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Title: Understanding Carcinoid Heart Disease: A Comprehensive Literature Review

Carcinoid heart disease (CHD) is a rare condition that affects individuals with carcinoid syndrome, a
set of symptoms resulting from carcinoid tumors. Managing and treating CHD requires a deep
understanding of its complexities, manifestations, and available interventions. A literature review on
this topic is indispensable for healthcare professionals, researchers, and patients alike.

Crafting a literature review on carcinoid heart disease is a challenging endeavor. It demands


meticulous research, critical analysis, and synthesis of vast amounts of scholarly articles, medical
journals, case studies, and clinical trials. Navigating through the intricate details of CHD, its
epidemiology, pathophysiology, diagnostic modalities, and treatment options requires expertise and
dedication.

One of the biggest hurdles in writing a literature review on carcinoid heart disease is the scarcity of
comprehensive resources. Due to the rarity of the condition, there is limited literature available, often
dispersed across various medical disciplines. Additionally, staying updated with the latest
advancements and discoveries in CHD research adds another layer of complexity to the task.

Furthermore, ensuring the accuracy and reliability of the information presented in the literature
review is paramount. Every detail must be meticulously verified to provide readers with trustworthy
insights and findings. This rigorous process demands time, effort, and expertise to compile a
literature review that meets the highest standards of academic rigor and integrity.

