GLUT2

• GLUT2 protein consists of 14 subunits and is encoded by the SLC2A2 gene, located at
q26.2 of chromosome 3.
• GLUT2 has only a relatively low affinity to glucose (Km ≈ 17 mmol/L), as well as a
low affinity to fructose, mannose, and galactose , but a high affinity to glucosamine
(Km ≈ 0.8 mmol/L).
• Glut2 is expressed in hepatocytes, absorptive epithelial cells of the intestinal mucosa
and kidney, and pancreatic beta cells.
•
In pancreatic beta cells, Glut2 can ‘sense’ increases in glucose levels and is required for
glucose-stimulated insulin secretion
• Glut2 can adapt its expression and function in response to environmental changes, such
as glucose availability in different body compartments

GLUT4

• Human GLUT4 has 509 amino acid residues and is encoded by SLC2A4 gene in the
human genome. It is mainly expressed in adipocytes and skeletal muscle.

• GLUT4 expressed in skeletal muscle cells, adipocytes, and cardiomyocytes. It is

principally responsible for insulin- dependent glucose uptake into muscle and adipose
cells.
• Insulin signalling leads to GLUT4 translocation to the cell membrane from intracellular
vesicles, which increases glucose uptake in cells, and achieves glucose homeostasis
(glycogen synthesis)

Dr. Lalit Pal

(Ph.D. NII, JNU, New Delhi)

Qualified CSIR / ICMR / DBT- JRF, GATE, BARC- OCES, ICAR-NET- ARS , TIFR-JGEEBILS, JNU / NII Ph.D.

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