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Disability & Rehabilitation, 2013; 35(9): 758–765

© 2013 Informa UK, Ltd.


ISSN 0963-8288 print/ISSN 1464-5165 online
DOI: 10.3109/09638288.2012.707747

Perspectives in Rehabilitation

 ole of comprehensive geriatric assessment in the management


R
of osteoporotic hip fracture in the elderly: an overview

Marina De Rui, Nicola Veronese, Enzo Manzato & Giuseppe Sergi

Department of Medicine-DIMED, Geriatrics Division, University of Padova, Padova, Italy


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Purpose: To highlight the advantages of comprehensive Implications for Rehabilitation


geriatric assessment (CGA) over usual care in the management
of elderly patients with fragility hip fractures in terms of Orthogeriatric management
reducing the related mortality and disability. Method: An
overview of publications on the topic was conducted using • Fragility hip fracture in older people is burdened by
the MEDLINE and EMBASE databases. Results: Several models an elevated incidence of complications, mortality and
of geriatric and orthopedic comanagement have been disability.
Disabil Rehabil 2013.35:758-765.

developed in recent years, all characterized by a variable • The global complexity of elderly people with hip
degree of integration, and they have been shown to reduce fracture requires an orthopedic and geriatric
complications, disability and mortality in elderly hip-fracture comanagement.
patients. Preoperatively, CGA should identify the comorbidities • The application of the comprehensive geriatric assess-
that need to be treated in view of surgery, so as to reduce ment during hospital stay is the best approach for the
the related risks. After surgery, CGA should deal with medical management of the elderly people with hip fracture.
complications and assure patients an early mobilization in • Before discharge the multidisciplinary team should
order to reduce short-term mortality and contain functional design a tailored rehabilitation plan and should also
decline. Before discharge, the orthogeriatric team should draw consider the secondary prevention of hip fracture.
up a tailored program to promote the patient’s functional
recovery and satisfactory quality of life, also covering the
approach to the more elderly patients with hip fractures thus
secondary prevention of fragility fractures by improving bone
requires both surgical management and geriatric handling [4].
quality and reducing the risk of falls. Conclusions: Fragility hip
The clinical effectiveness of comprehensive geriatric
fractures in the elderly people need to be managed by different
assessment (CGA) has been known for some time. Its use is
professionals working in close cooperation and adopting a CGA.
associated with improvements in the clinical management of
Keywords: Comprehensive geriatric assessment, elderly, hip elderly patients and an optimization of their passage through
fracture the health service network [5,6]. In recent years, several models
of geriatric and orthopedic cooperation have been developed
and implemented around the world [7]. Even if they differ in
Introduction
some aspects, they are all characterized by an integration of
Fragility hip fractures occur in older adults [1] and represent the surgical approach with a CGA, which is known to take
a growing problem for clinical, social and financial reasons. an interdisciplinary and multidimensional approach. This
Surgical correction is considered the most appropriate treat- model of care has proved successful in reducing in-hospital
ment for hip fracture and has been extended over the years to complications [8,9], length of hospital stay [10], readmission
frailer and older patients. The coexistence of multiple chronic rate [10], disability and mortality [9] in elderly patients with
disorders in such patients [2] raises the risk of peri- and post- osteoporotic hip fractures.
operative complications that may impair their functional recov- The aim of this work was to highlight the importance of
ery and raise the short- and long-term mortality rates [3]. The the geriatrician’s role in the management of elderly patients

Correspondence: Dr. Giuseppe Sergi, Clinica Geriatrica – Ospedale Giustinianeo (2° piano), via Giustiniani 2, 35128, Padova, Italy.
Tel.: 0039-049–8218492. Fax: 0039-049–8211218. E-mail: giuseppe.sergi@unipd.it
(Accepted June 2012)

