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KRAHMs HSB Study Guide
KRAHMs HSB Study Guide
April 2017
KHM
TABLE OF CONTENTS
Topic Page number Topic Page number
Living Organisms 3 Excretion and Homeostasis 40
Characteristics of Living Things 3 The Kidney 40
Cell Theory 3 The Skin 42
Photosynthesis 6 Homeostasis 43
Movement of Substances Coordination and Control 45
6
across Membranes
The Brain 46
Feeding Relationships among
7 Reflex Actions 47
Organisms
The Carbon and Nitrogen Cycle 9 The Eye 48
Nutrition 11 The Endocrine System 50
7 main nutrients 11 The Reproductive System 53
Constipation 14 Male and Female Reproduction 53
Diarrhoea 15 Menstrual Cycle 56
Balanced Diet 16 Methods of Birth Control 58
Malnutrition 16 Heredity and Variation 61
Body Mass Index 18 Mitosis and Meiosis 61
The Human Teeth 19 Inheritance 63
The Digestive System 21 Disease and its Impact on
66
Humans
Enzymes 21
Common Disease 67
Process of Digestion 22
Vectors 69
Absorption 24
Methods to Control the Growth
The Respiratory System 25 71
of Microorganisms
Gaseous Exchange 26
Immunity 72
Rescue Breathing 27
Drugs 73
Cellular Respiration 27
Impact of Health Practices on
The Circulatory System 30 74
the Environment
Components of Blood 32 Pollution 74
Arteries, Veins and Capillaries 33 Water Purification 76
Heart Disease 34 Sewage Disposal 77
Lymphatic System 35 Solid Waste Management 78
The Skeletal System 36
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LIVING ORGANISMS
Objectives
Describe the characteristics of living organisms
Compare the structures of unspecialized plant and animal cells and select microbes
State the functions of cell structures
Identify selected cells which make up the human body
Distinguish between osmosis and diffusion
Explain the importance of osmosis, diffusion and active transport in living systems
Explain the process of photosynthesis
Explain the ways in which other organisms depend on plants directly or indirectly for food
Explain the principles of a food chain
Construct a food chain from a selected habitat
Identify the trophic level of organisms in the food chain
Cell Theory
A cell is the structural unit of most organisms. All organisms are made up of cells.
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Microbes
Bacteria
Bacteria have a simple cell structure. They are surrounded by cell walls, which are not made of
cellulose, used to keep the cell’s shape and preventing it from bursting. Some bacterial species are
surrounded by a slime capsule that protects against other organisms and reduces the chances of
drying up. They have a nucleoid region with a loop of DNA within the cytoplasm – they have no
nucleus. Some bacterial cells have flagella for moving through water or other fluids. Some reproduce
by making spores (small reproductive structures) which germinate and divide in suitable conditions.
Fungi
Most fungi are multi-cellular. Each cell has a nucleus and a cell wall made of chitin. They reproduce
by making spores that are carried by the wind. Most feed on dead or decaying matter. They require
water for growth, oxygen for aerobic respiration and a suitable warm temperature.
Viruses
Viruses are only visible under a microscope. They are not cells, but particles made up of genetic
material (DNA or RNA) surrounded by a protein coat. All viruses are parasites that enter the cells of
other organisms (host) in order to multiply. They do not respire, cannot make their own protein or
genetic material. They take over host cells to produce new viruses. They can reproduce very quickly
and do not respond to antibiotics.
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Cell Specialisation/Differentiation
There are two types of cells in multi-cellular organisms:
Unspecialised cells - those which divide and have no specific function, e.g. stem cells
Differentiated cells - those which develop to perform one specific function. These cells form
tissues, e.g. muscle cell for muscle contraction; nerve cell to transmit nerve impulses
Differentiated cells are important because they allow the organism to be as efficient as possible at
carrying out its functions.
Tissue – a collection of similar cells working together to carry out the same function
There are 4 main types of tissues
1. Epithelial – covers and protects surfaces
2. Connective – connects between body organs and ‘packs’ between them
3. Nervous – conducts nerve impulses around the body for coordination
4. Muscle – contracts to bring about movement
Organ – a collection of different tissues working together to carry out one function, e.g. the heart is
made up of muscle tissue, nervous tissue, connective tissue and epithelial tissue
Organ system – a collection of different organs and tissues working together to carry out one major
function
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Movement of Substances across Membranes
Substances can enter or leave a cell either passively (diffusion, osmosis) or actively (active transport).
Diffusion
Diffusion is the movement of molecules or ions from a region of high concentration to a region of
low concentration until they are evenly distributed. It depends on the difference in the
concentrations of particles in two places. The difference in the concentrations is called the
concentration gradient.
Examples of diffusion in organisms
Place Particles which move From To
Small intestine Digested food products Small intestine lumen Blood in villus capillary
Lungs Carbon dioxide Alveoli Blood around the lungs
Lungs Oxygen Blood around the Alveoli
lungs
Capillaries Oxygen and dissolved Blood Body cells
nutrients
Capillaries Carbon dioxide and waste Body cells Blood
Synapse (gap) Neurotransmitters Neurone Neurone
Leaf Carbon dioxide Air space between Chloroplast
mesophyll cells
Osmosis
Osmosis is the overall movement of water from a dilute solution to a more concentrated solution
through a semi-permeable membrane. It is a special type of diffusion, where water moves from a
higher concentration of water to a lower concentration of water until the two concentrations
become equal.
Examples of osmosis in organisms
1. Absorption of water by plant roots
2. Re-absorption of tissue fluid into the venule ends of the blood capillaries
3. Absorption of water by the alimentary canal — stomach, small intestine and the colon
4. Cell membranes are selectively permeable — allow the passage of water and certain solutes
Turgid cells refer to those which are full of water so that the contents push against the cell wall.
Flaccid cells refer to those that have lost water and become limp.
Plasmolysis refers to the movement of the cell surface membrane away from the cell wall when the
cell loses water.
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Active Transport
Active transport is the energy demanding transfer of a substance across a cell membrane. It carries
substances against its concentration gradient, i.e. from a region of lower concentration to a higher
concentration. ATP generated by respiration supplies the energy for active transport.
Examples of Active Transport
1. Re-absorption of glucose, amino acids and salts by the proximal convoluted tubule in the
kidney
2. The absorption of mineral nutrients by plant roots
3. Sodium/potassium pump in cell membranes (especially nerve cells and red blood cells)
Photosynthesis
Photosynthesis is the chemical process by which green plants make their own food in the presence
of light energy.
This is done by converting light energy from the sun into chemical energy in glucose. The glucose
that is made is stored as starch and converted into other molecules.
Raw materials
Water – absorbed by root hairs by osmosis in the soil
Carbon dioxide – from the air through the stomata of plant leaves
Products
Glucose (sugar) – stores of chemical energy
Oxygen – by-product
Photosynthesis takes place in the chloroplasts found in the palisade and spongy mesophyll cells in
leaves of plants. Chloroplasts contain the green pigment chlorophyll which intercepts and traps light
energy and enzymes that catalyse reactions to make glucose.
Uses of glucose
Much of the glucose is converted to starch and stored. Glucose is broken down during respiration to
release energy for growth and cell activities. It can be converted to carbohydrates, lipids and
proteins and used for growth. It is also converted to starch and stored, e.g. potatoes, yam, rice,
dasheen.
Uses of oxygen
Some oxygen is used for respiration. Excess oxygen diffuses out of the leaf through the stomata.
Carbon Cycle
The carbon cycle shows how carbon atoms are continuously taken up, converted into compounds
and then recycled. The element carbon (C) is found in all organic molecules.
CO2 is taken from the atmosphere and from water, e.g. lakes and oceans, by photosynthesis in
plants, algae and some photosynthetic bacteria
CO2 is released to the atmosphere and to water by respiration, which occurs in all organisms
CO2 is released to the atmosphere by the combustion of wood and fossil fuels
Fossil fuels are formed from the dead and fossilised remains of organisms, e.g. coal, oil, gas,
peat
Carbon compounds, such as carbohydrates, fats and proteins, pass along food chains from
plants to herbivores and then to carnivores
Decomposers feed on dead and decaying plant and animal matter and release CO 2 by their
respiration
Some carbon compounds are not decomposed; instead they accumulate in carbon sinks.
Eventually these carbon compounds that have not decomposed form fossil fuels
Nitrogen Cycle
The nitrogen cycle is the circulation of nitrogen in the atmosphere and nitrogen-containing
substances in soil and living organisms. The element nitrogen (N) is found in many organic
molecules.
Importance
Convert nitrogen from its un-reactive form (nitrogen gas) to its reactive forms (nitrates,
nitrites and nitrogen oxides)
Makes nitrogen available for biological molecules, e.g. proteins, DNA, RNA
Allows nitrogen to be reused by living organisms
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Main processes of the nitrogen cycle
1. Nitrogen fixation
Nitrogen fixation is the process in which bacteria convert nitrogen gas from the air into ammonium
ions and nitrates.
