Proposed Title of the Project: The efficacy of 3D printed Microneedles in migraine.

1. Introduction (Sumaiya, Ima, fouzia, Nadia)

1.1 Define MN and its application (Nadia)

1.1 Migraine and Different Types of Migraine (Sumaiya)

1.2 Causes of Migraine (Sumaiya)

1.3 Diagnosis of Migraine (Sumaiya)

1.4 Treatment of Migraine (Nadia)

1.4 Conventional Therapy of Migraine and its limitations (evidence based)- (Sumaiya)

2. Overview of Microneedle (MN) Technology in Migraine (Sumaiya)

2.1 Properties of Microneedle (sumiaya)

2.2 Classification of Microneedle (Ima, Sumaiya, mayesha, Nadia)

2.2.1 Solid MN

2.2.2 Hollow MN

2.2.3 Hydrogel MN

2.2.4 Coated MN

2.2.5 MN Array

2.2.6 Dissolving MN

2.3 Application of MN (Ima, Sumaiya, Mayesha)

2.3 Therapeutic Application (Nadia)

2.3.1 Advantages of microneedles in transdermal drug delivery (sumaiya)

2.3.1 Roles of MN intransdermal drug delivery (nadia)

2.3.2 Disease treatment

2.3.3 Improves the way patients take medicines

2.3.4 Helps drug development and testing

2.4 Types of 3D printer (Ima, Nadia)

2.4. 1 SLA
2.4.2 FDM

2.4.3 PAM

2.4.4 DLP

2.4.5 CLIP

2.4.6 TPP

2.5 3D printed Microneedle in Migraine Drug Delivery (evidence based) (sumaiya)

3. Fabrication and Pharmacology (Sumaiya)

3.1 Device printing, sterilizaing and assembly (fouzia)

3.2 How Microneedles can be used for drug delivery (Nadia)

3.2 Polymer selection and Microneedle Simulation (sumaiya)

3.3 Simulation of engineered brain microvascular structure (Sumaiya, Ima)

3.4 Drug choice and Drug Loading in MN (Sumaiya, Ima)

3.5 Designing and Fabrication of 3D Printed MN (sumaiya, Ima)

3.6 In vitro study of Drug Release and Relative Bioavailability (evidence based) (Sumaiya, Ima)

3.7 Efficacy of MN dosage form in Pain Management (evidence based)

4. Different tests for administration

4.1 Microcapsule compression (fouzia)

4.2 Microcapsule extrusion (fouzia)

4.3 Surface topographgy (fouzia)

4.4 Mass flow capability and leak test (fouzia)

4.5 Cytotoxicity screening (fouzia)

4.6 Viability post extrusion and relative payload ( fouzia)

4.7 Failure force test (Ima)

4.8 Transendothelial permeability assay (Ima)

4.9 Immunological administration (Ima, mayesha)

5. Discussion and Opinion (Sumiaya,Ima, fouzia, Mayesha)

5. Observation and Discussion (Nadia)

5.1 Recent Trends and Challenges (Sumaiya)

5.2 Commercial Impact and Sustainability (Sumaiya)

5.3 Limitation to Commercialization (Sumaiya)

5.4 Potential of Future Aspects (Sumaiya)

5.5 Preventive Migraine treatment (Sumaiya)

5.6 Pharmacoeconomics of microneedle technology (Nadia)

6. Conclusion (Ima, Sumaiya, fouzia, mayesha, Nadia)

References