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http://dx.doi.org/10.1016/j.aorn.2015.08.002
ª AORN, Inc, 2015
www.aornjournal.org AORN Journal j 343
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Interpreting Arterial Blood
Gases Successfully 2.6 www.aorn.org/CE
ABSTRACT
Arterial blood gas (ABG) analysis is a crucial skill for perioperative nurses, in particular the RN circu-
lator. This article provides the physiological basis for assessing ABGs perioperatively and presents a
systematic approach to blood gas analysis using the Romanski method. Blood gas sample data allow
the reader to practice ABG interpretation. In addition, four case studies are presented that give the
reader the opportunity to analyze ABGs within the context of surgical patient scenarios. The ability to
accurately assess ABGs allows the perioperative nurse to assist surgical team members in restoring a
patient’s acid-base balance. AORN J 102 (October 2015) 344-354. ª AORN, Inc, 2015. http://dx.doi
.org/10.1016/j.aorn.2015.08.002
Key words: arterial blood gases, perioperative, Romanski method, blood gas interpretation.
1,2
Table 1. Components of Arterial Blood Gas Test Results
the nurse determine suitable interventions and treatments to blood pH because changes in the concentration of any ion will
help restore any acid-base imbalance in patients. Finally, result in a change in the overall blood pH.
four case studies and the correct answers are presented to
allow nurses to practice what they have learned. The normal range for pH in human blood is 7.35 to 7.45.
Neutral blood pH is considered to be 7.4. A pH
approaching 7.35 is considered acidic. Conversely, as the
THE NEED FOR ABG MEASUREMENTS
pH approaches 7.4, it is considered alkalotic.8 When
Blood gas interpretation can be useful in a wide variety of
carbon dioxide (CO2) concentration is increased in the
surgical procedures. The results of an ABG test can be
blood, via the respiratory system, water present in the
particularly helpful in any surgery in which large fluid shifts or
blood plasma (H2O) dissociates into Hþ and hydroxide
blood loss are expected (eg, bowel resection, Whipple proce-
ions (OH). Hydrogen and OH also react with sodium
dure, liver resection), thus providing information regarding the
ions (Naþ) circulating in the blood, which creates sodium
patient’s fluid status and metabolic state. A patient requiring
bicarbonate (NaHCO3). This leads to the following
fluid resuscitation can have a large base deficit and metabolic
chemical reaction:
acidosis.7 In any thoracic procedure, especially those in which
one-lung ventilation is used, blood gas analysis can provide CO2 þH2 O4H2 CO3 4Hþ þHCO3 4Naþ 4NaHCO3
information on adequate gas exchange. In addition to these
procedures, the anesthesia professional and surgeon rely on The amounts of the ions present can then shift back and
ABGs during cardiac, neurological, or long oncological forth depending on either the metabolic or respiratory state
procedures to direct care. of the individual. According to the Henderson-Hasselbach
equation, pH is calculated based on the relationship be-
INTERPRETING ABG MEASUREMENTS tween the concentrations of CO2 and HCO39(A/B Reg)
Successful interpretation of ABG results begins with an un- and is used to accurately determine pH in a solution such as
derstanding of pH and the effect of acidosis and alkalosis on blood. This equation is expressed as follows:
tissue oxygenation. The body’s regulation of Hþ is influenced
HCO3
by both the respiratory and metabolic systems. Nurses should pH ¼ 6:1 þ log10
0:03 pCO2
know the relationships between all the ions that contribute to
1
Table 2. Conditions Associated With Respiratory Acidosis by Physiological Mechanism
Central Nervous System Ventilation Control Peripheral Nervous System Ventilation Control Ventilation-Perfusion Mismatch
Anesthetic medication toxicity Myasthenia gravis Pneumothorax
Benzodiazepine overdose Poliomyelitis Pleural effusion
Opioid overdose Polymyopathy Atelectasis
Stroke Neuromuscular blockade Pneumonia
Spinal cord injury Pulmonary edema
1. Nelligan PJ, Deutschman CS. Perioperative acid-base balance. In: Miller RD. ed. Miller’s Anesthesia. 8th ed. Philadelphia, PA: Elsevier
Saunders; 2015:1811-1829.
