadgets, and social media or internet searches. The
information gleaned from these sources can be applied to a variety of fields, including precision medicine,
managing populations, making diagnoses, predicting prognoses, measuring the quality of care and
performance, and public health and research applications. By 2025, it is anticipated that the big data market
in healthcare would be worth $70 billion, representing a tremendous growth of 568% in just ten years.
Although using such a tool poses a variety of challenges, it also opens new opportunities for everyone in
the healthcare supply chain who supervises decision-making processes.
Keywords: Big Data, Analytics, Genomics, Precision Medicine, Health.
A-199
In-vitro assessment of anti-inflammatory activity of ethanolic
stem bark extract ofHibiscus Rosa Sinensis Linn.
Ayushi*, Sudhakar Kaushik
School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, Uttarakhand, India
ayushikhali612@gmail.com
Inflammation is a complex biological response that plays a key role in the body’s defence mechanisms
against various injuries and infections. However, chronic inflammation can lead to numerous diseases such
as arthritis, cancer and cardiovascular diseases. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely
used to treat inflammatory conditions, but their long-term use is associated with adverse effects. Therefore,
there is a need to explore alternative therapies for inflammation management. Plant extracts are an excellent
source of natural compounds that possess anti-inflammatory activity. The plant extracts contain a variety of
bioactive compounds, that have been shown to have potent anti-inflammatory activity. The study aims to
investigate the potential therapeutic benefits of ethanolic extract of Hibiscus rosa-sinensis in reducing
inflammation, which is a potent anti-inflammatory agent for acute and perhaps for chronic as well.
Extraction of the plant part was performed with ethanol in soxhlet apparatus and phytochemical screening
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of the ethanolic extract was performed to check the phytoconstituents and in-vitro anti-inflammatory
activity of extract was evaluated by using protein denaturation assay on Egg Albumin. Ethanolic extract
showed the presence of Flavonoids, phenols, terpenoids and steroids. Ethanolic Plant extract significantly
inhibited the denaturation of egg albumin while the diclofenac sodium was used as the reference drug.
Keywords: Flavonoids, Polyphenols, Protein Denaturation, Inflammation.
A-200
An Overview of Liposomes for Targeted Delivery
Aakash Tripathi*, Shalu Verma, Vikash Jakhmola
aakashtripathi7878@gmail.com
Liposomes are an effective drug delivery mechanism for several medications since they are nontoxic and
biodegradable. Additionally, because liposomes allow radiotracers to be attached to numerous sites, they
might be utilised to transport radioactive substances. A variety of drug delivery systems (DDS) have been
used to deliver drugs to the right locations while also extending the period that some molecules circulate in
the bloodstream. The drug carrier based on liposomes is one such system. Self-assembling vesicles called
liposomes are made of a lipid bilayer that creates a tight shell around an interior aqueous phase. Liposomes
are used as drug carriers in drug delivery systems because they are biodegradable and essentially non-toxic
vehicles that can encapsulate both hydrophilic and hydrophobic molecules. Different mechanisms for drug
release from the liposomal action, as well as different techniques for directing the liposomes to a particular
region, are used. It is a drug delivery system that is packed with a wide range of molecules, including
proteins, nucleotides, plasmids, and tiny drug molecules. Anti-tumour medications and antifungal
treatments have both been commercialised in liposomal form to date. The numerous liposome preparation
techniques, characterization, recent advancements, and applications are the main topics of this review.
Keywords:Liposomes, Drug Delivery, Targeted Therapy, Vesicles, Encapsulation.
A-201
A review: strategies for producing and developing genetically engineered plants for viral
resistance
Aman Rajput*, Bhupendra Kumar, Yogesh Tiwari, Smriti Kumari, Sidra Wazir
School of Pharmacy and Research, Dev Bhoomi Uttarakhand University, Dehradun, Uttarakhand, India
Plant viruses cause significant agricultural losses all around the globe. Cultural approaches &
Applications of biocide against arthropod, nematode, and plasmodiophorid vectors had little efficacy in
minimizing the effects of herbal viruses. The utmost efficient & cost-effective method of reducing plant
viral infections is to plant impervious farmers. Natural several causes of the opposition have been
widely used in conventional breeding to generate virus-resistant plants.Non raditional approaches have
also been employed effectively to give virusres istance by transferring virus-derived genes into
susceptible plants, containing viral coat protein, replicas, expression protein, nonsense-interfering
RNA, non-coding RNA, protease RNA viruses are not the only kind of genes since ribosome-
inactivating proteins, protease inhibitors, double-stranded RNAse, and RNA modifying enzymes also
fall under this category.
Keywords: Genetic engineering, DNA, Plantviruses, RNA, Socioeconomicfactors.
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A-202
Application of Nano-pore Sensors for Biomolecular Interactions & Drug Discovery
Asif Ali, Nidhi Nainwal*, Vikash Jakhmola
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Premnagar, Dehradun, 248007
Biomolecular interaction, including such protein-protein, protein-nucleic acid, & nutrients acid-ligand
interactions, play important roles in a variety of cellular signals and biological processes and present
promising therapeutic targets in a wide range of human disorders. The low efficiency and high expense of
traditional ensemble-averaging-based approaches for biomolecular modelling and high-throughput drug test
now place constraints on the development of new drugs. A developing technology for biomolecule single-
molecules sensing is nanopores. Nano-pore sensing is a widely used unique analytical technique in a variety
of domains, including protein/peptide analysis, nucleic acid sequencing, etc. There has been an increase in
demand for the detection of hazardous compounds due to the growing people's concerns about dietary
health and social security. The classification as well as selection of nanopores (biological, solid-state, and
Nano-pipette), various aptamer-based nanopore sensing strategies, and their benefits and prospects for use
in fields like environmental analysis, accuracy diagnosis, the pharmaceutical industry, along with security
are all covered in this. Additionally, the aptamer-target interactions, including recognition orientation,
binding locations, as conformation heterogeneity dissociation kinetics on the single-molecule level, have
been revealed using single-molecule nanopore sensors.In this article, we provide a summary of current
advances and future directions in biological & solid-state nanopore sensors' ability to detect single
molecules of a variety of biomolecular interactions in drug discovery applications.
Keywords: Bimolecular, Nano-pores, Protein, Peptide, Aptamer-target interaction.
A-203
Nanocarriers for effective management of pancreatic cancer
Nyanbeni, Nidhi Nainwal1*, Vikash Jakhmola
One of the deadliest cancers with an extremely low survival rate is pancreatic cancer. Although, over the
years the treatment for cancer has advanced so much, like the treatment for breast cancer, leukemia
however the treatment for pancreatic cancer hasn’t progressed. Some risk factors for pancreatic cancer may
be because of cigarette smoking, obesity, diet high in fat and meat etc. Pancreatic cancer response to most
of the chemotherapeutic agents are very poor. Through the advancement of nanotechnology platforms,
notable attempts have been undertaken in recent years to increase the efficacy and bioavailability of
medications and pharmaceuticals. Though there hasn’t been much progress in the treatment of pancreatic
cancer, new methods are still being investigated. Nanoparticles can be functionalized with antibodies or
aptamers to focus on the treatment solely on the malignant cells and prevent it from being endocytosed by
healthy cells, which is a critical function of nanoparticles in biomedicine. The majority of cancer cells are
the target once the patient receives the nanoparticles. Due to their potential as chemotherapeutic drug
delivery system, iron oxide nanoparticle has received a lot of attention. Inorganic nanoparticles seem to be
unique material for biological applications because of their distinctive magnetic, electrical, optical and
electrochemical capabilities. The high level of toxicity has a specific impact on the utilization of inorganic
nanoparticles for cancer therapy.
Keywords: Nanocarriers, Pancreatic cancer, Iron oxide, Nanoparticle.
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A-204
Protein derived biosensor for pharmacokinetic studies and drug screening
Saurav Chamoli, Nidhi Nainwal, Vikash Jakhmola
A time-consuming stage in drug screening is selecting between natural and synthetic chemicals for advance
information in new pharmaceutical formulations. To solve this issue, new technologies such as biosensors
are currently demonstrating their versatility and ability for regular clinical diagnosis.The development of
useful biosensors with use in clinical monitoring and disease detection has been speed up by the demand for
quick, cheap, portable, easy screening procedures. The building of biosensors has made use of proteins as
signal molecules. Biosensors depending on the linking of proteins to amperometric and optical sensors have
demonstrated the necessary selectivity, responsiveness, and accuracy when used to carry out analysis of the
data for the detection of a specific analyteHospitals may use enzyme-based biosensors for bedside drug
testing, emergency control, and patient treatment control, particularly in the treatment of cancer. These
devices can include a variety of microelectronic sensors and biosensors for multiparametric monitoring that
are sensitive to things like pH, conductivity, temperature, etc. The biosensors have also integrated in several
functional nanostructures. The most recent developments in customised biosensors, such as surface
plasmon resonance, fluorescence, photoelectrochemical, and electrochemical systems, with a focus on their
workings and uses in drug testing, efficacy assessment, and toxicity evaluation. As a result, we can build
biosensor which are smaller, more reliable biosensors with lower detection thresholds and significantly
fewer sample volume requirements have been created. Recent advances in microdevices hold the prospect
of streamlining pharmacokinetic investigations and bringing therapeutic medication monitoring to the
bedside in clinical practise.
Keywords: Biosensor, Pharmacokinetic, Optical, Sensors.
A-205
Pharmacist: A bridge between patient and physician
Vishwajeet Anand1, Amit Semwal2, Vikash Jakhmola1, Supriyo Saha1
1
2
College of Pharmacy Shivalik Campus,Dehradun, India
Among patients who receive polymedicine, the prevalence of drug-related disorders (DRP) has resulted in
substantial health risks and financial costs. Although the evidence is weak, effective CPP (clinical
pharmacist and physician) communication significantly reduces DRPs.Communication between doctors and
patients, as well as their knowledge and individual skill, are crucial components of health care. It makes it
easier for the doctor to collect patient data for diagnosis, a better course of treatment, and good medication
adherence. One of the most frequent issues in public health care is the physician-patient communication
gap, which can result in anything from a simple misunderstanding to death. Drug-related problems (DRP)
decreased medication adherence, an increase in adverse drug events, an increase in morbidity and mortality,
and increased medical costs are just a few of the health issues that can arise from poor communication. The
first point of contact with patients in the community and the health professional best suited to bridge the
communication gap between doctors and patients is the pharmacist. Since pharmacists are the primary
subject matter experts for drug information services, they offer accurate and thorough drug-related
information to patients as well as to other healthcare professionals. Through patient counselling and
education, they play a crucial role in the management of chronic diseases, the reduction of drug-related
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issues, the control of adverse drug events, the management of treatment costs, the promotion of lifestyle
modification, the enhancement of medication adherence, and the reduction of over-the-counter drug use.
Keywords: DRP, CPP, Pharmacist, Management.
A-206
Gene therapy for inherited problems in neonates
Bhawna*
Inherited diseases are the diseases that passes from parents to the offspring through the genes. When a
mutation occurs in the gene, it may cause some abnormal protein formation and may lead to some diseases
that may occur in child if the disease possessing gene is dominant. Examples of inherited diseases include
Alzheimer's disease, Arthritis, Cancer, Dementia, Diabetes, Heart disease etc. The treatment of genetic
diseases is near to impossible using conventional treatment methods. But, the gene therapy is an upcoming
approach for the treatment of genetic disorders but gene therapy is less effective in the adults. So, it is
necessary to perform gene therapy in the neonates susceptible to or suffering from inherited diseases. Gene
therapy is replacement of defective genes with normal genes. Here, the advantages, disadvantages,
challenges and applications of gene therapy will be reviewed and the use of gene therapy in different
diseases cure and treatment.
Keywords: Gene,Therapy, Inherited, Diseases, Neonates.
A-207
Role of Artificial Intelligence in disease management and health care system
Abhishek Bhatt*, Lata Bisht
School of Pharmaceutical Sciences & Technology, Sardar Bhagwan Singh University, Balawala, Dehradun,
Uttarakhand, 248001
bhattabhi10009@gmail.com
The advancement of computers and its technology has taken over all the dimensions of science. Artificial
intelligence (AI) is one of the core branches of Computer Science, which is now been used in all the areas
of science and technology, from core machine learning to medicine and healthcare system for disease
diagnosis, prevention and treatment of various disease. In medicine, artificial intelligence uses machine
learning models to investigate medical data and help to promote patient experiences and health outcomes.
Currently, in medical setting artificial intelligence plays a most important role in clinical decision and
imaging analysis. Clinical decision tools help in making quick decision about treatment therapy and
imaging analysis techniques are required to perfectly diagnose diseases using artificial intelligence tools,
such as ultrasound, magnetic resonance imaging, mammography, genomics, computed tomography scan,
etc. Overall the aim of present study is to covers the comprehensive survey based on artificial intelligence
techniques to diagnose and identify potential machine learning applications in the field of healthcare
system. Based on the various research studies, it has been concluded that artificial intelligence has potential
to completely revolutionize the diagnosis, prevention, and treatment various of diseases. It also assists
healthcare staff in expanding their knowledge, allowing them to spend more time providing direct patient
care and reducing weariness. However, it is important that artificial intelligence must be used in transparent
and ethical manner and the privacy patient should be protected.
Keywords: Artificial Intelligence, Healthcare, Machine Learning, Diagnosis, Imaging, Computer Science.
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A-208
Innovative research: evaluation of sunscreen activity of cream containing leaves extract of
Withania Somnifera for topical application
Sudhakar Kaushik*, Bhawana Bhatt, Payal Saxena
sudhakarkaushik59@gmail.com
Sunscreen formulations are required to protect the skin from damaging ultraviolet radiation, which causes
irritation, erythema (sunburn), generalized or localized hyperpigmentation (tanning), skin malignancies,
immunosuppression, and inflammation. Efficacious, high-quality products are in high demand currently.
Although chemical sunscreen compositions are widely available on the market, however, they are costly
and have a variety of side effects but there are some sunscreens also available with broad-spectrum UV
protection that are inexpensive, safe, and herbal. The present study was conducted to investigate the sun
protection activity of formulation of leaf extract of Withaniasomnifera.The present study was carried out to
evaluate the ethanol extract formulation SPF activity. The evaluation of sunscreen efficacy using hair
removed mice model was assessed by UV exposure of mice following sunscreen application. The
subjective analysis for the evaluation of sunscreen efficacy using hair removed mice model was done &
their average burn score was determined control group – 4.6 burn score, experimental group – 1.4, Standard
group – 0.8. The results obtained from the study revealed that Withaniasomnifera has got significant SPF
activity against UV radiation.
Keywords: Ultraviolet, Erythema, Erosion, Withaniasomnifera, Hyperpigmentation, Sun protection.
A-209
Automation and robotics for Sorting, Packaging, and Dispensing
Pranjal Bisht*1, Nandini Bhardwaj2, KiranDobhal1
1
2
MKP Girls PGCollege,10, New Road, Racecourse, Dehradun, Uttarakhand 248001
Automation can be defined as "the development and implementation of technologies for monitoring and
controlling the manufacture and the supply of goods “Permanent Automation, Customizable Automation,
Versatile Automation and Incorporated Automation” are the several types of automation system. Robotics
is a technological and scientific multidisciplinary field concerned with the design, production, and
application of physical robots. Packaging robotics have several advantages in a wide range of
manufacturing sectors they provide the velocity, precision, and efficiency that robotics manufacturing is
renowned for, while also offering a reasonably quick investment in returns (ROI) when used properly.
Increased automation with the use of robotics is especially noticeable in administering and sorting. This
includes increased agility and accuracy, as well as greater mobility and consistency. As the application of
robotics in the pharmaceutical industry advances, it is important to analyze the advantages of growing
innovations for the manufacturing sector. In the packaging sector, automation is utilized to control
container orientation, sealing, and tagging. Packaging robotics also requires a device that tracks activity,
looks for short feeder fills, broken containers, and consumption outcomes. Automation in dispensing can
speak to you because they're equipped with an automated system that automatically delivers the
medications. They may review your drugs to see if there are any issues with the new medicine you've been
given, or they can discuss the possibility of any over-the-counter remedies that could boost your regimen.
Industrial robotics for pharmaceutical applications has a bright future.
Keywords:Robotics, Automated Dispensing, Pharmaceutical Industry, Packaging.
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A-210
Natural product-based nanomedicine in the treatment of Inflammatory Bowel Disease: a
concise review
Harshit Mishra*, Rita Saini, Shivanand Patil
Department of Pharmacy, Shree Dev Bhoomi Institute of Education, Science and Technology, Dehradun
reetpharma@gmail.com
Many synthetic drugs and monoclonal antibodies are currently used to treat inflammatory bowel disease
(IBD). However, all these cause serious side effects and cause many problems with long-term use.
Numerous in vitro and in vivo experiments have shown that phytochemicals and natural macromolecules
from plants and animals reduce IBD-related complications with encouraging results. In addition, many of
them modulate enzyme activity, reduce oxidative stress, and regulate pro-inflammatory transcription factors
and cytokine release. The translational significance of natural nanomedicine and future strategies for
investigating natural product-based nanomedicine are discussed. Our main objective in this review is to
summarize the application of nanoparticle-encapsulated phytochemicals and macromolecules for the
treatment of IBD and IBD-related colorectal cancer.
Keywords: Inflammatory, Macromolecules, Nanomedicine, Encapsulated phytochemicals.
A-211
Nanosponges: A potential approach for drug delivery
Alka Singh*1, C.S. Chauhan2
1
Research Scholar, Faculty of Pharmacy Bhupal Nobles’ University, Udaipur (Rajasthan)-313001
2
Professor Bhupal Nobles’ University, Udaipur (Rajasthan)-313001
alkasingh1790@gmail.com
Nanosponges (NS) have shown considerable growth in medicine delivery using nanotechnology in recent
years. Nanosponges are new nanosized drug delivery system comprising of wonderful combination of
science and engineering in medicine that full fill the current state of treatment of various life-threatening
diseases. They are solid, porous, bio-compatible, nano-particulate three-dimensional structures that form
complexes with different lipophilic or hydrophilic drug molecules and have been used as drug carriers for
different drugs and can solve problems with solubility, absorption, penetration, bioavailability, in-vivo
stability, and can produce sustained and targeted distribution with maximal therapeutic efficacy. They can
be designed to prolong drug release in a controlled manner, stop protein and drug degradation, and target
medications to specific places. This review aims to describe various NS synthesis strategies and their
characterization. Owing to their benefits, NS are widely used in allied sciences, particularly in water
purification, and have not just been investigated for their potential in the pharmaceutical industry.
Keywords: Nanosponges, solubility enhancement, drug delivery.
A-212
Current Use and Future Prospects of Nanoparticles Containing Anticancer Drugs
Neeraj Kandpal, Tarun Gupta, Vasu Sharma, Jyotsana Suyal
The pathological process of cancer is quite complicated. Ineffectiveness, cytotoxicity, the development of
multi-drug resistance, and the creation of stem-like cells are only a few of the issues with today's
chemotherapy. Nanoparticle-based drug delivery provides some distinct advantages over conventional drug
delivery, including greater permeability and retention effect, improved stability and biocompatibility, and
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precision targeting. Materials with distinct optical, magnetic, and electrical properties, nanoparticles are
small (1–100 nm)sized object Several major criteria can be used to classify nanoparticles utilised in cancer
therapy. These nanoparticles, which target cancer cells, the tumour microenvironment, and the immune
system, have been modified for a variety of cancer therapies to overcome toxicity and lack of selectivity,
improve drug capacity, and increase bioavailability. Even though there has been more research, there
haven't been many more authorised nano-drugs over time. It has been demonstrated that overcoming
cancer-related drug resistance can be accomplished using nanoparticle-based drug delivery systems.
Research on targeted drug delivery using nano-carriers is still needed to lessen toxicity, increase
permeability and retention effects, and lessen -the protein corona shielding effect to improve clinical
translation. This article summarises a variety of nanomaterials that are currently used for anticancer
therapies and discusses the essential relevance of their physicochemical features in cancer management, as
well as the use and potential of new nanoparticles for drug administration in chemotherapy.
Keywords: Nanoparticles, Drug Delivery System, Chemotherapy, Applications.
A-213
Novel approaches of polyherbal matrix tablet in term of better therapeutic efficacy
Muskan Kumari Prasad, Jaya Rautela, Vikash Jakhmola
jayarautela01@gmail.com
Polyherbal tablets are a blend of various plant-based ingredients that have been used in traditional medicine
for centuries. Because of their possible therapeutic benefits and negligible side effects, these tablets have
become incredibly popular in recent years. Synergistic effects can result from combining various plants into
polyherbal pills, which can increase each herb's therapeutic potency. The most current developments in this
area are outlined in this update on polyherbal tablets. The potential benefits of polyherbal pills in treating
conditions like diabetes, cancer, cardiovascular disease, and respiratory ailments have been well
investigated. The effectiveness of polyherbal tablets in treating various disorders has been shown in a
number of preclinical and clinical investigations. The bioavailability and pharmacokinetics of polyherbal
tablets have also been greatly enhanced by the development of novel extraction and formulation procedures.
The creation of tailored delivery systems for polyherbal tablets has also been made possible using
nanotechnology and other cutting-edge techniques, increasing their therapeutic efficacy. Overall, this
update emphasizes the potential of polyherbal tablets as an additional treatment option for a variety of
illnesses.
Keywords: Polyherbal, Therapeutic efficacy, Bioavailability, Drug interactions.
A-214
Mucoadhesive agent in recent advancement of Nasal Drug Delivery System
Itika Guleria, Jaya Rautela*, Vikash Jakhmola
jayarautela01@gmail.com
The field of nasal drug delivery has gained significant attention in recent years due to its numerous
advantages over other drug delivery routes. Muco-adhesion, which refers to the ability of a material to
adhere to mucus, is a critical factor in enhancing the efficacy of nasal drug delivery. Muco-adhesive drug
delivery systems can improve drug residence time, increase absorption, and reduce the frequency of drug
administration. Maximizing the power of muco-adhesion in nasal drug delivery involves designing and
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developing muco-adhesive drug delivery systems that can effectively interact with nasal mucosa. Several
factors, such as surface energy, molecular weight, and the type of polymer used, can influence the muco-
adhesive properties of drug delivery systems. Understanding the relationship between these factors and
muco-adhesive properties is crucial in optimizing nasal drug delivery. Nasal drug delivery is a promising
route for delivering various drugs, including peptides, proteins, and vaccines. However, the nasal mucosa
presents numerous barriers to drug absorption, such as mucociliary clearance and enzymatic degradation.
Therefore, developing muco-adhesive drug delivery systems that can overcome these barriers is essential to
improve drug efficacy. In conclusion, maximizing the power of muco-adhesion in nasal drug delivery is a
critical factor in enhancing drug efficacy.
Keywords: Muco-adhesion, Nasal drug delivery, Enhanced efficacy, Mucoadhesive polymers.
A-215
Drug products of Recombinant DNA technology
Samiya, Taru Saklani, Vikash Jakhmola
Introduced are the moves toward making a recombinant DNA particle, instances of recombinant medication
items, a portrayal of DNA fingerprinting strategies for diagnosing infections, a conversation of the
protecting of recombinant medications, and a plan for this progressive biotechnology. Building a
recombinant DNA particle includes cutting the DNA into sections with limitation endonucleases and re-
joining the pieces in original game plans with ligase. Proliferating the particle in a microorganism, or
cloning, is important to expand the quantity of quality duplicates to work with identification of the quality
of interest and to create the protein it encodes. Recombinant DNA drug items have been fostered that
address the communicator, underlying, and modifier classes of proteins. Recombinant communicator
proteins incorporate interferons alfa-2a and alfa-2b and granulocyte-macrophage province invigorating
component (invulnerable framework modulators); epidermal development element and erythropoietin
(tissue fix advertisers); and human insulin, development chemical, and atrial peptide (digestion
modulators). Recombinant underlying proteins incorporate hepatitis B infection antibody and CD4 protein,
