Virology (Virus Structure & Replication) – Exam
Questions
[A] True (T) or False (X) Statements
• A peplomere is the basic unit of capsid structure.
• Helical nucleocapsids are composed of lipid and viral nucleic acid.
• Double-stranded RNA viruses do not exist.
• The viral capsid is composed of lipid capsomeres.
• The viral nucleocapsid is composed of the viral nucleic acid inside the viral envelope.
• Virus budding can occur from the cytoplasmic membrane only.
• Virus budding always occurs from the cytoplasmic membrane.
• Icosahedral viruses are called complex if they had an envelope.
• In its simplest form, a virus is composed of nucleic acid surrounded by an envelope.
• The origin of viral envelopes is the mitochondrial membrane.
[B] Multiple Choice Questions (MCQs)
• Virus capsids with icosahedral symmetry have: [a] 60 faces. [b] 12 vertices. [c] 20 borders. [d] 30
triangular faces.
• Matrix protein is an envelope-associated structure, which is responsible for: [a] Attachment with cell
receptor. [b] Assembly of new viruses. [c] Uncoating of viral envelope. [d] Release from host cell.
• Matrix protein is important during virus replication in the process of: [a] Attachment. [b] Assembly. [c]
Entry. [d] Release.
• Non-enveloped viruses release from infected cells by: [a] Endocytosis. [b] Exocytosis. [c] Cell lysis. [d]
Budding.
• Viruses can exit a susceptible cell by: [a] Exocytosis. [b] Budding. [c] A & B. [d] Endocytosis.
• One of these methods is NOT used for virus release from infected cells: [a] Exocytosis. [b] Budding. [c]
Endocytosis. [d] Cell lysis.
• The viral nucleic acid can be any of the following EXCEPT: [a] Segmented. [b] Circular. [c] Heteroploid.
[d] Single-stranded.
• Clathrin coated pits are formed during: [a] Virus entry by fusion. [b] Complete virus uncoating. [c] Virus
entry by endocytosis. [d] Virus assembly.
• The ion-channel protein of virus envelope is essential during the ______ stage of virus replication: [a]
Entry. [b] Uncoating. [c] Assembly. [d] Release.
• Icosahedral virus capsid has 12: [a] Angles. [b] Borders. [c] Faces. [d] Spikes.
• The chemical structure of the viral envelope is mostly: [a] Protein. [b] Lipid. [c] Carbohydrate. [d] DNA.
• The following is a factor affecting the outcome of virus infection of susceptible hosts: [a] Virus genes. [b]
Infecting dose. [c] Host immunity. [d] All of the above.
[C] List Only / Short Notes / Compare
• The stages (steps) of virus replication in the correct order of events.
• Differentiate between the helical and icosahedral symmetries of viral capsids.
• Give short notes on: Differentiate between the helical and icosahedral symmetries of viral capsids.
• The viral capsid is composed of peplomers.
[D] Answer Briefly
• Illustrate the single-cell replication cycle of a member of Picornaviridae (e.g., FMDV).
• The outcome of cell infection with a virus is one of the following: [a] No apparent change. [b]
Transformation. [c] All the above.
• The outcome of cell infection with a virus is not one of the following: [a] No apparent change. [b]
Proliferation. [c] All of the above. [d] None of the above.
