Location

NCHU

Dr. Congo Tak Shing CHING

Professor
Graduate Institute of Biomedical Engineering
Email: tsching@nchu.edu.tw
http://web.nchu.edu.tw/~tsching/

Biomedical Instrumentation
and Sensors Laboratory 2

Members in
Graduate Institute
of Biomedical
Engineering

Beauty
NCHU

3 4

Location and Space Researches

BME

6F Biomedical Tissue Biomedical

Biosensor
Imaging Engineering Instrumentation

Dr. T. S. Ching Dr. C. C. Chang Dr. G. J. Wang Dr. T. S. Ching

Dr. S. P. Lin Dr. K. C. Liao Dr. H. M. Wang Dr. K. C. Liao
Dr. C. H. Lai Dr. C. H. Lai Dr. S. P. Lin

6F, Applied Science & Technology building

5 6
 Dr. Ching’s
Research
Interests

Assistive
Devices
7 8

To Be a Foreign MSc Student in NCHU Outline

http://www.oia.nchu.edu.tw/index.php/en/for-students-en/study-at-nchu-en

 Application duration  Noninvasive transdermal metabolites extraction

– From September to October (Spring Semester)  Noninvasive transdermal drug delivery
– From February to March (Fall Semester)  Noninvasive tissue characterization
 Announcement  2D bioimpedance imaging system
– December (Spring Semester)
 Humanoid electromechanical hand
– June (Fall Semester)
 Computerized flatfoot diagnostic system
 Wisdom bed for paralyzed patient
9 10

Reverse Iontophoresis (RI)

 Electromigration
• General principle of electricity

Noninvasive Transdermal  Electroosmosis

Metabolites Extraction • Both charged and uncharged molecules

 Diffusion

11 Fig. source: http://www.datasync.com/~rsf1/eas06.gif 12

Pathways of Molecules Transport Electroporation (EP)

Fig. source: http://www.scf-online.com/english/37_e/skinpenetration37_e.htm 13 Fig. source: http://www.scf-online.com/english/37_e/images37_e/Skinpenetration37_08_large.jpg 14

Diffusion Cell for In Vitro Extraction Study Transdermal Extraction of Homocysteine by

RI
Phase duration-dependent

15s

• Current density = 0.3 mA/cm2

15 • PDSBdc = Phase duration of symmetrical biphasic dc 16

Transdermal Extraction of PSA by EP and RI Pre- to Post-Experimental Skin Impedance

* P<0.05,
** P<0.001

* P<0.05, ** P<0.001

Impedance measurement: 20Hz

17 18
Skin Recovery

60X 60X

Before, 74 V/cm Before, 592 V/cm

60X 60X

After, 74 V/cm After, 592 V/cm

19 20

Diffusion Cell Used in Human

21 22

Transdermal Extraction of Uric Acid in

Human

Noninvasive Transdermal
Drug Delivery

23 24
Applications of EP and Iontophoresis (IONP) Diffusion Cell for In Vitro Delivery Study

 EP
– Treatment of head and neck cancer
in human

 IONP
– Treatment of palmar and plantar hyperhidrosis

Fig. source: http://www.sweathelp.org/English/images/iontophoresis_using.jpg 25 26

Transdermal Delivery of Insulin Transdermal Delivery of Vitamin C

27 28

Tissue Bioimpedance
V=IxZ

Noninvasive Tissue Characterization

by Bioimpedance

29 Fig. source: http://www.medphysics.leeds.ac.uk/physci/renal/biaabout_files/tissue.gif 30

Cell Membrane and its Electrical Equivalent Equivalent Circuits and Models

Membrane conductance
is very low and Rm is
usually ignored

31 Fig. source: http://www.onkocet.onkocet.eu/userfiles/image/MEIK_BMcell.jpg 32

Data Processing Clinical Practice for Oral Cancer Detection

1
Z
 1  1  Visual inspection
 R 
 e 1 
 2fC   Ri – Unnoticed
 m

– Diagnosis delay
Z f 0  Re

New approach
Re Ri
Z f  
Re  Ri

Z  Re, Ri, Re/Ri

33 Fig. source: http://www.gla.ac.uk/Acad/Dental/OralCancer/clinical_photos3.htm 34

Electrical Properties of Tongue Tissues: Re

* P < 0.05

35 36
Electrical Properties of Tongue Tissues : Ri Electrical Properties of Tongue Tissues : Re/Ri

* P < 0.05

37 38

Pressure Sore Electrodes Placement

Fig. source: http://s2.hubimg.com/u/736033_f248.jpg

Fig. source: http://img.medscape.com/pi/features/slideshow-slide/pressure-ulcers/fig5.jpg 39 40

