anu) Gaull ail eae: Catal Atinal Ags (8 Use lar Qual Sally palit ( absense le panel Sal JS) Part 1 September 2023 Done by Dr.Mohammad Alahmad Phone : 00962785378899 1- Melanocyte to Keratinocyte concentration in skin is apprpximately : A-1:10 2-Th2 secrete : A-IL-2 B-IL-6 C-IL-3 D- IL-13-15 years old male come with single patch on the rightleg with clear center & red in periphery : A- Tinea corporis B- Urticarial vasculitis C- Erythema nodosum D- EAC 4- Photon in which spectrum have highest energy : A-Infrared B-UVC SOc ay Dee ROR Mea un ear C-UVA aie ale D- UVB 5- Which of the following is correct about ivermectin : A-Contraindicated during lactation B- Category B in pregnancy C-Treatment must be at least 2 weeks D- Approved for Rx of onchcerciasis 6- Most powerful antioxidant is : A-Vit C B-Vit E C-Zinc D-Vit D7- Which of the following mediator is stored in mast cells : A-Prostaglandin Pere ett etd B- Heparin eres Rue MN ae C-Leukotriens D2 DUE AC) D-Leukotrien D4 8-The most common ocular manifestation of rosacea : A-Blepharitis B-Keratitis . Ce ee eae) C- Scleritis Cee D-Iritis A Er 9- Which type of HPV associated with Periungual carcinoma : A-HPV 16 B-HPV 11 C-HPV6 D-HPV7 10- Staphylocococcus colonization of skin is related to A- Cathelicidin decrease B-Cathelicidin increase C-Th1 Increase D-Th2 Decrease11- Examination of hair shaft is in screening of : : A-Ataxia telangiectasia syndrome B- Chediak Hegashi syndrome C- Hyper IgM syndrome D- Hyper IgE syndrome oO eres regularly arranged small CMe 12- Which of the following is part of anchoring filament : A-Desmoglein B-Desmoplakin C- Plakoplagin D- Kalinin 13- Which of the following tumor is related with bazex syndrome ( Acrokeratosis paraneoplastica) : A-BCC Bazex syndrome ( Acrokeratosis paraneoplastica ) is B-SCC paraneoplastic dermatosis related to a Upper Cc DL rae el ole Dubre syndrome is related to multiple BCC D- Merkel CC14- Which of the following is most describes tincture: in water B- Alcohol-based Cea C- Propylene-Glycol D- Poweder in ointment 15- Which of the following is most describes Gel: A- Oil - in water B- Alcohol based eretr) C- Propylene glycol D- Poweder in ointment Peek eel ae eMC ela SECM EUS melt leMe amici See ema Rate Te EL cel tel eer Tit) Pre Matera s g variable amounts of propylene glycol. (oT Te mda s a ue hee) ete Be Maa tele ointments to which powder has been added 16- Which collagen is predominant in fetal skin : A-Collagen 1 B- Collagen 3 C-Collagen 2 D-Collagen 717- Electron beam therapy is used in Therapy of : A- CTCL B- KS C- Merkel CC D-Malignant melanoma 18- Donovoniasis is caused by : A-K granulomatis B- Chlamydia C-T. Pallidum D- H.Ducrai 19- Which part of the eye can be affected by PDL : A-Lens B- Cornea C-Sclera D-Retina Ces tu RE 2eerd Pee econ 20- Early Cutaneous manifestation of TSC is : A-Hypomelanotic macules B-Shagreen patch C- Periungual fibroma D- Angiofibroma21- Mechanism of action of acyclovir is : A-Viral Thymidine kinase B- Viral RNA polymerase C- Enhance CD8+ T- cell D- Viral DNA polymerase 22- The most common type of Metalloproteinase in skinis : A-Matrilysins B- Collagenase C- 92 Gelitabase D-Streomylesin 2 23- Differentiation of skin start in : A-Granular layer B- Basal layer C- Division of stem cell D-Stratum lucidum 24- Which type of panniculitis show Needle shaped cleft in Biopsy : A- Lupus panniculitis ee re) B- Pancreatic panniculitis COU e nese cg . . ae. De ea ed C- Post steroid panniculitis Uae ea) D- Erythema induratum Pec25- Swarm of bees is histological feature of : A- DLE B- Alopecia areata C- LPP D- Acne keloidalis 26- What is species of the causative pathogen in rhinoscleroma : A-Parasite , r 0 . GTC Ru B- Bacteria Pe acu ead C-Virus eee acc) D-Fungus 27- Lanoline refer to : A- Hydrous wool fat B- Parrafine C- Obrama Oil D- E- Wax 28- The origin of Birbeck granules is : A- Plasma membrane B- ER C- Golgi apparatus Tr D-Nucleas29- Which virus is associated with secondary vasculitis A- Rotavirus B-HPV C- Parvovirus D-HCV 30- CD4:CD8 ratio is : A- 1:4 B- 2:1 C-1:2 D-4:1 31- Appoptosis occur in response to : A-Virus B- Bacteria BSC cae eee coe C- Fungus are viral infection & tumor cells D- Parasite32- Several of complement component are : A-Enzymes B- Antibodies C- Glycolipid D- Cytokines 33- Which of the following is a chemotaxis : A-Bacterial product B-C4a 4 c- LTB4 1 Sa D- Interlukines ESenaT 4 4-C3a&CSa BUT ec ea eter Ri Uae Le 34- Fatty acid deficiency is correlated with : A-Increase linoleic acid B- Decrease oleic acid C- Decrease palmitic acid D-Accumulation of 5 , 8 , 11 Eicosatetrayonic acid PC re ua Ly Pea Ee See) 2- Low Linoleic acid EO tM eRe eater ue)35- Sebaceous glands of superficial eyelid margin are known as: A-Moll’s Gland DT ECU ee RUE CLC LL B-Gland of Zels NE See eur] A ua Ree uy C-Meibomian gland fi oa D- Montogomery gland 36- Mucosal mast cell differ from cutaneous type by : A-Bigger size B- Doesn't secrete histamine C- Different stimulant D- Doesn’t secrete trypsin 37- Factor XIlla is positive in : A-Dermatofibroma B- KS C-LCH D-MCC38- Which of the following is correct about Granular parakeratosis : A-More common in male B- Hx show thick Stratum corneum with basophilic cytoplasm C- Typically non pruritic D- Defect in processing profilaggrin to filaggrin is proposed mechanism 39- Which of the following is correct about Type 1 pityriasis rotunda : A-Less common in black B- Numerous & non scaly C- Associated with underlying malignancy D-Positive family history 40- All of the following is component of Ground substance except : A-HA B- Chondroitin sulfate C- Collagen VII D-Proteoglycan41- The main AA Of elastic tissue : A-Desmosin B-Glycine C- Proline D-Hydroxy proline 42- Which of the following induce hair depigmentation : A-Imatinib B-Erlotinib C- Nilotinib D-Dabrafenib 43- The most common cutaneous manifestation of cholesterol embolism is : A-Livedo reticularis B- Purpura C- Ulceration D-Gangrene 44- The highest Ig Type in newborn is : A-IgE B-IgA C-IgG D-igM45- Glomus cell is : A-Skeletal muscle cell B- Modified endothelial cell C- Vascular Smooth muscle cell D-Arterial malformation 46- The main component of gap junction is : A-Connexin B-Cadherine C- Filaggrin D-Occludin 47- First part of HF that cornify is : A-Huxley layer of IRS B- Henley layer of IRS C- Matrix D- Cuticle 48- Phagocytosis occur by which cell : A-Mast cell B- Eosinophil The main phagocytic cells are - Neutrophil, : De OR ere aoe} C-Lipocyte ; ; sy eT ie AS cee ad D- Basophil CoS Merete sity49- The systemic agent which show effect in renal pruritis : A-Doxepin B- Nalfurafine C- Paroxitime D-Naloxone 50- Blashko lines are : A-Line of normal skin development B-Line of abnormal skin development C- Follow venous supply D- Follow BV 51- Premalignant Leucoplakia is associated with : A-Dyskeratosis congenita B- Pachyonychia congenita C- Candida albican D- EBV- Associated hairy oral leucoplakia 52- The average trans-epidermal water loss is : A-500 ml B-200 ml c-20 ml D-1000 ml53- Malathione lotion 0.5% : A-Natural Botonical material B- Synthetic Pyrethrin C- Flammable isopropyl alcohol base D- Not safe in pregnancy 54- The Best T for viral transport media for viral culture is : A--5C B-5C Bes uaa Tc C- 25C Renee cee Ta D- 37C 55- TLR3 recognize all of the following except : A-Dsg 3 B- Lipopolysaccharide SOS mae ur ce ea) ST C-Viral dsRNA D-Lipoprotein re ta ates 56- Acrodermatitis continue of hallopeua : A-Intact Nail bed B- Affect proximal portion of finger C- Common presentation of psoriasis D- Can progress to another form of psoriasis57- Which metal salt cause heat energy when in contact with water & cause ulcer of the skin : A-Calcium oxide B- Arsenic salt C- Mercury salt D-Cobalt