Printable Worksheet with Quiz
Title: Understanding Protein Structure
Part A: Match the Terms
Match the protein structure with its correct description:
Structur
Description
e
A. Spiral or zig-zag folding (helix or
Primary
sheet)
Secondar B. Final 3D shape due to R-group
y interactions
Tertiary C. Sequence of amino acids
Quaterna
D. Multiple chains joined together
ry
Part B: Fill in the Blanks
1. Proteins are made up of building blocks called ____________.
2. The type of bond found in secondary structure is ____________
bond.
3. The 3D folded shape of a protein is known as its ____________
structure.
4. ____________ structure involves more than one polypeptide chain.
Part C: Label the Diagram
(Insert a diagram of a protein with labeled stages: straight chain → alpha
helix/beta sheet → folded shape → complex with multiple chains.)
Ask students to label:
Primary
Secondary
Tertiary
Quaternary
🧩 2. Classroom Activity: Build-a-Protein Game
Materials:
Colored beads or paper circles (each color = one amino acid)
Pipe cleaners/string
Labels for each level of structure
Steps:
1. Students create a "primary structure" with 10 beads in any
sequence.
2. Fold parts into helices or sheets = secondary structure.
3. Twist and fold further = tertiary structure.
4. Join 2–3 chains = quaternary structure.
💡 Alternative: Use marshmallows and toothpicks!
📌 3. Poster/Diagram to Display in Class
I can generate a printable A4/A3 poster showing:
Level Description Visual
Primary Chain of amino acids Bead chain
Secondar
Alpha-helix, Beta-sheet Spirals / Zigzag lines
y
Folded paper/crumpled
Tertiary Folded 3D shape
yarn
Quaterna Multi-chain protein Interlocked chains or
ry complex balls
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