and recombinant modifier proteins incorporate tissue plasminogen activator and superoxide dismutase
(specialists that split or graft natural atoms). Later on, quality deformities related with hereditary sicknesses
will be unwound, prompting the development of new restorative specialists intended to check or really
invert those imperfections. Recombinant protein medications will be additionally custom-made to upgrade
their action and particularity. These advances are so novel and earth shattering that patent security has been
stretched out not exclusively to recombinant medications however to the recombinant microorganisms
wherein they are fabricated. In cloning qualities, examiners straightforwardly utilize the protein plans that
happen normally. Fundamental exploration will before long prompt the designing of novel proteins with
determined capabilities.
Keywords: DNA, Biotechnology, Protein, Clones.
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A-216
Review on roll of traditional herbal drugs in treatment of Age-related CNS disorders.
Parul Sharma, Rishi Pal, Irfan Ali, Hema Chaudhary
K.R. Mangalam University, Gurugram
parulsharma1190@gmail.com
Natural drugs have always been a part of Indian tradition as well as in developing countries around the
world. Alzheimer’s disease is a neurodegenerative which mainly cause due to aging, cognitive impairment
and mood disorders. The conventionally used drugs possess many side effects and the cost of modern drug
is beyond the reach of most people with low income. Because of this need of alternative that are effective,
cheap, and safe is very common. In this review the roll of traditional herbal drugs treatment of various age-
related CNS disorders are presented.
Keywords: Alzheimer’s disease, CNS, Age, Safe.
A-217
Formulation and evaluation of transdermal therapeutic system for
delivering nano size Itraconazole
Ashutosh Badola*, Anjali Gurung
ashutosh.badolam.pharma@gmail.com
The main purpose of this study is to illustrate that Itraconazole is an antifungal drug that possess poor
solubility, gastrointestinal irritation, and first-pass effect. Hence, it was initially made as nanoparticles to
facilitate absorption and at a later stage, nanoparticles-loaded transdermal patches were developed using
promising nanoparticles. Nanoparticles were prepared with Eudragit RL 100 by ‘solvent displacement
technique’. Formulations were prepared by using different concentrations of Eudragit RL 100 and polyvinyl
alcohol and evaluated for drug content, drug release, entrapment efficiency, and mean particle size. The
obtained patches were evaluated for thickness, tensile strength, folding endurance, moisture absorption, and
moisture content and drug release showed biphasic release.
Keywords: Itraconazole, Nanoparticle, Transdermal Patch, Biphasic Release.
A-218
An overview: Viral infection and their mode of entrance in host cells
Akanksha Bhatt*,Neelima Kukreti,Surbhi Panwar, Prerna Uniyal
1
School of Pharmacy, Graphic Era Hill University, Clement town, Dehradun, Uttarakhand
akankshabhatt@gehu.ac.in
Disease caused due to infections is known from ancient time to human beings. The reason behind them is
different type of microorganisms like bacteria, virus, fungi etc. that alters the function of immune system.
The structure of virus is quite simple and consisting of protein coat, nucleic acid, viral enzyme and lipid
enveloped seen sometimes. The virus uses the host to grow, develop and complete its replication cycle. The
fight between human and virus is a continuous process as these are ultra microscopic agents having either
RNA/DNA in its genetic material. The awareness about the virus will be well known by knowing the
details repairing their mechanism of infection and involvement of host for its replication.
Keywords: Virus, Host, RNA, DNA.
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A-219
Essential oil: New hope to overcome antimicrobial resistance
Surabhi Shakya, Amit Kumar Verma
Dept. of Pharmacy, MJP Rohilkhand University, Bareilly, U.P
Essential oils are long back known to history and are used as an alternative approach for the treatment of
different ailments. The market area of essential oil is broad, and its uses are enormous. The volatile
constituents present in the different types of oils like clove oil, jojoba oil, palmarosa oil, rose oil, citronella
oil, lemongrass oil, borage oil, and many more are responsible for different- different pharmacological
activities. Many of the oils have the same active constituents and can provide synergistic effects. The
researchers of different areas concluded by their study that they are potent agents to combat the problem of
antibiotic resistance. Crude oil and its vapours are effective in many therapeutic activities. Synergistic
effect of essential oil with conventional antibiotics observed in many studies even in the cases of antibiotic-
resistant bacteria.
Keywords: Essential Oil, Antibiotic Resistance, Antimicrobial, Antibacterial, Aromatherapy.
A-220
Development and evaluation of oral dispersible film of local anaesthetic agent
Ruchi Sharma1, Deepika Joshi2*
1
GRD (PG) IMT Pharmacy, Dehradun, 248001, India
2
School of Pharmacy, Graphic Era Hill University, Clement TownDehradun, 248001, India
ruchisharma2511@gmail.com; ocimum05@gmail.com
To ensure patient compliance and effective drug delivery, the development of several polymeric oral dosage
forms. A convenient technique to administer medication is by oral dissolving film (ODF). The focus of this
work was to formulate a lidocaine based ODF using solvent casting method with a moderate thickness,
quick disintegration time, and local anaesthetic action. The polymeric film foundation of the ODF was
constructed using carbopol, glycerin, citric acid, and hydroxypropyl methyl cellulose by adjusting the ratio
of each excipient, the ideal composition was found. Significant differences in thickness existed in the range
of 0.03 ± 0.01 to 0.05 ± 0.01 mm. Drug content in the films was evaluated. Lidocaine Hydrochloride ODFs
formulation showed the release of 71.84% of lidocaine within 5 mins and 96.42% of lidocaine in 5 min.
According to these findings, lidocaine ODF was properly produced and demonstrated a quick release of
lidocaine for local anaesthetic action.
Keywords: Oral,Dissolving, Film, Lidocaine, Local Anaesthetic Action.
A-221
The newer skin model for Cosmeceuticals testing
Aashta Gajjar
IndukakaIpcowala College of Pharmacy, New Vidyanagar, Anand, Gujarat, India-388121
Cosmeceuticals are designed to serve a dual purpose: to provide desired esthetical effects and to treat
dermatological conditions. Natural products derived from plants and marine organisms are a novel source
of potential cosmeceutical active ingredients for incorporation into new formulations due to consumer
demands. Contrary to common perceptions, most regulatory agencies do not view cosmeceuticals as being
a separate category from cosmetics; thus, these products are not regulated accordingly, thereby forcing the
consumer to rely on the self-regulatory policies of the cosmetics industry. Cosmeceuticals are advertised as
having capabilities that include anti-aging, anti-acne, solar-protective, wound healing, and skin
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whitening. So, for the testing of the cosmeceutical products many new techniques have been developed.
The techniques used are in-vitro, Ex-vivo. The total ban of animal experiments by strict EU regulations,
scientists in the cosmetic industry have been relying on cultured primary cells in 2-D or 3-D. Our
comprehensive portfolio for dermatological portfolio not only offers scientists to work comfortably with 2-
D or 3-D cell cultures but also allows to generate organoids or perform co-culture experiments with
different cell types from matched donors.
Keywords: Skin, Cosmeceuticals, Industry, Cell cultures.
A-222
Nano Drug Delivery for Neurological Disorders
Rimpal Kanyal*
Devasthali Vidyapeeth Institute of Pharmacy
rimpalkanyal93.rk@gmail.com
Neurological disorders represent one of the major health issues worldwide. In the recent decade the
researcher and the drug designers have been broadly growing attention to new nanotechnology strategies to
improve the delivery of drug to the central nervous system (CNS). Nanotechnology has a great potential to
affect the treatment of neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, Brain
tumours, neuroAIDS and Brain stroke. The application of several functionalized nanomedicine on the
molecular and cellular levels has yielded a lot of promising progress in various fields including disease
diagnosis, gene delivery, cell therapy. Nano-neuroscience is thereby emerging as an exciting field of study
and a promising future direction for the treatment of various neurological disorders.
Keywords: Nanomedicine, AIDS, Tumours, Gene.
A-223
Precision Medicine
Shivam Kumar*
Precision medicine is one of the recent and powerful development in medical field, which has potential to
improve the driven practice of medicine. Precision medicine which enhances the ability to positive real time
decision support. The ambition of precision medicine is to design and optimize the pathway for diagnosis,
therapeutic intervention by using large multidimensional biological datasets that captures individual
variability in genes, function and environment. The power of precision medicine to personalize care is
enable by several data collection and analytics technology. The potential of precision medicine is to be
yield more precise diagnosis, predict disease risk before symptoms occurs and design customized treatment
plans that maximize safety and efficacy. Precision medicine marks and new relationship between genomics
and drug discovery, one that provide both inside into the mechanism and potential treatment options of a
single patient disease.it is making and impact on patients, health care, delivery system and research
participants. Precision medicine has become an essential issue in the medical community as the quality of
medical care is being empathized now a days.
Keywords: Precision, Medicines, Therapeutic, Intervention, Medicine.
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A-224
Medicinal Properties and Uses of Bryophyllum Pinnatum (Pattharchata)
Taru Saklani, Janhvi Dubey, Jasvinder Singh, Harsh Chaudhry, Tanuja Vyas
The well-known medicinal plant Bryophyllum pinnatum also referred to as PATTHAR CHATTA, has been
utilised in numerous traditional medical systems. This covers the treatment of debility generally fever,
smallpox, cough, asthma, headache, and convulsion. Steroids, alkaloids, flavonoids, terpenoids, fatty acids,
protein, vitamins, polysaccharides, and other substances have all been found as secondary metabolites from
B. pinnatum. Additionally, numerous investigations have demonstrated that B. pinnatum extracts and
purified substances have a wide range of pharmacological actions both in vivo and in vitro. These include
nephroprotective, hepatoprotective, antileishmanial, antiulcer, antihypertensive, anti-diabetic,
anticonvulsant, antiallergic activity. This botanical overview highlights the chemical components and
medical applications of plant. Traditional ethnomedical customs alleviate kidney stones and urine
insufficiency with Bryophyllum pinnatum. As an aspect of folk medicine for kidney and gall bladder
stones, several tribes from Uttar Pradesh, some districts of West Bengal, Maharashtra, the Nath people and
people in Dibrugarh of Assam use fresh leaf juice or powder. The presence of saponins and antioxidant
phytochemicals like flavonoids and polyphenols may have aided in the antilithiatic effect by causing the
stone to dissolve. It helps in maintaining good kidney health if leaf juice is taken in small prescribed
amount as it decreases oxidative stress on kidney and also help in detoxification of kidney. It has vegetative
leaves so it can be grown very easily for bulk availability to people. It can be a good source of green
medicine with very less or no side effects.
Keywords: Steroids, flavonoids, antiulcer, nephroprotective, saponins, alkaloids, phytochemicals.
A-225
Design expert based approach for statistical optimization of antihypertensive Losartan
potassium Nanoparticles using Box- Behnken Design
Bhawana Kapoor1, Bilandi Ajay2, Bhatt Sarswati Prakash3
1
Research Scholar, School of Pharmaceutical Sciences, RIMT University, Mandi Gobindgarh, Punjab; 2Principal,
College of Pharmacy, RIMT University, Mandi Gobindgarh, Punjab; 3Associate Professor, Uttaranchal Institute of
Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand
The aim of the present study was to optimize the formulation of losartan potassium loaded nanoparticles for
the management of hypertension. For the analysis, the polymer concentration, amount of surfactant, and
sonication time were chosen as independent variables while particle size and entrapment efficacy were
chosen as dependent variables. Design of experiments (DOE) approach was used to statistically evaluate
the effect of formulation variables on response variables. Experimental runs or formulation designs were
based on Box–Behnken designs and response surface methodology. According to this design, 17
formulations were prepared. The prepared formulations were evaluated for various physical and chemical
parameters. The results when analyzed, give the optimized nanoparticle formulation with particle size of
423.4 nm, zeta potential -11.4 mV, and entrapment efficiency 85.57%. The observed responses were
remarkably similar to the predicted values. The best fit model for optimized batch is Higuchi model with
highest r2 value of 0.935. It could be stated from the results that Box-Behnken Design with response surface
method using DOE based statistical approach is an efficient means to determine and optimize formulation
conditions within experimental conditions and can be used for subsequent formulation development.
Keywords: Nanoparticles, box-behnken design, response surface methodology, design of experiments.
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A-226
Polypharmacological and computational approaches to establish HDAC inhibitors in the
treatment of Alzheimer
Pallavi Pandey1, Samiya1, Sakshi Duklan1, Mohammad Asif2, Vikash Jakhmola1, Prinsa3, Supriyo Saha1*
1
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Premnagar, Dehradun-248007,
Uttarakhand, INDIA.
2
Department of Pharmaceutical Chemistry, Era College of Pharmacy, Era University, Lucknow, 226003, Uttar
Pradesh, India
3
Siddhartha Institute of Pharmacy, Saharastradhara Road Near IT-Park Dehradun 248001.
Alzheimer is a progressive cognitive condition with significant loss of neuronal functions, formation of
amyloid plaque and neurofibrillary tangles. Gamma secretase, acetylcholinesterase (AChE),
butyrylcholinesterase (BuChE) and GSK-3beta enzymes regulated the progression of Alzheimer disease.
HDAC6 enzyme also improved the axonal activity. In this manuscript, we repurposed the role of HDAC
inhibitors [HDACi(s)] towards the treatment of Alzheimer disease by inhibiting gamma secretase (6LQG),
AChE (7AIT), BuChE (6QAE) and GSK-3beta (3GB2) enzymes. Here we considered 60 HDACI then
filtered out 16 molecules using SWISS-ADME parameters. Docking score of Analog 45 and Analog 57
against 6LQG, 7AIT, 6QAE and 3GB2 were (-) 9.7 kcal/mol, (-) 13.5 kcal/mol, (-) 11.2 kcal/mol, (-) 9.7
kcal/mol and (-) 7.4 kcal/mol, (-) 11.5 kcal/mol, (-) 9.5 kcal/mol, (-) 7.8 kcal/mol respectively; whereas
rivastigmine showed docking score of (-) 5.3 kcal/mol, (-) 8.0 kcal/mol, (-) 7.2 kcal/mol, (-) 6.1 kcal/mol.
Based on docking score, we selected (E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-1,2,3-triazol-4-
yl)acrylamide (Analog 45), N-methyl-4-((3-(pyrrolidin-1-ylmethyl)-1H-indol-1-yl)methyl)benzamide
(Analog 57) and rivastigmine for further studies. Then we performed OSIRIS-MOLINPIRATION profiling
to observe the most effective and low toxic molecule. Analog 57 passed the criteria. Finally we performed
FMO and EPS analyses using (B3LYP) 6-311G+(d,p) to observe the electronic nature of the molecule.
HOMO orbital localized on indole nucleus and LUMO orbital localized on N-methyl benzamide group.EPS
analysis data showed that nitrogen atoms of pyrrolidine and indole [3-[(pyrrolidin-1-yl)methyl]-1H-indole
of this nucleus] and also O=C-N of benzamide nucleus were feasible for electrophilic attack. In the same
manner, benzene of indole ring and terminal methyl group of benzamide were the suitable for nucleophilic
attack. Finally we stated that N-methyl-4-((3-(pyrrolidin-1-ylmethyl)-1H-indol-1-yl)methyl) benzamide
repurposed for the management of Alzheimer.
Keywords: Polypharmacology, HDAC inhibitor, Alzheimer, Molecular docking, OSIRIS-
MOLINSPIRATION, FMO analysis, ESP analysis.
A-227
Dysfunction of Thyroid hormone during pregnancy
Ahmed AyuvaDawa*, Dipika Rawat
Uttaranchal College of Health Sciences, Uttaranchal University, Dehradun,Uttarakhand, India
Thyroid dysfunction in pregnancy is very bad, because it has a lot of effects on the mother and its baby.
Some of the problem encounters are eclampsia, prematurity, and congenital abnormality. Thyroid disorders
are ordinary encounter during pregnancy, due to complex hormonal changes during pregnancy. Subclinical
hypothyroidism is the most common thyroid disorder because there is an increase in thyroxine dose by 20 –
40% during first stage of pregnancy. Hyperthyroidism can be treated, unless it’s related to human chorionic
gonadotropin.in the first trimester Propylthiouracil should be given to the mother and in the second
trimester carbimazole may be offer to the mother. Hyperthyroidism is commonly encountered by women
with Graves’ disease or history of it due to thyrotropin receptor antibodies and so for this reason they have
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1 - 5% risk of fetal hyperthyroidism. So, treatment of hyperthyroidism in pregnant women is very important
and necessary for safe pregnancy with minimal maternal and neonatal complications.
Keywords:Thyroid, Pregnancy, Fetal, Hyperthyroidism.
A-228
Relationship of Blood Pressure on Type 2 Diabetes Mellitus patient
Okoro Chibuike Bonaventure*, Dipika Rawat
Uttaranchal College of Health Sciences,Uttaranchal University, Dehradun,Uttarakhand, India
Hypertension and type 2 diabetes are common comorbidities. Hypertension usually occurs to patients with
diabetes compared with those who do not have diabetes. Patients with hypertension have greater
probabilities of developing diabetes. The major cause of morbidity and mortality in diabetes is
cardiovascular disease, which is aggravated by hypertension. Diabetes and hypertension are closely
interlinked because of their similar risk factors such as endothelial dysfunction, vascular inflammation,
arterial remodelling, atherosclerosis, dyslipidemia, and obesity. There are health risks and complications
associated with type 2 diabetes when it isn’t diagnosed and treated in time which include eye damage, heart
disease and stroke, high blood pressure, kidney disease, mental health diseases and nerve damage &
amputation. There is no cure for type 2 diabetes, but it may be possible to reverse the condition to a point
where you do not need medication to manage it by controlling blood sugar through diet, oral medication, or
insulin injection. Insulin injections is often required for type 2 diabetes patients. This is delivered through a
small tube called catheter this is placed under the skin.
Keywords: Hypertension, Health, Diabetes, Insulin
A-229
In silico study of Tephrosia Purpurea phytocompounds as Antidiabetic agent
by targeting α-Glucosidase and α-Amylase enzyme
Shivani Rawat*
School of Pharmaceutical Sciences, Sardar Bhagwan Singh University, Balawala, Dehradun, Uttarakhand, India.
Tephrosia Purpurea (Sarapunkha) plant in traditional medicine used to treat diabetes mellitus. Rutin
phytochemical was found to improve b-cell granulation and damage in recent studies. Diabetes mellitus has
reached global epidemic extents predictable to affect 693 million adults by 2045. Problems caused by
diseases are like cardiac disease, diabetic nephropathy, retinopathy, and neuropathy which are the leading
cause of mortality. Diabetes mellitus targeting alpha glucosidase and alpha amylase enzymes receptors are
clinically effective. Gastrointestinal discomfort like flatulence and diarrhoea are major side effects that
leads to demand for discovering new drug candidates with improve beneficial effects and
tolerability.Conventional drug discovery is a very complex and slow process however, in silico techniques
can make this process simple and economic. To find out other phytoconstituents a virtual screening of 80
phytocompounds of plant is done against alpha glucosidase and alpha amylase enzymes.PyRx software
were used for the molecular docking studies, the results were visualized using Discovery Studio Visualizer.
All the docked structures were evaluated based on the binding affinity followed by ADMET and
Druglikeness analysis. Following phytoconstituents showing binding energies of lanceolatinabiflavonoid (-
9.3 kcal/mol), rutin (-8.4 kcal/mol), glabratephrin (-8.0 kcal/mol) are the best among all the
phytoconstituents for alpha glucosidase. (-)-isolonchocarpin (-8.6 kcal/mol), pongaglabol (-8.5 kcal/mol)
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showed the best result against alpha amylase. Tephrosia purpurea can serve as a good natural inhibitor to
block the enzymes and can be used in the treatment of Diabetes mellitus.
Keywords: Tephrosia Purpurea, Molecular Docking, Diabetes mellitus.
A-230
Baicalein loaded solid lipid nanocarriers for neurodegenerative disorders
Mansi Varshney, Poorvi Varshney*, Bhavna Kumar, Neeraj Kumar Sethiya, Manmohan Singhal
Faculty of Pharmacy, DIT University, Dehradun-248009, Uttarakhand, India
Varshneypoorvi74@gmail.com
Neurodegenerative disorders such as Parkinson disease, Alzheimer disease, etc are defined as
progressiveand chronic disorders which causeloss of neurons and oxidative stress. The treatment of brain
disorder is challenging due to presence of blood brain barrier and blood cerebrospinal fluid barrier, but the
discovery of nanotechnology has overcome this challenge. The main aim of this study is to formulate and
evaluate the Baicalein loaded solid lipid nanoparticles (SLNs) for the delivery to brain via intranasal route
for the treatment of neurodegenerative disorders. Solvent emulsification diffusion method was selected for
the preparation of baicalein loaded SLNs. The optimized formulation was characterized for parameters like
particle size, particle shape using Transmission electron microscope (TEM) and scanning electron
microscope (SEM), for drug and polymer interactions using differential scanning calorimetric (DSC) and
X- Ray Diffraction (XRD). The particle size of baicalein loadedsolid lipid nanoparticles was found to be
755.2 with a zeta potential of -32.5mV. The drug loading and entrapment efficiency of optimized
formulation was found to be 18.2 % ± 0.553 and 88% ± 0.553 respectively. Optimized formulation showed
the in- vitro drug release of 84.6% within 30 minutes. Hence, the achieved results proved that baicalein
SLN can be a futuristic approach to target the brain in neurodegeneration via intranasal delivery.
Keywords: Alzheimer’s, Baicalein, Intranasal delivery, Parkinson’s, Solid lipid nanoparticles.
A-231
Nanocarriers: A potential tool for topical delivery of Antihypertensive drugs
Archana Sharma, Rupa Mazumder, Ganesh Kumar
Noida Institute of Engineering & Technology (Pharmacy Institute), Greater Noida, India
hiarchanasharma@rediffmail.com
Hypertension is considered a high blood pressure condition when systolic pressure is 140 mm Hg or more
and diastolic pressure is approx. 80 to 90 mm Hg. Today hypertension is one of the popular cardiovascular
diseases which affect mankind in mass all over the world. However, there are a surplus amount of oral
antihypertensive drugs are available in the market, still, the management of disease with oral therapy is
associated with various critical GI side effects and requires long term treatment. Apart from this
conventional delivery system also suffers from extensive first pass metabolism and poor patient
compliance. Hence there is an urge to develop such a type of delivery system that not only effectively
deliver the drugs with improved bioavailability but also bypass the obstacles of the conventional delivery
system. In this context, the topical delivery system shows an eminent pathway by enhancing drug delivery
through the skin and avoiding first pass metabolism. But the use of chemical enhancers restricts its utility,
therefore it is desirable to prepare a topical delivery system by replacing the adversity of chemical enhancer
with some novel methodology. Nanocarriers are proved to be a promising alternative, the smaller particle
size leads to increased drug permeability, improved stability and bioavailability, and thus better patient
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compliance. This present article provides an overview of different antihypertensive drugs formulated as a
nanocarrier for topical delivery of drugs with reduced side effects, enhanced bioavailability, and better
patient compliance.
Keywords: Antihypertensive drugs, Nanocarriers, Topical delivery system.
A-232
Development of unnatural amino acids (UAA’s): A trendy scaffold for innovative
pharmaceutical research
Rupali Joshi*, Gurjeet, Ajay Singh Bisht
Himalayan Institute of Pharmacy & Research, Dehradun-248007, Uttarakhand, India
Unnatural amino acids synthesis is a region of research that has gained a lot of interest in modern years.
The accessibility of different synthetic routes for new unnatural amino acid derivatives and related
compounds will be a critical point in the designing of novel molecules that impersonate the conformation of
the natural, active peptides. These molecules (peptidomimetics) are specially designed to show the high
receptor affinity and selectivity with enhanced bioavailability and metabolic stability of the drug molecule.
Thus, this study focuses on detailed synthetic methods and analogues leading to synthesize variety of
unnatural amino acids including various schemes that includes enantioselective synthesis and microwave-
assisted synthesis also. Development of new methods for the synthesis is currently attracting the organic
chemists due to the discovery of many chemical entities with their varied biological activities. As it is
already known, amino acids are the important biological molecules. They are the building blocks of
proteins, and the twenty proteogenic L-amino acids (exception of glycine) are ubiquitous to all living
organisms on earth.Unnatural amino acid (D-amino acids or amino acids with non-natural side chains) and
their polymers that contain β- and γ-amino acids are known as "foldamers." These foldamers form long-
lasting, predictable structures that are very stable and resistant to proteolytic degradation. They can be
designed to interact with specific targets and have applications in medicine, materials and general
healthcare.Unnatural amino acids are of particularly interest for drug development and drug optimization.
So there is growing interest for the synthesis of various unnatural amino acids and their derivatives as new
medicines and other pharmaceuticals. Various organic chemist and researchers were developing different
protocols but still there is a great need of a drug candidate which is more effective and more selective.
Current study summarized various synthetic methods and procedures and their pharmaceutical uses. All
mentioned research shows a remarkable creativity of those procedures and also involved in the design of
novel unnatural amino acid and their derivatives. Without any doubt, it can be concluded that novel
synthetic methodologies to construct various unnatural amino acids will continue to provide new ways for
pharmaceutical drug design.
Keywords: Unnatural Amino Acids, Peptidomimetics, Enantioselective Synthesis, Optimization,Design.
A-233
Interest towards versatility of Iridoids and its novel mechanistic approach
Monika*, Neeraj Kumar
Research Scholar, School of Pharmaceutical Sciences, Shri Guru Ram Rai University,Patel Nagar, Dehradun-248001,
Uttarakhand, India
The active substances that found the plant world are called iridoids. These are the varieties of
monoterpenoid, also present in some mammals, in the general form of cyclopentanopyran. They are
generally dicotylendous plants that are more common in the plantae kingdom, including the
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Scrophulariaceae, Pyrolaceae, Oleaceae, Labiatae, Rubiaceae, Gentianaceae, Apocynaceae, Lamiaceae,