Nitrogen can be fixed by:
Bacteria that live in soil and convert nitrogen gas to nitrates in the soil to be absorbed by
plants
Bacteria that live in plant roots nodules, e.g. legumes, convert nitrogen gas to nitrates in
plants
Lightning that causes nitrogen and oxygen to react together to form nitrogen oxides that form
nitrates in the soil
2. De-nitrification
De-nitrification is the process in which nitrates in the soil are converted to nitrogen gas by
denitrifying bacteria. Denitrifying bacteria live in water-logged soils and survive in conditions with
very low oxygen. De-nitrification reduces soil fertility because it removes nitrates in the soil.
3. Decay
Plants and animal decompose to ammonium compounds in the soil by fungi and bacteria. Animal
wastes, e.g. faeces and urine, are decomposed by bacteria in the soil.
4. Nitrification
Nitrification is the process in which ammonium compounds are converted to nitrates by nitrifying
bacteria in 2 steps:
i. Ammonium compounds are converted to nitrites in the soil by nitrosomonas bacteria.
ii. Nitrites are converted to nitrates in the soil by Nitrobacter.
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NUTRITION
Objectives
Describe the major nutrients and their sources
State the function and the main sources of vitamin A, B 1, C, D and the minerals calcium and
iron
State the functions of water in the body
State the role of dietary fibre in the body
State the cause, symptoms and treatment of deficiency diseases
Describe the causes and effects of constipation and diarrhoea
Explain what is meant by a balanced diet
Explain the effects of malnutrition on the human body
Determine Body Mass Index (BMI)
Nutrient – a food substance that provides energy and is necessary for the growth and repair of living
organisms.
7 main nutrients:
Proteins Vitamins Lipids Roughage
Carbohydrates Water Minerals
Proteins
Proteins are large molecule made from amino acids. They contain carbon, nitrogen, hydrogen,
oxygen. Some also contain sulphur, phosphorus.
Carbohydrates
Carbohydrates are groups of molecules made by plants that supply much of our energy. They contain
carbon, oxygen and hydrogen. There are three types of carbohydrates:
1. Monosaccharides – the simplest carbohydrates. Food sources include biscuits, cakes and
honey.
2. Disaccharides – made up of two monosaccharides. Food sources include cane and beet sugar,
fruit and milk
3. Polysaccharides – complex carbohydrates made of long chains of many simple sugar units.
Food sources include bread, pasta, potato, cassava and yams
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Reducing sugars are the simplest carbohydrates that produce a brick-red precipitate in blue
Benedict’s Solution. They include:
All monosaccharides, e.g. glucose, fructose, galactose
All disaccharides except sucrose, e.g. maltose and lactose
Non-reducing sugars are complex carbohydrates, which remain blue in Benedict’s Solution. They
include:
The disaccharide sucrose
Polysaccharides, e.g. starch, glycogen, cellulose
Sources: butter, margarine, lard, peanuts, milk, cheese, castor oil seeds, pork
Minerals
Minerals are inorganic substances needed in small amounts by organisms.
Deficiency Results
Mineral Rich Sources Function in:
Iron Liver; eggs; dark, green, Forms haemoglobin in red Anaemia
leafy vegetables; kidney; blood cells
red meats
Iodine Seafood; iodised table salt; Production of thyroxine Goitre and
cheese which controls metabolic reduced growth
rate
Calcium Dairy products; dried Formation of bones and Rickets
beans and peas; tinned teeth; assists in blood
tuna/salmon; green clotting; muscle contraction
vegetables
Phosphorus Fresh vegetables; dairy ATP production; formation Rickets
products; liver; meat; of bones and teeth,
eggs; fish; nuts formation of DNA and RNA
Sodium and Fresh vegetables; milk; Nerve impulse conduction Rarely deficient
potassium liver
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Vitamins
Vitamins are organic substances needed in small amounts in the body
The 2 types of vitamins:
1. Water soluble vitamins – vitamin B, C
Easily assimilated in the body and mixes with blood
Need to be eaten regularly because excess is excreted
2. Fat soluble vitamins – vitamin A, D, E, k
Absorbed from fats and oils in the diet and can be stored in the body
Functions: Allows peristalsis to occur - a series of controlled muscular movements that push food
down the gut
Allows for easy elimination of faeces - soft and digested foods do not stimulate
peristalsis
Prevent constipation and haemorrhoids - retains water causing softer, bulkier faeces
Constipation
Constipation is the inability or difficulty to defecate. It occurs when bowel movements become
difficult or less frequent. Going longer than 3 days without a bowel movement causes faeces to
become harder and more difficult to pass.
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Diarrhoea
Diarrhoea is the passing of loose or watery faeces more than 3 times a day. The body can become
dehydrated quickly as a result of the loss of water in the faeces.
Causes: Occurs when fluid cannot be absorbed from bowel contents or when extra fluid is secreted
into the bowel. Can be caused by:
Consuming contaminated food or water
Consuming too much alcohol and/or coffee
Allergic reactions to food
Intestinal damage
Laxative abuse
Medication side effects
Treatment: Often goes away without treatment because the immune system automatically fights
the infection. These steps can help:
Drink plenty fluids to avoid dehydration
Let it run its course
Take over the counter anti-diarrhoeal medicines
Avoid fatty, spicy or heavy foods
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Balanced Diet
Diet – the quantity and quality of the different types of food that a person eats
Balanced diet – a diet that provides energy and nutrients in the right quantities to remain in good
health
Food group – a group of different foods that provide the same nutrients in roughly the same
proportions
Factors Affecting Energy Needs of Different People: size, sex, age, occupation, and climate.
Malnutrition
Malnutrition is the result of lack of a balance in the diet, caused by either a shortage of nutrients or
eating too much of them.
Examples: Starvation Anorexia nervosa Kwashiorkor
Obesity Bulimia nervosa Marasmus
Starvation
Starvation is a shortage or complete lack of food that extends over a period of time. It leads to a
deficiency of energy and nutrients. It is the most extreme form of malnutrition and can lead to
permanent organ damage and death.
Treatment: Rest and warmth; glucose followed by food in small quantities that increase over time.
Obesity
Obesity is a medical condition where a person is 30% or more above their recommended weight
(being overweight due to having too much body fat).
N.B. – obesity ≠ overweight
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Cause: Taking in more calories than the body needs (the body stores unused calories as fat).
This can be caused by: Excessive alcohol consumption Environment
Inactive lifestyle Genes and family history
Health conditions Emotional factors
Medicines
Treatment: Having a lifestyle change, e.g. active lifestyle; eat healthy well-balanced meals, etc.
Taking medication
Surgery, e.g. Gastric binding/bypass, liposuction
Risks: Coronary heart disease; hypertension; stroke; type-2 diabetes, prostate cancer, cervical
cancer, arthritis
Anorexia Nervosa
Anorexia is a psychological eating disorder that makes persons lose more weight than is considered
healthy for their age and height by not eating enough.
Causes: The exact causes are unknown; however, factors thought to play a role include genes,
hormones and social factors.
Treatment: Aimed at restoring normal body weight and eating habits. Treatment includes increasing
social activity; reducing the amount of physical activity; using schedules for eating.
Bulimia Nervosa
Bulimia is an illness where persons binge on food then purge themselves to prevent weight gain.
Purging may include: vomiting, excessive exercise, laxative or diuretic abuse.
Causes: Combinations of factors thought to play a role, e.g. genes, trauma, cultural factors,
psychological factors, social factors
Treatment: Support groups for patients with mild conditions and no health problems; therapy for
those that don’t respond to support groups.
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Marasmus
Marasmus is a protein-energy malnutrition (PEM). It is a severe form of malnutrition consisting of
chronic wasting away of fat, muscle and other body tissues and is prevalent in areas with chronic
hunger, contaminated water supply and inadequate food supply.
Treatment involves a special feeding and rehydration plan and close medical observation. These
include intravenous fluids, oral rehydration solutions and naso-gastric feeding tubes.
Kwashiorkor
Kwashiorkor is a protein-energy malnutrition (PEM) often found in children and commonly seen in
developing regions of the world with famine, limited food supply and low levels of education.
Causes: Inadequate amounts of protein in the diet despite a reasonable intake of calories
Complications: Untreated kwashiorkor may cause coma, permanent mental and physical disability
and shock.
Treatment: Correct blood and body fluid levels and treat any infections. Then reintroduce food
slowly starting with small amounts with carbohydrates then high protein foods and vitamin and
mineral supplements. N.B. – many malnourished children may develop lactose intolerance.
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Human Teeth
The teeth are accessory organs of the digestive system in the mouth that aid in mechanical digestion.
Functions: For mastication (chewing) - They cut, tear and grind food in the mouth
Enables food to be mixed with saliva
Allows food to be swallowed easier
Types of Teeth
Type Number in Form and Function
Adult
Incisor 8 Located at the front of the mouth, relatively flat or ‘chisel-
shaped’ and used for cutting into food.
Canine 4 Have a single pointed surface used for tearing and shredding
(cuspids) food.