758
Hip fracture and CGA in the elderly 759
with hip fractures, and to identify the essential steps that geri- the clinical and social complexity of elderly hip fracture
atricians should take to reduce patients’ short-term mortality, patients.
facilitate their admission to a rehabilitation program and thus
contain their long-term disability.
Comprehensive geriatric assessment
In clinical practice, geriatricians make use of a CGA, a mul-
Methods
tidimensional process that has long prevailed as the best
A literature database search was performed electronically via approach to the management of elderly patients. It requires
OVID (MEDLINE and EMBASE), combining the term “hip an interdisciplinary team consisting of nurses, occupation
fracture” with the following MeSH keywords: “management”, and physical therapists, general practitioners and geriatric
“geriatric” “multidisciplinary”, “comanagement”, “co-care”, physicians. CGA can make use of several evaluation tools
“approach”, “comprehensive geriatric assessment”. The term to explore an elderly patient’s clinical, functional, cognitive,
“orthogeriatric” was sought separately. We also performed nutritional and social domains and thus obtain a global pic-
specific searches on effective inpatient care models for hip ture, optimize the patient’s long-term treatment, and plan the
fracture patients. The search was restricted to articles pub- resources required and the use of services.
lished in the English language from 1980 to January 2012. Several scales are available for use in CGA to quantify a
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In addition, a manual check on the reference lists in the patient’s performance and follow it up over time, and they are
articles and reviews identified was also conducted to seek also useful for estimating the mortality risk [15].
any additional sources of information. Data were extracted The standard evaluation scales are: the activities of daily
independently by two investigators. The criteria for includ- living (ADL) [16] and instrumental activities of daily living
ing the articles in this overview were randomized controlled (IADL) [17] indexes for defining the level of functional depen-
trials and observational clinical studies on the management dence/independence; the Mini Mental State Examination
of hip fracture in elderly people. The exclusion criteria were (MMSE) [18] for assessing cognitive status; and the Mini
certain types of publication (letters to editors or single case Nutritional Assessment (MNA) [19] to examine the patient’s
reports) and patients with a mean age below 60 years. The nutritional status.
Disabil Rehabil 2013.35:758-765.

outcome measures examined were: mortality, length of hospi- The clinical usefulness of the CGA for elderly inpatients
tal stay, functional status, medical complications, destination had already been demonstrated in the 1980s, indicating ben-
after discharge, recurrent fracture risk and the prescription of efits for standard medical care in terms of a better cognitive
antiresorptive drugs. Among 119 studies identified, 68 met and functional status, a lower mortality rate and a diminished
the inclusion and exclusion criteria, and were eligible for our usage of acute care and long-term institutional services [5].
analysis. The particular features and potential of the CGA make it
useful in managing elderly patients with hip fractures too.
This is a field in which CGA has proved capable of improving
Reasons for orthogeriatric comanagement
functional outcomes and reducing mortality rates and health-
The main reasons why elderly people with hip fractures care costs, both during hospitalization and in the patient’s
need orthogeriatric comanagement are: their age [11] and a long-term follow-up [7,20].
high prevalence of comorbidities [12], accounting for their
remarkable global complexity and frailty. These conditions Models of orthogeriatric integration
are most likely to give rise to perioperative medical and sur-
gical complications, and to accelerate functional decline and Taking the traditional approach, a patient with a hip fracture
mortality [13]. is admitted to an orthopedic ward where an orthopedic team
The fragility hip fracture rate increases exponentially with provides medical, surgical and nursing care, referring to con-
age, especially over 75-year-old [11], and the mean age of hip sultants to cope with specific issues if necessary.
fracture patients is likely to rise in years to come. According to Because patients with hip fractures are often elderly and
Morin et al. [12], moreover, 97% of patients admitted for hip have comorbidities [11,12], ever since the 1950s models of
fractures have more than one concomitant disease, and 44% orthogeriatric cooperation have been developed and imple-
have more than six comorbidities. Patients with ≥3 chronic mented worldwide, providing for an integrated management
medical conditions have a 2.5-fold risk of death [3], and this by a geriatric and orthopedic team, taking an interdisciplinary
risk increases with the severity of their concomitant chronic and multidimensional approach typical of CGA.
diseases [14]. Finally, a variety of perioperative medical As proposed by Kammerlander et al. [7], this orthogeriat-
complications are reported in these patients [10], especially ric integration can take place according to four main models
cardiovascular and respiratory events, which give them an (Table I):
eight-fold short- and mid-term mortality risk [3]. Model 1: Orthopedic ward and geriatric consultant
In addition, the high disability rate after hip fracture coin- service – this model resembles the traditional approach.
cides with family and social changes that also contribute to Patients are admitted to the orthopedic ward and managed
the need for a tailored discharge plan. by the orthopedic team. If necessary, a geriatrician’s opin-
All these factors underscore the need for an integrated ion can be requested to deal with specific issues. Compared
multidimensional and interdisciplinary approach to address to the traditional method, this model has achieved better

