of

FluvoxamineReceptor affinity profile[85][86][87]

Site Ki (nM)

SERTTooltip Serotonin transporter 2.5

NETTooltip Norepinephrine
1,427
transporter
5-HT2C 5,786
α1-adrenergic 1,288
σ1 36

Fluvoxamine is a potent selective serotonin reuptake inhibitor with around 100-fold affinity for
the serotonin transporter over the norepinephrine transporter.[47] It has negligible affinity for
the dopamine transporter or any other site, with the sole exception of the σ1 receptor.[88][13] It behaves
as a potent agonist at this receptor and has the highest affinity (36 nM) of any SSRI for doing so.
[88]
This may contribute to its antidepressant and anxiolytic effects and may also afford it some
efficacy in treating the cognitive symptoms of depression.[89] Unlike some other SSRIs, fluvoxamine's
metabolites are pharmacologically neutral.[90]