Figure 2. The oxyhemoglobin dissociation curve (also known as the oxygen-hemoglobin dissociation curve). O2 ¼
oxygen, PaCO2 ¼ partial pressure of carbon dioxide, PaO2 ¼ partial pressure of oxygen, SaO2 ¼ oxygen saturation.
an increase in the affinity of Hgb for O2. This results in a interventions that may be needed to assist the patient in
higher saturation of Hgb with O2 than at neutral pH at returning to a normal pH.
the same PaO2. The converse is true for acute acidosis, in
which pH levels are decreased. When this occurs, there is a PaO2 and PaCO2
decrease in the affinity of Hgb for O2, and this results in The PaO2 and PaCO2 values represent the status of a patient’s
less O2 saturation of Hgb than occurs at neutral pH for respiratory function. If the PaO2 values fall below 80 mm Hg,
the same PaO2. To see this more clearly, locate the * on this may indicate that the patient does not have sufficient
the curve in Figure 1 at PaO2 30 mm Hg and you will see oxygen to adequately fuel cellular aerobic respiration. Cells
that a patient with acidosis will only have 42% saturation, that are not adequately oxygenated are unable to fuel the tri-
while at the same PaO2, a patient with normal pH will cyclic acid cycle production of adenosine triphosphate (ATP),
have an SaO2 of 60%. the primary source of cellular energy. In this situation, the cells
resort to using anaerobic respiration. Anaerobic respiration is
less efficient than aerobic and contributes protein acid waste in
Respiratory and Metabolic Compensation the form of lactic acid. As lactic acid builds up in the patient’s
Two main organs regulate acid-base balance: the lungs and the circulation, it increases the severity of acidosis.8
kidneys. The respiratory system regulates the amount of car-
bonic acid in the blood by controlling PaCO2, and a patient’s Patients with hypoxemia have inadequate PaO2 levels. Hyp-
respiratory rate will change to attempt to correct PaCO2 levels oxemia may exist in diseases that inhibit O2 from reaching the
that are out of the normal range. Respiratory regulation and bloodstream in the lungs, such as COPD and emphysema.
compensation can occur within minutes. If patients are unable Other conditions, such as anemia or acute blood loss from
to compensate via their own respiratory system, mechanical trauma, decrease the oxygen-carrying capacity of blood by
interventions such as a ventilator, continuous positive airway decreasing the amount of available Hgb.8
pressure (CPAP), or bilevel positive airway pressure (BiPAP)
may be needed. Respiratory rate influences PaCO2 levels in arterial blood.
When there are increases in a patient’s ventilatory rate, such as
The patient’s kidneys control the NaHCO3 buffering sys- occur in anxiety states or as a result of sudden anemia from any
tem and are able to excrete both Hþ and HCO3 into the cause, PaCO2 levels will decrease. Levels of PaCO2 below
urine. Metabolic compensation occurs primarily in the 35 mm Hg produce primary respiratory alkalosis. Increases in
kidneys and can take from three to five days to occur. When respiratory rates that result in alkalosis are rare events
acidosis persists, the kidneys are also able to produce new compared with respiratory acidosis. Respiratory acidosis exists
HCO3, which further contributes to the restoration of when PaCO2 rises above 45 mm Hg. Levels of PaCO2 rise in
normal pH.9 When there is a large of amount of Hþ medical conditions that also cause decreases in PaO2.
present in the renal tubules, more Hþ is excreted in the
urine than HCO3, which results in the urine becoming SaO2
more acidic and the blood becoming more alkalotic. Hemoglobin saturation with oxygen is expressed as a per-
Because it takes time to filter blood in the kidneys, this centage. As discussed earlier, the saturation of Hgb is directly
process is much slower than the regulation of CO2 by related to PaO2. The normal range for SaO2 is 80% to 100%.