Premolar 8 Usually have 1 or 2 roots, have larges surfaces with 2 main
(bicuspids) cusps for grinding food.
Molar 12 Located at the back of the mouth, are blunt and have 2 to 3
roots. Have 4 cusps for crushing and grinding food.
Care of Teeth
The following guidelines can be used to help take
care of teeth:
1. Brush regularly and properly at least twice
daily, preferably after every meal to remove
plaque
2. Brush with fluoride-containing tooth paste to
strengthen the enamel
3. Floss daily to remove debris between teeth
4. Change toothbrush every 2-3 months
5. Use mouth rinse (containing fluoride) after
brushing to remove some remaining food
particles
6. Eat nutritious and balanced meals that
contain calcium, phosphorus, vitamin C,
vitamin D. Section through a molar tooth
7. Avoid sugary and starchy foods which can
remain on tooth surfaces and acidic foods and beverages that can damage the enamel.
8. Visit your dentist (twice yearly) for professional cleanings and oral exams.
Tooth Decay
Tooth decay results in the formation of dental cavities caused by a combination of food, bacteria,
not brushing teeth regularly and the improper brushing of teeth.
Plaque is a clear, sticky substance that covers teeth and gums that is produced by saliva, mucus, food
and bacteria. It can be controlled by proper brushing and flossing. If not removed, it hardens into
tartar.
The Process of Tooth Decay
Tooth decay is caused by bacteria living on food left on teeth. The foods are fermented by the
bacteria to produce acids. The acids destroy the enamel and the dentine, exposing the pulp cavity
and allow bacteria into the living tissue. The cavity made holds more food allowing the same process
to continue, resulting in tooth decay.
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Enzymes
Enzymes are biological catalysts that are made by cells to speed up chemical reactions in the body
(catalysts speed up chemical reactions). They catalyse reactions that would otherwise take too long
to enable us to survive by reducing the energy needed for the molecules to react together. They
remain unchanged at the end of the reaction.
Properties of Enzymes
1. Proteins
2. Catalysts - they are not changed by the reaction and can be used multiple times
3. Specific - they act on a particular substrate
4. pH and temperature sensitive - they work best at certain pH and temperatures
5. Change substrate to products
6. Denatured (inactivated) at high temperatures and destroyed by boiling
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Role and Importance of Enzymes in Digestion
Enzymes break down large food molecules into smaller ones so that they can diffuse through the
intestinal wall into the blood. Large food molecules cannot pass through the intestinal wall.
Large food molecules – starch, protein, fats
Small food molecules – glucose, amino acids, fatty acids, glycerol
Process of Digestion
Mouth:
Food ingested and mechanical digestion takes place (mastication) so that the food can be swallowed.
Chemical digestion - Food is mixed with saliva and is lubricated for swallowing. Saliva contains
salivary amylase which converts starch to maltose.
The tongue pushes food to the back of the mouth to be swallowed. After swallowing, food move
down oesophagus to the stomach
Stomach:
Mechanical digestion - Food is mixed by contraction of muscular walls
Chemical digestion - Gastric juices released. It is composed of:
i. Hydrochloric acid (HCl) which kills bacteria, provide acidic conditions for pepsin to work and
stop salivary amylase activity
ii. Pepsin - activated by HCl and breaks down large proteins to shorter polypeptides
iii. Rennin (found in young children) - causes milk to clot so it can be acted upon by pepsin
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Food is then converted into chime and exit through the pyloric sphincter into the small intestine.
Small Intestines:
Duodenum – the 1st part of small intestine where food is digested. It receives:
i. Bile from gall bladder via the bile duct to emulsify fats. Bile contains sodium bicarbonate that
neutralises stomach acid
ii. Pancreatic juice from pancreas via the pancreatic duct that contains:
Sodium bicarbonate that neutralises stomach acid
Trypsin which break down peptides
Lipase which breaks down fats to fatty acids and glycerol
Pancreatic amylase which breaks down starch to maltose
Ileum – the largest part of small intestine where intestinal juice is secreted. In the ileum:
Maltase breaks down maltose to glucose
Peptidases break down peptides to amino acids
Absorption takes place
Glucose: Some is distributed to body cells to be used for respiration. Excess glucose is converted to
glycogen in liver and muscles, where it is stored.
Fatty acids and Glycerol: These are reformed to fats within the lacteals of villi. They then pass into
the blood stream via lymph vessels of the lymphatic system. Some are stored around vital
organs for insulation and protection.
Amino Acids: They can be assimilated (used for making new cell material, repairing damaged tissue
and forming enzymes and hormones). Excess amino acids cannot be stored; they are
deaminated in the liver (converted into carbohydrates by the removal of the nitrogen group).
The nitrogen group is converted to urea and is excreted in urine.
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Absorption
The ileum is well adapted for absorption to take place. The ileum has many villi which increase the
surface area for absorption.
Structure of a Villus
Structure Feature Function
Micro-villi Tiny finger-like projections Provides larger surface area for absorption
Lacteal Extensive and found at the Absorb fatty acids and glycerol that are
centre of villi reformed into lipids and transports them
into the lymphatic system
Blood capillaries Lead to hepatic portal vein Absorb glucose and amino acids and
transports them to the liver
Epithelial cells Single cell layer with many Allows diffusion of digested food.
mitochondria Mitochondria supply energy for active
transport of molecules
Mucus cells Found in the epithelium For food passage
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Breathing Mechanism
This shows how the movement of intercostals and
diaphragm changes the volume and pressure of the
thoracic cavity, facilitating the movement of air in
and out of the lungs.
Human respiratory system
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Inspiration Expiration
External intercostal muscles Contract Relax
Internal intercostal muscles Relax Contract
Diaphragm Contracts (flattens) Relaxes (arches)
Rib cage Moves up and out Moves down and in
Volume Increases Decreases
Pressure Decreases Increases
Movement of air Air flows in Air flows out
Lung Capacity
Tidal air - the volume of air breathed in
and out during quiet breathing (½ L).
Found by breathing out the amount
you would normally expire during
quiet breathing.
Vital capacity - the volume of the most air that can be blown out after fully breathing in. Found by
breathing in as far as you can and then blowing out as much air as you can.
Residual volume - the amount of air that cannot be removed from lungs by expiration (1 L)
Gaseous Exchange
Gas exchange is the diffusion of O 2 and CO2 out of the blood in the alveoli of lungs. It allows for the
supply of O2 and removal of CO2. The physical process that facilitates gas exchange is diffusion.
The gas exchange surface (respiratory surface) is the alveoli in the lungs which are surrounded by
many blood capillaries.
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Gas Exchange in the Alveolus of Lungs
The blood in capillaries contains less O 2
than the alveoli so O2 diffuses from
alveoli into the blood in the capillaries.
The blood in capillaries contains more
CO2 than the alveoli so CO2 diffuses out
of the blood in capillaries into the
alveoli.
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Aerobic Respiration
Aerobic respiration utilises oxygen obtained when we breathe and occurs in the mitochondria of
cells. Glucose is combined with oxygen and is broken down into carbon dioxide and water. Energy is
released at each step of the breakdown of glucose. The energy is used to convert adenosine
di-phosphate (ADP) to adenosine tri-phosphate (ATP). Each ATP molecule acts as a packet of energy.
C6H12O6 + 6O2 6CO2 + 6H2O + energy (2880 kJ)
Anaerobic Respiration
Anaerobic respiration occurs in the cytoplasm of cells without oxygen. Glucose is not completely
broken down.
Anaerobic respiration in yeasts:
C6H12O6 2C2H5OH + 2CO2 + energy (210 kJ)
Human cells usually respire aerobically, except during strenuous activity. After a while of sustained
activity, the oxygen supply becomes inadequate, even with the increase breathing and heart rate,
causing the muscle cells to respire anaerobically. A smaller amount of energy is produced during
anaerobic respiration.
Fatigue occurs when the lactic acid (waste product) accumulates in the muscles and causes them to
ache.
Oxygen debt is the oxygen required to convert the lactic acid back to glucose so that it can be
broken down completely in aerobic respiration.
Lung Damage
Chronic Bronchitis
This is condition in which the bronchi and bronchioles become inflamed and obstructed with
phlegm. This causes continuous heavy coughing up of phlegm. This mucus interferes with lung
defences leading to bacterial infections. Phlegm accumulation and narrowing of bronchioles makes
breathing difficult.
Emphysema
This condition occurs when alveoli walls are destroyed causing larger air spaces to be formed. Larger
air spaces lead to smaller surface areas for the uptake of oxygen. Lungs lose their elasticity as fibrous
tissue is laid down.
