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Blindness

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318 Blindness

Kogevinas M, ’t Mannetje A, Cordier S, et al. (2003) Occupation and Zeegers MP, Kellen E, Buntinx F, and van den Brandt PA (2004) The
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National Research Council, Board on Environmental Studies and
Toxicology. Subcommittee to Update the 1999 Arsenic in Drinking
Water, Report, Committee on Toxicology (2001) Arsenic in Drinking Relevant Websites
Water: 2001 update. Washington, DC: National Academy Press.
Pereg D and Lishner M (2005) Non-steroidal anti-inflammatory drugs for
the prevention and treatment of cancer. Journal of Internal Medicine http://www.nlm.nih.gov/medlineplus/bladdercancer.html –
258: 115–123. MedlinePlus, U.S. National Library of Medicine and National
Van der Meijden AP (1998) Bladder cancer. British Medical Journal 317: Institutes of Health: Bladder Cancer.
1366–1369. http://www.who.int/schistosomiasis/en/ – World Health Organization:
Vogelstein B and Kinzler KW (2004) Cancer genes and the pathways Schistosomiasis.
they control. Nature Medicine 10: 789–799.

Blindness
S Resnikoff and R Pararajasegaram, World Health Organization, Geneva, Switzerland
ã 2008 WHO. Published by Elsevier Inc. All rights reserved.

Blindness is a health and social concern of significant public In this classification, blindness is defined as visual acu-
health dimensions that, until recently, has not received the ity of less than 3/60 (20/400 or 0.05) or corresponding
attention it warrants on the global health agenda. field not greater than 10 degrees in the better eye, with best
As will be seen, the majority of the world’s blind live possible correction. Low vision is defined as visual acuity
in developing regions and in the impoverished regions of less than 6/18 (20/70 or 0.30) but equal to or better than
of rapidly economically developing countries. There has 3/60, or corresponding visual field not greater than
been, however, as seen in recent studies, a transition from 20 degrees in the better eye, with best possible correction.
infection- and nutrition-related causes of blinding eye Some of the definitions, such as ‘best corrected’ in the
diseases to those of a chronic nature that generally stem current classification, have been under review, because they
from noncommunicable disorders, referred to as the do not reflect the true magnitude of uncorrected refractive
‘epidemiological transition.’ This is in keeping with the error as a cause of visual impairment, including blindness.
demographic transition that is occurring at an enhanced Such defective vision resulting from refractive error has
pace in the developing regions of the world, consequent remained masked as a result of the existing definition.
to their inevitable population momentum. These transi- The use of the concept of ‘presenting vision’ instead
tions have far-reaching consequences for population eye of ‘best corrected vision’ will overcome this anomalous
health, with all its implications in terms of underdevelop- definition. The current definition is being amended. In
ment, social costs, and poverty alleviation in general, and addition, there is currently confusion over the use of
the quality of life of affected individuals and communities, the term ‘low vision’ to describe the various categories
in particular. The lowered life expectancy consequent of visual impairment other than blindness. It has been
to becoming blind is an illustrative example. recommended that the use of the term ‘low vision’ be
avoided for use in this context.
What Is Blindness?

There is no simple answer. The reason for this is that Epidemiology


until recently there has been great variation in the defini-
tion of blindness from one country to another. This is There are some limitations inherent in describing the
despite the availability of a definition and classification epidemiology of visual impairment and blindness. These
dating back to 1972 that has found international accep- stem from the use of different definitions and visual cut-
tance and was included in the 10th revision of the WHO off points for the different categories of visual impairment
International Statistical Classification of Diseases Injuries in different studies. However, more recent epidemiol-
and Causes of Death. ogical surveys have begun to use more standardized
Blindness 319