the lungs.9 The SaO2 value represents the amount of oxygen available to
the patient’s tissues from the arterial blood. Values less than
Actions of pH 80% may not be sufficient to meet the oxygen needs of tissues,
A patient’s pH level indicates the status of acid-base balance. especially tissues that have normally high oxygen consumption
Values less than 7.35 indicate that the patient is experiencing requirements (eg, brain, heart, kidneys). Low SaO2 levels
acidosis, while values above 7.45 indicate alkalosis. However, along with low PaO2 values indicate that the patient is in a
information about pH values are insufficient to diagnose the hypoxemic state, which requires supplemental oxygen
cause of an imbalance or to determine whether the body is administration. Hypoxemia is classified as mild, moderate,
attempting to compensate in response to the imbalance. Other or severe:
ABG measurements that are crucial for determining the pa- mild hypoxemia is defined as a PaO2 of 60 mm Hg to
tient’s full physiological status include PaO2, PaCO2, SaO2, 70 mm Hg,
bicarbonate, and the base excess or base deficit. These mea- moderate hypoxemia is defined as a PaO2 of 40 mm Hg to
surements guide the perioperative team toward instituting 59 mm Hg, and
Compensation for Acidosis and Alkalosis While most blood gas results provide all the measurements
After the nurse identifies the cause of the pH imbalance discussed previously, it is possible to analyze an ABG without
(whether the respiratory component [PaCO2] or the metabolic SaO2 and base deficit/base excess values. The hypothetical
component [HCO3]), the remaining value is used to deter- ABG scenarios to follow discuss how the RN can analyze test
mine whether the patient’s body is making an effort to correct results. These four examples lead the reader through ABG
the condition. If the anesthesia professional identifies an analysis using a step-by-step process, and sidebars 1 through 4
provide the RN with additional case studies of the ABG results are critically low. However, a complete patient history and
that demonstrate how to determine the patient’s conditions physical examination also are needed before any treatment is
and potential interventions. carried out. If the patient has COPD, attempting to increase
oxygenation could disable the patient’s respiratory drive
Scenario 1 centers in the brain.
On room air, the patient has a pH of 7.24, PaCO2 of 38 mm
Hg, PaO2 of 80 mm Hg, and HCO3 of 15.5 mEq/L. Scenario 3
While undergoing surgery via general anesthesia, the pa-
In step 1, the RN should look at the pH. In this case, the
tient’s pH is noted to be 7.45, PaCO2 is 32 mm Hg, PaO2 is
pH value is below the low end of normal (ie, 7.35), which
138 mm Hg, HCO3 is 23 mEq/L, base deficit is 1 mEq/L,
indicates acidosis.
and SaO2 is 92%.
In step 2, the RN should evaluate the results for respiratory
or metabolic components. In this scenario, the PaCO2 is In step 1, the nurse determines that the pH indicates alka-
normal and the HCO3 indicates acidosis. losis. The patient’s PaCO2 is in the alkalotic range, while the
In step 3, the RN should look for the value consistent with HCO3 is at the low end of the normal range.
the pH results. The value that is consistent with the pH in In step 2, the nurse evaluates for respiratory or metabolic
this scenario is the HCO3, indicating a metabolic cause. components and determines that the patient is in respiratory
In step 4, the RN should evaluate for evidence of alkalosis.
compensation. To do this, he or she would search for the The consistent value (step 3) is the PaCO2, which is below
value that is not consistent with the pH. In this scenario, normal range and is consistent with the alkalotic pH value.
that is the PaCO2, which is within normal range, indicating Because the HCO3 is in the normal range, there is no
that there is no compensation occurring. compensation (step 4), and the base deficit and SaO2 are
both in normal range.
After this analysis, the nurse determines that this patient is in
metabolic acidosis with no compensation. These data are Based on these results, the nurse determines that this patient
insufficient to determine an appropriate intervention. The is in respiratory alkalosis with no compensation. To correct
nurse needs to perform a physical assessment and review the this, the anesthesia professional may attempt to overcome
patient’s history to guide the next steps in treatment. the alkalosis by hyperventilating the patient (as indicated by
the high PaO2) or may gather more data to determine
Scenario 2 whether the hyperventilation of the patient may be causing
The patient has a pH of 7.39, PaCO2 of 51 mm Hg, PaO2 of the respiratory alkalosis. More data are needed to guide
59 mm Hg, and HCO3 of 30 mEq/L. further intervention.
Starting with step 1, the nurse notes that the pH is in in the
Scenario 4
normal range, using 7.4 as an absolute value to determine
The ABG results indicate that the patient’s pH is 7.27, PaCO2
the presence of acidosis or alkalosis; 7.39 is lower than 7.4,
is 55 mm Hg, PaO2 is 93 mm Hg, HCO3 is 41 mEq/L, base
so the patient is experiencing acidosis.
excess/base deficit is 10 mEq/L, and SaO2 is 82%.
In step 2, the nurse notes that the patient’s PaCO2 is higher
than normal, indicating acidosis, and the HCO3 is in the Based on these results, the nurse determines that the pa-
alkalotic range. tient’s pH is acidotic (step 1).