Factor Reason
Rest / sleep Carbon dioxide is removed and inactivity means little is produced
Fresh air Only 0.03% carbon is present
Drugs Stimulants increase metabolic rate while depressants decreases it
Exercise Carbon dioxide and lactic acid accumulate in the blood
Weight More work has to be done with a larger body
Anxiety Adrenaline released increases the metabolic rate
Poor ventilation accumulates carbon dioxide in inspired air
Environmental factors
Air pollution by cars increases carbon dioxide in inspired air
Combustion All burning increases inspired carbon dioxide
Low pressure affects breathing and muscles work harder to
Altitude compensate; lack of oxygen above 3000m causes carbon dioxide to
increase in the blood
Carbon monoxide is converted to carbon dioxide and inspired;
Smoking
causes shortness of breath; particles constrict bronchioles
Illness E.g. asthma constrict bronchioles
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Multi-cellular organisms have more bulk than single-celled organisms. The distance between surface
and centre is much greater and diffusion is not efficient enough to deliver nutrients to all cells of the
body. Also, they do not have enough body surfaces to obtain enough oxygen to all cells. Therefore a
circulatory system is needed to carry substances to and from all cells in the body.
External structures of the human heart Internal structures of the human heart
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The Parts of the Heart
Structure Function
Vena cava Carries deoxygenated blood from the body into the right atrium
Right atrium Receives deoxygenated blood from the body and pumps it into the right
ventricle
Right ventricle Pumps deoxygenated blood into the pulmonary artery
Pulmonary artery Carries deoxygenated blood from the heart to the lungs
Pulmonary vein Carries oxygenated blood from the lungs to the left atrium
Left atrium Receives oxygenated blood from the pulmonary veins and pumps it into the
left ventricle
Left ventricle Pumps oxygenated blood into aorta
Aorta Carries oxygenated blood from the left ventricle to rest of the body
In a single circulation, the blood pressure would drop too low by time it reaches the lungs. Therefore
the heart utilises a double circulation to maintain the blood pressure both to the lungs and the body.
It also ensures that oxygenated and deoxygenated blood are kept separate.
There are 2 circulations of blood:
1. Pulmonary circulation: the passage of blood from the heart to the lungs and back to the heart
2. Systemic circulation: the passage of blood from the heart, around the body and back to the heart
Blood Pressure
This is the force exerted on the walls of the arteries that is needed to pump blood to all parts of the
body. There must be a difference in pressure between arteries and veins for blood flow to occur.
Arteries – high blood pressure
Capillaries – lower blood pressure
Veins – lowest blood pressure
A heart beat is the combined contractions of the atria and ventricles. The heart beats at about 72
beats per minute.
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Blood Flow Through the Heart
One complete heart beat is called a cardiac cycle and involves the following stages:
a. Diastole – atria and ventricles relax and blood enters the heart from the vena cava and
pulmonary veins.
b. Atrial systole – both atria contract at the same time, decreasing their volume, thus
increasing their blood pressure, pushing blood into the ventricles.
c. Ventricular systole – both ventricles contract after the atria have contracted (atria are
now relaxed), decreasing their volume, thus increasing their blood pressure, pushing blood
into the pulmonary artery and aorta.
Serum - The remainder of the blood after RBC’s, WBC’s and clotting factors have been removed. It is
used in diagnostic tests, e.g. testing for iron deficiency.
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Factors Affecting the Ability to Transport Oxygen
Anaemia – mostly caused by a lack of iron in the diet.
Carbon monoxide – this gas binds permanently to haemoglobin, thus reducing the volume of
oxygen that can be carried by RBC’s and causes drowsiness and death.
High altitudes – there is less oxygen in the air at high altitudes. Persons living or travelling
there acclimatise by forming many more RBC’s.
Blood Clotting
A blood clot consists of a mesh of fibres that trap blood cells and platelets at the surface of the
wound.
Importance:
Prevents infection by preventing the entry of pathogens through damaged skin
Prevents excessive blood loss from damaged blood vessels
An artificial pacemaker is a small device placed in the thorax that uses electrical impulses to prompt
the heart to beat at a normal rate.
Functions
Help control an abnormal heart rhythm (fast/slow)
Coordinate electrical signalling between the atria and ventricles
Adjust heart rate to changes in activity
Monitor and record the heart’s electrical activity and heart rhythm
Heart Disease
These are all the diseases of the heart and circulatory system. They include coronary heart disease,
heart failure, heart valve disease and strokes.
Coronary thrombosis: the blockage of or reduced blood flow in the coronary artery, commonly
caused by atherosclerosis and arteriosclerosis.
Coronary artery: the blood vessel that supplies blood to the heart muscle
Atherosclerosis: occurs when the internal diameter of the arteries become reduced due to
cholesterol (fatty material) deposits on the walls
Arteriosclerosis: occurs when the walls or the arteries harden and become less elastic
Hypertension
This is consistently high blood pressure. Hypertension increases the risks of cardiovascular problems,
e.g. angina, stroke, heart attack. It is more likely in persons who smoke, are overweight, drink
excessive alcohol, exercise little or eat a high fat and/or salt diet.
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Lymphatic System
The lymphatic system is a second transport system in the human body which consist of a network of
organs, lymph nodes, lymph ducts, and lymph vessels that make and move lymph from tissues to the
bloodstream.
It is a major part of the body's immune system that includes the tonsils, spleen, and thymus.
Functions
Transport tissue fluid back into the blood
Transports fats, particularly from villi to blood
Remove excess fluid, protein and foreign material from tissue spaces
Body defence – microbes are destroyed in lymph glands by WBC’s
Lymph is drained tissue fluid. It is a colourless fluid that transports lipids and contain many WBC’s.
It flows in one direction due to valves in large lymph vessels.
Tissue fluid is leaked plasma from capillaries that surrounds the cells transporting substances
between tissue and blood.
Lymph vessels pass through lymph nodes and carry lymph to the subclavian vein (base of the neck).
The subclavian vein returns lymph back to the blood.
Joints
Joints occur where 2 bones meet. Without joints movement would be impossible. They are classified
by their range of movements. There are 3 groups of joints:
1. Fixed, immovable or fibrous joints – no movement occur
2. Slightly movable joints – allows a small degree of movement
3. Synovial or freely movable joints – allows friction-free movement
Hinge joint – movement in one plane
Pivot joint – rotation
Ball and socket joint – movement in any plane
Gliding joint – have flat articulating surfaces that slide over one another easily
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2. Fast twitch fibres
Theses mainly use glucose as their source
of energy and, because they lack an energy
store, fatigue quickly. They develop more in
sprinting athletes.
Locomotion
Locomotion is the movement from place to
place. Humans are bipedal, which allows us to
stand upright. Locomotion is important because
it helps us to:
i. move away from danger
ii. find food
iii. escape predators
iv. exercise
v. find a mate. Human skeleton
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Factors Affecting the Muscular and Skeletal Systems
i. Diet
Protein is needed for collagen fibres.
Calcium and phosphates are needed to harden the bone matrix.
Vitamin D stimulates the uptake of calcium from the gut.
Deficiencies in calcium and vitamin D can lead to osteoporosis.
People who consume more energy than required store fat that add weight to the body
and increase strain on muscles.
ii. Posture
Posture is the position of the body. Good posture allows the muscles to use as little
energy as to maintain the position of the body. Poor posture puts a strain on muscles
causing them to lose their tone. More energy is needed by the muscles to keep the
body upright, leading to fatigue and backache.
N.B. - Muscle tone is the partial contraction of muscle that helps to maintain posture
iii. Obesity
Excess body fat puts much strain on the skeleton, especially the joints. People who are
overweight and obese increase their risk of developing arthritis.
v. Exercise
Regular exercise causes more capillaries to develop inside the muscles, the muscles to
become larger, muscle tone to improve, joints to become more flexible.
Extreme forms of exercise may lead to the risk of muscle and bone damage.
Lack of exercise makes muscles weak, flabby and slack and joints lose their flexible
movement and strength.
vi. Arthritis
Painful condition in the joints; cartilage may become worn and ligaments distorted.
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Excretion
Excretion is the removal of waste products of metabolism from the body and substances in excess of
requirements. Metabolic waste refer to products made by chemical reactions in the body, e.g.
carbon dioxide, urea, hydrogen peroxide. The human excretory products are carbon dioxide, urea,
bile pigments, water and mineral salts.
Importance: Excretions are toxic. If allowed to accumulate to high concentrations they would
damage the body tissues.
The Kidneys
Paired bean shaped, dark red organs attached
to the back of the abdomen
Composed of tiny tubules called nephrons
that filter blood and produce urine
Function – get rid of toxins and excess water
and controls blood composition
The Nephron
Part Function
Bowman’s capsule Ultrafiltration – blood pressure forces fluid part of the into the tubule
Convoluted tubules Selective re-absorption of glucose, salts and water into the blood
Loop of Henle Absorption of water by osmosis from collecting ducts to concentrate urine
Collecting ducts Concentration of urine; pass urine to ureter
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Ultrafiltration
Ultrafiltration is a process that
separates very small particles of
different sizes, e.g. molecules or
ions.
The afferent arteriole has a larger
diameter than the efferent
arteriole causing blood in the
glomerulus to be under high
pressure. The pressure forces
substances that are small enough
through the capillary walls, into the
Bowman’s capsule. Large blood
protein molecules and RBC’s do not usually pass through. The fluid formed in the Bowman’s capsule
is called the glomerular filtrate or ultrafiltrate and is mainly made up of water, glucose, salts
(sodium, chloride, potassium), amino acids and urea.
