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Evidence-based safe practice guidelines for

I.V. push
medications By Ann D. Shastay, MSN, RN, AOCN

WHILE MUCH EMPHASIS has been placed on the improvement


of I.V. infusion safety, little published evidence or standardized best
practices are associated with I.V. push injections. Although health-
care organizations typically require competency validation for
nurses and other professionals with I.V. administration responsi-
bilities, much of this validation focuses on placing and managing
vascular access devices. Graduate nurses may learn much of their
I.V. therapy/I.V. medication delivery information, and gain most of
their experience, from a coworker or preceptor during initial job
orientation. These factors contribute to variation in knowledge
and skill development and a lack of standard practices across
ROY S COTT

organizations, potentially compromising patient safety.

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To address unsafe practices and the medication or solution; disinfec- uncluttered, and functionally sep-
at-risk behaviors associated with the tion of the I.V. access port, needleless arate location using organization-
preparation and administration of I.V. connector, or other vascular access approved, readily available drug
push medications in adults, the Insti- device before medication administra- information resources and sterile
tute for Safe Medication Practices tion; and use of personal protective equipment and supplies. Special
(ISMP) obtained an educational grant equipment if contact and exposure to procedures, including the use of a
from BD to hold a national summit of blood or body fluids is possible. dedicated workspace, are considered
expert stakeholders. The 56 partici- • Withdraw I.V. push medications essential to maintain asepsis when
pants included representatives from from glass ampules using a filter nee- I.V. push medications are prepared
hospitals and other frontline provid- dle or straw, unless specific drugs for immediate use in less than an
ers, professional organizations such as preclude their use. Although contro- International Standards Organiza-
the Infusion Nurses Society (INS) and versial, the use of a filter needle or tion (ISO) Class 5 environment.
the ECRI Institute, regulatory bodies straw to reduce the risk of glass par- ISO, an independent international
such as the FDA and The Joint Com- ticle contamination was supported by a organization, has established “clean-
mission, and product vendors. Dur- consensus of summit participants after room” levels ranging from Class 1
ing the 2-day summit, participants careful consideration of its impact on (cleanest) to Class 9 (least clean)
reached consensus on various prac- safety and its ability to be implement- based on factors such as level of en-
tices for I.V. push medications, relying ed in most healthcare organizations. vironmental pollutants.3 For more
on the synthesis of the best evidence • Dilute I.V. push medications only about cleanroom levels, visit www.
currently available, expert opinion, when recommended by the manu- iso.org.
and manufacturers’ guidelines. Regu- facturer, supported by evidence in The Association for Professionals in
latory requirements were also ac- peer-reviewed biomedical litera- Infection Control and Epidemiology
knowledged and included as appro- ture, or in accordance with ap- (APIC) suggests that, in addition to a