Loganiaceae, and Verbenaceae families. They come from the biosynthesis of 8-oxogeranial and are
normally present in plants as glycosides, frequently linked to glucose. Iridoids are bicyclic cis-fused
cyclopentano pyrans from a structural perspective. Oleuropein and amarogentin are examples of
secoiridoids, which are created when a bond in the cyclopentane ring is broken. These are the components,
usually found in the fresh leaves and juvenile stems of plants, but sometimes rarely in the fruits and sprouts,
that belong to the broad and extended class of cyclopentane pyran monoterpenes. Iridoids' metabolites are a
topic of interest to researchers due to their versatile spectrum of biological activities like neuroprotective,
hepatoprotective, anti-inflammatory, antitumor, hypoglycaemic, and hypolipidemic activities along with
advantages like offering a fresh approach for the creation of new drugs and research focusing on. In order
for a rational consumer of information to be useful in the creation of therapeutic options, the present
review's goal is to give extensive information about iridoids and its biological activity.
Keywords:Iridoids, Oleuropein, Hypoglycaemic, Hepatoprotective, Hypolipidemic.
A-234
Therapeutic potential of Curcuma Caesia (black turmeric) for topical drug delivery
Kushwaha Amit*, Kapoor Bhawana, Kala Shivani
Maya College of Pharmacy, Dehradun, Uttarakhand, India
Curcuma Caesia commonly known as black turmeric is one of the rare perennial herbs that is now a day
widely being exploited by the researchers for its therapeutic benefits or pharmaceutical applications. It is
native to northeastern and central India where it is used for numerous medicinal purposes. Its medicinal
properties come from different parts of its plant such as rhizomes, leaves, roots, inflorescence, and flowers.
Various active constituents present in the plant like alkaloids, terpenes, glycosides, steroids, volatile oils,
proteins, carbohydrates, anthraquinones contribute to its broad-spectrum biological activities including
antioxidant, anti-inflammatory, antimutagenic, antitumoral, wound healing, antibacterial, analgesic,
antifungal and anti-angiogensis effects etc. In recent studies by researchers, pharmaceutical use of these
therapeutic benefits of black turmeric mainly involves the formulations for topical drug delivery mainly
using its rhizomatous extract. Topical gel formulation is gaining more attention due to its better application
property and stability in comparison to other topical preparations like creams and ointments. Use of nano
system based approach in topical formulations of curcuma can further aid in its percutaneous absorption.
Studies suggest that novel system based topical formulations of Curcuma Caesiacan contribute greatly to
the treatment of various skin ailments such as fungal infection, eczema, atopic dermatitis etc.
Keywords: Curcuma Caesia, topical gel, atopic dermatitis, anti-inflammatory, antioxidant
A-235
Mishandling of pMDI and DPI inhalers in Asthma and COPD
Manish Kumar*, Poonam Joshi
Uttaranchal Institute of Pharmaceutical Sciences, Premnagar, Dehradun-248007, Uttarakhand, India
drmanishkumar06@gmail.com
Asthma and COPD are persistent respiratory diseases that affect large numbers of people around the world.
These infections require drivers to use medications carried in inhalers, such as pMDI(compressed metered
dose inhaler) and DPI (dry powder inhaler) inhalers. However, the suitability of these inhalers often
depends on legal handling and use. Misuse of these inhalers can lead to f aulty prescription delivery and
poor treatment results. Common mistakes in handling these inhalers include not shaking the pMDI before
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use, not preparing it, performing an incorrect inhalation procedure, not cleaning the inhaler regularly and
use a n expired inhaler. Failure to shake pMDI before use can lead to a dosing conflict, as can failure to
prepare it. The wrong inhaler strategy can lead to improper drug delivery to the lungs, and failure to
consistently clean inhalers can lead to discoloration and reduced prescription fit. Similarly, the use of
expired inhalers can lead to faulty delivery of the drug. Misuse of pMDI and DPI inhalers can lead to
devastating side effects, prolonged hospital stays and decreased personal satisfaction in patients with
asthma and COPD. Patients should be legally prepared for the most effective method of using an inhaler
and should follow the manufacturer's instructions carefully. Healthcare providers should educate patients
about the importance of legal care and use of inhale rs and should screen patients for inhaler use to ensure
compliance and availability. Together, the legal handling and use of pMDI and DPI inhalers are essential to
viable treatment of asthma and COPD. Healthcare providers should provide patients with intensive training
in the p roper use of the inhaler and should monitor their use of the inhaler to ensure compliance and
appropriateness. Patients should also be aware of common mistakes when using the inhaler and shou ld do
everything possible to avoid these mistakes to ensure optimal treatment results.
Keywords: Patient, Healthcare, Asthma, Treatment, Prescription, COPD, Inhaler, Medication, Compliance.
A-236
Artificial Intelligence: An achievement of modern Health Care System
Lakshaya Sharma*, Abhishek Sharma
iamtheonerw@gmail.com
Pharmaceutical corporations and chemical experts’ priorities research in the area of drug development and
design. However, there are barriers and difficulties that affect medication design and development due to
low efficacy, off-target delivery, time requirements, and high cost. Microarray data, proteomics, and
genomics put a stumbling block in the drug discovery process. Although image recognition and other fields
have greatly benefited from another disruptive technology artificial intelligence (AI), such developments in
drug discovery are uncommon. The use of artificial intelligence in pharmaceutical technology has grown
over time, and it may help save time and money while also improving our understanding of the connections
between various formulations and process parameters. A subfield of computer science called artificial
intelligence deals with the use of symbolic programming to solve problems. To make the pharmaceutical
profession more effective, numerous studies are being conducted to enhance the currently available AI
technologies. The role of AI in the drug development process is briefly discussed in the current article,
which then examines the numerous AI tools at the disposal of contemporary pharmacists to help with more
effective operation.
Keywords: Artificial Intelligence, Drug discovery, Microarray data.
A-237
Monkey Pox
Himanshu Pandey*, MahamedhaDeorari, Vikash Jakhmola
pandeyhimanshu0447@gmail.com
Monkey pox is a viral disease that was first discovered in 1958. Seeing the cases of monkey pox increasing
in more than 75 countries, World Health Organisation have declared monkey pox as a global health
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emergency. According to the World Health Organization, the first symptoms of monkeypox were identified
in 9-month-old boys. The symptoms of monkey pox can be measured in two-way, Invasion Prior Period
and Skin rash period. Invasive Prior occurs in about 6 to 13 days. It is the phase in which that the virus
raises your body temperature to the optimum level with each beat of your body. The time to start cavitation
is 5 days, and our body will have high fever, cold, body pain, heat week ness severe rashes appear on the
body in 2- 3 days. The rash comes first on our face, it effects 95% of the face, and it affect up to 75% of the
hands and legs then affect 70% of the membrane inside the mouth, it is so dangerous that in 20% of case it
effect the cornea and conjunctiva of the eye. monkey pox virus is spread by airborne and droplets, monkey
pox can be passed from man to man from animal to man even if you meet an infected person. There is no
exact cure for chickenpox. Most infections range from mild to severe. Treatment is usually systemic,
including antibiotics and pain relievers to control pain. A person who has been vaccinated against smallpox
in previous doses is five times safer than someone who has not been vaccinated against smallpox.
Keywords:Smallpox, Monkey Pox, Viral Disease, World Health Organization.
A-238
Onychomycosis: Current Therapy and Future Provocation
Ayushi*, Nidhi Nainwal, Mansi Butola,Vikash Jakhmola
12ayushichauhan@gmail.com
Microbial invasion of the nail bed, nails plate, or maybe both are known as onychomycosis. Many kinds
may trigger onychomycosis, but the pathogens of the group Trichophyton have become particularly
common. Candida is one of the additional organisms, and it is more typical with fingertip infections.
Normally, the cuticles are misshapen and have white or yellow discoloration. Onychomycosis health
condition involves toenail fungus, a tendency of nail fibrosis, greater age, exposure to just a participant who
has onychomycosis/tinea pedis, diabetes or peripheral vascular conditions, and immunocompromise.The
diagnosis may be made by damp mounts, subculture, polymerase chain response, or a combination of each
of these techniques. When necessary, oral itraconazole or oral terbinafine are used as treatments. They
provide much higher cure rates, shorter treatment plans, and fewer adverse events than in the past.
Terbinafine has a cure rate of between 70 and 80 percent with an extremely good tolerance character,
making it even more beneficial than griseofulvin, fluconazole, and even itraconazole at controlling this
illness. The most economical agent is terbinafine. Nonetheless, a few problems still exist that will pose
difficulties in treating onychomycosis in the future, not even the smallest of which is the 20% likelihood of
persistent treatment failure. To maximize the chances of a clinical and mycological cure in a number ofsuch
instances, surgery might have to come before pharmacological therapy. Also, the period of therapy must be
better tailored to each individual instance by early detection.
Keywords: Onychomycosis, Nail Infection, Microbial Invasion, Trichophyton.
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A-239
Comprehensive review on the medicinal plant of northeast region of INDIA
(Solanum torvum)
Himanko Gogoi, Sanskriti Rai
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University
himankogogoi@gmail.com,
The Northeast region of India i.e., Assam, Arunachal Pradesh, Meghalaya, Manipur, Nagaland, Mizoram,
Sikkim, and Tripura are known for their rich fauna and containing enormous amounts of both discovered
and undiscovered plants that possess immense medicinal values and could be of very much use to the
healthcare and pharmacy globally. For all major types of illnesses prevalent in this area, the traditional
medical system is crucial and even the Rigveda and the Atharvaveda both mention how these ancient
medicinal treatments have been working wonders for the local and indigenous tribes from times
immemorial. This is also owing to the fact that the traditional medicinal plant extracts are the only source of
basic healthcare for them. One important medicinal source is the fruits of Solanum torvum (or Turkeyberry)
that are regularly used in North-East Indian food preparations as they are very nutritious and rich in iron.
According to clinical tests conducted on these berries, its contents were determined as Iron (76.869mg/kg),
Manganese (19.466 mg/kg), Copper (2.642mg/kg) and Zinc (21.460mg/kg). It was also found to contain
Vitamin A (0.078mg/100g) and Vitamin C(2.686mg/100g) respectively. As such, these berries may be used
as a haematinic in order to treat anaemia. They also show antioxidant properties due to the presence ofgallic
acid and ferulic acid. In spite of this, no such formulations are being made from these berries that could be
taken by pediatric,geriatric or pregnant women (as they are more prone to iron deficiency) without any
problem. If Solanum torvum berries were formulated in the form of candies, they could be easily available
in the market and show positive effects on women.
Keywords: Medicinal plants, Northeast, Pediatric, Geriatric, Solanumtorvum, Haematinic, antioxidant
A-240
Formulation and Evaluation of Floating Microsponges for ODDS
Rohit Sharma*
Himalayan Institute of Pharmacy &Research, Dehradun, Uttarakhand-248007
Oral route is most preferable route of drug delivery due to easy administration, flexibility in formulation,
low cost and patient compliance. Oral controlled release drug delivery system shows some restriction
associated with gastric emptying time. Too rapid and variable gastric emptying could result in inadequate
drug release from dosage form into absorption window leading to low efficacy of administered
dose.Controlled release drug delivery system (CRDDS) provides drug release at a expectable,
predetermined and controlled rate. CDDS is capable to maintain optimum drug concentration in the body
for extended time period, increase activity of duration for short half‐life drugs, reduced dosing frequency,
reduced side effects and drug wastage and better patient compliance. This system is able to improve gastric
residence time, thus improve drug solubility, minimize drug wastage and improve bioavailability. Floating
drug delivery system has application for local drug deliveries to the stomach.Microsponges are small
sponge like micron size spherical units and contain active pharmaceutical ingredient. Microsponges consist
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of an innumerable of interconnecting voids within a non-collapsible structure with a large porous

