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SUMMARY
This guideline sets out an antimicrobial prescribing strategy for acute otitis
media (ear infection). It aims to limit antibiotic use and reduce antimicrobial
resistance. Included are recommendations on antimicrobial
prescribing, managing acute otitis media in children and young people,
and choosing a treatment.
Antimicrobial Prescribing
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10/26/23, 11:45 AM Otitis Media (Acute): Antimicrobial Prescribing
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10/26/23, 11:45 AM Otitis Media (Acute): Antimicrobial Prescribing
Give advice about the usual course of acute otitis media (about 3
days, can be up to 1 week).
Offer regular doses of paracetamol or ibuprofen for pain. Use the
right dose for the age or weight of the child at the right time, and
use maximum doses for severe pain.
Consider eardrops containing an anaesthetic and an analgesic for
pain (see table 1 for choice of treatment) if:
an immediate oral antibiotic prescription is not given (see the
sections, Children and young people who may be less likely to
benefit from antibiotics, Children and young people who may
be more likely to benefit from antibiotics, and Children and
young people who are systemically very unwell, have
symptoms and signs of a more serious illness or condition, or
who are at high risk of complications), and
there is no eardrum perforation or otorrhoea.
Review treatment if symptoms do not improve within 7 days or
worsen at any time.
Explain that evidence suggests decongestants and antihistamines
do not help symptoms.
Reassess at any time if symptoms worsen rapidly or significantly,
taking account of:
alternative diagnoses, such as otitis media with effusion (glue
ear)
any symptoms or signs suggesting a more serious illness or
condition
previous antibiotic use, which may lead to resistant organisms.
Children and Young People Who May Be Less Likely to Benefit from
Antibiotics
Consider no antibiotic prescription or a back-up antibiotic
prescription (see table 1 for choice of treatment), taking account of:
evidence that antibiotics make little difference to symptoms (no
improvement in pain at 24 hours, and after that the number of
children improving is similar to the number with adverse
effects)
evidence that antibiotics make little difference to the
development of common complications (such as short-term
hearing loss [measured by tympanometry], perforated eardrum
or recurrent infection)
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10/26/23, 11:45 AM Otitis Media (Acute): Antimicrobial Prescribing
Children and Young People Who May Be More Likely to Benefit from
Antibiotics (Those of Any Age With Otorrhoea or Those Under 2 Years
With Infection in Both Ears)
Consider no antibiotic prescription with advice (see the second
recommendation in the section, Children and young people who
may be less likely to benefit from antibiotics), a back-up antibiotic
prescription with advice (see the third recommendation in the
section, Children and young people who may be less likely to
benefit from antibiotics) or an immediate antibiotic prescription (see
table 1 for choice of treatment), taking account of:
evidence that acute complications such as mastoiditis are rare with
or without antibiotics
possible adverse effects of antibiotics, particularly diarrhoea and
nausea.
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10/26/23, 11:45 AM Otitis Media (Acute): Antimicrobial Prescribing
Children and Young People Who Are Systemically Very Unwell, Have
Symptoms and Signs of a More Serious Illness or Condition, or Are at
High Risk of Complications
Offer an immediate antibiotic prescription (see table 1 for choice of
treatment) with advice (see the last recommendation in the section,
Children and young people who may be more likely to benefit from
antibiotics).
Refer children and young people to hospital if they have acute otitis
media associated with:
a severe systemic infection (see the NICE guideline on sepsis)
acute complications, including mastoiditis, meningitis,
intracranial abscess, sinus thrombosis or facial nerve paralysis.
Choice of Treatment
Phenazone 40
mg/g with Apply 4 drops two or three times a day for up to 7 days
lidocaine 10 mg/g
Use only if an immediate oral antibiotic prescription is not
given, and there is no eardrum perforation or otorrhoea
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10/26/23, 11:45 AM Otitis Media (Acute): Antimicrobial Prescribing
Amoxicillin
1 to 11 months: 125 mg three times a day for 5 to 7 days
Alternative first choice oral antibiotic for penicillin allergy or intolerance (for people
who are not pregnant)
Clarithromycin
1 month to 11 years:
Erythromycin
8 to 17 years: 250 mg to 500 mg four times a day or 500 mg
to 1,000 mg twice a day for 5 to 7 days
Second choice oral antibiotic (worsening symptoms on first choice taken for at
least 2 to 3 days)
Co-amoxiclav
1 to 11 months: 0.25 ml/kg of 125/31 suspension three times a
day for 5 to 7 days
days
[A] See the BNF for children for appropriate use and dosing in specific populations, for
example, hepatic impairment and renal impairment.
[B] The age bands apply to children of average size. In practice, the prescriber will use
the age bands in conjunction with other factors such as the severity of the condition
and the child’s size in relation to the average size of children of the same age. Doses
given are by mouth using immediate-release medicines, unless otherwise stated.
References
© NICE 2022. Otitis media (acute): antimicrobial prescribing. Available from: www.nice.org.uk/ng91. All rights
reserved. Subject to Notice of rights.
NICE guidance is prepared for the National Health Service in England. All NICE guidance is subject to regular
review and may be updated or withdrawn. NICE accepts no responsibility for the use of its content in this
product/publication.
Cite this: Otitis Media (Acute): Antimicrobial Prescribing - Medscape - 31 March 2022.
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