1. Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ.

Bronchiolitis-associated hospitalizations among US children, 19801996. JAMA. 1999;282(15):14401446 Abstract/FREE Full Text 2. Pelletier AJ, Mansbach JM, Camargo CA Jr.. Direct medical costs of bronchiolitis hospitalizations in the United States. Pediatrics. 2006;118(6):24182423 Abstract/FREE Full Text 3. Hall CB, Weinberg GA, Iwane MK, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med. 2009;360(6):588598 CrossRefMedline 4. Behrendt CE, Decker MD, Burch DJ, Watson PH. International variation in the management of infants hospitalized with respiratory syncytial virus. International RSV Study Group. Eur J Pediatr. 1998;157(3):215220 CrossRefMedlineWeb of Science 2005;115(4):878884 Abstract/FREE Full Text 6. Willson DF, Horn SD, Hendley JO, Smout R, Gassaway J. Effect of practice variation on resource utilization in infants hospitalized for viral lower respiratory illness. Pediatrics. 2001;108(4):851855 Abstract/FREE Full Text 8. Agency for Healthcare Research and Quality. Management of Bronchiolitis in Infants and Children. Rockville, MD: Agency for Healthcare Research and Quality; 2003. AHRQ publication No. 03-E014 11. Wright AL, Taussig LM, Ray CG, Harrison HR, Holberg CJ. The Tucson Children's Respiratory Study. II. Lower respiratory tract illness in the first year of life. Am J Epidemiol. 1989;129(6):12321246 Abstract/FREE Full Text 12. Wolf DG, Greenberg D, Kalkstein D, et al. Comparison of human metapneumovirus, respiratory syncytial virus and influenza A virus lower respiratory tract infections in hospitalized young children. Pediatr Infect Dis J. 2006;25(4):320324 CrossRefMedlineWeb of Science 13. Mansbach JM, McAdam AJ, Clark S, et al. Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department. Acad Emerg Med. 2008;15(2):111118 CrossRefMedlineWeb of Science 14. Boivin G, De Serres G, Ct S, et al. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis. 2003;9(6):634640 MedlineWeb of Science 15. Kahn JS. Epidemiology of human metapneumovirus. Clin Microbiol Rev. 2006;19(3):546557 Abstract/FREE Full Text 16. van den Hoogen BG, de Jong JC, Groen J, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719724 CrossRefMedlineWeb of Science 17. Williams JV, Tollefson SJ, Heymann PW, Carper HT, Patrie J, Crowe JE. Human metapneumovirus infection in children hospitalized for wheezing. J Allergy Clin Immunol. 2005;115(6):13111312 CrossRefMedlineWeb of Science 18. Williams JV, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5):443450 CrossRefMedlineWeb of Science 19. Paranhos-Baccal G, Komurian-Pradel F, Richard N, Vernet G, Lina B, Floret D. Mixed respiratory virus infections. J Clin Virol. 2008;43(4):407410 CrossRefMedlineWeb of Science 20. Semple MG, Cowell A, Dove W, et al. Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis. J Infect Dis. 2005;191(3):382386 Abstract/FREE Full Text 21. Caracciolo S, Minini C, Colombrita D, et al. Human metapneumovirus infection in

young children hospitalized with acute respiratory tract disease: virologic and clinical features. Pediatr Infect Dis J. 2008;27(5):406412 CrossRefMedlineWeb of Science 22. Rakes GP, Arruda E, Ingram JM, et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care: IgE and eosinophil analyses. Am J Respir Crit Care Med. 1999;159(3):785790 Abstract/FREE Full Text 23. Miller EK, Lu X, Erdman DD, et al. Rhinovirus-associated hospitalizations in young children. J Infect Dis. 2007;195(6):773781 Abstract/FREE Full Text 24. Peltola V, Waris M, Osterback R, Susi P, Hyypia T, Ruuskanen O. Clinical effects of rhinovirus infections. J Clin Virol. 2008;43(4):411414 CrossRefMedlineWeb of Science 25. Korppi M, Kotaniemi-Syrjanen A, Waris M, Vainionpaa R, Reijonen TM. Rhinovirus-associated wheezing in infancy: comparison with respiratory syncytial virus bronchiolitis. Pediatr Infect Dis J. 2004;23(11):995999 MedlineWeb of Science 26. Janssen R, Bont L, Siezen CL, et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis. 2007;196(6):826834 Abstract/FREE Full Text 27. Siezen CL, Bont L, Hodemaekers HM, et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Pediatr Infect Dis J. 2009;28(4):333335 CrossRefMedlineWeb of Science 28. Devereux G, Litonjua AA, Turner SW, et al. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr. 2007;85(3):853859 Abstract/FREE Full Text 29. Mansbach JM, Camargo CA Jr.. Bronchiolitis: lingering questions about its definition and the potential role of vitamin D. Pediatrics. 2008;122(1):177179 FREE Full Text 30. Yorita KL, Holman RC, Sejvar JJ, Steiner CA, Schonberger LB. Infectious disease hospitalizations among infants in the United States. Pediatrics. 2008;121(2):244252 Abstract/FREE Full Text 31. Carroll KN, Gebretsadik T, Griffin MR, et al. Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan. Pediatrics. 2008;122(1):5864 Abstract/FREE Full Text 32. Leader S, Kohlhase K. Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000. J Pediatr. 2003;143(5 suppl):S127S132 MedlineWeb of Science 33. Shay DK, Holman RC, Roosevelt GE, Clarke MJ, Anderson LJ. Bronchiolitisassociated mortality and estimates of respiratory syncytial virus-associated deaths among US children, 19791997. J Infect Dis. 2001;183(1):1622 Abstract/FREE Full Text 34. Thorburn K. Pre-existing disease is associated with a significantly higher risk of death in severe respiratory syncytial virus infection. Arch Dis Child. 2009;94(2):99103 Abstract/FREE Full Text 35. Romero JR. Palivizumab prophylaxis of respiratory syncytial virus disease from 1998 to 2002: results from four years of palivizumab usage. Pediatr Infect Dis J. 2003;22(2 suppl):S46S54 CrossRefMedlineWeb of Science 36. Wang D, Cummins C, Bayliss S, Sandercock J, Burls A. Immunoprophylaxis against respiratory syncytial virus (RSV) with palivizumab in children: a systematic review and economic evaluation. Health Technol Assess. 2008;12(36):iii, ixx, 186 Medline 37. American Academy of Pediatrics, Committee on Infectious Diseases. Modified