© 2013 Informa UK, Ltd.


760 M. De Rui et al.

Table I. Studies included in the analysis of orthogeriatric models


Source Model Type Sample (age) Main outcomes (orthogeriatric management vs usual care)
Kennie et al. (1998) [21] 1 RCT 108 patients (>65) Higher rate of patients independent in ADL (41 vs. 25%)
Shorter hospital stay (24 vs. 41 days).
Lower institutionalization rate (10 vs. 32%)
Naglie et al. (2002) [22] 1 RCT 279 patients (>70) No significant differences in disability rates and placement 6
months after surgery
Ho et al. (2009) [20] 2 Prospective 554 patients (>65) Lower time to surgery (1 vs. 2 days; p = 0.001), shorter hospital stay
(8.3 vs. 9.7 days, p = 0.001); lower short- and long-term mortality
(p < 0.05)
Zuckerman et al. (1992) 2 Prospective 491 patients (>65) Fewer post-operative complications (p < 0.05) and transfers to
[23] intensive care units (p < 0.001)
Higher percentage of patients with improved walking ability
(56.3 vs. 18.2%)
Lower institutionalization rate (8.1 vs. 19.3%)
Antonelli Incalzi et al. 2 Prospective 761 patients (≥70) Lower mortality rate (p < 0.01), no significantly shorter hospital
(1993) [28] stay
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Marcantonio et al. (2001) 2 RCT 126 patients (>65) Lower risk of delirium (OR = 0.64; 95% CI: 0.37–0.98; p < 0.05) or
[24] severe delirium (OR = 0.40; 95% CI: 0.10–0.89; p < 0.05)
Roberts et al. (2004) [29] 2 Prospective 369 patients (>65) Longer hospital stay (+6.5 days; p < 0.0005)
Greater improvement in ambulation at discharge (OR = 1.6, 95%
CI: 1.0–2.6, p = 0.033)
Trend towards fewer admissions to long-term care (OR = 0.6, 95%
CI: 0.3–1.0, p = 0.058)
Koval et al. (2004) [27] 2 Retrospective 1065 patients (>65) Shorter hospital stay (13.7 vs 21.6 days)
Lower in-hospital (1.5 vs 5.3%) and 1-year (8.8 vs 14.1%) mortality
Disabil Rehabil 2013.35:758-765.

