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Gut-Brain 23 Agustus 2020
Gut-Brain 23 Agustus 2020
Muzal Kadim
Gastrohepatology Division, Child Health Department
Medical Faculty, Universitas Indonesia
I declare
No conflict of interest
in my presentation
Gut nutrition
Small bowel
45%
55%
Blood circulation
Colon
70%
Bacteria SCFA
Fiber
30%
Blood circulation
Microflora
1014 micro-organism
Gut microflora
>10000 species
0,5-1 Kg
Trigger neutransmitter
Modern lifestyle negatively affects
our microbiota
John F. Cryan and Timothy G. Dinan. NATURE REVIEWS | NEUROSCIENCE VOL 13 | OCTOBER 2012
Gut Microbiota:
A Potential Regulator
of Neurodevelopment
Enteric Nervous System and Vagus Nerve
Circulation
Interaction through the Immune System
Gut Microbes and the Brain:
Paradigm Shift in Neuroscience
GABA
Serotonine
Dopamine
SCFA
Cytokines
second brain
gut ~ brain
Growth and
Development
Mental health problems
affect about 1 in 10 children
include depression, anxiety and
conduct disorder
Grenham, S., Clarke, G., Cryan, J. & Dinan, T. G.
Brain–gut–microbe communication in health and disease. Front. Physiol. 2, 94 (2011).
Genetic Psychological
Enviroment factors
Neuroendocrine
Neuronal
Neuroimmune
Endocrine
N. Vagus
Immune ENS
GABA
Serotonine Gut-brain
Dysbiosis Dopamine
disoders
SCFA
Cytokines
Conclusions:
Early gut microbiota modulation with probiotics may modify the
growth pattern of the child by restraining excessive weight gain
during the first years of life
Conclusions:
The limited evidence suggests that probiotics have the potential
to improve child growth in developing countries and in under-
nourished children.
More research is needed to explore this further
Early gut microbiota composition — a
possible target to reduce the risk of
developing neuropsychiatric disorders?