‫بسم هللا الرحمن الرحيم‬

‫نتقدم بالشكر لمن ساعدنا في كتابة أسئلة امتحان‬

) ‫( كل الشكر لمجموعاتي على جهدهم‬
Part 1 September 2022
Done by Dr.Mohammad Alahmad
Phone : 00962785378899

1- Mast cell derived from bone marrow express :

A- CD34
B- CD6
C- CD20
D- CD68

2- Cell derived from bone marrow is :

A- Fibroblast
B- Keratinocyte
C- Langerhans
D- Merkle cell

3- All of the following are tinea capitis variant except:

A- Kerion
B- Favus
C- Gray patch
D- Tinea Amanticia
 4- Defect in EBS is :
A- K5 & 14
B- K15 & 4
C- K8 & 18
D- K6 & 11

5- Herpes gestation site of lesion is :

A- Subcorneal
B- Basal layer
C- Lamina lucida
D- Sublamina dense

6- BM dominant collagen is :
A- V
B- IV
C- VII
D- III

7- Number of collagen in skin is :

A- 6
B- 12
C- 20
D- 30
 8- Wave length for Vit D synthesis is :
A- 290-320
B- 320-400
C- 400-600
D- 600-800

9- Dot in circle sign is seen in :

A- Eumycetoma
B- Sporotrichosis
C- Trichosponiosis
D- Blastomycosis

10- The responsible defect for Cicatricial pemphigoid

with adenocarcinoma is :
A- BPAG2
B- BPAG1
C- Laminin 332
D- Integrin Beta-6

11- Which of the following is not seen by 6-14 weeks

of gestation :
A- Merkel cell
B- Melanoblast
C- Phagocytic macrophage
D- Keratinocyte
 12- The percent of hair in anagen phase is :
A- 70%
B- 95%
C- 90%
D- 5%

13- Diagnostic technique for heritable blistering

disease :
A- ELISA
B- PCR
C- Immunomapping
D- Immunoblotting

14- Which one is not non collagenous dermal

component :
A- Loricrin
B- Fibulin
C- Fibronectin
D- Integrin

15- KHG- keratohyaline granules contain :

A- Keratin
B- Profillagrin
C- Ceramide
D- Sequeline
 16- Defect of fillagrin not seen in :
A- AD
B- Atopic asthma
C- Psoriasis
D- Icthyosis vulgaris

17- Anagen effluvium is:

A- Direct toxic effect on mitotic activity of H.matrix
B- Appears after 24-48 hours after cessation of CT
C- Appear after 3-4 months of CT
D- Increase number of hair in resting phase

18- The tensile of strength after 2 weeks :

A- 5%
B- 25%
C- 50%
D- 75%

19- Sporothrix Schenckii culture in :

A- Hot & humid
B- Hot & dry
C- Cold & humid
D- Cold & dry
 20- Scrub typhus is caused by :
A- R.tsutsugamushi
B- R. Conorii
C- R.Quintae
D- Bartonella

21- Vesicular lesion after sun is related to Interlukin :

A- 2
B- 12
C- 10
D- 4

22- Organ that least affected by leprosy :

A- Testicles
B- LN
C- Liver
D- Lung

23- Insertion of anchoring filament from

hemidesmosome to :
A- Lamina lucida
B- Lamina densa
C- Sublamina densa
D- Reticular dermis
 24- Which of the following as considered as anchoring
fibril :
A- Collagen VII
B- Collagen I
C- Collagen III
D- Collagen IV

25- Eccrine gland is not present in :

A- Mouth epithelium
B- Labia minora
C- Face
D- Palms

26- Anhcoring filament is mainly composed of :

A- Collagen IV
B- Laminin 332
C- Collagen VII
D- BPAG2

27- Which of the following is most potent

anaphylotoxin :
A- C1
B- C3a
C- C5a
D- C5b
 28- Eccrine gland development occur firstly in :
A- Palms & soles
B- Face
C- Scalp
D- Axilla

29- The main component of adherens junction is :

A- Connexin
B- Desmosome
C- Cadherin
D- Selectin

30- Secretion of sebaceous gland mainly by which

manner :
A- Apocrine
B- Merocrine
C- Eccrine
D- Halocrine

31- Mechanism of action of Acyclovir via inhibition of :