definitions and methodologies based on them. As such, glaucoma, 12%; age-related macular degeneration, 8.7%;
the recent estimation would more closely reflect the real trachoma, 3.6%; corneal opacity (various causes excluding
situation. trachoma), 5.1%; diabetic retinopathy, 4.8%; onchocercia-
sis, 1%; childhood blindness (various causes), 3.8%; and
other causes, 12.9%.
Magnitude and Causes of Visual Impairment The above conditions also predominate as causes of
visual impairment not amounting to blindness. However,
The estimate of the global magnitude of visual
in light of the data that have been recently determined in
impairment in relation to the 2002 world population was
relation to uncorrected refractive error, it is seen that this
updated using the most recent available data on blindness
represents the major causes of visual impairment, if pre-
and low vision (Pascolini et al., 2004). The number of
senting vision rather than best corrected vision is used as
people globally who are visually impaired is an estimated
the criterion, as has been recommended.
161 million, of whom 36.8 million are blind (Resnikoff et al.,
Figure 1 depicts the causes and their relative magni-
2004). A more recent estimate based on presenting vision
tude from a global perspective.
has revealed the true magnitude of visual impairment, now
estimated at 314 million (Resnikoff et al., 2007), with an
estimated 153 million cases due to uncorrected refractive
error alone, of which 8.2 million are in the blind category.
Inequity in Eye Health Status and Causes
Thus the most recent update indicates that globally
of Visual Impairment
there are 314 million persons who are visually impaired
(when presenting vision is used in studies), of whom
There is wide variation in both the prevalence and under-
45 million persons are blind.
lying causes of visual impairment and blindness based
on geographical location, demographic structure, gender,
socioeconomic status, and health system development. An
Causes of Visual Impairment Including
estimated 90% of the world’s visually impaired persons
Blindness
live in developing parts of the world.
According to WHO estimates (2002) (in, Resnikoff et al., Figure 2 illustrates the geographical distribution of
2004), the causes of blindness are as follows: cataract, 47.8%; global blindness.

Glaucoma
12% Other causes
13%

Age-related macular
degeneration
9%

Corneal opacity
5%

Diabetic retinopathy
5%

Onchocerciasis
1%
Childhood blindness
4%

Tracoma Cataract
4% 48%

Figure 1 Global causes of blindness (best corrected visual acuity). with permission from Resnikoff S, et al. (2004) Global data on visual
impairment in the year 2002. Bulletin of the World Health Organization 82: 844–851.
320 Blindness

Europe trachoma, medical treatment together with interventions


10% such as vector control, personal hygiene, (e.g., face washing),
Americas
and environmental improvement are employed.
South East Asia
10%
27%

Social Determinants
Eastern
Mediterranean An understanding of the underlying social determinants
10% of eye health is a necessary prerequisite not only for
an understanding of the public health dimensions of the
problem, despite the availability of appropriate knowl-
edge, technology, and skills, but also for preventing and
Africa controlling the many determinants and diseases that lead
17% Western Pacific to visual impairment.
26%
However, when dealing with these conditions as
Figure 2 Regional distribution of visual impairment, by WHO
regions.
causes of vision impairment and blindness in a population
setting, the existence of social determinants is often over-
looked. These include various barriers to uptake of
services. Health illiteracy, poverty along with its related
Vision Impairment Across the Life Spectrum deprivations, physical and social distance from health
Visual impairment is not equally prevalent across various facilities, and cultural beliefs and barriers predominate.
age groups of the population. For instance, over 82% of all In general, these factors determine the availability,
persons who are blind are 50 years and over. However, this accessibility, and affordability of services even when
cohort currently represents only 19% of the global popu- they are provided. Compounding these determinants of
lation. Those persons 50 years and older therefore bear a visual impairment is the inequitable distribution of ser-
disproportionate load of blindness. vice in terms of geographic distribution, quality, cost, and
At the other end of the life spectrum, blindness in accountability.
childhood has a lower absolute prevalence, constituting
only an estimated 1.4 million children, or 3.8% of global
blindness. A child going blind in early childhood and Prevention of Blindness: What Can Be
surviving to, say, 50 years of age has many years of blind- Done?
ness ahead. Therefore in terms of ‘years of blindness,’
Cataract
childhood blindness ranks second to blindness from cata-
ract in adults, and merits to be addressed as a global Cataract remains the leading cause of blindness, account-
priority in public health ophthalmology. ing for nearly half of all cases, as shown in Figure 1,
except in the most developed countries.
This is certainly not due to the lack of an effective
Gender Disparities intervention.
Evidence-based, cost-effective interventions are being
Gender variations have been reported in all age groups practiced to deal with the surgical management of cata-
and in all regions of the world. Consistently, for reasons ract (Baltussen et al., 2004). Removal of the affected lens
such as limited access and uptake of eye care services, of the eye and replacement with a synthetic posterior
females are at a higher risk than males of being visually chamber intraocular lens (IOL) is standard practice the
impaired or blind. world over. Refinements in technology and approaches
in IOL material and design ensure a near normal restora-
tion of vision for the large majority of patients. In low- and
Biological Determinants
middle-income countries, it has been estimated that
Many of the causes that result in visual impairment and the cost-effectiveness ratio of these surgical interven-
blindness have biological determinants such as genetic tions are below US$200 per disability-adjusted life year
background, age, and gender. These are nonmodifiable, (DALY) averted, and less than US$24 000 in high-income
and prevention or treatment of these are related to biomed- countries.
ical interventions. These include treatment for cataract However, to be able to minimize the magnitude of
and trichiasis (in trachoma) or a mix of interventions, as in cataract as a cause of blindness, interventions must go
glaucoma and diabetic retinopathy. Where underlying eco- beyond technology to outcome-oriented interventions
logical determinants prevail such as in onchocerciasis and that vigorously address the various social determinants
Blindness 321