priate. All summit participants were proved institutional guidelines. clean and dry workspace, parenteral
volunteers and received no compen- Dilution of medications before ad- medication preparation must be per-
sation beyond travel and meeting ex- ministering a medication I.V. push formed away from obvious contamina-
pense reimbursement. may be required by the manufac- tion sources such as water and sinks.4
Based on guidelines issued by turer; whenever possible, this should Advance preparation of immediate-use
summit participants and prepared by occur in the pharmacy before the syringes or I.V. infusions (the night
ISMP, this article summarizes impor- medication is dispensed. Unneces- before or even hours before) outside of
tant safe practice guidelines for the sary dilution adds complexity to the an ISO Class 5 environment is consid-
preparation, labeling, and administra- drug administration process and in- ered a controversial issue, and this
tion of I.V. push medications for adult troduces an avoidable risk of making practice isn’t supported by APIC, the
patients. For the full guidelines and a medication errors and contaminating U.S. Pharmacopeial Convention
complete listing of participants and sterile I.V. medications or solutions. (USP), INS, or ISMP.
references, visit http://www.ismp.org/ A recent ISMP survey of nurses • Provide instructions and access
Tools/guidelines/IVSummitPush/ (RNs and LPNs) suggested that un- to the proper diluent when recon-
IVPushMedGuidelines.pdf. necessary dilution of I.V. push medi- stitution or dilution is necessary
cations happens frequently, even with outside of the pharmacy sterile
PREPARING I.V. medications provided in prefilled compounding area. If reconstitution
PUSH MEDICATIONS syringes or pharmacy-dispensed sy- or dilution of a medication is neces-
The following guidelines represent ringes that contain a patient-specific sary, take steps to provide ready
consensus standards for safe practices dose.1 An earlier study found that access to the proper diluent and in-
associated with the preparation of I.V. errors related to dilution most fre- structions for reconstitution or dilu-
push medication prescribed for adults. quently included using the wrong tion to support safe practice. In some
• Use sterile technique when pre- diluent.2 ISMP has also received re- facilities, this consists of pharmacy-
paring and administering I.V. push ports of errors related to the adminis- prepared kits; in other facilities, this
medications, flush/locking solu- tration of the wrong medication or information is available in an elec-
tions, and other parenteral solu- solution due to unlabeled or misla- tronic medication administration
tions administered by direct I.V. beled syringes of diluted medications. record (eMAR) in an expanded view
injection. Sterile technique includes • If dilution or reconstitution of as part of the eMAR entry.
hand hygiene before and after prepa- an I.V. push medication becomes • Do not withdraw I.V. push medi-
ration and administration of medica- necessary outside of the pharmacy cations from commercially avail-
tions or solutions; disinfection of the sterile compounding area, per- able, cartridge-type syringes into
medication access diaphragm on a vial form these tasks immediately another syringe for administration.
or neck of an ampule before accessing before administration in a clean, This type of system was introduced to

