Pagerers euuusdas KA IPQ EDUCATIONAL SPECIALISTS, INC. MANOR REVIEW CENTER THE APRIL 2024 PHARMACIST LICENSURE EXAMINATION DRILLS: Module 1 re Pharmaceutical Chemistry (20%) ‘What is the Paul's ExclusioniPrinciple?: T. | Which elements are referred to as the Iiadsiop ‘A. No two electrons in an atom may have the same Group vir 1 | principal quantum number eco - 8. An atom cannot have’? electrons in the sa Z| 1Mn ~ 80 (> C._| Enerey level or orbital that have the same set of WEN. ® MaFe_ C. No more than 2 electrons may have the same ALI set of quantum numbers Bin D. Electrons in an atom may differ by, at most, one cunt of four quantum numbers oe 2. [What property decreates from left to right, whieh increases from top to bottom? ‘A Electron affinity - emowise 8B. Nonmetallic property D | c.ttectronegativity - ruowe D. Metallic property) E. lonization energy _~ euro 3. [ Which of the following statements best describe @lements in the Periodic Table? ‘Helium Is the first element in Group 1A. + Ye"? "Vf Nonmetals occupy the upper right area of the Z| periodic table IR Metals are located in the left area of the periodic table Ve Diagonally related elements are known as Bridge elements ALI 8.1 Il 1V C11 tl |oamiw - ri Which of the following i (BEQ) fae © ANH -¥9 Cosa o | BNa - 1 cms) ‘aqialkaline earth metal?” | DAK — te Coton Al * [BERD - ea towgy C40) cl 288 Der ine In + C0, Th the reaction: UF | When U is added, where will the reaction shift? ‘B.Left Neither D. Insufficient data be coreiet, © ‘Identify the Lewis add in the equation: crs Bch = Bch" ACI dor BaBe) - oer" ace eee D. Cannot be determined ‘Which group is referred to as the Coinage? ‘Group Q ~ Beh (Hors oe) B.Groupils ~vriaiie mere D.GroupliiA v eocos wr 6. _|.Which groups referred to as the Alkali Metals? ‘AlGroup IVA €. Group IIA . Group IIIA 11 Ifthe fon product is greater than Ksp, the sol is: (BQ) = kw = Sat. A Saturated HME = fupcct usupersaurstedmy —«<¥" ~ veh. C. Unsaturated . Cannot be determined ‘Allof the following statements about SOMBIIRY Is not true, EXCEPT?’ ‘A. For'many solids dissolved In liquid water, the solubility increases wt B. Increased temperature causes a decrease in kinetic energy. Therefore, as the temperature increases, the solubility of a gas decreases . Decreasing the surface area of a substance Increases its solubility D.NOTA, E.VIA 3 States thatthe Snopy of pure, eying To | at absolute zero temperature ig zero) ScoustsanstneretaMey 8B, Second law of thermodynamics C. Zeroth law of thermodynamics 0. First law of thermodynamics Scanned with CamScannerPagers 7 The following are Woe about acids & bases, Jar According to Arrhenius, acids are proton donors. II, According to Lewis concept, acids are electron acceptors ik According to Bronsted-Lowry concept, bases are proton donors IV, According to Lewis concept, bases are electron donors ALI Cath v At, NIV 'B. Chemical Change, ~ C. Evaporation . Substitution reaction 2. Which of the folowing is used as the unit of | measure for radioactivity? Aree B.ci c.6y Dsv 7. ‘Released by an acid ina solution (BEG) ‘Photon |B. Proton €. Neutron D. Hydroxide 23, w 1 Becquerel is equivalent to B.2.7 x10* Curie )8.2.7x10%Curie® €.2.7x10* Curie D.2.7x10"* Curie The following willreact with water forming anacid_ | solution, EXCEPT: 8. Carbon Sulfur Dioxide D. Nitrogen Dioxide | The following elements form Basie oxides, EXCEPT | 8. Calcium . Strontium D. Magnesium Em ‘Most penetrating ofall typesaf radiation A. Alpha particles 8. Beta particles ©. Gamma rays» D. x-rays Sete particles BanliateUelve up __em A100 8.10 ‘92000 76. What is the normality of sulfurie acid containing 73.52/50 mL of solution? (MW= 98 g/mol) A.20N B.25N D.10N ‘Which ofthe following refers to Rn of Rema | feaction whereby a abba sits Int set Substances? bus te B. Single replac ue C. Double displacement fea _ Which ofthe Towing true for water? ~ Pinned acta pone i. Spld oem is more dense than its liquid form ‘pf radioactive particles passing