Selective Re-absorption
The glomerular filtrate contains useful substances which the body needs. Therefore, the body
reabsorbs them into the blood capillaries from various parts of the nephrons.
Proximal Convoluted Tubule – all glucose is reabsorbed by active transport into the
capillaries
Loop of Henle – some water is reabsorbed into the capillaries by osmosis
Distal Convoluted Tubule – salts and some water reabsorbed into capillaries; maintain correct
salt concentration in the blood
Collecting Duct – re-absorption of some water into capillaries (under control of ADH)
Kidney Failure
Causes of kidney failure
include: blood loss,
blood poisoning, severe
dehydration, severe
burns, hypertension and
diabetes.
Diagram of a nephron
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The Skin
The skin is the largest organ in the human body. It helps us to resist infections, excrete, avoid
dehydration, regulate temperature and covers the body. It is composed of many tissues and is made
up of 3 layers:
1. Epidermis – thinner outer tissue of the skin composed of 2 layers
2. Dermis – inner layer of the skin, which is composed of many tissues, such as nervous, muscle
and connective tissues
3. Subcutaneous fat – tissue immediately below the dermis, which forms an insulating layer and
provides food storage
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Homeostasis
Homeostasis is the ability of an organism to maintain a constant internal environment in spite of
changes from the surroundings. The control mechanisms are automatic and self-regulatory and
ensure that cells survive and function efficiently.
There are 2 types of mechanisms
1. Negative feedback mechanism
A system in which a change from the normal state is detected and triggers corrective
actions to restore the normal state
More common in the body, where the body detects changes initiates a mechanism to
bring it back to normal
E.g. – control of body temp., water balance, blood sugar, pH
2. Positive feedback mechanism
Less common in the body, where a stimulus initiates more of the same reaction
E.g. – oxytocin production in childbirth that stretches the birth canal which stimulates
more oxytocin to be produced.
Insulin
Insulin is secreted from the beta cells of the islets of Langerhans in the pancreas. Receptors in the
islets of Langerhans detect an increase in blood sugar. The increase causes the β -cells to secrete
insulin. Insulin causes the liver to convert the excess glucose to glycogen, which increases the uptake
of glucose in body cells. Insulin also converts some sugar to fat and increase sugar oxidation.
Glucagon
Glucagon is secreted from the alpha cells of the islets of Langerhans in the pancreas. Receptors in
the islets of Langerhans detect a decrease in blood sugar. The decrease causes the α-cells to secrete
glucagon. Glucagon acts on the liver cells to cause the breakdown of glycogen to glucose.
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Regulation of Water
Osmoregulation is the control of the body’s water content by osmosis. It involves the maintenance
of the concentration of the body fluids by controlling the water and salt content of the blood.
Kidneys are largely responsible for the water balance in the body. One kidney function is to control
the correct amount of water and salts in body fluids. Water can also be secreted by skin and lungs.
Osmoreceptors in the hypothalamus detect the amount of water in the blood which flows past them
If there is not enough water, the osmoreceptors cause the pituitary gland to secrete anti-diuretic
hormone (ADH). ADH causes the capillaries around the collecting ducts in the kidney nephrons to
reabsorb more water from urine, producing less, more concentrated urine. If there is too much
water, ADH is not secreted, producing a large amount of dilute urine.
Regulation of Temperature
Humans maintain a constant body temperature and are fairly independent of environmental
temperature. This is done by balancing heat production and heat loss. The skin helps maintain a
constant body temperature. The hypothalamus acts as a thermostat. It contains thermoreceptors
which sense the temperature of blood running through it. The thermoreceptors send messages
along the nerves to the parts of the body that regulate temperature.
Diabetes
Diabetes insipidus is a condition where the body produces large volumes of dilute urine due to the
lessened secretions of ADH from pituitary gland. This prevents the kidneys from reabsorbing water
into the bloodstream.
Diabetes mellitus is a condition where the body fails to regulate the concentration of glucose in the
blood.
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Definition of Terms
Stimulus - a change in the external or internal environment of an organism which brings about a
response
Response - a change in the activity of a part or the whole of the organism, which results from the
stimulus
Receptor - the organ or cell that detects a specific stimulus and initiates a nerve impulse
Conductor - specialised conductor cells (neurones) that transmit nerve impulses
Effector - the organ or cell (muscle or gland) that responds to a stimulus or the arrival of a nerve
impulse
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The Brain
The brain acts as a central exchange for
information passed to it from all the sensory
receptors. It coordinates various actions of the
body and stores information (memory). It is
located within the cranium which has an
opening for the spinal cord to pass. In the brain,
grey matter is found on the outside and white
matter on the inside. The brain has 4
inter-connecting chambers called ventricles
that contain cerebrospinal fluid (CSF) and is surrounded by tough membranes called meninges.
Reflex Actions
A reflex action is a quick automatic response to a stimulus, not involving the cerebrum of the brain. It
does not require conscious control and protects the body quickly from danger.
E.g. – spinal reflexes and cranial reflexes
Reflex arc – the pathway between the receptor and effector
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Cranial Reflex Action
These are reflexes in the head region, e.g. blinking and constriction or dilation of the pupil in light.
Pupil Reflex: Allows the iris to contract and dilate to change the size of the pupil.
The pupil controls the amount of light which enters the eye and protects the retina from
‘over-exposure’.
Mechanism:
1. High levels of light strike photoreceptors (rods and cones) in retina
2. Nerve impulse transmits along sensory neurone of optic nerve
3. Impulse coordinated by relay neurones in midbrain
4. Relay neurone transmit impulse through motor nerves to muscle in iris to make pupil smaller
Voluntary Actions
Voluntary actions are those actions controlled by conscious decisions. They are more complex and
may have variable outcomes.
Process
1. Your own thoughts or stimulus starts a nerve impulse in the brain
2. The brain decides whether or not to respond to the stimulus
3. The impulse passes down the white matter of spinal cord
4. Motor neurones in spinal cord transmit the impulse to the effector muscle that will act to
bring about the desired action
Accommodation
Accommodation is the adjustment of the lens for focusing on near and distant objects. The activity of
eye involves: 1) Alteration in pupil size to adjust light strength
2) Alteration in lens shape according to the distance of the object from the eye
Focusing on distant objects:
The ciliary muscles relax, pulling the suspensory ligaments tight, thinning the lens. The thin lens
refracts the light less, focusing the image sharply on the retina.
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Defects in Vision
A vision defect is any condition that prevents proper focusing of light on the retina.
Cataract: Occurs when the lens becomes opaque and light cannot pass through, so the person is
unable to see. It can be corrected through surgery.
Astigmatism: Occurs when the surface of the lens or cornea is irregularly curved. Lines of different
orientations come to focus at different points in the eye. It can be corrected by cylindrical lenses that
balance out these irregularities.
Glaucoma: Occurs when too much fluid gathers in front of the lens, causing a build up of pressure
within the eye. The increased pressure can damage the optic nerve. Vision is poor and the sufferer
may experience sightless areas in the field of vision. Early stages can be treated with eye drops and
oral medication. Later stages may require surgery to treat it.
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Roles of Reproductive Hormones in the Body
Hormone Secreted by Function Other Points
Stimulates the growth of
Follicle stimulating
Pituitary gland follicles and production of
hormone (FSH)
oestrogen
Luteinising Controls ovulation; forms
Pituitary gland
hormone (LH) corpus luteum
Controls development of
male sex organs and
Testosterone Testes
secondary sexual
characteristics
Controls development of
female secondary sexual
Oestrogen Ovary follicles characteristics; thicken
uterine wall; control
menstruation
Prepares uterine wall for
Corpus luteum
implantation; maintains
(after ovulation);
Progesterone uterine lining; stops
placenta (during
ovulation; stimulates
pregnancy)
prolactin secretion
Helps initiate and maintain
breast milk production in
Prolactin Pituitary gland
pregnant and nursing
women
Its production is
Causes uterine
Oxytocin Pituitary gland associated with positive
contractions during labour
feedback mechanism
Stimulates testes to make
Luteotrophic testosterone; stimulates
Pituitary gland
hormone (LTH) corpus luteum to secrete
progesterone
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REPRODUCTIVE SYSTEM
Objectives
Distinguish between sexual and asexual reproduction
Describe the structure and function of the reproductive system in human beings
Describe the menstrual cycle
Explain ovulation, fertilisation, implantation and development of embryo
Describe the birth process
Outline the importance of pre-natal and post-natal care
Explain how birth control methods prevent pregnancy
Explain the advantages and disadvantages of birth control methods
Discuss the issues related to abortion
Explain the importance of family planning
Reproduction is the ability of the organism to produce new individuals of the same species.
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Structure Function
Contain seminiferous tubules that produce sperm; secretes testosterone.
Testis Seminiferous tubules also contain nurse cells that nourish and protect the
developing sperm.