Finding a consistent value (step 3), the nurse sees that the The elevated PaCO2 indicates acidosis, and the elevated
value that matches the acidotic state is PaCO2, indicating HCO3 indicates alkalosis (step 2).
that the cause of the acidosis is respiratory. The value that is consistent (step 3) with the pH is the
To determine if compensation is occurring (step 4), the PaCO2; this indicates that acidosis is from a respiratory
nurse sees that the patient’s HCO3 is greatly elevated, cause.
indicating a metabolic effort to compensate. The HCO3 value is not consistent with the pH and is in
the alkalotic range, so there is a metabolic attempt to
Based on the assessment, the nurse determines that this
compensate (step 4).
patient is in respiratory acidosis with complete metabolic
compensation because the pH has returned to the normal However, compensation is only partial because the pH has not
range (ie, just 0.1 below absolute normal of 7.40). This returned to normal. The nurse determines that this patient is
patient may need supplemental oxygen because PaO2 levels in respiratory acidosis with partial metabolic compensation;
Blood Gas Measure Values Acidotic? Alkalotic? Normal? Case Study Three
pH 7.37 Yes Mr W is a 78-year-old man with a history of recent pul-
Partial Pressure 58 mm Hg Yes monary embolism and cardiovascular stent placement for
of Carbon
Dioxide coronary artery disease. Other significant comorbidities
(PaCO2) include bronchoalveolar carcinoma, surgically treated by
Partial Pressure 65 mm Hg No partial lung removal of the left upper lobe, and seizure
of Oxygen
(PaO2) disorder. He presents at an emergency department with
Concentration of 29 mEq/L Yes sudden vision changes in his left eye. Computed tomog-
Bicarbonate raphy reveals an occipital mass, and the emergency physi-
(HCO3)
cian refers him to a neurosurgeon. The day before Mr W
Base Deficit/ 0 mEq/L
Base Excess undergoes surgery for right occipital craniotomy to remove
Oxygen 87% No the brain lesion, he has an episode of respiratory distress
Saturation and complains of chest pain. The nurse acts on an existing
(SaO2)
order to have a respiratory therapist draw an arterial blood
gas (ABG), which shows the following results.
Results: This patient is in respiratory acidosis with full Oxygen 97% Yes
Saturation
metabolic compensation. (SaO2)
Results: This patient is in respiratory alkalosis with no Step 2 (evaluate respiratory and metabolic compo-
compensation. nents): PaCO2 is in the normal range; HCO3 is alkalotic.
Step 3 (determine consistent value): The HCO3 value
Interpretation: This scenario can be caused by hyperven- is consistent with the pH, so the cause of imbalance is
tilation associated with pain and/or anxiety. The respiratory metabolic.
distress the patient is experiencing also may be related to the Step 4 (determine compensation): PaCO2 is in the
complaint of chest pain and not an oxygenation/ventilation normal range, so there is no compensation occurring.
mismatch from the previous lung surgery or a pulmonary Base excess is elevated and SaO2 is normal.
embolism. If the patient is hyperventilating, the nurse
should take measures to calm and reassure the patient to Results: This patient is in metabolic alkalosis with no
help him slow his breathing. Additionally, assessing for pain compensation.
and obtaining analgesic medication orders is also an option.
Intervention: There is presence of a base excess, which in-
1. Romanski SO. Interpreting ABGs in four easy steps. Nursing. dicates that the patient may need fluid resuscitation and/or
1986;16(9):58-64.
blood products to correct the acute anemia associated with
Case Study Four the vaginal blood losses. The RN circulator should be ready
Ms P is a 67-year-old woman with recent episodes of to assist the anesthesia professional by helping to establish a
postmenopausal vaginal bleeding and the following secondary IV access or an arterial line. Circulating volume
comorbidities: cerebral palsy with chronic pain and spas- may need to be replaced with either IV lactated Ringer’s
ticity, neurogenic bladder, hypothyroidism, hyperlipidemia, solution or blood products. Other interventions to consider
hypercholesterolemia, peripheral artery disease, systolic include reviewing the patient’s history for recent episodes of
heart failure, chronic hypokalemia, hypomagnesemia, vomiting, nasogastric tube placement with suction, and
controlled type 2 diabetes, mitral valve disorder, and acute diuretic use leading to volume and electrolyte depletion.
anemia. Her physician has cleared her to undergo a total Other diagnostic tests may include checking the patient’s
abdominal hysterectomy with bilateral salpingo- hematocrit, basic chemistry panel, and blood glucose.
oophorectomy and possible pelvic and periaortic lympha- 1. Romanski SO. Interpreting ABGs in four easy steps. Nursing.
denectomy. The anesthesia professional draws an arterial 1986;16(9):58-64.
blood gas (ABG) during the first 30 minutes of the pro-
cedure, which shows the following results.