through tissue would depend upon which of the Following characteristics? Le The ability of the radiation to penetrate the tissue I. The nature of radiation emitted by radioactive elements IL The energy of radiation IV, The dose rate of the radiation ALM c_paeHas igh specific heat IV. Has low surface tension | vtundergoes seltionization AA Mt 8.,1V,V OLIV Zig] when water undergoes elecroWas Tommie jen & Oxygen/molecules, which of the ® | following changes describes this occurrence? a7] inane Te oo ding the hanating & storage Radioactive materials should never be touched byhand > |. Sufficient protective clothing must be used while handling the materials ~ © | radioactive materials should be Keptin suitable ‘A. Physical Change, labeled cont IV, should be cost effective ¢ ALI 8.1, 1V Scanned with CamScannerComponents of mixtures makes use of difference p | msohent anny? A A. Decantation | Betvaperation C. Chromatography D.Distilaton Which “among the processes of separating | 29. | The following are principles of chromatography) excepT: A. Site B. charge Dipl Oe Alon Bland i candy D.tandi , ELM {T. | Manel conti ‘1D | A Copper 6. Nickel Ag 50, Eofomaton ore lal mest commonly determined by which ofthe folowing © | anaiytical methods? fy [A-Nuclear Magnetic Resonance 1% Ka Determination . Mass Spectrophotometry 38. | SOW BI + 25% P+ 25% ST eal Metal yen ¢ O. Solder EPmers iden Wy, 37. | Movement of particles im the Body which is also ‘means solvent shifts isreferred t6 ‘A Passive diffusion © | 8. Facilitated transport ‘38. | Type of phosphorus thatispolsonous ‘Red ~ wales €] 8. lack - cum D.NOTA sport, EXCEPT: (BEQ) A~] 8. Expenditure of energy . Carrier mediated D. Follow saturation Kinetics BZ.| The following are characterises of active] ¢ 40. | Giron doside estored ie: J Gla container 02? %, Semen =e *UPGiaivepntainer | D:Gray container E.Green container 357] Which of the folowing represents The URTOT | fea?” Alumina ~ ant C | a.Poie wit oF 268 ual D. Nuggets “| What reagent canbe used to test for lek, ving |» ted precipitate? | Methanol & Name 8. Dimethyihyoxime Pyridine in acetic anhydride Ammonium molybdate 34 Compounds that result from = combination of electron donor & a metal forming 2 rng structure ‘scallea = Atigand © | a. tactam rng rust 0. Prodrug 35. | A complex structure whereby the interactant a 8.3 molecule hat is composed of both | 2 non-polar & a polar portion? (BEQ) 8. Self.assocated aggregate C.Cathrate Du inclusion Complexes 756. | Elements in atmosphere (EQ) (L | Wydrogen is 14 times lighter than air 1 | i. Nitrogen isheaver than Oxygen Mt Hydrogen was discovered by Cavendish 2_| The postive result when ric alae combined | with ammonium ticeya A Beal blue © | vvtecaree €.Turbuls ue .Thenara's biue “43. | Carbon tetrachloride exhibits an brown color when lsd ins sokton Ong / | @EQ Alodine ® 1B Bromine Fluorine D. Ethylene “4, | Which are true from these statements? 71, arsenates give chocolate brown precipitate to silver nitrate test , / |. acsnites give yellow precipitate to siver nitrate test Ii, Citrate given with Denige’s reagent results toa purple color IV. Tertate given with Denige’s reagent result to anemerald green color Ati Scanned with CamScannerPages Civ 1 IV 45. | Caused by the excessive ingestion of NaHCO} &.| 8. Wilson disease . Parakeratosis 0. Shavers disease 76. | Bordeaux mixture: | wecontains lime & cupric sulfate - /eUsed as fungicide Il, Contains lime & cuprous sulfate WV. Used as anti-acne cu, ot Which of the folowing subst xystalzation upon exposure to air? As Copper sulfate fh | t.Sodium hydroxide mn. Sodium carbonate IV. Ammanium chloride BV cu DL ‘Ferrous ammonium sulfate Green vitriol a8. €.Oespers salt D.Fergon % E.Toleron 4 ‘Compound responsible for thepinkcoloraF | usp Cait Nate 8B. Magnesium Nitrate C Sodium Nitrate | o:Potessium Ntraté The predominant phyilogilarion ouside the /} A. Phosphate ° |eceae €. Sulfate 0. Bicarbonate 32] which are the dssoved compounds foundin ara | 7] water? f. Calcium Salts [ak Magnesium Salts 1 Polyhydroxy Ketones W. Manganese Salts amy? 8th cui Dit 33. which of the following compounds exhibits ‘ that makes it suitable to. fp | Magnesium sutate 8. Calium Hydroxide C:Aluminum Hydroxide . Barium Sulfate ‘54. | Which among the following salts is used’as an ‘A Sodium Carbonate 1) | 8. Sodium iodide : C. Sodium Sulfate 55. | The wate for injection oO 3a static water C.Water for injection [:D,Purified watsy | Which of the following is used-to '/) movement by increasing. 