rates
Shyu et al. (2005) [26] 2 RCT 137 patients (>65) Better physical function (hip flexion, walking, ADL, quadriceps
peak force)
Greater reduction in body pain and better mental health
Fisher et al. (2006) [25] 2 Prospective 951 patients (>60) Fewer post-operative medical complications (49.5 vs. 71.0%;
p < 0.001), lower mortality rate (4.7 vs. 7.7%; p < 0.01) and
6-month rehospitalization rate (28 vs. 7.6%)
Higher rate of antiresorptive (12–69%; p < 0.01) and anti-throm-
botic (63–94%; p < 0.01) drug prescriptions
No difference in-hospital stay or discharge destination
Gilchrist et al. (1988) [31] 3 RCT 222 patients (>65) No difference in mortality, hospital stay or discharge destination
Stenvall et al. (2007) [30] 3 RCT 199 patients (>70) Higher probability of regaining independence in ADL at 4 and 12
months (OR = 2.51; 95% CI: 1.00–6.30 and OR = 3.49; 95%
CI: 1.31–9.23)
Higher probability of improving functional status (OR = 3.01;
95% CI: 1.18–7.61)
Khasraghi et al (2005) [8] 4 Retrospective 510 patients (>65) Lower time to surgery (63 vs. 35% had surgery within 24 h)
Fewer medical complications (36 vs. 51%)
Shorter hospital stay (5.7 vs. 8.1 days)
Vidan et al. (2005) [9] 4 RCT 395 patients (>65) Shorter hospital stay (16 vs. 18 days; p = 0.06)
Lower in-hospital mortality (0.6 vs. 5.8%; p = 0.03) and complica-
tions (45.2 vs. 61.7%; p = 0.003)
Higher rate of recovery at 3 months (57 vs. 44%; p = 0.03)
Friedman et al. (2009) [10] 4 Prospective 314 patients (>65) Shorter time to surgery (24.1 vs. 37.4 h) and hospital stay (4.6 vs.
8.3 days)
Fewer post-operative infections (2.3 vs. 19.8%) and complications
(30.6 vs. 46.3%)
Gregersen et al. (2012) 4 Retrospective 495 patients (>65) Shorter hospital stay (15 vs. 13 days)
[32] Higher antiresorptive drug prescription rate (67 vs. 2%)
No significant differences in institutionalization, readmission and
mortality rates.
RCT, randomized controlled trial; ADL, activities of daily living.

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Hip fracture and CGA in the elderly 761
functional outcomes, shorter hospital stays (24 vs. 41 days CGA for the elderly with hip fracture
on average) and lower institutionalization rates [21], even
for demented patients [22]; Whatever the orthogeriatric model used the cooperation
Model 2: Orthopedic ward and daily consultation between orthopedic and geriatric specialists and the other team
service – this is a variant of Model 1, the difference being members should ensure a multidimensional assessment with a
that the geriatrician is consulted daily, not only “on request”. view to restoring patients to their previous clinical, functional
Geriatricians continue to act only in an advisory capacity, and cognitive status. CGA should investigate the patient’s pre-
however. This model has been seen to coincide with signifi- fracture clinical, cognitive and functional profile in order to
cantly fewer medical and surgical complications [23–25], alert the team to any potential perioperative complications and
lower rates of disability [26] and in-hospital [25,27] or establish an achievable functional recovery plan.
long-term mortality [28,29], and ultimately a reduction in CGA should be completed and then revised throughout
healthcare costs [20]; the hip fracture patient’s time in hospital – from admission
Model 3: Geriatric ward and orthopedic consultation to discharge – and it should give rise to an appropriate, tai-
service – this has led to better functional outcomes [30], lored discharge plan. The best way to ensure a high degree
but has been unable to significantly reduce the mortality of integration between the operators involved is to adopt the
rates [31]; orthogeriatric model.
Figure 1 shows the main objectives of CGA and the actions
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Model 4: Orthogeriatric service – this is the model with the


greatest degree of complexity and integration, since the it should trigger in the pre- and post-operative stages, and
orthopedic and geriatric teams jointly manage the patient before discharge.
from admission to discharge. They are assisted by an in-
terdisciplinary team that includes nurses, social workers, Preoperative phase
physiotherapists, dieticians, and others. This model has re- In the preoperative phase (Figure 1), the multidimensional
duced the time to surgery [8], medical complications [8,9], assessment should focus on operating the patient as quickly
length of hospital stay [10], readmission and disability as possible and with the lowest possible risk.
rates [9,10] and in-hospital and long-term mortality rates As shown in Table II, comorbidities are very common in
Disabil Rehabil 2013.35:758-765.

[9]. According to Gregersen et al. [32], moreover, by com- elderly people with hip fractures and a sizable percentage of
parison with the usual care, this integrated approach pays these patients have acute medical problems or flare-ups at the
more attention to the secondary prevention of fractures, as time of their hospital admission.
demonstrated by a higher percentage of patients discharged CGA should therefore analyze the severity of coexisting
with a prescription of calcium/vitamin D (67 vs. 2% under chronic diseases and identify any pathological conditions that
the usual care) and antiresorptive therapy (10 vs. 1%). the fracture may have brought to light. The number of a patient’s

Figure 1. Flowchart showing the role of comprehensive geriatric assessement (CGA) in the management of hip fragility fracture in the elderly patients.