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allowing you to focus on understanding and addressing the complexities of CHD effectively.
Approximately 90% of all carcinoid tumours are located in the gastrointestinal system of which the
most common sites are the appendix and terminal ileum. To browse Academia.edu and the wider
internet faster and more securely, please take a few seconds to upgrade your browser. AV.
Preoperative TTE assessment showing thickening of the AV and MV. A comprehensive imaging
evaluation is necessary for an accurate. We present a series of imaging findings in CHD patients who
have successfully undergone simultaneous surgical replacement with bioprosthetic valves of 1 to 4
heart valves. When treated medically, and in appropriate cases surgically, significant benefits in
overall quality of life and long term survival can be achieved. Carcinoid heart disease is a rare, but
interesting and important cause of intrinsic tricuspid and pulmonary valve disease leading to
significant morbidity and mortality caused by right heart failure. TR. Postoperative CMR imaging
showing the bioprosthetic TV (G and. A small group of patients has been managed by valve
replacement. The management of patients with carcinoid syndrome is difficult. Carcinoid heart
disease is a rare, but interesting and important cause of intrinsic tricuspid and pulmonary valve
disease leading to significant morbidity and mortality caused by right heart failure. The most
malignant of the carcinoid tumours tend to arise from the ileum and must be invasive or metastasise
to produce the carcinoid syndrome which is characterised by facial flushing, intractable secretory
diarrhoea, and bronchoconstriction. The first page of the PDF of this article appears above. RV, right
ventricle; TV, tricuspid valve; TR, tricuspid. Zacks J, Bhattacharyya S, Cuthbertson DJ, Dobson R.
Despite intensive research, the definite etiology of these valvular lesions has not been established.
Yoshioka Y, Matsumura N and Konishi I: Recurrence of a carcinoid. The prognosis of patients with
carcinoid syndrome varies with the origin of the tumor and extent of metastases. Timmermans P: The
path to surgery in carcinoid heart disease: A. Pellikka PA, Mullany CJ and Kvols LK: Outcome of
cardiac surgery. Institutional Review Board (Houston, TX, USA) approved the study. M, Horsch D,
Winkler RE, Klimovsky J, Lebwohl D, Jehl V, Wolin EM. The incidence of carcinoid tumours is
approximately 1 in 75 000 of the population 1 of whom about 50% develop carcinoid syndrome.
Lopez-Mattei J and Yusuf SW: Carcinoid heart disease. Heart. Seward JB, Callahan JA, Pitot HC
and Kvols LK: Carcinoid heart. HV: Quadruple valve replacement in patients with carcinoid heart. A
comprehensive imaging assessment may contribute to establishing optimal surgical timing. Hombach-
Klonisch S: INSL5 is a novel marker for human. Bioprosthetic valves are generally preferred in CHD
due to decreased need for anticoagulation, despite concern for premature degeneration. Merrick SH
and Rao RK: Transcatheter pulmonic valve replacement in.
Carcinoid heart disease is a rare, but interesting and important cause of intrinsic tricuspid and
pulmonary valve disease leading to significant morbidity and mortality caused by right heart failure.
Seward JB, Callahan JA, Pitot HC and Kvols LK: Carcinoid heart. A comprehensive imaging
assessment may contribute to establishing optimal surgical timing. CMR showed severe right atrium
and right ventricle enlargement. You may have mistyped the address or the page has been moved.
The most malignant of the carcinoid tumours tend to arise from the ileum and must be invasive or
metastasise to produce the carcinoid syndrome which is characterised by facial flushing, intractable
secretory diarrhoea, and bronchoconstriction. Merrick SH and Rao RK: Transcatheter pulmonic
valve replacement in. Although valvular dysfunction most often coexists with flushing and diarrhea,
the findings of tricuspid regurgitation or stenosis occasionally provide the first clue to the presence
of the disease. Bioprosthetic valves are generally preferred in CHD due to decreased need for
anticoagulation, despite concern for premature degeneration. Postoperative TTE showing the
bioprosthetic TV, without residual. We review the current literature regarding the pathophysiological
basis of the disease, the cardiovascular complications, and the currently available treatment
strategies. Modern approaches are associated with significantly improved survival rates, even in
multivalvular, complex cases. Grozinsky-Glasberg S, Steeds RP, et al: Diagnosing and managing. PA,
pulmonary artery; RA, right atrium; RV, right ventricle. Despite an understanding of the
neurohormones that carcinoid tumors secrete, their various antagonists and inhibitors have been only
partially successful in providing symptomatic relief. Effect of valvular surgery in carcinoid heart
disease: An. The prognosis of patients with carcinoid syndrome varies with the origin of the tumor
and extent of metastases. You will be able to get a quick price and instant permission to reuse the
content in many different ways. AS and Schoen FJ: Bioprosthetic tricuspid valve stenosis
