Overview

Levorphanol is an analgesic opioid that is FDA approved for the {{{indicationType}}} of chronic
pain, pain (moderate to severe) and premedication for anesthetic procedure - Surgical
procedure. Common adverse reactions
include cardiovascular: hypotension, dermatologic: pruritus, gastrointestinal: constipation, nause
a, vomitingpsychiatric: altered mental status, disturbance in mood.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)
 Dosage should be individualized based on degree of pain, clinical setting, physical
condition of the patient, and kind and dose of concurrent medication
 Pain, chronic: initial, total daily dose 1/15 to 1/12 of total daily dose of oral morphine;
wait 72 h between dose adjustments
 Pain (Moderate to Severe): up to 1 mg IV injection in divided doses, may repeat in 3
to 6 h as needed; max 4 to 8 mg daily
 Pain (Moderate to Severe): 1 to 2 mg IM/SC, may repeat in 6 to 8 h as needed; max
3 to 8 mg IM daily
 Pain (Moderate to Severe): 2 mg orally, may repeat in 6 to 8 h as needed; may
increase dose up to 3 mg every 6 to 8 h if needed; max 6 to 12 mg daily
 Premedication for anesthetic procedure - surgical procedure: 1 to 2 mg IM/SC 60 to
90 min before surgery

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)
 Safety and effectiveness in pediatric patients have not been established
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information about Off-Label Guideline-Supported Use of Levorphanol in pediatric
patients.
Non–Guideline-Supported Use
There is limited information about Off-Label Non–Guideline-Supported Use of Levorphanol in
pediatric patients.

Contraindications
 Levorphanol is contraindicated in patients hypersensitive to levorphanol tartrate.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use
There is limited information about Off-Label Guideline-Supported Use of Levorphanol in adult
patients.
Non–Guideline-Supported Use
There is limited information about Off-Label Non–Guideline-Supported Use of Levorphanol in
adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)
 Safety and effectiveness in pediatric patients have not been established
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information about Off-Label Guideline-Supported Use of Levorphanol in pediatric
patients.
Non–Guideline-Supported Use
There is limited information about Off-Label Non–Guideline-Supported Use of Levorphanol in
pediatric patients.

Contraindications
 Levorphanol is contraindicated in patients hypersensitive to levorphanol tartrate.