surface.Microsponges drug delivery system provides controlled release of active ingredients, it offers
various advantages over other technology like improved product stability, reduced side effects, increased
elegance and increased formulation flexibility.Microsponges are mostly used for topical administration and
recently for oral administration also. They can be combined in to conventional dosages forms like
ointments, creams, lotions, gels, tablets and powder and provide broad package of benefits and thus provide
formulation flexibility. Microsponges are ranging from 5-150 μm.
A-241
Development and in-vitro characterization of liposomal embedded in-situ ocular gel of
Dorzolamide hydrochloride for the treatment of Glaucoma
Mohini Rawat*, G. Gnanarajan
Research Scholar, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel nagar,
Dehradun (Uttarakhand) India (248001)
Liposomes is the most common and well-designed nano-carriers for drug targeting delivery. They
have improved therapies for a range of biomedical applications by the help of stabilization
therapeutic compounds, to overcome obstacles to cellular and tissue up-take, and improve bio-
distribution of drug to target sites in vivo. The drug is released from liposomes embedded in-situ
oculargel through diffusion technique. The main objective for this drug delivery system was to
improve bioavailability and enhance the contact resistance time of drug in the eye. Liposomes
were successfully prepared by Reverse phase evaporation technique, and evaluated for
morphology, particle size, entrapment efficiency, zeta- potential, polydispersity-index, drug
content. The invitro studies shows that this dosage form holds great promise for drug release. As a
result, liposomes design showed nearly spherical vesicles. The EE % and DC % could reach up to
88.9% and 92.1% respectively. In vitro release studies show a lipid concentration increase
prolong release of drug from liposomes. Melting point evaluation, IR scan and UV scan of
dorzolamide sample was performed. From the result of above studies, it is concluded that the drug
is dorzolamide. After performing the preformulation study it is found the drug is stable in all ph. In
analytical studies calibration curve of dorzolamide was performed in phosphate buffer pH 5.6, pH
7.4 and pH 6.8. On the basis of study, it was concluded that standard plot was suitable for use in
further analytical studies. Batches of liposomes shows incorporation efficiency increased with
increase in concentration of polymer. Surface of prepared liposomes was characterized with the
help of scanning electron microscopic method.
Kerywords: Ocular Drug Delivery, Liposomes, Nanoparticles, In-situ ocular gel, Glaucoma,
Dorzolamide Hydrochloride.
A-242
Comparative HPTLC profile and Antimicrobial activity of Leaves and Rhizomes of Acrous
calamus Linn
Akriti Rawat, Akash Tyagi, Ajay Singh Bisht
Himalayan Institute of Pharmacy & Research Rajawala, Dehradun (Uttarakhand)
ajay86_pharma@yahoo.com
Present communication attempts to evaluate the comparative study of leaves and rhizomes of
Acorus calamus Linn. (Family; Araceae) using High Performance Thin Layer Chromatography
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(HPTLC). HPTLC is an advanced versatile chromatographic technique for quantitative analyses