that predicate the high prevalence of cataract and other Glaucoma


blinding conditions in developing countries. Even in these
This comprises a group of conditions that lead to irrevers-
countries, studies have demonstrated the wide disparity
ible vision loss and blindness through damage to the optic
in cataract surgical rates (defined as the number of cata-
nerve (optic neuropathy). WHO has estimated that 4.5 mil-
ract surgeries carried out per 1 million population annu-
lion persons are blind due to glaucoma (Resnikoff et al.,
ally), surgical outcome, and population coverage, not only
2004). Published projections indicate that by 2010, 4.5 mil-
between countries but also between regions in the same
lion persons will be blind from open-angle glaucoma and
country.
3.9 million from primary angle-closure glaucoma. Given
The equitable provision of efficient and effective
the aging of the world population, these numbers are set
health systems delivering eye care should be an essential
to increase further by 2020 (Quigley and Broman, 2006).
public health priority for all developing countries.
Significant improvement in treatment interventions
has been made in recent years, such as laser therapy,
medication, and surgery to prevent vision loss from glau-
Trachoma coma. However, given the fact that the tools currently
required for the identification, assessment, and manage-
The SAFE strategy (Surgery, Antibiotics, Facial cleanliness,
ment of early glaucoma are often lacking, particularly in
Environmental improvement) is an integrated approach
poorer parts of the developing world, the management of
based on the principles of primary health care recom-
glaucoma at a community level holds many challenges.
mended by WHO to help eliminate blinding trachoma in
a sustainable manner. The four elements complement each
other and comprise a mix of primary, secondary, and Childhood Blindness
tertiary preventive interventions, with strong community
involvement and educational activities. Childhood blindness results from a number of causes that
Studies on the cost-effectiveness of these interventions range from genetically determined and congenital condi-
are limited. However, the few reported studies point to a tions to micronutrient deficiency (vitamin A) and infective
range of approximately US$4 to US$82 per DALY averted conditions (measles, ophthalmia neonatorum, rubella) to
across trachoma-endemic areas, in the case of trichiasis conditions requiring specialized surgical treatment such
surgery. In the case of antibiotic treatment, it has been as childhood cataract, glaucoma, and retinopathy of
estimated that across the endemic regions studied, the prematurity. In developed and rapidly economically devel-
cost per DALY averted ranged between US$4000 to oping regions of the world, retinopathy of prematurity is
US$220 000, depending on whether the drug is part of a more than an emerging problem. With increased survival of
donation program or is calculated at the market price. low birth weight and low gestational age infants, there is
already an upsurge in vision loss from this cause.
Uncorrected refractive errors comprise a significant
cause of vision impairment, particularly among certain
Diabetic Retinopathy ethnic groups. These have implications for child develop-
Diabetic retinopathy, already a leading cause of blindness ment and education, future employment prospects, and
in working-age populations in developed countries, is performance.
fast assuming epidemic proportions worldwide with the Considerable regional variations between and within
upsurge of diabetes mellitus even in developing countries. countries exist with regard to the magnitude and causes
The causes of vision loss are multifactorial and are closely of childhood blindness. Services for children are arranged
linked to the duration of diabetes. Other risk factors in- through vision screening in schools and community centers
clude uncontrolled blood sugar, high blood pressure, and with follow-up assessment and provision of spectacles.
increased blood lipids. A concerted primary eye care approach could control
Besides controlling the disordered metabolic state, and minimize causes related to poverty and deprivation
available interventions include periodic examination of such as malnutrition, measles, and harmful traditional
the ocular fundus through dilated pupils, early identifi- practices. Other causes such as cataract, glaucoma, and
cation of sight-threatening lesions, and treatment with retinopathy of prematurity require specialized surgical
laser photocoagulation. Health promotion and patient edu- care and management, including low vision care and
cation are important supportive interventions. A multidisci- inclusive education of affected children.
plinary team approach to care of these patients is desirable.
Extended follow-up with careful monitoring and tracking of
patients is important. In patients with some residual vision Uncorrected Refractive Errors
that is not amenable to further treatment, low-vision care These include conditions such as myopia (nearsighte-
should be offered. dness), hypermetropia (farsightedness), and astigmatism.
322 Blindness