associated. Early recognition of CHD with a multimodality approach may improve outcome, even in
complex cases. A collaboration between the Oncology and Cardiology teams is essential for the
long?term management of CHD patients. Early and late outcomes of surgical treatment in carcinoid
heart. Carcinoid heart disease is a rare, but interesting and important cause of intrinsic tricuspid and
pulmonary valve disease leading to significant morbidity and mortality caused by right heart failure.
The mitral and aortic valves can also be affected, albeit rarely, in certain circumstances such as the
presence of a patent foramen ovale. Despite intensive research, the definite etiology of these valvular
lesions has not been established. Inc.), without perioperative complications and with symptoms. You
can download the paper by clicking the button above. H, arrows), aortic valve (I and J, thin arrows),
and pulmonary. Once the carcinoid syndrome has developed, approximately 50% of these patients
develop carcinoid heart disease which typically causes abnormalities of the right side of the heart.
V, Economopoulos N and Machairas A: Carcinoid syndrome from a. Carcinoid heart disease is a
rare, but interesting and important cause of intrinsic tricuspid and pulmonary valve disease leading to
significant morbidity and mortality caused by right heart failure. Despite an understanding of the
neurohormones that carcinoid tumors secrete, their various antagonists and inhibitors have been only
partially successful in providing symptomatic relief. Bioprosthetic valves are generally preferred in
CHD due to decreased need for anticoagulation, despite concern for premature degeneration.
Anderson Catheterization Laboratory Registry at The University of. A comprehensive imaging
assessment may contribute to establishing optimal surgical timing. The most malignant of the
carcinoid tumours tend to arise from the ileum and must be invasive or metastasise to produce the
carcinoid syndrome which is characterised by facial flushing, intractable secretory diarrhoea, and
bronchoconstriction. Once the carcinoid syndrome has developed, approximately 50% of these
patients develop carcinoid heart disease which typically causes abnormalities of the right side of the
heart. Once the carcinoid syndrome has developed, approximately 50% of these patients develop
carcinoid heart disease which typically causes abnormalities of the right side of the heart. A small
group of patients has been managed by valve replacement. To browse Academia.edu and the wider
internet faster and more securely, please take a few seconds to upgrade your browser. Skulstad H,
Aakhus S, Thiis-Evensen E and Edvardsen T: Evaluation. AV. Preoperative TTE assessment showing
thickening of the AV and MV. We present a series of imaging findings in CHD patients who have
successfully undergone simultaneous surgical replacement with bioprosthetic valves of 1 to 4 heart
valves. You can download the paper by clicking the button above. Modern approaches are associated
with significantly improved survival rates, even in multivalvular, complex cases. M, Horsch D,
Winkler RE, Klimovsky J, Lebwohl D, Jehl V, Wolin EM. The first page of the PDF of this article
appears above. SMB, JLM, SH, PK, AD, DH, JY, BK, IG and CI were responsible for. A
comprehensive imaging evaluation is necessary for an accurate. Postoperative TTE showing the
bioprosthetic TV, without residual. Early and late outcomes of surgical treatment in carcinoid heart.
While CMR 9 months prior showed normal cardiac chamber sizes. Early recognition of CHD with a
multimodality approach may improve outcome, even in complex cases. The mitral and aortic valves
can also be affected, albeit rarely, in certain circumstances such as the presence of a patent foramen
ovale. JE, Del Bigio MR, Krcek J, Hoang-Vu C, Klonisch T and. MRI and CT revealing carcinoid
heart disease. Eur Radiol. The surgical decision in these patients was based on a multimodality
cardiovascular approach, including transthoracic and transesophageal echocardiography and cardiac
magnetic resonance. Pellikka PA, Mullany CJ and Kvols LK: Outcome of cardiac surgery. We review
the current literature regarding the pathophysiological basis of the disease, the cardiovascular
complications, and the currently available treatment strategies.
They also differ in their ability to metastasize, thus presenting an even more varied clinical picture.
Lopez-Mattei J and Yusuf SW: Carcinoid heart disease. Heart. Bioprosthetic valves are generally
preferred in CHD due to decreased need for anticoagulation, despite concern for premature
degeneration. Early and late outcomes of surgical treatment in carcinoid heart. Despite a common
origin from neural crest tissue, the tumors are partially differentiated, as evidence by the different
secretory products of foregut, midgut, and hindgut carcinoids. Other less common sites include the
bronchus and gonads. AS and Schoen FJ: Bioprosthetic tricuspid valve stenosis associated.
Hombach-Klonisch S: INSL5 is a novel marker for human. The incidence of carcinoid tumours is
approximately 1 in 75 000 of the population 1 of whom about 50% develop carcinoid syndrome.
MRI and CT revealing carcinoid heart disease. Eur Radiol. Carcinoid heart disease represents the