salt 58- Initial diagnostic test for dermatomyositis is : A-CBC B- Creatine kinase C-ANA D-KFT 59- Which of the following is used to assess liver fibrosis before doing liver biopsy : A-AST B- ALT DES LCE OU ARE) C- AST/ALT D- Alkaline phosphatase 60- Which cytokines is the main macrophage- activating cytokines : A-INF-Gamma B- TNF C-IL-1 D-IL-261- Macula caerulea is a feature of : A-Scabies B- Pubic lice C- Head lice D-Body lice 62- Fusion protcin is component of which of the following Anti-TNF : A-Adalimumab B-Infliximab C- Etanercept D- Certulizumab 63- Which of the following sunscreen category has efficacy against UVA : A-Benzophenone B-Cinnamate C- PABA D-Salicylate 64- Which of the following Describe DH feature on IF : A-Linear IgA by DIF B- Linear IgA by IIF C- Granular IgA by DIF D-Granular IgA by IIF65- Which of the following topical antipruritic medication cause ACD : A-Pramoxine B- Capsaicin C- Menthol D- Emollient 66- Most important mediator of pruritis is : A-Substance p B-IL-1 C-IL-2 D- Nerve growth factor Among choices > Substance p , IL-2 & NGF PCE ou Cu IL-2 has more potency for pruritis 67- Spongiosis is an epidermal edema mainly in : A-Basal layer B- Spinous layer C- Granular layer D- Stratum corneum 68- Which anesthetic agent can be given to patient has amide allergy : A-Lidocaine B- Benzocaine C- Prilocaine D-Procaine69- Which of the following is a melanogenic inhibitor : A-Nitric Oxide B- Catecholamine C- Sphingolipid D-Neurotrophins 70- Number of hair emerging from hair pores on beard or body areas : A-1 B-2 c-3 D-5 71- Slapped cheeks followed by lacy eruption on extremities caused by : A-ssDNA B-dsDNA C-ssRNA D-dsRNA 72- Proteoglycan that regulate thrombin is : A-Dermatan B- Heparin C- Dextran D-Chondroitin73- Which of the following drugs cause Gingival hypertrophy : A-Tetracyclin B- Cyclosporin C- Hydroxyurea D-MTX 74- Which of the following is correct about atypical juvenile PRP : A-Resolved by age of 3 years B- Has chronic course C- Less familial case D- Most common type of Juvenile PRP 75- The mechanism of action of fluconazole is : A- Inhibits 14-alpha-demethylase B- Inhibits squalene epoxidase C- Disrupts microtubule mitotic spindle formation D- None of the above 76- Which of the following is Inhibitor of purine synthesis : A-MTX B- Cyclosporine C- Mycophenolate Mofetil D-Hydroxyurea77- Which of the following is a caue of ptyrigium inversum unguis : A-LP B- Systemic sclerosis C-GVHD D-Pemphigus 78- Leukocyte adhesion deficency III is characterized by: A- Bleeding diasthesis B- Hypotonia C-Short stature D-High neutrophil in tissue 79- The pathogenesis that occur in Pemphigus Vulgaris in : A- Intercellular B-BM C- Papillary dermis D-Reticular dermis80- Most common manifestation of Isotretenoin administration : A- Cheilitis B- Nephrotoxicity C- Sexual dysfunction D-GI symptoms 81- Which of the following is mandatory for keratinocyte differentiation : A-Zinc B- Calcium C- Copper D-Magnesium 82- Which of the following is correct about Acantholytic EBS : A-Natal teeth B- Erosion at birth C- Foci of alopecia D-Subepidermal blister on Hx 83- Eosinophilic abscess is characteristic of : A-Pemphigus vulgaris B- Pemphigus Vegetans C- Paraneoplastic pemphigus D-Pemphigus Foliaceous84- Which of the following determine hair follicle length : A-Anagen phase B-Catagen phase C- Telogen phase 85- Malignancy associated with sweet syndrome : A- CML B- AML C- Lymphoma D-Chronic myelomonocytic leukemia 86- About trichotillomania , which of the following is correct :: A-Normal Hair follicle size B- Extensive inflammation C- Decrease terminal hair D-Decrease Catagen hair 87- Fibroblast cell is : A-Derived from BM B- Derived from bone C- Highly concentrated in reticular dermis D-Secretory cell88- Diabetic dermopathy is predominant in : A-Scalp B-Shin C- Trunk D-Forearm 89- Which of the following