Age-related presbyopia also falls within this category. There Concepts of Primary Eye Care and the
are an estimated 153 million persons with visual im- Domains of Prevention of Blindness
pairment due to uncorrected refractive errors (not includ-
ing presbyopia), in other words, presenting visual acuity less The basic principles of primary health care, as enshrined
than 6/18 in the better eye. This comprises the commonest in the Alma Ata declaration (1978) and subsequent World
cause of visual impairment. The proportion of uncorrected Health Assembly resolutions, provide the basic frame-
refractive errors varies based on cultural norms, gender, and work for the development of health systems that could
availability and affordability of services. provide equitable, comprehensive, and sustainable eye
Services to correct disabling refractive errors should care as an integral part of health care.
include identification of persons requiring correction, Primary health care, of which prevention of blindness
assessment and prescription of appropriate correction, needs to be an integral part, consists of:
and the provision of spectacles that are affordable and
Essential health care based on practical, scientifically
cosmetically acceptable.
sound, and socially acceptable methods and technology
made universally accessible to individuals and families in
Age-Related Macular Degeneration the community through their full participation and at
a cost that the community and country can afford to
This condition presents an emerging challenge given the
maintain at every stage of their development in the spirit
rapidly escalating number of older populations globally. It
of self-reliance and self determination.
is already the major cause of blindness in the developed
countries. While there is greater knowledge regarding Primary eye care comprises a simple but comprehen-
the cause and pathophysiology of the disease, efforts at sive set of promotive, preventive, curative, and rehabilita-
prevention and treatment have not been promising until tive activities that can be carried out by suitably trained
now. Ongoing research has suggested the potential value primary health-care workers, who in turn are supported
of newer treatment modalities, but the outcome of such by a referral system that ought to comprise secondary and
treatment on a large scale has yet to be determined. In the tertiary level of services and in some regions provide
interim, much can be gained through the provision of mobile services.
low-vision care to improve the functioning and quality
of life of these patients.
Available Primary Eye Care Interventions
Low Vision to Eliminate Avoidable Blindness
The following definition was agreed upon to identify
Cataract, glaucoma, a corneal opacities (from various
persons who could benefit from low-vision care:
causes), diabetic retinopathy, trachoma, and onchocerciasis
A person with low vision is someone who, after medical, lend themselves to potential health promotion, prevention,
surgical, and/or standard refractive intervention, has a treatment, and rehabilitative strategies.
corrected visual acuity in the better eye of less than 6/ Similar interventions are possible in the case of child-
18 down to and including light perception or a central hood blindness.
visual field of less than 20 degrees, but who uses or has the Another area in which primary-level services could
potential to use vision for the planning and/or execution provide effective support is in vision screening, early
of a task. detection, and appropriate referral of persons of all age
groups with uncorrected refractive error. This constitutes
Currently there are no global estimates of the number
a large segment of the population across the life spectrum
of people with low vision who would benefit from low-
that could benefit from appropriate corrective services.
vision services. Based on available data, this is estimated
to be around 40–65 million. However, with the advancing
age of the population and a concomitant increase in age-
related chronic diseases such as glaucoma, diabetic reti- Economic Implications of Visual
nopathy, and macular degeneration, the unmet need for Impairment and Blindness
low-vision services could rapidly escalate.
The coverage of low-vision services currently is Studies on the economic losses to individuals and society
extremely sparse, even in developed countries. Low- from visual impairment and the economic gains from the
vision care needs to be developed in close collaboration application of cost-effective interventions to prevent
with the correction of uncorrected refractive errors, and blindness and restore sight provide supportive evidence
follow the same principles, such as affordability and for investment in blindness-prevention programs. The
acceptability. economic burden of avoidable visual impairment includes
Blindness 323