with high sample throughout and is complementary to HPLC/GLC. It provides a chromatographic
drug fingerprint. It is therefore suitable for monitoring the identity and purity of drugs. The
HPTLC technique in standardization is required for quantification of marker components by area
under curve, determination of the accurate RF values for the marker components, determination of
the purity of the substance (peak purity) and determination of the absorption maxima of the
substance. Since the plant contains various volatile and non-volatile components so paper
advocates the quantitative study using hexane extract. Acorus calamus Linn. is a well known
medicinal plant in traditional medical systems having various ethno-pharmacological uses. As the
official source of the plant is roots and rhizomes, but here study had been done comparatively with
leaves. Previously leaves of Acorus calamus were not regarded as useful part of plant, but recently
there is growing interest in leaves of the said plant. The leaves are considered to possess various
activities such as an insect repellent, when cut up and kept with grain storage; anti-hyperlipidemic;
anti-diabetic; antipsychotic; anti-inflammatory and analgesic. As there is no detailed work reported
in leaf constituents of the plant, therefore the study revealed specific quantitative HPTLC data for
the plant for future standardization work. HPTLC analysis of both leaves and rhizomes showed the
presence of Asarone, β- sitosterol, lupeol and Ursolic acid when matched with marker compounds.
Antimicrobial activity was also performed using ethanolic extract through cold percolation method
against Staphylococcus aureus, Pseudomonas aeruginosa, Escherischia coli and Salmonella typhi.
The extract was foud to have positive results against all.
Key words: Acorus calamus Linn., HPTLC, standardization, Marker compounds
A-243
Formulation and Evaluation of Mucoadhesive tablets for gastro-retentive drug
delivery using natural polymers
Saheda Begam, Satyam sah
Himalayan Institute of Pharmacy & Research, Dehradun,
Uttarakhand-248007
Oral drug delivery is the most widely utilized route of administration among all the routes [nasal,
ophthalmic, rectal, transdermal and Parental routes] that have been explored for systemic delivery
of drugs via pharmaceutical products of different dosage form. Oral route is considered most
natural, uncomplicated, convenient and safe [in respect to Parenteral route] due to its ease of
administration, patient acceptance, and cost-effective manufacturing process 1. Oral route is the
oldest and most convenient route for the administration of therapeutic agents because of low cost
of therapy and ease of administration leads to higher level of patient compliance. Approximately
50% of the drug products available in the market are administered orally and historically, oral drug
administration has been the predominant route for drug delivery. Tablets are the most popular oral
formulations available in the market and are preferred by patients and physicians alike. In long
term therapy for the treatment of chronic disease conditions, conventional formulations are
required to be administered in multiple doses and therefore have several disadvantages. Sustained
release formulations are preferred for such therapy because they maintain uniform drug levels,
reduce dose and side effects, better patient compliance, and increase safety margin for high
potency drugs2. A tablet consists of one or more drugs (active ingredients) as well as a series of
other substances used in the formulation of a complete preparation. Dosage forms that can be
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retained in stomach are called Gastroretentive Drug Delivery Systems (GRDDS). GRDDS can
improve the controlled delivery of drugs that have an absorption window by continuously
releasing the drug for a prolonged period of time before it reaches its absorption site thus ensuring
its optimal bioavailability. The approaches are used to increase the retention of an oral dosage
form in the stomach include Bioadhesive systems, Swelling and expanding systems, High density
systems and Low density (Floating) systems.
Keywords: Miucoadhesive, GRDDS, Bioadhesive, Bioavaialability.
A-244
Awareness of Intellectual Property Rights among different Universities of INDIA
Ritesh Jha, Pallavi Ghilidiyal
Since almost 150 years ago, the word "intellectual property" has been used to denote the broad area of law
that includes copyright, patents, designs, and trademarks, as well as a number of related rights. In order to
maximize the commercial value of IP, it is crucial to protect it. The purpose of this research is to evaluate
and comprehend the level of intellectual property rights (IPR) knowledge among Indian academics.
Intellectual property rights are currently a prevalent topic of study across all academic fields. Not just for
attorneys, judges, and law students, but also for engineers, scientists, artists, technicians, farmers, and
researchers, it is crucial. Intellectual property is seen as a representation of national wealth that can help the
countries economic grow. However, a nation's intellectual property system will either succeed or fail
largely based on how well-informed the populace is. A descriptive research was carried out to determine
how familiar students were with the idea of IPR Law and to offer potential solutions for its avoidance. The
study's goals were to assess the researcher's level of familiarity with the idea of intellectual property rights,
laws defending them, knowledge of particular IPRs, and the impact of those laws, as well as to propose
potential measures to stop the unauthorized use of IPRs. The study focuses on three key areas: the level of
IP awareness among Indian academics, whether current IP knowledge is useful for commercialization, and
whether Indian academics' current IP knowledge is enough to support their careers and bring in money from
their inventions.
Keywords: IPR, Indian Academics, Knowledge, Awareness.
A-245
Aerosol of Paracetamol
Aman Kumar, Vikash Jakhmola
Uttararanchal Institute of Pharmaceutical Science, Uttaranchal University, Dehardun, Uttarakhand 248007
Aerosol of paracetamol is important because it is a way to deliver of the medicine in lungs or respiration
directly. Aerosol depends upon the function of response of bioavailability .it shows the bioavailability to
approx. 80 to 90%. I know many cases where the patient have fears to tablet or Injection, they also feel
trauma .This research introduced works faster than tablets but slower than Iv .it is also easy to take as a
specific quantity is given for child and adult people. Sometimes a child dos is harder to administration they
expels all medicaments but Aerosol have a quality to absorption in mouth with different variant in Flavors
.Aerosol of paracetamol research may decrease the trauma of patient. Administration of aerosol is easy as
the patient must inhale the given amount of dose through inhaler. Aerosol in a way that when a person
inhales the medicine ,it goes to the lungs and from there it absorbed by the blood stream to the body as
aerosol is in form of fumes or gas particles of paracetanol it is easy to get absorbed by the body and start its
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effect immediately. Aerosol of paracetamol is inhaled (through mouth) aerosol goes to larynx and then
proceed towards trachea goes to primary bronchi >>>> secondary >>> bronchiole >>>> alveoli >>>>
capillary to the main stream of blood .It’s work like inhaler that many Asthmatic patient are using basically
it is contained Powder or liquid that is in highly pressure in the small chamber that easy to carry but
Aerosol of paracetamol is contained liquid or gas. Aerosol of paracetamol research needs deep attention on
the Gaseous or fumes Projection on one time as a specific quantity of Doses form. Other use of aerosol of
paracetamol is pharmaceutics and biomedical fields are highlighted or enhancement is possible.
Keywords: Bioavailability, Administration, Enhancement, Medicament.
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ABOUT THE UNIVERSITY
THE UNIVERSITY CAME INTO ESTABLISHMENT IN 2013, VIDE UTTARANCHAL UNIVERSITY ACT, 2012 (UTTARAKHAND ACT. NO.
11 OF 2013) AS A PRIVATE UNIVERSITY AND IS LOCATED IN DEHRADUN, THE CAPITAL CITY OF THE INDIAN STATE OF
UTTARAKHAND. THE UTTARANCHAL UNIVERSITY HAS BEEN RECOGNIZED BY THE UNIVERSITY GRANTS COMMISSION,
GOVERNMENT OF INDIA UNDER SECTIONS 2(F) AND 12(B) OF THE UGC ACT, 1956, AND OTHER STATUTORY BODIES OF THE
STATE AND THE NATION. THE UNIVERSITY HAS BEEN ACCREDITED WITH THE PRESTIGIOUS “A+ GRADE” BY THE NATIONAL
ASSESSMENT AND ACCREDITATION COUNCIL (NAAC). UTTARANCHAL UNIVERSITY HAS BECOME THE FIRST PRIVATE
UNIVERSITY IN THE STATE OF UTTARAKHAND TO RECEIVE A NAAC A+ GRADE IN THE FIRST CYCLE OF ACCREDITATION AND
THIS FIRMLY POSITIONS US AMONG THE TOP 5% HEIS OF THE NATION. LOCATED IN A SPRAWLING CAMPUS IN THE HEART
OF DEHRADUN, PROVIDING THE BEST FACULTY AND FACILITIES TO PROMOTE ACADEMIC EXCELLENCE, UTTARANCHAL
UNIVERSITY HAS STATE-OF-THE-ART INFRASTRUCTURE, FACILITIES, A LUCRATIVE EDUCATIONAL AMBIANCE, AND DIVERSE
CULTURE.
ABOUT UTTARANCHAL INSTITUTE OF PHARMACEUTICAL SCIENCES