is correct about ETN A-Non delf-limiting disease B-Spare palms & soles C- Neutrophilic infiltration D-Half of the patients are premature 90- Stretching of the skin in glaborous & hairy skin is responsible of : A-Meissner corpuscle B- Ruffini corpuscle C- Pacinian corpuscle D-Free nerve ending 91- Androgen receptos is present in: A-Apocrine glands B-Eccrine glands Sree Ue cue end BCU eC eee ae C- Miessner corpuscle Greens92- Stains for fungal spres & hyphae is : A- PAS B- Congo red C- Giemsa stain D-H& E 93- Which of the following stains can demosostrate melanocyte : Melanocyte can be stained with bloch DOPA reaction , A-Bloch dopa reaction Bes aE B- Silver stain CT eu c) C- Fontana masson stain D- Congo red I think need the except > Congo red 94- Which of the following elements is stained blue by Giemsa stain : A-Amyloid B- Nuclei of cell C- Mast cell granule D-Acid- fast organism 95- Histamine exert its effect via : A-Postcapillary venule sphincter constriction B-Constriction of large arteries C- Acting on H2 receptor on mast cell D-Venular endothelial contraction96- Acquired icthyosis characterized by : A-Asymmetrical B- Associated with lymphoma C- Occur in upper limb D-Differ than ichthyosis vulgaris 97- PUVA-induced acrobollous dermatosis is characterized by : A- Non-sterile Bullae B- Tense bullae C- Latent manifestation D-Affect proximal extremities 98- Ischemic change in nail is associated with : A-Beta blocker B-Retinoid C- Psoralene D-Tetracyclin 99- Which part of hemidesmosome attach to keratin filament : A-Lamina lucida B-Sublamina densa C- Inner plaque of hemidesmosome D-Outer plaque of hemidesmosome100- Which of the following is found in fungal & mycoplasma while absent in bacteria : A-Chitin B- Chlorophyll C- Sterol D-Muramic acid 101- PDL target which of the following : A-Water B- Melanin C- Blood D-None of the above 102- Which of the following differentiate between congenital & acquired angioedema : A-C4 B-C2 c-C1 D-CH50 103- Which of the following is correct about nail : A-It is protective B- Nail bed is formed by collagen C- Act as defensive unit D-Nail bed resemble epidermis of skin104- Pili multigemin : A-More common in beard area in male B- Less common on scalp of children C- Occur in pubic area in pregnant D-Each single hair has different hair bulb 105- Regarding corneal layer & bilamellar lipid layer , the true is : A-Physically loosely attached B- Chemically attached by hydroxyl bond C- Attached by lipid & envelope D-Attached by non-covalent bond Rae eunar OSCE iy erg 106- BV of skin differ from BV of internal organ by : A-Wider lumen B- Wall more tough nero C- Pass into dermis by crossing fat lobules oni D-Blood supply is just enough to supply skin 107- Histology of blood supply to skin : A-One capillary to one Dermal papillae B- Two capillary to one dermal papillae C- One capillary to tip of papilla & one capillary to base D-Branched capillaries to one papillary dermis108- IL-1 } Chemotaxis of T lymphocyte 109- Cytokine that responsible for Ig switching is IL-4 110- The responsible for adhesion between Langerhans & keratinocyte is = E- Cadherin 111- Botulinium toxin block which mediator > Acetycholine 112- Normal human eccrine function is regulated by > Sympathetic cholinergic 113- The Main collagen in granulation tissue > III 114- All of the following amide group anesthesia except > Tetracaine 115- Autoantibodies against BPAG2 is most characteristic of > BP116- Leukotrienes are derived from ® Arachidonic acid 117- Which of the following molecules associated with EC adhesion & wound healing ® Fibronectin 118- Cytokines that cause hyperemia is => IL-1 119- Oral hairy leukoplakia is associated with > EBV 120- Bacteria differ from fungus in = Need neutral pH of 6.5-7 er BSW! aa OI gerrly Abu! odm arord § pdl (po) Std! 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