6smotic oad of the| gastrointestinal tract ‘A Bentonite 8. Kaolin Pumice a Which of the following are deliquescent | substances?” oi a NaOH .c20 We Nanos 1. NaCl Aut 8.1, [Simethicone is a component of several antacid formulation, how isit chemically classified? ©” = 8, Ketone Alcohol D. Wax Scanned with CamScannerof the following preparations iemade up of | 8 combination of non-ionic surfactant with iodine? | fw | A Stongiodinesouton BePovidone todin® . lodine in Potassium lodide solution D.Tincture of lodine , Hexyla-methybutanoate | coButy-3-methylhexanoater . Butyl-2propylbutanoate 60. |For a compound to be aroma smusthave the Tolowing areneaer J+ planar (flat) & cyclic Isp? hybridization 4. follows the 4ne2rule v7 66,} Bentene-1,3diol” 7 ‘A. Hydroguinone © | axyiene | c.catechol 0. Orcinol 'G7,| Which of the following is NOTTRUET A. The Cahn-ingold-Prelog rules are used for ® IV, cumulated double bonds ® naming enantiomers & diastereomers =~ | notation Fe our wth Nahe Got same C1, 0, 1H, IV side is described as (Z)-somer_ o.hiat O.NOTA GT] Troeatowt resonance GB | aston one of te Tew pong efeve a] involves delocalization of both sigma & pi bonds | peudamonaseruginesa Which of te structures ‘th Overall charge ofthe system remains the same IL Bonding can be expressed by one single Lewis. formula AL Na ‘62. | Which is TRUE for alcohols? ‘A. Water solubility Increases as the molecular | weight increases Polarity decreases with Increase in nlmber of 0 | Hydroxyl groups . Water solubility decreases with the branching ofthe carbon cain of eholda gy Which statements best eharacterizé [iP they do not alter nthe order of thei Atoms fk | They differ in the order and kind of atoms « lit. They differ inthe spatial arrangement oftheir | atoms IV. They 40 sot differin thelr configuration ALIN? } 8, 1,1V ca I DL it * | c.2,3-binyéroxybutanediot D.Ethanedioic acid @5,| Name the following structure! v NY LX De 0 |W. xanthines ‘69,| Which are the two chemical groups that comprise | alpha agonist?” tePhenylethylamines l.Catecholamines ‘Wie2-Arylimidazolines ALi mv cum oni? A. Hexyl-3-methylbutanoate 70. | A semisynthetic tetracycline used in SIADH * ‘A. Minocyeline B. Tigecycline 4 | c.onytetracycline 0; Demeclocyctine > Scanned with CamScannerPaget 71. | Based on the following reaction: > ol 5 Antabuse (Disufram) to 2-diethythiocarbamic acid seat 7B: | wich of he following enzymes itnvoWved inthe eo process of sullonstion?” A.Sulataes conse “were v | The reactant must have likely undergone C. DT-Diaphorase - Ree D, Monoamine Oxidases -(r0 eho |The gombination “Trimethoprim . Methylation | Sulfamethoxazole's also known as: ral EARC f 72. | Which of the followir I ‘is also used as'| espiecesiis) D. Miconazole of ecaee me gen weet 1. | Which ofthe following combinationtherapyisthe C.Lamivudine? canto D. Efavirenz . 73.| what is the methanism— of action P| i. Tiimethancim? (BEQ) - ovine Metron Y | A Inhibits protein synthesis 0. Pride saline gun (67) Pr | 8. competitive inhibitor for the incorporation of [7 PABA - Sanmene® ee aeons or ‘viggering lta Folate reductase inhibitor? effect ofthe microorganism inchide . Destruction of bacterial cell wall -p**s% inode iis 7 ine antimalarial age Te Ntroso pe vivax. & P. ovale? & is: effective. in | metydronya fs | exoerythrocytiestage of mali 1v. lodoquinol 0 |B. choroguine' = 4 anni ‘Amv C.Amodiaquine m4 Quinine sites ote cul. 75. wich {muro we aaa e Sulfate? DLW. ¥ A. Has