UTTARANCHAL INSTITUTE OF PHARMACEUTICAL SCIENCES (UIPS), ESTABLISHED WITHIN THE VAST, CLEAN, AND GREEN
CAMPUS OF UTTARANCHAL UNIVERSITY, HAS BECOME A RECOGNIZED BRAND IN EDUCATION AND RESEARCH IN
PHARMACEUTICAL SCIENCES. UIPS FOCUSES ON EXCELLENCE IN TEACHING AND RESEARCH. IT STRIVES TO PREPARE
STUDENTS TO BECOME PHARMACISTS AND PHARMACEUTICAL SCIENTISTS WHO WILL BE LEADERS IN THE PHARMACY
PROFESSION. AT UIPS, WE OFFER PROFESSIONAL PHARMACY EDUCATION FROM BASIC TO DOCTORAL LEVEL WITH A
FOCUS ON BUILDING A STRONG FOUNDATION FOR OUR STUDENTS. BESIDES BEING MODERN, THE TEACHING SYSTEM
EMPLOYED HERE IS INNOVATIVE AND APPLICATION-ORIENTED. ADDITIONALLY, WE HAVE WELL-EQUIPPED LABORATORIES,
HIGHLY QUALIFIED AND EXPERIENCED FACULTY, AND SUPPORTING STAFF. PRACTICAL EXPOSURE IS ENSURED BY
TRAINING DURING SUMMER/WINTER VACATION IN COMMUNITY/HOSPITAL FOR THE FIRST YEAR AND SECOND YEAR
STUDENTS, AND INDUSTRIAL TRAINING & RESEARCH PROJECTS FOR THE THIRD/FINAL YEAR DIPLOMA/DEGREE STUDENTS.
THE STUDENTS ARE ENCOURAGED TO DO OPEN-ENDED LABORATORY-ORIENTED AND STUDY-ORIENTED PROJECTS AT THE
DEGREE LEVEL. SEMINARS, GUEST LECTURES, AND WORKSHOPS BY EMINENT SPEAKERS FROM INDUSTRY, HOSPITALS,
RESEARCH INSTITUTES, AND EDUCATIONAL TRIPS & INDUSTRIAL VISITS EXPOSE STUDENTS TO THE BASIC AND ADVANCED
CONCEPTS OF PHARMACY EDUCATION.
ABOUT THE CONFERENCE

