The SPDR® S&P® Biotech ETF (XBI) which seeks to provide investment results that, before

fees and expenses, correspond generally to the total return performance of the S&P®
Biotechnology Select IndustryTM Index (the “Index”). It provides exposure to the
Biotechnology segment of the S&P TMI and tracks a modified equal weighted index which
provides the potential for unconcentrated industry exposure across large, mid and small cap
stocks.1

Link: https://www.ssga.com/us/en/intermediary/etfs/funds/spdr-sp-biotech-etf-xbi#holdings

The NASDAQ Biotechnology Index (NBI) is designed to track the performance of a set of
securities listed on The NASDAQ Stock Market® (NASDAQ®) that are classified as either
biotechnology or pharmaceutical companies, and is a modified market capitalization
weighted index.2 The NBI is reconstituted annually in December in accordance with a set of
eligibility criteria including minimum market capitalization and average daily trading volume,
among other criteria.3

1
https://www.ssga.com/us/en/intermediary/etfs/funds/spdr-sp-biotech-etf-xbi
2
https://indexes.nasdaqomx.com/docs/FS_XNBI.pdf
3
https://ir.ambrx.com/news/news-details/2023/Ambrx-to-be-Added-to-the-NASDAQ-Biotechnology-Index-NBI/
default.aspx#:~:text=The%20NBI%20is%20reconstituted%20annually,Biotechnology%20Index%2C%20visit
%20this%20link.

1
Link: https://indexes.nasdaqomx.com/docs/FS_XNBI.pdf

Other indexes and funds to look at in the pharma space…

The VanEck Pharmaceutical ETF (PPH) seeks to replicate as closely as possible, before fees
and expenses, the price and yield performance of the MVIS® US Listed Pharmaceutical 25
Index (MVPPHTR), which is intended to track the overall performance of companies involved in
pharmaceuticals, including pharmaceutical research and development as well a production,
marketing and sales of pharmaceuticals.4

4
https://www.vaneck.com/us/en/investments/pharmaceutical-etf-pph/overview/

2
Link: https://www.vaneck.com/us/en/investments/pharmaceutical-etf-pph/holdings/

The iShares U.S. Pharmaceuticals ETF (IHE) seeks to track the investment results of an index
composed of U.S. equities in the pharmaceuticals sector.5

5
https://www.ishares.com/us/products/239519/ishares-us-pharmaceuticals-etf#:~:text=The%20iShares%20U.S.
%20Pharmaceuticals%20ETF,equities%20in%20the%20pharmaceuticals%20sector.

3
Link: https://www.ishares.com/us/products/239519/ishares-us-pharmaceuticals-etf#:~:text=The
%20iShares%20U.S.%20Pharmaceuticals%20ETF,equities%20in%20the%20pharmaceuticals
%20sector.

The iShares Global Healthcare ETF (IXJ) seeks to track the investment results of an index
composed of global equities in the healthcare sector.6

Link: https://www.ishares.com/us/products/239744/ishares-global-healthcare-etf

6
https://www.ishares.com/us/products/239744/ishares-global-healthcare-etf