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the marketplace to save time and • When necessary to prepare
reduce the potential for medication more than one medication in a
errors by limiting the number of steps single syringe for I.V. push admin-
required to prepare an injectable istration, limit preparation to the
medication. With their easy-loading pharmacy. Combining more than
cartridges, these syringes may also one medication in a single syringe
help avoid delays in drug administra- for I.V. push use is seldom necessary
tion. Over the years, however, nurses and error-prone. This practice could
have adopted an unsafe practice of also result in unwanted changes in
using the prefilled syringe cartridges the medications due to incompat-
as single-dose or multiple-dose vials ibilities. Unless required for immedi-
by withdrawing the medication from ate use, compounding more than
the cartridges.5 Using the cartridges as one drug in a single syringe should
vials can lead to contamination be- be carried out in the pharmacy, in a
cause the cartridges weren’t intended USP-compliant cleanroom.
to be used in this manner. This unsafe • Never use I.V. solutions in contain-
practice also can lead to dosing errors, ers intended for infusion, including
drug mix-ups, and other types of mini bags, as common-source con-
medication errors, particularly be- tainers (multiple-dose products) to
cause the prepared syringes are often prepare I.V. flush syringes or to di-
unlabeled. Utilizing the cartridges as lute or reconstitute medications for
vials is also not economical when Label all clinician-prepared one or more patients in clinical care
comparing the cost of prefilled sy- areas. I.V. infusion bags are labeled
ringes or vials of the same medication.
syringes unless the by the manufacturer as single-dose
• Do not dilute or reconstitute I.V. medication or solution is containers, and as such are intended
push medications by drawing up prepared at the bedside for administration as a single dose for
the contents into a commercially and administered use promptly after the container is
available, prefilled flush syringe opened. Any unused portions should
of 0.9% sodium chloride. Com-
immediately. be discarded.7 APIC standards also
mercially available prefilled syringes suggest never using I.V. solution bags
of 0.9% sodium chloride and hepa- legal liability for any adverse events or bottles to obtain flush solutions,
rin are regulated by the FDA as occurring from this practice.6 diluents, or for any other purpose for
devices, not as medications. These The mislabeling that occurs when more than one patient.4 Examples in
devices have been approved for the medications are added to a prefilled the literature can be found in which
flushing of vascular access devices, syringe and a secondary label isn’t the use of common-source infusion
not for the reconstitution, dilution, applied creates significant risk for bags has resulted in the administration
and/or subsequent administration of errors. In many cases, the manufac- of contaminated injection solution.
I.V. push medications. Such use turer’s label is permanently affixed to Some respondents to an ISMP sur-
would be considered “off label” and the syringe barrel and contains vey erroneously suggested this prac-
isn’t how manufacturers intended product codes and a barcode as well tice was safe because they discarded
these products to be used. These as specific information about the the solution after 24 hours. However,
prefilled flush syringes haven’t been fluid and its volume. When another limiting use to 24 hours doesn’t pre-
tested for product safety when used medication is added to this syringe, vent disease transmission if the bag
in this manner. the manufacturer’s label can’t be becomes contaminated.8 The CDC’s
Warnings intended to limit the use amended without covering the origi- guideline for safe injection practices
of prefilled syringes for medication nal information.6 In that case, a sy- also indicates that practitioners
preparation and administration appear ringe may remain labeled as 0.9% shouldn’t use bags or bottles of I.V.
on some syringe barrels, clearly stating sodium chloride, for example, even solution as a common source of sup-
“I.V. flush only.” Some manufacturers though it also contains the diluted ply for multiple patients.9 If the solu-
have also limited or removed the gra- or reconstituted medication. This tion becomes contaminated, it could
dation markings on the prefilled flush unsafe practice is widespread and transmit disease to many patients.
syringes in order to prevent measure- many who use it mistakenly believe
ment of a secondary medication in the the risk of an error is insignificant. LABELING I.V. PUSH
flush syringe. When prefilled syringes Summit participants disagreed with MEDICATIONS
are used in an off-label manner, the this view and arrived at a consensus The following guidelines represent
practitioner and employer bear the that the practice must be eliminated. consensus standards for safe practices