UTTARANCHAL INSTITUTE OF PHARMACEUTICAL SCIENCES (UIPS) IS HOSTING A TWO-DAY INTERNATIONAL CONFERENCE
ON THE TITLE “INNOVATION IN PHARMACY AND PHARMACEUTICAL SCIENCES: FROM DISCOVERY TO PRACTICE.” THIS
CONFERENCE IS AN OPPORTUNITY TO EXPLORE NEW AREAS AND ENGAGE IN TOP-LEVEL DISCUSSION RELATING TO
MEDICINE, LIFE-SCIENCES, AND RELATED FIELDS.
ONE OF THE MOST DISTINCTIVE FEATURES OF THE PHARMACEUTICAL FIELD IS CONTINUOUS INNOVATION. THE
DEVELOPMENT OF NEW DRUGS MAY BE ESSENTIAL FOR PRESERVING HUMAN LIFE'S QUALITY OR EVEN DURATION.
INNOVATION IS ULTIMATELY WHAT DEFINES THE PHARMACEUTICAL FIELD. RESEARCH AT THE FOREFRONT OF SCIENCE,
THE DEVELOPMENT OF NEW KNOWLEDGE BASES, THE DISCOVERY OF NOVEL MEDICINES, AND THE ENHANCEMENT OF
ALREADY-EXISTING MEDICATIONS ARE THE DRIVING FORCE FOR THE PHARMACEUTICAL FIELD. THE OCCASIONAL SUCCESS
OF DEVELOPING A NOVEL MEDICINE IN A FIELD WHERE THERE ARE NO EXISTING TREATMENTS IS THE MAJOR
CHARACTERISTIC OF THE PHARMACEUTICAL SCIENCES.
ALTHOUGH INNOVATION IS THE LIFEBLOOD OF ANY INDUSTRY, THE DISCOVERY AND DEVELOPMENT OF NEW MEDICINES IS
ACCOMPANIED BY A HOST OF UNIQUE CHALLENGES, ETHICAL IMPLICATIONS, AND SOCIAL RESPONSIBILITIES. THE GOALS
OF THIS INTERNATIONAL CONFERENCE ARE TO SYNTHESISE SOME OF THE KNOWLEDGE THAT ALREADY EXISTS ABOUT
ORGANISATIONAL AND STRATEGIC ISSUES IN DRUG INNOVATION AND TO CLARIFY THE COMMON BEHAVIOURS,
ORGANISATIONAL STRUCTURES, MODES OF COOPERATION, AND INTERDEPENDENCE PATTERNS THAT ARE CRUCIAL TO ITS
SUCCESS. THIS CONFERENCE WILL SERVE AS A CATALYST FOR ADDITIONAL STUDY AND OPEN THE DOOR TO A MORE
SYSTEMATIC KNOWLEDGE OF THE FACTORS THAT INFLUENCE THE DEVELOPMENT OF EFFECTIVE AND EFFICIENT DRUGS AS
WELL AS THEIR BOUNDARY CONDITIONS.
ADDRESS:
ARCADIA GRANT, P.O. CHANDANWARI,
PREMNAGAR, DEHRADUN,
UTTARAKHAND-248007 INDIA