Analysis of ABGs and Interventions for
Blood Gas Measure Values Acidotic? Alkalotic? Normal? Perioperative RNs
pH 7.49 Yes Major procedures are not the only instances during which
Partial Pressure 39 mm Hg Yes blood gas analyses are important. In any patient with pul-
of Carbon monary disease (eg, COPD, severe asthma, interstitial lung
Dioxide
(PaCO2)
disease), a blood gas analysis also may be critical. For
Partial Pressure 249 mm Hg Elevated example, patients with severe COPD may have an elevated
of Oxygen baseline PaCO2. Decreasing the patient’s PaCO2 to normal
(PaO2)
perioperatively may suppress respiratory drive. This affects
Concentration 30 mEq/L Yes
of Bicarbonate
the anesthesia professional’s ability to extubate the patient
(HCO3) at the end of the procedure because the patient would lack
Base Deficit/ 6 mEq/L Elevated the “normal” hypercapneic drive to breathe, which is higher
Base Excess
than for healthy adults. This may necessitate the need for
Oxygen Saturation 99% Yes
(SaO2)
ventilator support in the postanesthesia care unit or the
intensive care unit. In the postanesthesia care unit or the
intensive care unit, blood gas measurement can provide
Using the Romanski method,1 the RN interprets the important insight into the etiology of a patient’s altered
ABG analysis. mental status or varied respiratory pattern. The case studies
give the reader an opportunity to practice ABG analysis
Step 1 (evaluate pH): The pH value clearly indicates
using the Romanski method and increase confidence in
alkalosis.
clinical ABG analysis.
Continuing Education:
Interpreting Arterial Blood Gases
Successfully 2.6 www.aorn.org/CE
PURPOSE/GOAL
To provide the learner with knowledge specific to interpreting arterial blood gases (ABGs).
OBJECTIVES
1. Explain what ABGs are.
2. Discuss what ABGs measure.
3. Discuss how acidosis and alkalosis may be identified using ABG results.
4. Explain how the nurse can determine whether respiratory or metabolic factors are causing an imbalance.
The Examination and Learner Evaluation are printed here for your convenience. To receive
continuing education credit, you must complete the online Examination and Learner Evaluation
at http://www.aorn.org/CE.
7. As CO2 increases, it forces the hydrogen ion concentration 9. Which element represents metabolic changes in acid-base
to increase and the patient’s blood becomes more alkalotic. status?
a. true b. false a. Intracellular HCO3.
b. Partial pressure of PaCO2.
8. What might be seen in the ABG results of a patient with c. Base excess.
alkalosis? d. Extracellular HCO3L.
1. A decrease in CO2.
2. An increase in CO2.
3. A pH of 7.5 or higher. 10. Which element represents respiratory changes in acid-
4. A pH of 7.4 or lower. base status?
a. 1 and 3 b. 2 and 4 a. pH. b. PaO2.
c. 1, 2, and 4 d. 1, 2, 3, and 4 c. Base excess. d. PaCO2.
Continuing Education:
Interpreting Arterial Blood Gases
Successfully 2.6 www.aorn.org/CE
8A.
Will you change your practice as a result of reading this
article? (If yes, answer question #8A. If no, answer
question #8B.)
4. Explain how the nurse can determine whether respiratory 8B. If you will not change your practice as a result of
or metabolic factors are causing an imbalance.
reading this article, why? (Select all that apply)
Low 1. 2. 3. 4. 5. High 1. The content of the article is not relevant to my
practice.
CONTENT
2. I do not have enough time to teach others about the
5. To what extent did this article increase your knowledge of
purpose of the needed change.
the subject matter?
3. I do not have management support to make a
Low 1. 2. 3. 4. 5. High
change.
6. To what extent were your individual objectives met? 4. Other: __________________________________
Low 1. 2. 3. 4. 5. High
7. Will you be able to use the information from this article 9. Our accrediting body requires that we verify the time
in your work setting? you needed to complete the 2.6 continuing education
1. Yes 2. No contact hour (156-minute) program: _____________