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associated with labeling I.V. push • Alternatively, if a practitioner pre- ADMINISTERING I.V.
medications prescribed for adults. pares one or more medications or PUSH MEDICATIONS
• Appropriately label all clinician- solutions away from the patient’s The following guidelines represent
prepared syringes of I.V. push bedside, immediately label each sy- consensus standards for safe practices
medications or solutions, unless ringe, one at a time, before prepar- associated with administering I.V. push
the medication or solution is pre- ing the next medication or solution. medications prescribed for adults.
pared at the patient’s bedside and is • Bring only one patient’s labeled • Perform an appropriate clinical
immediately administered to the syringe(s) to the bedside for ad- and vascular access site assessment
patient without any break in the ministration. Group consensus de- of the patient before and after the
process. Facilities should provide all termined that completing an entire administration of I.V. push medica-
drug preparation areas (inpatient and sequence of preparing, scanning, and tions. An appropriate clinical assess-
outpatient) with commercially avail- administering a medication for I.V. ment includes an evaluation of the
able preprinted labels that allow for push injection before the preparation prescribed therapy for the patient’s
easy application on syringes, and pro- of a second parenteral medication will age and clinical status (reason for
vide prompts for appropriate docu- limit the possibility of error due to drug treatment), the drug name, dose,
mentation of the intended drug and syringe swap. If more than one sy- route, rate of administration, and fre-
contents (including drug name and ringe must be prepared, completing quency. The practitioner should assess
concentration/dose). Medications or the preparation and labeling of one the patient for therapy indications
solutions in unlabeled syringes are syringe at a time is the safer approach. and contraindications, have knowl-
unidentifiable and have been mis- • Provide clinical units with blank edge of the size and type of venous
taken for different medications or or printed, ready-to-apply labels, access device, confirm that the vascu-
solutions and administered to the including sterilized labels where lar access device is functional (for ex-
wrong patient, in the wrong dose, needed, to support safe labeling ample, aspirating for positive blood
and/or by the wrong route. Many practices. An American Nurses As- return and encountering no resistance
errors associated with unlabeled sociation study identified that the when manually flushing a vascular
containers have resulted in serious top reasons nurses don’t label sy- access device), and verify that the pa-
patient harm or death. ringes included concerns that the tient is clinically suited for the pre-
• If the clinician needs to prepare labels may cover the measurement scribed I.V. push medication.13 For
and administer more than one sy- gradation on the syringe barrel, im- example, perform a comprehensive
ringe of medication or solution to pairing the ability to accurately pain assessment using a validated and
a single patient at the bedside: check the dosage, and lack of a suit- appropriate pain rating scale both
—prepare each medication or so- able label. Preprinted, ready-to-apply before and at the appropriate time
lution separately, and immediately labels, including available sterilized (typically within 30 minutes) after
administer it before preparing the labels where needed, can support administering an I.V. opioid.
next syringe. safe labeling practices.12 As with any medication, the prac-
—or, if preparing several I.V. push • Immediately discard any unat- titioner administering an I.V. push
medications at a time for sequen- tended, unlabeled syringes contain- medication should carefully review
tial I.V. push administration, label ing any type of solution. Unlabeled the vial or syringe label; confirm
each syringe as it’s being prepared, syringes should always be considered accuracy of the patient, drug, dose/
before the preparation of any sub- unidentifiable unless prepared at the strength, route, and time the medica-
sequent syringes. bedside and administered immedi- tion is due by comparing the drug
It’s not safe to prepare a syringe ately by the preparer. Administration label against the prescription or
away from the patient’s bedside and of an I.V. push medication from an MAR; confirm the integrity of the
carry it unlabeled to the bedside, even unlabeled syringe, even if the practi- container (intact; no leaks), check for
if the intent is to administer it imme- tioner “thinks” that he or she knows any visible contamination (precipi-
diately. Clinicians have been unex- what the unlabeled syringe contains, tate, lack of clarity); verify the po-
pectedly interrupted or distracted carries high risk and has resulted in tency (within the beyond-use date);
while carrying an unlabeled syringe to severe patient harm and even death.10 and validate that any special storage
the bedside, increasing the risk of a • Never prelabel empty syringes in conditions have been met.10,13
mix-up.10 Also, The Joint Commis- anticipation of use. Errors have Before, during, and after adminis-
sion National Patient Safety Goal occurred when a prelabeled syringe tration, practitioners should assess
(03.04.01) requires practitioners to was mistakenly selected and the the patient’s venous access site for
“label all medications, medication wrong medication or solution was any signs of infiltration or extravasa-
containers (for example, syringes, drawn into the syringe. Instead, la- tion, monitor the patient for poten-
medicine cups, basins), or other solu- bel each syringe immediately after tial adverse events and reactions, and
tions on and off the sterile field.”11 preparation, one at a time. be prepared to initiate appropriate