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IPPS 2023

APRIL 21, 22 2023

Dear esteemed delegates

Welcome to the International Conference on Innovation in Pharmacy and Pharmaceutical Sciences,

Together, we can shape the future of pharmacy and pharmaceutical sciences.

Prof. (Dr.) Satbir S Sehgal

Prof. (Dr.) Dharam Buddhi

It’s my privilege to address the two days International Conference on “Innovation in

I admire all participating hands implicated in the endeavor.

Prof. (Dr.) Rajesh Bahuguna

I am glad to know that Uttaranchal Institute of

With best wishes

Prof. Durgesh Pant

Prof. (Dr.) Vikash Jakhmola

Dr. Nidhi Nainwal

I add my best wishes for a successful and fruitful conference.

A-26 Pharmacognosticalpreliminary phytochemical screening Neetu Singh,Arvind Negi 14

A-63 Formulation, evaluation of scaffold and comparative Lovely Chaurasia, 35

A-77 Proteomics Aarti Sati , Vibhanshu Bansal 43

A-78 Microneedle Patches: A Novel Approach for Transdermal Vanadan Sahani 43

A-170 Bioelectric Medicines: A revolution in Modern Medicine Muskan Bhagat, Sayantan 91

A-229 In silico study of Tephrosia Purpurea phytocompounds as Shivani Rawat 119

A-237 Monkey Pox Himanshu Pandey, 123

premature greying and minimisation of hypogonadism, scleroderma, myotonic dystrophy and

Parkinson’s is a disorder in which dopaminergic neurons degenerate. It is also identified by occurrence of

Micro-emulsions offer an innovative way to deliver insoluble medications, safeguard labile

cellulose derivatives (such as sodium carboxymethylcellulose, methylcellulose, hydroxypropyl

Nanotechnology offers promising applications in medicine, especially pharmaceuticals to deliver drugs

previous research on the pharmacological activity, phytoconstituents, ethnobotanical qualities, and

Keywords: Butterfly pea, Neutraceuticals, Bioactive metabolite, Microencapsulated, Aphrodisiac.

A hydrotrope is a compound that solubilises hydrophobic compounds in aqueous solutions. Hydrotropes

Iridoids showed anticancer, antiproliferative, cardioprotective, hepatoprotective, antihyperglycemic, and

are few parameters of how biotechnology is influencing pharmaceutical research. In aspect of

Keywords: ADME, Gastroplus, WinNonlin, PK Analix, XlSimEst.

Keywords: Acne Vulgaris, Withaniacoagulans, Anti-microbial, Anti-acne.

Keywords: UV, Radiation, Sun burn, Skin aging, DovyalisCaffra.

Scrophulariaceae, Pyrolaceae, Oleaceae, Labiatae, Rubiaceae, Gentianaceae, Apocynaceae, Lamiaceae,

of an innumerable of interconnecting voids within a non-collapsible structure with a large porous

(HPTLC). HPTLC is an advanced versatile chromatographic technique for quantitative analyses

Keywords: Bioavailability, Administration, Enhancement, Medicament.

ABOUT UTTARANCHAL INSTITUTE OF PHARMACEUTICAL SCIENCES

ABOUT THE CONFERENCE

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