KOMKES 14

Albuterol vs
Levalbuterol
Faza Najmi Atsila D - 052111133218
Topik dan
Jurnal Tabel PICOT Kesimpulan
guidelines
Perbandingan Efektivitas Albuterol dan

Levalbuterol pada Pediatric Asthma

 P I C O T

Population Intervention Comparison Outcome Time

Intervention

Pediatric asthma Use of Use of albuterol Efficacy Up to 1-year

patients levalbuterol comparison follow-up period
between both
groups
1. Yuan, J et al. 2017. Clinical outcomes of levalbuterol versus racemic albuterol
in pediatric patients with asthma: Propensity score matching approach in a
medicaid population. Pediatric pulmonology, 52(4), 516-523.
2. Punj, A et al. 2009. Levosalbutamol vs racemic salbutamol in the treatment
of acute exacerbation of asthma. Indian Journal of Pediatrics, 76(11), 1131-
1135.
3. Schreck, DM et al. 2005. Comparison of racemic albuterol and levalbuterol in
the treatment of acute asthma in the ED. American Journal of Emergency
Medicine, 2005(23), 842-847.
4. Carl, JC et al. 2003. Comparison of Racemic Albuterol and Levalbuterol for
Treatment of Acute Asthma. The Journal of Pediatrics, 2003(143), 731-736.
5. Nelson, HS et al. 1998. Improved bronchodilation with levalbuterol compared
with racemic albuterol in patients with asthma. Journal of Allergy and
Clinical Immunology, 102(6), 943-952.
 P I C O T
Journal
Population Intervention Comparison intervention Outcome Time
8,172 asthmatic Use of levalbuterol Use of racemic albuterol Fewer asthma-related ED 12-month follow-
1 patients aged 2-18 visits on levalbuterol group up period
years
60 asthmatic Use of Use of racemic Improvement in PEFR, SpO2 1-hour follow-up
2 children aged 5-18 levosalbutamol salbutamol (albuterol) and asthma score on period
years (levalbuterol) levosalbutamol group
234 children with Use of levalbuterol Use of racemic albuterol Lower patient admission 9-and 3-month
3 acute asthma aged rates to hospital from ED on consecutive
1-18 years levalbuterol group follow-up periods
482 children with Use of levalbuterol Use of racemic albuterol Reduced number of 9-month follow-
4 acute asthma aged hospitalizations on up period
1-18 years levalbuterol group
3,062 children with Use of levalbuterol Use of racemic albuterol Greater FEV response on 4-week follow-up
moderate-to- levalbuterol group period
5 severe asthma
aged 12 years or
older
PEFR = Peak Expiratory Flow Rate; SpO2 = Blood oxygen level; FEV = Forced Expiratory Volume
• Levalbuterol terbukti lebih efektif dalam menangani pediatric
asthma
• Pemberian levalbuterol menunjukkan respon PEFR, SpO2, asthma
score, dan FEV yang lebih baik daripada setelah pemberian
albuterol
• Angka pasien yang memerlukan penanganan rawat inap
menurun setelah dilakukan peralihan pengobatan dari albuterol
ke levalbuterol
• Pasien gawat darurat yang diberikan levalbuterol cenderung
tidak memerlukan penanganan lebih lanjut jika dibandingkan
dengan pasien yang diberikan albuterol
Terima Kasih!
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