Epididymis Stores sperm
Scrotum Suspends testes outside the body cavity at lower temperature
Vas deferens
Transports sperm to the urethra
(sperm duct)
Cowper’s gland
(bulbo-urethral Secretes part of seminal fluid containing lubricant
gland)
Secretes part of seminal fluid containing alkalis to buffer residual urine in
Prostate gland
urethra and acidity of vagina
Secretes part of seminal fluid containing amino acids and sugar as the
Seminal vesicles
energy source for the sperm
Urethra Transport sperm and urine
Urethra muscle Contracts to ejaculate sperm
Erectile tissue Fills with blood to erect penis
Penis Inserted into vagina during intercourse
Foreskin Covers the end of the penis
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Structure Function
Ovary Produce ova; secrete oestrogen
Oviduct funnel Collects ova released from the ovaries
Contains ciliated epithelium which move ova from the ovary to uterus;
Oviduct (fallopian tube)
site of fertilisation
Where the foetus develops during pregnancy; supplies the foetus with
Uterus
nutrients
A ring of muscles at the end of the uterus; allows blood and cells to pass
Cervix
out during menstruation; allows sperm to enter during intercourse
Vagina Receives penis during intercourse; passage for baby at birth
Vulva Surrounds vaginal opening
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The Menstrual Cycle
The menstrual cycle is a series of changes that takes place in the female body to prepare for the
possibility of pregnancy coordinated by hormones. The cycle itself is typically averaged at 28 days.
The menstrual cycle is counted from the 1st day of one period to the 1st day of the next period. It
includes the following processes:
Menstruation: the elimination of the thickened uterine lining (endometrium ) through the
vagina
Ovulation: the release of an ovum from a mature ovary follicle in the ovary
Fertilisation: the fusion of the male and female gamete to form the zygote (in the fallopian
tube)
Implantation: the embedding of the embryo into the uterine lining (occur approx. 7 days
after fertilisation)
Day 1:
Progesterone and oestrogen levels
drop after previous cycle which
signals the uterine lining to be shed.
Bleeding lasts about 4 – 7 days.
Day 7:
Bleeding has stopped. FSH stimulates
follicles to develop on ovaries. Each
follicle contains one ovum.
Day 7 – 14:
One follicle reaches maturity causing
oestrogen levels to increase.
Oestrogen causes the uterine lining
to thicken and stops the release of
any more FSH.
Day 14:
LH causes mature follicle to burst and
release ovum from ovary follicle
(ovulation). The ruptured follicle
develops into the corpus luteum
which secretes progesterone.
Progesterone maintains the thickness
of the uterine lining.
Day 25 – 28:
No fertilisation occurring: Corpus luteum and ovum degenerates causing a drop in progesterone
leading to the shedding of the uterine lining and ovum (menstruation).
Fertilisation occurring: Corpus luteum continues to secrete progesterone to maintaining the uterine
lining for pregnancy and to prevent the release of another ovum.
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Development of the Embryo
Fertilisation occurs when one sperm with 23 chromosomes combine with an ovum with 23
chromosomes to produced a fertilised ovum (zygote) that has 46 chromosomes in all.
After fertilisation, the zygote moves down the oviduct it divides by mitosis to form a ball of cells
(embryo). The embryo gets nutrients from the yolk sac. When the embryo reaches the uterus it
implants itself into the lining. The embryo cells divide and grow and the placenta grows along with
the embryo.
By 11 weeks after fertilisation, the cells organise into different organs changing the embryo to a
foetus. At this stage the foetus grows until it is ready for birth.
Placenta: Finger-like projections that form between the embryo and the uterine wall which allows
the exchange of nutrients and waste products between mother and baby without the mixing
of blood.
Umbilical cord: Joins the placenta to embryo. It contains an artery that takes blood and waste from
the foetus into the placenta and a vein that returns blood and nutrients to the foetus.
Amnion: Strong membrane surrounding the embryo which secretes amniotic fluid that helps support
the foetus and acts as a shock absorber to protect the developing foetus from mechanical
damage.
Stage 1: Foetus stimulates maternal pituitary gland to secrete oxytocin. This starts uterine
contractions that cause the amnion to burst allowing the fluid to pass out. Contractions cause
further release of oxytocin which causes more contractions (positive feedback mechanism).
Stage 2: Increased uterine contractions push the baby through the cervix and then the vagina.
Stage 3: Baby is expelled head first. Uterine wall continues contracting to expel the afterbirth
(placenta and umbilical cord).
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Prenatal (ante-natal) Care
This includes the care and advice needed during pregnancy for the mother along with checks on the
foetal growth. Aspects include:
Healthy diet
Mild exercise and rest
Health precautions, e.g. avoiding infections, tobacco, alcohol and other drugs
Regular doctor visits to provide blood tests, blood pressure measurements, urine analysis,
weight gain and uterus size
Post-natal Care
This provides advice to the mother on her diet, behaviour and care for the baby. Aspects include:
Checks on the baby’s growth and development
Checks to ensure no uterine bleeding and damage or infection of cervix and vagina
Education on the value of breast milk and weaning the baby onto semi-solid and solid foods
Vaccination program to baby to help build up active immunity
Diphtheria, whooping cough, tetanus, meningitis, hepatitis B, measles, mumps, rubella, pneumonia,
tuberculosis, chicken pox
Breast Feeding
Prolactin stimulates milk production in mammary glands. Suckling stimulates the release of milk. The
first milk is a yellow-coloured fluid called colostrum that is rich in nutrients for growth and
antibodies for protection against infections. Benefits of breast feeding include:
i. Ensures maternal care from birth
ii. Give baby passive immunity (breast milk contains antibodies from mother)
iii. Gives baby all essential nutrients except iron
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c. Rhythm Method: restricting sexual intercourse to the ‘safe period’.
th th
There I no intercourse between the 11 – 17 day of the menstrual cycle (fertile
period).
It does not prevent STI’s and is unreliable because the menstrual cycle may vary
making it easy to miscalculate the fertile period.
2. Chemical Methods
This is the use of spermicidal jellies, creams and foams that destroy sperm in the female
tract during intercourse. They are not very effective on their own but are more effective if
used with a barrier method.
c. Diaphragm (Cervical Cap):A rubber dome that fits over the cervix at the upper end of the
vagina
It prevents the passage of sperm into the uterus, which prevents fertilisation.
It is about 85% effective in preventing pregnancy.
4. Hormonal Methods
a. Oral Contraceptive Pills: Pills containing hormones related to oestrogen and progesterone
that inhibits FSH and stops the development of ova.
They prevent ovulation and fertilisation.
They are 90 – 100% effective in preventing pregnancy.
5. Surgical Methods: Involve cutting and sealing of tubes through which gametes pass.
a. Tubal Ligation: Cutting and sealing end of the oviduct to prevent ovulation.
It makes fertilisation impossible.
It is an irreversible process.
b. Vasectomy: Cutting and sealing the vas deferens to prevent sperm passing from testis to
the rest of the semen.
It is a reversible process.
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Abortion
Spontaneous Abortion (miscarriage): The loss of a foetus before the 20th week of pregnancy. It
frequently occurs and is a natural way of preventing the birth of some abnormal babies.
Induced Abortion: This can be done either medically using hormones or surgically to remove the
foetus/embryo and placenta from the uterus.
Medical abortion involves the taking of hormones to terminate the pregnancy but only during the
early stages. They are effective up to 9 weeks into pregnancy.
Surgical abortion involves the termination of the pregnancy by either suction in the early stages
(first 6 – 12 weeks) or by scraping in advanced stages of pregnancy (12 – 15 weeks).
Foetus in uterus
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The genetic information needed to control the human body is carried in 23 different chromosomes.
Human body cells are haploid, meaning they contain tow copies of each chromosome (46
chromosomes in total). Human sex cells (gametes) are haploid, meaning that they contain one copy
of each chromosome (23 chromosomes in total).
Mitosis
Mitosis is a type of cell division which makes 2 new cells with exactly the same number and kinds of
chromosomes as the parent cell (diploid cells). It occurs in all body cells except in gamete formation.
Mitosis maintains the species chromosome number, thus ensuring that all body cells have the full
chromosome number.
1. Chromosomes become shorter and fatter (easily seen). Each chromosome makes an exact
copy of itself, forming 2 chromatids joined together by a centromere.
2. The nuclear membrane breaks down and chromosomes line up along the middle of the cell.
3. Chromatids separate and move to opposite sides of the cell becoming new chromosomes.
4. A nuclear membrane forms around each group of chromosomes to make 2 identical nuclei.
5. The cytoplasm divides and the cell membrane develops down the middle of the cell to divide
it into 2 new identical cells (clones).
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Meiosis
Meiosis is a type of cell division which results in the formation of cells containing half the number of
chromosomes as the parent cell (haploid cells). It occurs during gamete formation.
A human cell has 46 chromosomes: 23 from the mother and 23 from the father. Each chromosome
from the mother pairs with a corresponding chromosome from the father. These are called
homologous pairs.
1. Each chromosome makes an exact copy of itself, forming two chromatids joined together by a
centromere.