the direct costs in terms of resources spent in individual Partnerships for Prevention of Blindness
and community care, including the various components of
Global and Regional Initiatives
the eye care system at all levels, and the indirect costs,
which comprise a range of productivity losses, with Onchocerciasis Control Program (OCP)
their far-reaching implications, social and rehabilitative This was established in West Africa in 1974. The objec-
expenses, impaired quality of life, and premature death. tives of this international collaboration were to eliminate
Studies have been published to highlight the economic onchocerciasis in the 11 countries covered by the pro-
aspects of some of the commoner individual blinding gram and consequently improve the socioeconomic con-
conditions such as cataract, trachoma, onchocerciasis, dition of the people, who largely comprised an agrarian
glaucoma, and diabetic retinopathy. Most of these have society.
been carried out in developed countries.
For instance, an Australian study (Taylor et al., 2004)
assessed the overall economic impact of the five most African Program for Onchocerciasis Control
prevalent visually impairing conditions (75% of all This was launched in December 1995 with the sole aim of
causes) in Australia (Figure 3). This included cataract, eliminating onchocerciasis from the African countries
age-related macular degeneration, glaucoma, diabetic ret- where the disease continued to be endemic. The region
inopathy, and errors of refraction. The economic analysis covered extended to 11 countries beyond those included
predicted an estimated direct cost of AU$1.824 billion in OCP. While WHO serves as the executing agency, the
(US$1.3 billion). Indirect costs were estimated to add a fiscal agency is the World Bank.
further AU$8 billion (US$5.6 billion) to the annual eye The primary strategic objective was to create, by 2007,
care budget for 2004. These estimates cannot be easily a system of community-directed distribution of ivermec-
extrapolated to other parts of the world, however, due to tin, as a microfilaricidal agent, donated at no cost by
different disease patterns, health-care costs, work force Merck. Much success has been achieved toward reaching
wage structures, and social security systems. this objective, and steps are underway to use community-
There has been an effort to calculate on a global directed distributors in the control of coexistent diseases
basis the projected annual personal productivity loss of such as lymphatic filariasis and trachoma that respond to
individuals over the period 2000–2020 (Frick and Foster, periodic administration of appropriate medications.
2003). The conservative annual estimate amounts to US
$42 billion for the year 2000. This figure was projected to Onchocerciasis Elimination Program
rise to US$110 billion per year (in year 2000 dollars) by for the Americas
2020, if then-current prevalence levels showed no This is a regional initiative for Brazil, Colombia, Ecuador,
decrease. If, however, the implementation of VISION Guatemala, Mexico, and Venezuela, initiated in 1991. The
2020 showed successful outcomes (see ‘VISION 2020: goals are to eliminate morbidity and to interrupt trans-
The right to sight’), it was estimated that the annual mission of river blindness. This is a partnership program,
productivity loss would increase to only US$58 billion including the six countries, the Pan American Health
(in year 2000 dollars). It was further estimated that the Organization, the private sector, specialized institutions,
overall global saving that could accrue over 20 years and international nongovernmental developmental orga-
would amount to US$223 billion. nizations. The program strategy is to provide sustained
mass distribution of ivermectin every six months, with
the aim of reaching at least 85% of the at-risk population.

Total $1824.4m
WHO Global Alliance for the Global Elimination of
AMD $19.4 m
1%
(Blinding) Trachoma (GET 2020)
Cataract $326.6 m GET 2020 was constituted in 1997 to provide support and
18% technical assistance to a number of international institu-
Other 59% 8% Glaucoma $144.2 m tions and organizations, nongovernmental development
$1095.9 m organizations, and foundations in working toward elimi-
14% nation of trachoma as a public health problem, using the
Refractive error SAFE strategy. The Alliance meets on an annual basis and
$261.3 m involves concerned member state representatives. The
agenda includes the sharing of information on the prog-
Figure 3 Cost of eye diseases, 2004, AU$, by condition. AMD,
age-related macular degeneration. Source: Taylor H, et al. (2004) ress of national programs, research initiatives and results,
Clear Insight: The Economic Impact and Cost of Vision Loss in future plans, and reports on available financial and in-
Australia. Melbourne: Center for Eye Research Australia. kind resources.
324 Blindness