most intriguing aspect of this syndrome. The prognosis of patients with carcinoid syndrome varies
with the origin of the tumor and extent of metastases. Cuthbertson DJ: The clinical presentation and
management of. Error: 404 Go back to home page Stay Connected With Semantic Scholar Sign Up
What Is Semantic Scholar. Enriquez-Sarano M, Foster E, Grayburn PA, Hahn RT, Han Y, Hung J.
Despite an understanding of the neurohormones that carcinoid tumors secrete, their various
antagonists and inhibitors have been only partially successful in providing symptomatic relief. The
first page of the PDF of this article appears above. A comprehensive imaging evaluation is necessary
for an accurate. Primary diseases of the tricuspid or pulmonary valves are uncommon, but the more
likely causes might include congenital abnormalities, rheumatic heart disease, or infective
endocarditis. Primary diseases of the tricuspid or pulmonary valves are uncommon, but the more
likely causes might include congenital abnormalities, rheumatic heart disease, or infective
endocarditis. It is believed that CHD most commonly involves the right side of. The management of
patients with carcinoid syndrome is difficult. Yoshioka Y, Matsumura N and Konishi I: Recurrence
of a carcinoid. Schneeberger Y, Reichenspurner H and Gulbins H: Failing stentless. In patients with
extensive metastatic disease, one must carefully consider whether the risks and trauma of cardiac
surgery for palliation are justified. While CMR 9 months prior showed normal cardiac chamber sizes.
The incidence of carcinoid tumours is approximately 1 in 75 000 of the population 1 of whom about
50% develop carcinoid syndrome. Transthoracic echocardiogram is generally considered the key
imaging modality, but cardiac magnetic resonance can add valuable information, particularly in the
assessment of pulmonary valve function or multivalvular disease. Early recognition of CHD with a
multimodality approach may improve outcome, even in complex cases.
Valve replacement can provide survival benefits in patients with CHD, but the optimal timing for the
intervention is uncertain, with data suggesting a trend of improved survival with earlier intervention.
AA: Carcinoid heart disease: Current understanding and future. Cuthbertson DJ: The clinical
presentation and management of. Primary diseases of the tricuspid or pulmonary valves are
uncommon, but the more likely causes might include congenital abnormalities, rheumatic heart
disease, or infective endocarditis. Error: 404 Go back to home page Stay Connected With Semantic
Scholar Sign Up What Is Semantic Scholar. Timmermans P: The path to surgery in carcinoid heart
disease: A. Merrick SH and Rao RK: Transcatheter pulmonic valve replacement in. Roos-Hesselink
JW: Carcinoid heart disease: Outcomes after surgical. You may have mistyped the address or the
page has been moved. Zacks J, Bhattacharyya S, Cuthbertson DJ, Dobson R. We review the current
literature regarding the pathophysiological basis of the disease, the cardiovascular complications, and
the currently available treatment strategies. Despite an understanding of the neurohormones that
carcinoid tumors secrete, their various antagonists and inhibitors have been only partially successful
in providing symptomatic relief. Primary diseases of the tricuspid or pulmonary valves are
uncommon, but the more likely causes might include congenital abnormalities, rheumatic heart
disease, or infective endocarditis. Hombach-Klonisch S: INSL5 is a novel marker for human.
Carcinoid heart disease is a rare, but interesting and important cause of intrinsic tricuspid and
pulmonary valve disease leading to significant morbidity and mortality caused by right heart failure.
JE, Del Bigio MR, Krcek J, Hoang-Vu C, Klonisch T and. The surgical decision in these patients
was based on a multimodality cardiovascular approach, including transthoracic and transesophageal
echocardiography and cardiac magnetic resonance. Telotristat etiprate, a novel serotonin synthesis
inhibitor, in. Anderson Catheterization Laboratory Registry at The University of. You will be able to
get a quick price and instant permission to reuse the content in many different ways. Semantic
Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI.
A and Harringer W: Triple valve replacement in a patient with. Bioprosthetic valves are generally
preferred in CHD due to decreased need for anticoagulation, despite concern for premature
degeneration. RV, right ventricle; TV, tricuspid valve; TR, tricuspid. V, Economopoulos N and
Machairas A: Carcinoid syndrome from a. They also differ in their ability to metastasize, thus
presenting an even more varied clinical picture. Approximately 90% of all carcinoid tumours are
located in the gastrointestinal system of which the most common sites are the appendix and terminal
ileum. A collaboration between the Oncology and Cardiology teams is essential for the long?term
management of CHD patients. Lang RM, et al: Recommendations for noninvasive evaluation of.
Although valvular dysfunction most often coexists with flushing and diarrhea, the findings of
tricuspid regurgitation or stenosis occasionally provide the first clue to the presence of the disease.

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