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interventions should an adverse ed.14 Therefore, practitioners who to the patient, unless contraindi-
event occur.10,13 administer I.V. push medications cated in current evidence-based
• Unless its use would result in a over a period of seconds to minutes literature, or unless the proximal
clinically significant delay and po- must have immediate access to a site is inaccessible for use, such as
tential patient harm (for example, watch or clock with a second hand or during a sterile procedure. Access
delaying emergency administra- with a digital display of minutes and points closest to the patient are
tion of I.V. atropine for symptom- seconds. Because not all locations preferable for use during I.V. push
atic bradycardia with a pulse), use where I.V. medications are adminis- medication administration and sub-
barcode scanning or similar tech- tered have a viewable wall clock, it’s sequent flushing procedures, as they
nology immediately prior to the suggested that the practitioner wear allow the medication to reach the
administration of I.V. push medi- a watch. central circulation as soon as pos-
cations to confirm patient identifi- The rate and volume of the sible with a minimal amount of
cation and the correct medication. subsequent flush can also result in flushing required. Medications ad-
Use of approved automation and oth- unintended rapid or delayed adminis- ministered I.V. push in a distal port
er technology to confirm the correct tration of a drug. The medication left (away from the patient) may linger
patient and drug prior to I.V. push in any dead space in tubing or cath- in the I.V. tubing of an existing line,
administration is a more efficient and eters will be flushed into the vascular and thus may actually be adminis-
effective error-reduction strategy than system at the same rate that the flush tered at a later time based on the
a manual check performed by a prac- or associated compatible I.V. solution infusion rate of the existing I.V.
titioner. Even in an emergency, some is being administered. fluids, or it may not actually be ad-
automated dispensing cabinet (ADC) • Assess the patency of central ministered at all if the I.V. line is dis-
systems can aid in the accurate selec- venous access devices using, at a lodged or discontinued before the
tion of medications by requiring bar- minimum, a 10 mL diameter-sized medication reaches the patient. The
code scanning at the ADC once a syringe filled with preservative-free use of distal ports for I.V. medication
medication is selected from the ADC 0.9% sodium chloride. Once pa- administration has occasionally re-
screen. This can be accomplished even tency has been confirmed, I.V. sulted in patient harm if the patient
if a prescription has yet to be entered push administration of the medica- was no longer being monitored
into the electronic health record. tion can be given in a syringe ap- when the full dose of medication
• Administer I.V. push medications propriately sized to measure and finally reached the patient.10
and any subsequent I.V. flush at the administer the required dose. Care On occasion, the proximal port
rate recommended by the manufac- should be taken when assessing for may be unavailable when a patient is
turer, supported by evidence in central venous access device patency positioned under sterile drapes for a
peer-reviewed biomedical litera- to avoid possible catheter rupture. procedure. In this case, using the
ture, or in accordance with ap- Manufacturers recommend using, at next proximal port to the patient is
proved institutional guidelines. Use minimum, a 10 mL diameter-sized appropriate. When using a more dis-
an appropriate volume of the subse- syringe for assessing patency be- tal site, staff need to be aware of and
quent I.V. flush to ensure that the cause a syringe of this size generates account for the dead space in the
entire drug dose has been adminis- lower injection pressure than a sy- tubing after I.V. push medication
tered. Rates for I.V. push medication ringe with a small diameter, such as administration to ensure that the
administration listed as “slow” or a 5 mL syringe. After patency has entire dose has been administered at
“fast” are considered ambiguous and been established, however, medica- the intended rate of injection.
should be clarified. In some cases, the tions can be administered in a sy-
speed at which a practitioner adminis- ringe appropriately sized for the Reporting errors
ters a medication makes a therapeutic dose of the I.V. push medication re- improves safety
difference or may contribute to an quired.13 Many facilities have created Report adverse events, close calls
adverse reaction. An example would policies stipulating that a 10 mL (near misses), and hazardous
be the inappropriately slow adminis- syringe be used for all procedures conditions associated with I.V.
tration of I.V. push adenosine to treat involving a central venous access push medications internally within
stable, regular, narrow-complex device, when in fact, it isn’t neces- the healthcare organization as well as
tachycardia with a pulse refractory to sary to introduce risk through a sy- in confidence to external safety orga-
vagal maneuvers. Practitioners who ringe-to-syringe transfer in order to nizations such as ISMP for shared
administer I.V. push medications administer medications. learning. Healthcare providers and
without a watch or second hand tend • When administering I.V. push safety agencies use error and adverse
to underestimate the time that has medications through an existing event reporting programs to learn
passed, often administering medica- I.V. infusion line, use a needleless about actual and potential safety
tions at a rate faster than recommend- connector that’s proximal (closest) risks and the underlying system and

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behavioral circumstances that lead to delivered. In addition, sharing er- 8. Institute for Safe Medication Practices. Perilous
infection control practices with needles, syringes,
human errors. The goal of learning rors and close calls with an external and vials suggest stepped-up monitoring is needed.
from events is to create reliable sys- PSO allows the entire healthcare ISMP Medication Safety Alert! 2010;15(24):1-3.
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to make safe behavioral choices. Shar- learned. ■ Advisory Committee. 2007 Guideline for Isolation
Precautions: Preventing Transmission of Infectious
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common, preventable adverse oc- 7. U.S. Pharmacopeial Convention. The
currences, a healthcare organization Pharmacopeia of the United States of America, 35th The author and planners have disclosed no potential
Revision and The National Formulary. 13th ed. conflicts of interest, financial or otherwise.
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and to enhance the quality of care Convention; 2012:11. DOI-10.1097/01.NURSE.0000494641.31939.46

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