VISION 2020: The Right to Sight national action plans have been formulated and are being
On January 18, 1999, WHO’s then Director General, implemented.
Dr. Gro Harlem Brundtland, launched the Global Initia- Overall, there is greater global awareness of the dimen-
tive for the Elimination of Avoidable Blindness under the sion of the problem of visual impairment, including blind-
title ‘VISION 2020: The Right to Sight.’ The initiative ness, as a public health concern.
was spurred by the dismal global data on blindness that This has led to the all-important political commitment
became available in the mid-1990s. These data were at all levels to eliminate avoidable blindness as a public
compounded by the predicted near-doubling of the global health problem globally before 2020. It has also led to the
magnitude of visual impairment and blindness by the year development of partnerships among a variety of partners,
2020, with many of the underlying causes being pre- such as WHO, member countries, international nongov-
ventable or treatable. These predictions were based on ernmental developmental organizations and institutions,
demographic projections and a presumed relatively academia, the corporate sector, and civil society.
unchanged eye care delivery as part of national health- The ultimate goal is to establish a sustainable, equita-
care systems. Such a scenario was likely to be realistic ble, and comprehensive eye care system as an integral part
in the developing countries, where the problem was of national health systems based on the principles of
greatest and the resources for eye care are severely primary health care.
limited. Moreover, these countries were beset with com-
peting demands for resources from limited health budgets
See also: Alma Ata and Primary Health Care: An Evolving
to control other priority diseases such as HIV/AIDS,
Story; Helminthic Diseases: Filariasis.
malaria, tuberculosis, and childhood diseases.
The initiative was thus seen not only as a health chal-
lenge but also as a moral imperative that needed to be
urgently addressed. Citations
VISION 2020 is a collaborative effort conceived by the
World Health Organization and the International Agency Baltussen R, Sylla M, and Mariotti SP (2004) Cost effectiveness analysis
for the Prevention of Blindness and its constituent mem- of cataract surgery: A global and regional analysis. Bulletin of the
World Health Organization 82(5): 338–345.
bers. The objective was to support member countries by Frick KD and Foster A (2003) The magnitude and cost of global
providing technical and financial support to realign and blindness: An increasing problem that can be alleviated. American
strengthen existing national programs or to initiate and Journal of Ophthalmology 135(4): 471–476.
Pascolini D, Mariotti SPM, Pokharel GP, et al. (2004) 2002 global
develop new national programs aimed at the collective update of available data on visual impairment: a compilation of
achievement of the common goal of eliminating avoidable population-based prevalence studies. Opthalmic Epidemiology 11
blindness globally. (2): 67–115.
Resnikoff S, Pascolini D, Etyáale D, et al. (2004) Global data on visual
The initiative identified three strategic components as impairment in the year 2002. Bulletin of the World Health
the Framework for Action: Organization 82: 844–851.
Resnikoff S, Pascolini D, Mariotti SP, and Pokharel GP (2008)
. Cost-effective disease control; Global magnitude of visual impairment caused by uncorrected
. Human resource development; refractive errors in 2004. Bulletin of the World Health Organization 86:
63–70.
. Infrastructure, including appropriate technology.
Taylor H, Keete J, and Mitchell P (2004) Clear Insight: The Economic
Impact and Cost of Vision Loss in Australia. Melbourne, Australia:
The overarching supportive elements included advo- Center for Eye Research.
cacy, public awareness campaigns, resource mobilization,
and improved governance and management of health
systems, including monitoring and evaluation for quality
Further Reading
assurance.
Partnership development was a key factor.
Johnson GJ, Minassian DC, Weale CA, and West SK (eds.) (2003) The
The underlying guiding principle was delivering eye Epidemiology of Eye Diseases, 2nd edn. London: Arnold.
care as an integral part of primary health care.
Global political commitment to VISION 2020 was forth-
coming in 2003 and 2006 through the unanimous adop- Relevant Websites
tion by the WHO member states of resolutions WHA
56.26, Elimination of Avoidable Blindness, and WHA 59.25, http://www.cehjournal.org/ – Community Eye Health Journal.
Prevention of Avoidable Blindness and Visual Impairment, http://www.icoph.org/ – International Council of Ophthalmology.
respectively. http://www.nei.nih.gov/ – National Eye Institute.
http://www.v2020.org/ – Vision 2020: The Right to Sight.
At the national level, a number of countries have signed http://www.who.int/blindness/en/ – WHO, Prevention of Blindness and
national declarations of support, and outcome-oriented Visual Impairment.

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