2. Homologous chromosomes come together and pieces of genetic information are exchanged
between chromatids (crossing over). The chromosomes line up along the middle of the cell.
3. Homologous pairs separate and move to opposite sides of the cell.
4. The cell splits to form 2 cells with the haploid number.
5. The chromosomes line up along the middle of the cell where the chromatids separate from
each other.
6. The nuclear membrane form around each group of chromosomes forming 4 new different
cells.
Meiosis ensures that each daughter cell has the haploid number of chromosomes so that the diploid
number can be restored after fertilisation. It also ensures a different combination of genes in each
daughter cell for variation among offspring.
Variation
Variation refers to the differences between individuals of the same species, which arises as a result
of genetic makeup and environmental conditions.
Mutations
A mutation occurs when there is a change in the amount or arrangement of DNA in a cell which
alters a characteristic. There are 2 types of mutations:
1. Gene mutation – a change in the arrangement of a single gene. Conditions caused by such
mutations include albinism, Huntington’s disease, sickle cell anaemia.
2. Chromosomal mutation – a change in the number of chromosomes in a cell or a change to
the structure of the chromosome. Conditions caused by such mutations include Down’s
syndrome, Turner syndrome, Klinefelter syndrome, triple X syndrome.
Inheritance
Gene – a segment of DNA on a chromosome
Allele – different forms of the same gene that occupy the same position on homologous
chromosomes.
Genotype – the genetic makeup of an organism with respect to specific alleles.
Phenotype – the characteristics shown due to the effect of the genotype.
Homozygous – alleles at a specific position on homologous chromosomes that are the same, e.g. AA
or aa
Heterozygous – alleles at a specific position on homologous chromosomes that are different, e.g. Aa
Dominant – the allele that shows its effect in the phenotype, even in the presence of a different
allele, and controls the normal condition, e.g. A.
Recessive – the allele that has no effect in the phenotype in the presence of another different allele.
It is expressed only when 2 are present, e.g. a.
Genetic diagrams show the phenotype and genotype of parents and the possible genotypes and
phenotypes of the offspring.
Monohybrid inheritance is the passing down of a single characteristic from parent to offspring and
involves a single pair of genes.
Carrier - a person that appears normal but has the recessive allele along with the dominant allele
(heterozygous).
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Monohybrid Recessive Inheritance
This arises from the inheritance of 2 recessive alleles. The dominant allele controls the normal
condition. Example:
Albinism
An albino lacks the skin pigment melanin and the pigment in the iris.
Dominant allele for normal skin pigment: A
Recessive allele for albino condition: a
Example: Two parents are carriers for albinism. What are the chances of having an affected child?
Their albino child grows up and has children with a normal person. What are the possible genotypes
of their children?
Sex-linked Characteristics
These characteristics are determined by other genes on the sex chromosomes and are carried on the
X chromosome. They mostly affect males. Haemophilia (bleeder’s disease) and colour blindness are
sex-linked recessive conditions.
Example:
1. A carrier female for haemophilia married a normal male. What is the possibility of their having
a haemophiliac child?
2. A carrier female married a colour blind male. What is the possibility of their having a colour
blind son? What is the possibility of their having a colour blind child?
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Genetic Engineering
Genetic engineering is the changing of one or more characteristics of an organism by inserting genes
from another organism into its DNA.
The foreign DNA can come from another individual of the same species, a different species or
synthesised DNA.
Advantages
Improved food quality
Resistance of crops to pests, diseases, environmental conditions and herbicides
Food to match population growth
Treat medical disorders
Growth hormone production to treat dwarfism
Insulin production for diabetics
Vaccines
Cancer and genetic disorders diagnosis and treatment
Disadvantages
Lack of understanding of the impact on human health and the environment
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Definition of Terms
Health - a state of complete physical, mental and social well-being and free from disease or infirmity
[World Health Organization (WHO)]
Disease is any change from normal health in which the health of the organism is impaired.
A disease can be classified as:
1. Communicable (infectious) – caused by a pathogen and can be passed from one person to
another
2. Non-communicable (non-transmissible) – cannot be passed from one person to another or
acquired from a disease vector
Diseases are detected by signs and symptoms. Symptoms are subjective, i.e. what a person feels.
Signs are objective, i.e. what an observer can detect.
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Types of Diseases and Examples
1. Infectious – influenza, typhoid, STIs, dengue, rabies, measles
2. Deficiency – night blindness, beri-beri, scurvy, rickets, anaemia
3. Degenerative – heart disease, Alzheimer’s disease, osteoarthritis, cancer
4. Inherited – albinism, sickle cell anaemia, haemophilia, colour blindness, Huntington’s disease
5. Mental – anxiety, neurosis, stress, depression
6. Self-inflicted – cancer, bronchitis, heart attack, addiction from cigarette smoking, excessive
alcohol consumption and overeating
AIDS
Human immunodeficiency virus (HIV) destroys T-lymphocytes which weakens the immune response
to invading pathogens.
Acquired immune deficiency syndrome (AIDS) causes patients to die from other opportunistic
infections, e.g. pneumonia, tuberculosis.
Causative agent Human immune-deficiency virus (HIV)
Spread/ Sexual intercourse, blood transfusions, intravenous injections, mother to foetus
infection (congenital),breast feeding
Signs/ Weakened immune system, cough, fever, skin rashes, swollen lymph glands,
symptoms lack of WBCs
Control Avoid sexual relationships with infected persons, avoid unprotected sexual
intercourse, no sharing of intravenous needles, avoid contact with blood from
other persons, screening for virus
Treatment No cure, anti-retroviral drugs (expensive, many side effects), education on
sexual behaviour
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Effects of STI’s on the Mother and Foetus
Bacteria causing gonorrhoea and syphilis can cross placenta of mother leading to a damaged foetus,
stillbirth and babies born with abnormalities, e.g. eye defects.
Viruses causing HIV and hepatitis can cross placenta of mother to foetus. HIV can also be transmitted
through breast milk.
Mothers with herpes virus have worse symptoms during pregnancy and babies may be infected at
birth leading to nervous complaint, blindness and death.
Mosquito as a Vector
Mosquitoes directly transfer pathogens to humans by biting or piercing the skin and are vectors for
insect borne diseases. Only the female adult mosquito can bite and infect. They are attracted to the
body by the smell of sweat. Mosquitoes require stagnant water for the development of their egg,
larvae and pupa stages.
Malaria Dengue
Mosquito vector Anopheles Aedes aegyptii
(feeds after
dawn and before
dusk)
Causative agent Protozoan Virus
Plasmodium DEN 1 to 4
Signs/symptoms High fever, Fever, severe
weakness headaches,
muscle and joint
pain, rash
Treatment Drugs e.g. No specific
quinine treatment, rest
and plenty fluids
Metamorphosis of the mosquito
Houseflies as a Vector
Houseflies transmit pathogens that enter the body in food and cause food poisoning. The major
source of infection includes feeding, defecating and walking from organic waste and faeces to food
eaten. Little pools of digestive juices rich in harmful bacteria is left on food after feeding. The fly may
defecate while flying over food. Bacteria from hairs on the fly’s body may drop off while it walks on
food.
Female can lay 120 – 150 eggs in one batch with 5 batches in one lifetime.
Control: Kill adults, remove breeding grounds, e.g. rubbish heaps.
Disease prevention: Keep food covered, properly store cooking utensils
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Life Cycle of a Housefly
Houseflies undergo complete metamorphosis with distinct
egg, larva, pupa and adult stages. Eggs are laid singly but are
piled in small groups. Larvae emerge within 8 – 20 hours, and
immediately feed on and develop in the material in which the
eggs were laid. Larvae go through 3 moults and complete their
development in 4 to 13 days at optimal temperatures. Pupae
complete their development in 2 – 6 days. Adults can live
15 – 25 days. Without food, adults survive only about 2 – 3
Metamorphosis of a housefly
days.
Rats as a Vector
Rats are opportunistic survivors that often live with and near humans. As pests, they cause
substantial food loss, property damage and transmit diseases that pose a threat to public health.
Controlling Vectors
Controlling vectors helps prevents the spread of communicable fatal diseases, e.g. leptospirosis,
dengue fever, gastroenteritis. Vectors can be controlled by removing breeding grounds and
destroying the vectors.
Hygiene
Hygiene refers to the various measures a person takes to avoid infection, maintain cleanliness and
ensure good health. It is important for eliminating body odours, social acceptance, the prevention of
infections and the prevention of dental carries.
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Methods to Control the Growth of Microorganisms
Heat treatment to preserve liquids by destroying most bacteria present.
Pasteurisation The liquid is alternately heated and cooled to destroy bacteria that turn it
sour.
Ultra-high Food is heated to over 135⁰C and rapidly cooled before packaging to kill
temperature (UHT) virtually all microbes and their spores on a wide range of foods.
Boiling Water boils at 100⁰C at which few organisms can survive.
Pressurised steam is used to destroy microbes. It is used for the
Autoclaving decontamination of laboratory waste and the sterilisation of laboratory
equipment.