© 2013 Informa UK, Ltd.


762 M. De Rui et al.
comorbidities on admission is directly associated with the onset off at around 10% at 30 days [3], reaching almost 20% after 3
of post-operative complications, the short-term mortality rate months [11].
[3,33], mid- and long-term functional impairment [34] and the In the early post-operative period, the interdisciplinary
refracture risk [35]. According to Roche et al. [3], patients with team should investigate and handle possible complications of
three or more concomitant diseases have a 30-day mortality surgery and its interaction with the patient’s comorbidities.
risk about 2.5 times higher than patients with no comorbidities. The more common post-operative complications are shown
Given the high prevalence of chronic diseases among hip in Table III: the conditions that most influence perioperative
fracture patients [14], the CGA should help the orthogeriatric mortality are heart failure (HR = 8), lung infections (HR =
team to identify which of the patient’s comorbidities take the 3.9) and pulmonary thrombo-embolism (HR = 4.5) [3].
highest priority for treatment [36]. The orthogeriatric team’s While the primary role of CGA in this phase is to contain
assessment and action should be as prompt as possible to reduce the high mortality rate, limiting functional and mental decline
the time to surgery because any delay raises the incidence of post- should also be considered an important goal. The high dis-
operative medical complications, regardless of any pre-existing ability rate following hip fracture may modify patients’ pas-
comorbidities [37], and is associated with a higher short- and sage through the health service network after discharge [47].
long-term mortality risk (OR: 1.41 and 1.32, respectively) [38]. Taking their pre-fracture walking ability into account, the
CGA should also investigate the presence and intensity orthogeriatric team should do its utmost to assure patients
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of pain, which often goes verbally unexpressed and con- an early mobilization and speedy rehabilitation [48] in order
sequently undertreated in the elderly [39], particularly in to reduce the incidence of complications [49] and improve
demented patients [40]. Untreated pain worsens quality of the patients’ mid- and long-term functional autonomy
life, accelerates cognitive decline [41] and increases the risk of [50,51]. CGA should also provide pain treatment because
delirium (RR: 5.4), even in patients who were previously not post-operative pain is associated with a greater long-term
cognitively impaired [42]. functional dependence [52], and it should manage cogni-
Finally, the preoperative assessment should explore nutri- tive and behavioral issues to prevent the onset of delirium,
tional status, identify conditions of malnutrition and ensure a which in itself doubles the risk of functional impairment and
tailored calorie intake. Low albumin levels and BMI increase death [53–55].
Disabil Rehabil 2013.35:758-765.

