CELL MEDIATED
IMMUNITY
HARMANDEEP SINGH. ROLL NO. - 26
*Type of AQUIRED
IMMUNITY
*mediated by T lymphocytes .
Cannot identify antigen directly.
Require APC
Macrophages,dendritic cells, B cells.
Roles of cell mediated immunity.
Protect host against fungi, most of
virus and intracellular bacterial
pathogen eg myobacterium tuberculosis
Participate in graft rejection
Immunological surveillance and
immunity against cancer
Stages of cellular immune responses
Antigen processing and
presentation
Recognition of antigen by T -
lymphocyte
T lymphocyte -
activation(differentiation)
Attack phase of CMI
Antigen is phagocytosed by APC
Degraded into polypeptide
fragment.
Association with MHC antigen
Expression on surface
Recognition of antigen by t lymphocyte.
*. T lymphocytes have TCR ( T cell receptor) specific to particular antigen
Mature T lymphocytes
CD8 cells . CD4 cells
Recognise combination of antigen recognise combination of antigen and
MCH II
And MCH I -
TCR + ANTIGEN MHC COMPLEX = IMMUNOLOGICAL SYNAPSE
T cell
differentiation
CD8 type CD4 type
Tc cells Ts cells T helper cells
(T cytotoxic) (T suppressor)
Released into lymph
Enter blood and distributed throughout body '
T memory cells are also produced Generate secondary response
AttackCytotoxic
phase T cells
of CMI
perforin mediated killing Cytotoxic substances.
Apoptosis
T cell bind to target cell, T cell release cytotoxic tumour
necrosis factor beta
Secrete perforin substance
calcium permeability increase
Punch hole in membrane
Enzymes activated
Target cell burst
Nucleus degradation
-
T helper cells T suppressor cells
Th 1 Th2 Regulate
activity of Tc cells
Secrete IL2 and gamma secrete IL 4 and 5 Prevent
Tc cells from destroying
interferons Interact with B cells
Body’s own tissues
Cellular immunity. Humoral immunity
Thank you
