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Ssell Pediatrics 04.cerebral Palsy & Ataxias
Ssell Pediatrics 04.cerebral Palsy & Ataxias
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Spastic hemiplegia (25%): -
Cause: Stroke: in utero or neonatal due to Thrombophilic disorders,
Infection, Genetic/developmental, Periventricular hemorrhagic infarction
C.F.:
-Decreased spontaneous movement on the effected side and show hand
preference at a very early age.
- Circumduction gait, dystonia on running, growth arrest of affected side.
Equina varus, walking on tip to, ankle clonus, increases DTR.
-About one third of patients have a seizure disorder that usually develops in
first year or 2nd.
-25% have cognitive abnormalities.
Dx. A CT scan or MRI study may show an atrophic cerebral hemisphere with a
dilated lateral ventricle contra lateral to the side of affected extremities.
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Unlike spastic diplegia, the upper extremities are generally more affected than
the lower extremities in extrapyramidal CP.
Feeding may be difficult, and tongue thrust and drooling may be prominent.
Speech is typically affected because the oropharyngeal muscles are involved.
Speech may be absent or sentences are slurred.
Generally, upper motor neuron signs are not present, seizures are uncommon,
and intellect is preserved in many patients.
dyskinetic CP is the type most likely to be associated with birth asphyxia.
Athetoid CP can also be caused by kernicterus secondary to high levels of
bilirubin, and in this case the MRI scan shows lesions in the globuspallidus
bilaterally.
Extrapyramidal CP can also be associated with lesions in the basal ganglia and
thalamus caused by metabolic genetic disorders such as mitochondrial
disorders and glutaric aciduria.
Diagnosis of CP:
-History (also review pregnancy and delivery records).
-Physical exam (including thorough neurologic exam).
-EEG, CT scan, MRI.
-Tests for hearing and visual functions.
-Genetic evaluation in patients with congenital malformations or evidence of
metabolic disorder.
Management
Multidisciplinary approach
1) Pediatrician: co-ordinating role
2) Physiotherapist.is involve with the child from an early stage, help in
preventing severe contractures and deformity.
3) Occupational therapist. Is involved in adapting the environment to aid
the child functioning. Use of adaptive equipment (motorized wheel
chair, special feeding device).
4) Communication therapist: is involved early, providing help with feeding
problem and later with speech
5) Surgery: for CDH. (Adductor tenotomy and psoas transfer and release),
rhizotomy procedure (division roots of spinal nerve) which used in
severe spastic diplegia, tenotomy for Achilles’ tendon.
6) Care for lower urinary tract dysfunctions.
7) Drugs
a. Treatment of severe spasticity by: oral diazepam, oral baclofen,
dantrolene, intrathecal baclofen, and botulinum toxin injected into specific
muscle groups.
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b. Botulinum toxin could be injected into salivary glands to reduce the
severity of drooling that is seen in 10-30% of patients with CP.
c. reserpine or tetrabenazine can be useful for hyperkinetic movement
disorders including athetosis or chorea.
d. treatment of dystonia by small doses of levodopa. Artane and
Carbamazepine is sometimes useful
e. Treatment of seizures by anticonvulsant.
8) Hearing aids.
9) Special education.
Prevention: -
1) Good pre natal care.
2) Prevention of kernicterus.
3) Care for LBW infants.
4) Treatment of apneic episodes.
5) Prenatal treatment of the mothers in premature labour with magnesium
sulfate.
6) several large trials have shown that cooling term infants with hypoxic-
ischemic encephalopathy to 33.3°C for 3 days, starting within 6 hr of
birth, reduces the risk of the dyskinetic or spastic quadriplegia form of
CP.
Ataxias
Ataxia is the inability to make coordinated movements, usually due to a
disorder of the cerebellum and/ or sensory pathways in the posterior columns
of the spinal cord. Ataxias may be generalized or primarily affect gait or the
hands and arms. They may be acute or chronic.
Causes of acute or recurrent ataxia
1- Brain tumors.
2- Drugs: piperazine, phenytoin, alcohol.
3- Encephalitis (brain stem).
4- Migraine: Basilar, and Benign paroxysmal vertigo.
5- Post infectious/ immune:
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a- Acute cerebellar ataxia (ACA): occurs primarily in children between
1-3 years of age and is a diagnosis by exclusion. It often follows a
viral infection like (varicella, coxsackie virus, or echo virus) infection
by 2-3 weeks.
b- Cerebellar abscess.
c- Acute labyrinthitis.
6- Trauma.
7- Vascular disorders: Cerebellar hemorrhage, and Kawasaki disease.
8- Pseudo ataxia (Epileptic).
9- Genetic disorders: (Maple syrup disease, and Pyruvate dehydrogenase
deficiency).
Causes of Chronic or Progressive Ataxia
1- Brain tumors: Cerebellar tumors, Medulloblastoma, Ependymoma,
Supra tentorial tumors, Neuroblasoma.
2- Congenital malformation: Dandy-Walker malformation, Chiare
malformation.
3- Hereditary ataxia: Abetalipoproteinemia, Ataxia- telangectasia,
Friedreich ataxia.