long-term mortality (OR: 5.8 and 1.16, respectively) [43], Maintaining an adequate nutritional status is another
while protein supplementation reduces post-operative com- important aspect to bear in mind during a patient’s hospital
plications [44]. stay because metabolic stress and fasting periods for the pur-
pose of diagnostic tests and anesthesia can precipitate latent
Postoperative phase conditions of malnutrition [56]. A poor nutritional status is
In this phase (Figure 1), the main goals of the orthogeriatric associated with a higher rate of complications and death [57].
team should be to reduce the short-term mortality rate and Frail elderly patients given a more caloric diet and protein
prevent mental and functional decline. This phase is burdened supplementation after hip fracture repair had a better muscle
by a high mortality rate, especially during hospitalization and performance than controls who did not receive the same
in the first 3 months after surgery [11], probably due to the supplementation [58]. In addition to the anthropometric
combined effects of the trauma, major surgery, comorbidities parameters and biohumoral markers of nutritional status and
and low physiological reserves [45]. hydration, the multidisciplinary team should also consider
Previous studies [9,10,46,47] have shown that the in- the patient’s ability to eat properly unassisted. Duncan et al.
hospital mortality rates vary between 2.5 and 10%, then level [46] found that introducing dietetic or nutritional assistants
in an acute trauma ward to encourage and assist elderly
Table II. Common comorbidities and acute or exacerbated medical patients at mealtimes improved their calorie intake and
problems in elderly patients admitted for fragility hip fracture (range of nutritional status, and reduced their in-hospital and 4-month
prevalence in the different studies). mortality.
Comorbidities %
Hypertension 42–55 [4,9,33,34] Table III. Common complications after hip fracture surgery in the
Cardiovascular disease 24–45 [3,4,33] elderly patients (range of prevalence in the different studies).
Dementia 18–46 [9,33] Complications %
Asthma or COPD 5-16 [3,11] Delirium 28.3 [10]
Cerebrovascular disease 11–18 [3,4,11,33] Infections 11–13 [3,9,10,37]
Diabetes 9–23 [3,4,9] Pressure sores 11.8 [9,37]
Cancer 8–12 [3,11,33] Heart failure 4.2–5 [3,9,10]
Renal disease 3 [3] Arrhythmia 1.6 [9]
Acute medical problems or flare-ups on admission Renal failure 6.8 [10]
Poorly compensated heart failure 13–30 [14,33] DVT/PE 2–5.3 [3,10,37]
Blood pressure abnormality 17 [14] Bleeding 1–1.6 [3,10]
Respiratory failure 7.4 [14] Myocardial infarction 1 [3]
Abnormal INR 6–6.5 [14] Stroke 0.5–1 [3,10]
COPD, chronic obstructive pulmonary disease; INR, international normalized ratio. DVT/PE, deep vein thrombosis/pulmonary embolism.

Disability & Rehabilitation


Hip fracture and CGA in the elderly 763
Before discharge to hospital [69]. Both these approaches demand a multidisci-
Before discharge, the orthogeriatric team should reassess plinary team and effectively improve the functional recovery
patients to pinpoint their global complexity and the amount of elderly people after a hip fracture.
of care they need, drawing up an appropriate program to
promote their global recovery. The overall objectives of the
Conclusions
discharge plan are to facilitate a functional recovery, preserve
the patient’s active involvement in life and restore their prior Fragility hip fractures in the elderly patients need to be man-
living conditions as far as possible. Tailored discharge plans aged differently from fractures in younger adult patients. The
should involve patients’ families and consider their prior clinical and social complexity of elderly patients demands a
functional status and post-fracture mobility, their self-care close cooperation between different professionals (orthopedic
ability, any caregiver’s competence, and the social support specialists, anesthesiologists, geriatricians, physiotherapists,
available. and nurses). The primary goals of the orthogeriatric team
Another crucial issue concerns the secondary prevention should be to reduce the complications, mortality rate and
of fragility fractures, which includes reducing the risk of falls functional impairment. The team should also refer patients
and improving bone quality. to the most appropriate rehabilitation program with a view
Patients who have had a hip fracture are at high risk of to reducing the need for institutionalization and facilitating
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recurrent falls and more than 53% of them fall at least once the patients’ functional recovery and reintegration in their
in the 6 months following discharge [59]. CGA has proved social network. The discharge plan should also include the
helpful in reducing the incidence and severity of post-fracture prevention of secondary hip fractures by treating osteopo-
falls by means of periodic medication reviews to eliminate any rosis and reducing the risk of falls. The orthogeriatric team
unnecessary medication (especially psychoactive drugs), treat should conduct and extend the use of comprehensive geriatric
hypotension, improve visual acuity, provide assistive devices assessments.
and physical therapy, including balance, strength and endur-
ance training [30]. The prevention of falls should also include Declaration of Interest: The authors have no conflict of inter-
the assessment and management of environmental hazards, est to declare. No funds were used for the preparation of this
Disabil Rehabil 2013.35:758-765.

e.g. removing clutter and loose rugs, adding stair rails and overview.
grab bars, and improving lighting [60].
Osteoporosis is a common disease in the elderly [61] and
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