 Myalgia

 Fatigue
 Nausea
[3] [4]

Post Polio Syndrome

Post-polio syndrome (PPS) is a condition that affects individuals who have
previously had an initial poliovirus infection. PPS typically emerges after a
period of at least 15 years of stability following the initial infection. The
syndrome is characterized by the onset of new weaknesses, central and
peripheral fatigue, musculoskeletal pain, and atrophy of previously unaffected
muscles. The prevalence of PPS among people previously infected with
poliovirus varies, with reported rates ranging from 20% to 75%. This
condition can significantly impact various aspects of individuals' lives,
including bodily functions, mobility, and physical strength, thereby affecting
their ability to maintain an independent life. [9][10]

Despite extensive research, the exact cause of PPS remains elusive. It is

thought to develop from persistent stress on damaged motor units in
individuals with poliomyelitis. One prevailing hypothesis suggests an
imbalance between chronic denervation and reinnervation mechanisms
crucial for maintaining muscle function. Another theory, rooted in muscle
biopsy findings, proposes the reactivation of latent viruses in motor neurons
as a potential contributor to PPS. [11][12]

PPS can occur after 40 years of stable health following poliovirus infection
and is the most prevalent progressive motor neuron disease in the USA. It is
estimated that about 15–20 million people are living with polio worldwide and
about 20%–80% of them will develop PPS. [10][13]