Tissue Electrical Properties: Impedance

* P < 0.05

33.81 Hz  125.57 Hz
41 42
 Architecture of the 2D Imaging System

2D Bioimpedance Imaging System

43 44

The 2D Imaging System The Measurement Probe

45 46

The Working Interface Quantification and Localization of Changes

47 48
Quantification and Localization of Biological
Changes

Humanoid Electromechanical Hand

49 50

Architecture of the Interactive System System Operation Modes

51 52

Rehabilitation Mode Demonstration of Interactive System

53 54
 Hardware

38 cm 鋁箱 綠光LED燈

21 cm 38cm
Computerized Flatfoot 66 cm
鋁箱
Diagnostic System

自動恆光功
強化玻璃 攝影機
率控制電路
自動恆光功率控制電路
55 56

Software
System Platform Interface

Employing the idea

of angiography

57 58

Procedures of Flatfoot Diagnosis Footprint Captured at Different Color Light

在受測者腳上貼定位點

受測者站上鋁箱，全身放鬆雙腳與肩同寬

開啟LED燈
White Red
拍攝一張足底影像

關閉LED燈 Green

拍攝一張足底影像

上傳至系統操作平台進行足底影像分析
Blue Yellow
59 60
Imaging Processing: Arch Index Calculation

Wisdom Bed for Paralyzed Patient

61 62

System Architecture System Platform Interface

63 64

The Wisdom Bed The Working Interface: No Movement

65 66
The Working Interface: Moving Other Applications of the System

01 Stylish design
Stylish design
02

03 Stylish design
Stylish design 04

67 68

References: Journal Articles References: Patents

 Congo Tak-Shing Ching and Jhih-Hao Chen. An Non-invasive, Bioimpedance-based 2-Dimensional  復健機械手系統。中華民國，發明第I577365，專利權期間：2017年4月11日至2035年9月10日
Imaging System for Detection and Localization of Pathological Epithelial Tissues. Sensors and
Actuators B: Chemical 2015; 206: 319–326  智慧床。中華民國，發明第I561230，專利權期間：2016年12月11日至2035年9月10日
 Congo Tak-Shing Ching and Wei-Yi Chih. Design and evaluation of an affordable and programmable
mobile device, capable of delivering constant current and high voltage electric pulses of different  檢測系統及資料處理裝置。中華民國，發明第I445951，專利權期間：2014年7月21日至2032年1
waveforms for biomedical and clinical applications. Sensors and Actuators B: Chemical 2014; 194: 月12日
361–370
 Congo Tak-Shing Ching, Tai-Ping Sun and et al. A circuit design of a low-cost, portable and  電腦化扁平足診斷系統。中華民國，新型第M528494，專利權期間：2016年9月11日至2026年4
programmable electroporation device for biomedical applications. Sensors and Actuators B: Chemical 月24日
2012; 166–167: 292–300
 Congo Tak-Shing Ching, Lin-Shien Fu and et al. Use of electroporation and reverse iontophoresis for
extraction of transdermal multibiomarkers. International Journal of Nanomedicine 2012; 7: 885–894
 Congo Tak-Shing Ching, Mei-Yun Chou and et al. Tissue electrical properties monitoring for the
prevention of pressure sore. Prosthetics and Orthotics International 2011; 35: 392–400
 Congo Tak-Shing Ching, Tzong-Ru Chou and et al. Simultaneous, non-invasive and transdermal
extraction of urea and homocysteine by reverse iontophoresis. International Journal of Nanomedicine
2011; 6: 417–423
 Chih-Kuei Lee, Congo Tak-Shing Ching and et al. Noninvasive and Transdermal Measurement of
Blood Uric Acid Level in Human by Electroporation and Reverse Iontophoresis. International Journal
of Nanomedicine 2010; 5: 343–349
 Congo Tak-Shing Ching, Tai-Ping Sun and et al. A Preliminary Study of the Use of Bioimpedance in
the Screening of Squamous Tongue Cancer. International Journal of Nanomedicine 2010; 5: 213–220
 Tai-Ping Sun, Congo Tak-Shing Ching and et al. The use of bioimpedance in the detection/screening of
tongue cancer. Cancer Epidemiology 2010; 34: 207–211

69 70

Acknowledgements 醫工所研究群

BME

Biomedical Tissue Biomedical

Biosensor
Imaging Engineering Instrumentation

Dr. T. S. Ching Dr. C. C. Chang Dr. G. J. Wang Dr. T. S. Ching

Dr. S. P. Lin Dr. K. C. Liao Dr. H. M. Wang Dr. K. C. Liao
Dr. C. H. Lai Dr. C. H. Lai Dr. S. P. Lin

71 72
Assistive
Devices
73 74