a. t & pleasant tasted “3 |. | Which of the following combination therapy’ is A Emetine & Dehydroemetine v ‘. Metronidazole & ledoquinol , Trimethoprim & Salfamethoxazole CT which of the following are Casiied "a Jamebicdes 76. ‘Emetine & Dehydroemetine ‘ 1, Nitvoimidazole derivatives such!” a8 / | Metronidazole” Wf arsenical compound: Carbarsone 2 C Jv. bimercaproty cM 3 oscars wUm TS ™89G) .Lng AwILW WT Biotransformation reaction includes the BLM following, EXCEPT?” ‘ArMethlationy ON, Ar | 8. Hydroxyation G5. which ofthe folowing isthe etaboTne of the ed €.Deamination dye" prontosil responsible for antimicrobial D.Hydrolysis_v / |v? 76 Ar example of gine conjugation pathway? of, | A sutfomethoxazote ‘A Phencl to Phenotsuifote \usmnmeamides © |e. eenzcieatd Hippuric acy . Sulfacetamide C.Noradrenaline to Epinephrine D.Sulfapyridine Scanned with CamScannerDerivatives of Benzyisulfonylurea are useful as? % | A.Spasmolytics © | 8-Anti-infammatory D. Dlureties 87,| Which of the following anesthetics is the most| ne to hydrolysis: * A. Xylocaine jem = rote C |B Lidocaine seases= WAP coProcaine D.Prilocaine BE,| which of the following statements best] characterize Gamma-amina butyric acid?’ shits the major inhibitory neurotransmiter inthe brain v D | w.ttis biosynthesized from Glutamic Acid Il High levels of GABA may be linked to anxiety or mood disorder / | IV. GABA is degraded by a Pyridoxal-dependent enzyme, GABA transaminase, producing Sutyric ‘acid & Succinic acid semi-aldehyde Atal B.m,V The Structure presented above faith following) asadverse effets, EXCEPT” < ‘A. Hypotension 8. Reflex tachycardia. | CAV block * D.Twoof the above 90. ‘Nos. 90-87: Choose from the following: Af Lonly is correct 8B. If ll only is correct (. 1 & Ware correct: D-III & UN are correct EMAL N &ilare correct Hortiones that form lipophilic esters without prior structural modifications clude: Jartydrocortisone th Testosterone il. Progesterone Ti-[ Insulia preparations What contain @ mmodiving protein include: * jet? Insulin Glargine 1. Regulr Insulin Ii tsophane Insulin 82. | Conditions that tend to increase the action of ani] ‘orally administered drug that undergoes Phase:tt © | metabotism include: 1 | Emterohepaticrecreyation st Enzyme saturation IM. First pass effect 3. | Which of the following statements concerning | }\evpaso are correct?” lk The CvP7, CYPL1 & CYP27 subfamilies are © J involved in Cholesterol metabolism & | 0.4 single drug may be metabolized by multiple isoforms of CYP4SO Ii The majority of Xenobiotics, or drugs, are metabolized by CYP&B & CYPLA subfamilies 94. | Metabolic reactions’ Tkely'to be affected by | protein-deficient dietinclude/s: 1 [ik Glycine Conjugation / p | Hydrolysis IM Glucuronidation_ af — of Meperiing PE st [groups present in Meperidine include: ester {iWTertiary Amine ML Carboxylic Acid “ ‘Meperidine is dassfied a LL Weak Acid salt We Weak Base >og ‘7. | Assuming that Meperidine Is absorbed after oral administration & that a large percentage of the dose is excreted unchanged,» the effect of {h| alkalinization ofthe urine will increase its: s2Duration of Action I. Rate of Excretion Iu onization in the Glomerular Filtrate 96. | Which of the following indicators can be used in, the titration of Quinine? » 4eBromophenol Blue pka = 4.0 If Methyl Red pKa = 5.1 O | .Cresot Red pka = 8.3 IV, Chlorophenol Blue pka = 6.0 AL 8.11, wv Osu 89. | Nos. 99-100" Phytopharmaceutical compounds: lit. atropine Colchicine Ml. Curcumin Scanned with CamScannerPages of 8 Wa Digoxin 7 V.Gingerol VI. Eugenol VI. Hesperidin « ‘vile Quinine Which of the phytopharmaceuticals "are classified as alkaloids? B.1,1V, Vil, ill Cull, V, V, Vit D.1, il, V, Vit Which of the following will develop a gree! which turns slowly to dark green blue coloration, when an aliquot portion of the residue obtained by dissolving the unknown-in hot methanol is’ treated with ferric chloride TS? (BEQ). —— B. Atropine C. Digoxin D. Quinine Scanned with CamScanner