A- DNA polymerase
B- Thymedine kinase
C- Helicase primase complex
D- Nuocloside reverse transcriptase
 32- Which of the following is not performed mediator
of mast cell :
A- LT C4
B- Histamine
C- Heparin
D- Tryptase

33- Malphagian layer is :

A- Stratum spinosum & Basal layer
B- Stratum spinosum & stratum granulosum
C- Stratum granulosum & Stratum corneum
D- Stratum spinosum alone

34- Stratum germinatum is synonym of :

A- S.Corneum
B- S.Basale
C- S.Granelosum
D- S.Spinosum

35- Tinea nigra is caused by :

A- Malassezia Spp
B- Phaeoannellomyces werneckii
C- Piedra hortea
D- Trichosporum Spp
 36- Culture media for lishmaniasis :
A- Thayer martin
B- Nicolle– Novy–MacNeal
C- Lowenstein Janson
D- Chocolate agar

37- Immunostaing for leishmania amastigote is

A- CD2
B- CD1a
C- CD3
D- CD20

38- The main function of nail is :

A- It is protective
B- Defense weapon
C- Water preservation
D- Sensation

39- Ceruminous gland is considered as :

A- Sebaceous glands
B- Apocrine gland
C- Eccrine gland
D- Endocrine gland
 40- Major protein in cornified cell envelope :
A- Fillagrin
B- Loricrin
C- Keratin
D- Envoplakin

41- Marfan syndrome has defect in :

A- Fibulin
B- Fibrillin
C- Collagen
D- LTBP-4

42- Chancroid is :
A- Superficial clean ulcer
B- Deep clean ulcer
C- Superficial clean ulcer
D- Deep dirt ulcer

43- Which medication with warfarin increase risk of

bleeding:
A- Dapsone
B- Chloroquine
C- Griseofulvin
D- Ketoconazole
 44- Roseola infantum is caused by :
A- HHV5
B- HHV6
C- Parvovirus
D- HHV7

45- The main function of SC fat is :

A- Water store
B- Energy store
C- Electrolyte balance
D- None of the above

46- Lamellar icthyosis is caused mainly by :

A- K1
B- Filaggrin
C- TGM1
D- Steroid sulfatase

47- Most specific sign for nail psoriasis :

A- Nail pitting
B- Oil drop
C- Onycholysis
D- Splinter haemorrhage
 48- Which of the following is IL12/23 inhibitor :
A- Secukinumab
B- Ustekinumab
C- Guselkumab
D- Adalimumab

49- Mikulcks cell present in :

A- LGV
B- Leishmaniasis
C- Rhinoscleroma
D- Blastmycosis

50- TSC is disease caused by mutation in chromosome:

A- 17
B- 9/16
C- 22
D- 10

51- Masson trichrome stain keratin :

A- Red
B- Blue
C- Black
D- Yellow
 52- Toe nail completely grow in :
A- 6 month
B- 12 month
C- 6 weeks
D- 18 months

53- If hapten is formed , which cell deal with it :

A- Langerhan cell
B- Mast cell
C- Keratinocyte
D- Merkel cell

54- Which of the following not produced by

keratinocyte :
A- IL-1
B- IL-2
C- IL-10
D- IL-6

55- Hertoghe’s sign is seen in all of the following

except :
A- AD
B- Lupus Vulgaris
C- Scleroderma
D- Lepsrosy
 56- Most common ANA pattern associated with SLE is
:
A- Rim
B- Speckled
C- Homogenous
D- Nucleolar

57- Rose spot occur in :

A- Typhoid fever
B- Typhus
C- RMSF
D- Roseola infantum

58- Which of the following lasers is in the infrared

spectrum?
A- Erbium
B- Excimer
C-Q-switched Ruby
D-Frequency Doubled Nd:Yag

59- Messiner corpuscle detect :

A- Temperature
B- Vibration
C- Light Touch
D- Pressure
 60- Treatment of choice of PCT is :
A- Phleepotomy
B- Antimalarial
C- Sunscreen
D- No effective therapy

61- In icthyosis vulgaris , the granular layer is :

A- Diminished or absent
B- Thickened
C- Normal
D- Irregular

62- Most common Ig that fix Complement :

A- IgE
B- IgM
C- IgA
D- IgD

63- About hereditary angioedema :