Food contents are processed and sealed in an airtight container providing
Canning or bottling long shelf life. The packaging prevents microbes from entering and
proliferating inside.
Refrigeration Food is cooled causing microbe growth to be slowed.
Dehydration Water is removed from food to prevent growth of microbes.
Osmotic pres- Sugar or salt is added to the food making it impossible for most microbes
ervation reproduce, e.g. jams, jellies.
Vacuum packaging Removal of oxygen to prevent aerobic respiration by microbes.
Use of smoke Heat removes water which slows microbe growth.
Pickling The addition of ethanoic acid lowers pH reducing growth of microbes.
Food is cooled to below -18⁰C thus preventing the growth of microbes but
Deep freezing
not killing them.
Definition of Terms
Disinfection - the use of chemicals to destroy pathogens
Disinfectants - applied to surfaces, equipment or other inanimate objects to eliminate pathogens.
They are stronger and more toxic than antiseptics.
Antiseptics - applied to living skin or tissue to prevent infection by eliminating pathogens.
Antibiotics - a chemical produced by living organisms which destroy bacteria.
Antigen - a large molecule that causes lymphocytes to make and release antibodies.
Antibody - protein molecules that destroy pathogens.
Antitoxin -- antibodies made to destroy toxins.
Sterilisation – the complete destruction of all microorganisms present on a substance
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Antifungal agents
These agents are used to treat fungal infections.
E.g. – Antifungal cream can be used to treat ringworm and are liberally applied to the infected area
and its surroundings.
Definition of Terms
Immunity - the body’s resistance to suffering from a disease.
Vaccine - a biological preparation containing parts of microbes or whole microbes that have been
killed or weakened to stimulate the body’s own immune system to protect against subsequent
infection or disease.
Immunisation - the process where a person is made immune or resistant to an infectious disease,
typically by the administration of a vaccine.
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Types of Immunity
1. Natural innate active immunity - inborn immunity
2. Natural innate passive immunity - passed from mother to foetus and baby
3. Natural acquired active immunity - antibodies produced by a natural infection, e.g. TB
4. Artificial acquired active immunity - antibodies produced by a vaccine, e.g. polio vaccine
5. Artificial passive acquired immunity - serum injection contains antibody, e.g. antiserum to
snake bites and tetanus
Definition of Terms
Drug - a substance taken into the body that influences chemical reactions in the body.
Prescription drugs - drugs that should be taken under medical advice for the prevention or cure of
diseases.
Drug abuse - the taking of drugs in excess, or for reasons other than their medical use.
Drug dependence - the addiction caused when a person repeatedly take a drug that they rely on for
support.
Psychological dependence - when an individual feels that they must have the drug in order to live.
Physical dependence - when the body’s metabolism is changed due to taking the drug so that when
the drug is removed strong withdrawal symptoms are produced.
Classification of Drugs
1. Narcotic drugs (opiates) - opium, morphine, heroin, methadone (drugs obtained from unripe
seed pods of opium poppy)
2. Sedatives - tranquillisers, sleeping pills (slows down body functions)
3. Stimulants - cocaine, amphetamines, caffeine
4. Hallucinogens - marijuana (cannabis), LSD, ecstasy
5. Performance enhancing drugs - anabolic steroids, hormones, diuretics
6. Alcohol - beer, wines, spirits (affect body tissues and change behaviour)
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Pollution is the changing and harming of the environment by the action of humans.
A pollutant refers to any substance or form of energy that causes harm when released into the
environment.
Pollution can be categorized according to its source.
Source of Pollutant Effects on Humans and the Environment
1. Domestic
Detergents Contains phosphates (a plant nutrient), causes eutrophication
Sewage Improper disposal causes eutrophication and water contamination
2. Industrial
CO2 A greenhouse gas contributing to global warming
SO2 Damages plants, forms acid rain, irritates respiratory systems
Heavy metals, e.g. mercury Accumulates in food chains; harms the immune and reproductive systems
and lead of marine mammals
3. Agricultural
Pesticides Kills non-target species, so reducing biodiversity
Fertilisers and farmyard Run-off into water, causes eutrophication
manure
Methane Emitted by anaerobic bacteria in flooded rice fields and by cattle; also by
landfill sites
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Air Pollution
Air pollution is the contamination of air by any pollutant that modifies the natural characteristics of
the atmosphere.
The types of air pollution, their origin(s) and their consequences
Type of Pollution Causes Damage
Global warming Carbon monoxide, Increase in global temperature causes:
methane, nitrogen dioxide Polar Ice caps to melt.sea levels rise and low
lying areas are flooded
Rainfall is reduced in tropics leading to
droughts and famine
Stronger winds which lead to more storms and
hurricanes
Acid rain Sulphur dioxide, nitrogen Low pH in rivers leads to death of fish
dioxide Low pH of soil leads to less photosynthesis by
plants
Breathing problems in humans
Damage to limestone and concrete buildings
Depletion of ozone Chlorofluorocarbons, More ultra-violet (UV) light reaches the Earth’s
layer hydrocarbons surface, increasing mutations which can give rise
to cancers caused
Carbon monoxide Car exhausts, gas Reduction in the transport of oxygen by the blood
appliances, cigarettes
Noise Drills, loudspeakers, cars, Hearing problems, headaches, stress
lorries, aeroplanes
Water Pollution
Water pollution is the alteration of water by pollutants so that it is no longer suitable for the human
needs.
The types of water pollution, their origin(s) and their consequences
Type of Pollution Causes Damage
Eutrophication Nitrates and phosphates in Increases in plant growth on the surfaces of
sewage, farmyard slurry, ponds, rivers and lakes leading to an algal bloom.
detergents/washing Oxygen depletion leads to death of aerobic
powders and fertilisers organisms.
Suspended solids Domestic and industrial Makes the water very murky so no light can get to
waste the plants. Photosynthesis is therefore prevented.
Toxic chemicals Lead, mercury, zinc, iron, Miscarriages, birth defects, severe learning
pesticides, oil difficulties in children. Oil can harm much animal
and plant life.
Radioactivity Nuclear power stations, Genetic defects, death
waste from hospitals
Heat Heated water from Aerobic organisms in rivers and streams die
industry
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The Water Cycle
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Proper vs. Improper Sewage Disposal
Sewage refers to human waste (faeces and urine) from toilets, dirty water from sinks, showers and
baths, drain water and waste from industry, hospitals and abattoirs.
Improper sewage disposal can spread disease pathogens and contaminate drinking water. It occurs
when sewage is disposed into open water, or on land the land and when cracked sewage pipes are
used.
Proper sewage disposal occurs when sewage is removed from houses in pipes together with water
to flush it along.
Sewage Treatment
The process involved in sewage treatment includes:
1. Piping sewage from houses and factories to treatment plant
2. Screening which removes large objects that are incinerated or sent to landfill
3. Grit settling tank where grit and sand settle out, are collected and sent to landfill
4. First sedimentation tank where large particles settle and become sludge
5. Sludge is removed and treated to form methane or agricultural fertiliser
Sludge can be treated by using:
i. Biological filter or percolating filter where sewage is sprayed onto stones covered with
microorganisms, e.g. bacteria and protozoa, which feed on the organic matter and convert
it into simple inorganic matter.
ii. Activated sludge where compressed air is pumped through aeration tanks containing
microorganisms which break down the organic material.
6. Any remaining water (effluent) is then sufficiently unpolluted to be passed into a river or the
sea
Pit Latrines
A pit latrine is a hole at
least 3m deep into
which faeces and urine
drop. Pit Latrines should
be located several
meters from the house
and some distance
away from streams,
wells or any source of
drinking water in order
to avoid contamination.
N.B. - Disinfectant
should not be added
since it kills the bacteria
that decomposes the
faeces.
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Solid Waste Management
Landfill Sites
A sanitary landfill site should be dug out of the ground and lined to prevent toxic liquid wastes
leaching away into the soil and entering waterways or ground water. The topsoil is removed first,
then pits are dug and the waste tipped in. The topsoil is replaced so that the land will not be wasted.
Pits made by mining are often filled in this way (land reclamation).
Landfill sites uses machinery to compact the volume, sort out, to recycle and select for different uses
the various wastes. Compacting refuse makes it difficult for vectors, e.g. rats, to penetrate and
reduces the volume to make it easier to handle and take up less space at landfill sites. Soil bacteria
and fungi decompose the organic components of the rubbish into carbon dioxide and methane. As a
result, gases are given off and the volume of rubbish decreases.
Reuse: Use again, for the same or different purpose, e.g. bottles
Reduce: Try to buy only what is needed, avoiding unnecessary materials, e.g. extra packaging on
goods
Recycle: Use to make new products, e.g. wood to make paper
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Advantage
Resources and materials will last longer and cost less for future generations
Generate income from recycling
Fewer landfill sites
Less pollution from decomposing waste
Disadvantage
Time consuming to sort waste
Specialized lorries needed for collection
Non-biodegradable waste refers to waste that will not decay. Such material should be compacted
for disposal in landfill sites if cannot be recycled. Example: most plastics, metal, rubber, glass.
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