International Conference On

"Emerging cutting
Edge Research & Innovations in Pharmaceutical, Life
Sciences & Technology"-2024
1st author Khushi Chouksey, 2nd Dr. Vijay kumar Singh & 3rd Dr. Veena Devi singh
Corresponding author-Dr. Veena singh
(PHD Research Scholar)
Shri Rawatpura College of Pharmacy, Shri Rawatpura Sarkar University,
Raipur ( Chattisgarh), Pin-492015
Presenting author mail id:- khushi2021chouksey@gmail.com
(Associate professor)
Sagar Institute of Pharmacy and Technology- SIPTEC, Near International Airport, Jaipur Road,
Gandhi Nagar Bhopal,
Madhya Pradesh 462036 , India

THERAPEUTIC POTENTIAL OF NATURAL BIOACTIVES

FOR MANAGEMENT OF
NEURODEGENERATIVE DISORDERS: INSIGHTS AND
FUTURE TRENDS
Abstract
An important worldwide health issue is the gradual loss of neurons; structure and
function caused by neurodegenerative illnesses. Current pharmaceutical therapies often provide
symptomatic relief but don't stop the spread of illness. Therefore, it is vital to investigate cutting-
edge therapy approaches. The therapeutic potential of natural bioactives is examined in this
review, a promising area in the treatment of neurodegenerative illnesses. These bioactives, which
come from a variety of sources including plants, fungus, and marine creatures, exhibit a wide
range of neuroprotective benefits, such as anti-inflammatory, antioxidant, and anti-
amyloidogenic qualities. In a thorough analysis of the available data on their molecular activity,
we place special emphasis on how they interact with cellular pathways and receptors linked to
neurodegeneration. Key data from pre-clinical and clinical trials examining the neuroprotective
potential of these bioactives are also included in the review. Although there are still a number of
difficulties, such as bioavailability problems and possible toxicity, new technical developments
provide chances for the improvement of bioactive delivery. Offering a thorough introduction of
this quickly developing profession, future views and trends are also covered, including
personalised medicine and massive clinical trials. By highlighting the potential of natural

ART MATERIALS
bioactives as a frontier in the creation of cutting-edge treatments for neurodegenerative diseases,
this review opens the door for further investigation in this field.

Enhanced Drug Delivery Targeted Therapy

Nanoparticles can improve Functionalized
the delivery of drugs to the nanoparticles can be
brain by crossing the designed to specifically
blood-brain barrier (BBB) target diseased cells or
more efficiently or by being tissues within the CNS,
administered directly into the increasing the precision of
central nervous system treatment and reducing
(CNS). This enables higher collateral damage to
drug concentrations at the healthy cells. This
target site, leading to targeted approach
improved therapeutic enhances therapeutic
outcomes while minimizing efficacy and minimizes
systemic side effects off-target effects.

Future Trends
The future of nano therapeutics for neurological disorders is marked by promising advancements poised
to revolutionize treatment paradigms. Precision medicine approaches tailored to individual patient
profiles, multimodal nanoparticles combining therapeutic and diagnostic functionalities, innovative
targeting strategies for precise drug delivery to the brain, and the integration of biomimetic and
gene-editing technologies represent key trends driving progress in this field. Additionally, the
development of implantable nano devices for real-time monitoring and on-demand therapy, coupled with
the utilization of bioinformatics and computational modeling tools for optimized nanoparticle design,
underscores the transformative potential of nano therapeutics in neurology. As more nano-based
therapies progress from preclinical research to clinical translation and regulatory approval, the future
holds immense promise for addressing unmet medical needs, improving treatment outcomes, and
enhancing the quality of life for patients with neurological disorders.

Conclusion
The search for efficient treatment solutions for neurodegenerative illnesses, which place a huge health burden on people worldwide, is still
underway. Due to their many modes of action and possible neuroprotective qualities, natural bioactives have become an attractive area of research.
The goal of this study was to provide an overview of the state of the science around the therapeutic potential of natural bioactives in treating
neurodegenerative diseases.