A- AD disease
B- Always associated with wheal
C- Steroid can be line of therapy
D- All of the above
 64- All of the following cause nail pigmentation except
:
A- B12 Hypervitaminosis
B- Post kala azar dermal pigmentation
C- Antimalarial
D- Wilson

65- Ehrlich magic bullet is :

A- Cephalosporin
B- Penicillin
C- Chloroquine
D- Isoniazide

66- Subcorneal blistering , Acantholysis & neutrophilic

infiltrate is characteristic of
A- LABD
B- Pemphigus herpetiformis Most likely is IgA
C- P.vegetans Pemphigus
D- PNP

67- About nail psoriasis , which of the following is

incorrect :
A- Splinting haemorrhage may occur
B- Nail pitting is most common
C- Toe nails are more affected than finger nail
D- Secondary candida infection can develop
 68- Which of the following not used in guttate
psoriasis :
A- BBUVB
B- NBUVB
C- Excimer
D- UVA

69- Which of the following about skin appendages &

their location is correct :
A- Eccrine gland in Papillary dermis
B- Apocrine gland in mid dermis
C- Sebaceous gland in reticular dermis
D- Hair follicle in reticular dermis

70- Which test become positive firstly in case of

syphilis :
A- TPHHA
B- RPR
C- FTA
D- VDRL

71- Which IL increase in Herpes simplex after Sun

exposure :
A- IL-6
B- IL-4
C- IL-10
D- IL-12
 72- About Darier disease , Which of the following is
false :
A- AD disease
B- 10% affect Hands
C- Start in teenagers
D- Red & white bands are pathognomonic

73- Fogo Solvagem is caused by antibodies against:

A- Desmocollin
B- Dsg 1
C- Desmoplakin
D- Plakoglobim

74- Hair growth rate per day is:

A- 30-40 micron
B- 3-4 micron
C- 300-400 micron
D- > 400 micron

75- SG secretion is controlled by :

A- Testesterone
B- Steroid
C- Estrogen
D- Thyroxine
 76- Which of the following is true about
melanosome :
A- Spheroid melanosome synthesize brown-black
eumelanin
B- Elliptical melanosome have microvesicular
structure
C- Elliptical melanosome synthesize red-yellow
pheomelanin
D- Melanosomes are positioned after golgi apparatus
in secretory pathway

77- SLE mostly occur with deficiency of :

A- C1q
B- C5
C- C3
D- C2

78- The ratio of melanocyte to keratinocyte in

basal layer
A- 1:6
B- 1:10
C- 1:20
D- 1:40
 79- Keratinocyte that represent epidermal
differentiation has :
A- K5 & K14
B- K1 & K10
C- K4 & K13
D- K8 & 18

80- Which of the following is AR disease

A- XP
B- IP
C- NF
D- TSC

81- Keratin that involve in palmoplantar area is :

A- K6
B- K10
C- K9
D- K18

82- About Langerhans cell which of the following

is incorrect :
A- CD1a
B- HLA-DR & chromogranin
C- Pigmented granule
D- Non phagocytotic
83- Melanoblast development is seen :
A- Mid of first trimester
B- End of trimester
C- Second trimester
D- Third trimester

84- Abot APM ➔ role in thermoregulation

85- Not true about apocrine gland ➔ High

secretory output

86- Function of PG / GAG in dermis ➔Water

preservative

87- Phytotoxicity ➔ cause PI hyperpigmentation

88- not mechanism of action of retinoids

➔Inhibition of apoptosis

89- Adipocye produce ➔ IL-6

90- Non antimicrobial peptide ➔ Substance p

91- Eccrine gland develop from basal layer➔ +10

weeks
92- Cicatricial pemphigoid with ocular➔ Integrin
alpha6 beta 4

93- Most common type of pruritis receptor ➔

Free nerve ending C fiber

94- Main component of gap junction ➔ Connexin

95- Desmoplakin is homolog to ➔ BPAG1

96- Merkel cell origin Similar to ➔Keratinocyte

97- Incorrect about mast cell➔ Smaller than

basophils & eosinophils

98- Keratohyaline granule ➔Mark the last living

layer of epidermis

99- The required time for keratinocyte to leave

basal layer to surface of skin ➔ 2 weeks

100- Latent desquamation ➔ Observed only after

scratching the lesion

101- Chronic idiopathic urticaria ➔ IgE

Autoantibodies

102- Correct about HF➔ ORS contain melanocyte