recommendations for use of palivizumab for prevention of respiratory syncytial virus infections. Pediatrics. 2009;124(6). Available at: www.pediatrics.org/cgi/reprint/peds.20092345 38. Shaw KN, Bell LM, Sherman NH. Outpatient assessment of infants with bronchiolitis. Am J Dis Child. 1991;145(2):151155 Abstract/FREE Full Text 39. Voets S, van Berlaer G, Hachimi-Idrissi S. Clinical predictors of the severity of bronchiolitis. Eur J Emerg Med. 2006;13(3):134138 CrossRefMedline 40. Mansbach JM, Clark S, Christopher NC, et al. Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department. Pediatrics. 2008;121(4):680688 Abstract/FREE Full Text 41. Schuh S, Canny G, Reisman JJ, et al. Nebulized albuterol in acute bronchiolitis. J Pediatr. 1990;117(4):633637 CrossRefMedlineWeb of Science 42. Mallory MD, Shay DK, Garrett J, Bordley WC. Bronchiolitis management preferences and the influence of pulse oximetry and respiratory rate on the decision to admit. Pediatrics. 2003;111(1). Available at: www.pediatrics.org/cgi/content/full/111/1/e45 43. Schroeder AR, Marmor AK, Pantell RH, Newman TB. Impact of pulse oximetry and oxygen therapy on length of stay in bronchiolitis hospitalizations. Arch Pediatr Adolesc Med. 2004;158(6):527530 Abstract/FREE Full Text 44. Unger S, Cunningham S. Effect of oxygen supplementation on length of stay for infants hospitalized with acute viral bronchiolitis. Pediatrics. 2008;121(3):470475 Abstract/FREE Full Text 45. Bajaj L, Turner CG, Bothner J. A randomized trial of home oxygen therapy from the emergency department for acute bronchiolitis. Pediatrics. 2006;117(3):633640 Abstract/FREE Full Text 46. Tie SW, Hall GL, Peter S, et al. Home oxygen for children with acute bronchiolitis. Arch Dis Child. 2009;94(8):641643 Abstract/FREE Full Text 47. Church NR, Anas NG, Hall CB, Brooks JG. Respiratory syncytial virus-related apnea in infants: demographics and outcome. Am J Dis Child. 1984;138(3):247250 Abstract/FREE Full Text 74. Zorc JJ. Diagnosis and management of bronchiolitis. In: David TJ ed. Recent Advances in Paediatrics. London, United Kingdom: Royal Society of Medicine Press; 2009:1527 75. Bisgaard H. A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med. 2003;167(3):379383 Abstract/FREE Full Text 1. Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ. Br o n c h i o l i t i s - a s s o c i a t e d h o s pi t a l i z a t i o n s a mo n g US c h i l dr e n , 1980 1996. JAMA. 1999;282:1440 1446 2. Parrott RH, Kim HW, Arrobio JO, et al. Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex. Am J Epidemiol. 1973;98: 289 300 3. Langley JM, LeBlanc JC, Smith B, Wang EE. Increasing incidence of hospitalization for bronchiolitis among Canadian children, 1980 2000. J Infect Dis. 2003;188:1764 1767 4. Garrison MM, Christakis DA, Harvey E, Cummings P, Davis RL. Systemic corticosteroids in infant bronchiolitis: a meta-analysis. Pediatrics. 2000;105(4). Available at: www.pediatrics.org/cgi/content/full/105/ 4/e44 5. Flores G, Horwitz RI. Efficacy of 2-agonists in bronchiolitis: a reappraisal and meta-analysis. Pediatrics. 1997;100(suppl):233239

6. Mallory MD, Shay DK, Garrett J, Bordley WC. Bronchiolitis management preferences and the influence of pulse oximetry and respiratory rate on the decision to admit. Pediatrics. 2003;111(1). Available at: www.pediatrics.org/cgi/content/full/111/1/e45 7. Hall CB. Managing bronchiolitis and respiratory syncytial virus: finding the yellow brick road. Arch Pediatr Adolesc Med. 2004;2004:111112 8. Roosevelt G, Sheehan K, Grupp-Phelan J, Tanz RR, Listernick R. Dexamethasone in bronchiolitis: a randomised controlled trial. Lancet. 1996; 348:292295 9. Swingler GH, Hussey GD, Zwarenstein M. Randomised controlled trial of clinical outcome after chest radiograph in ambulatory acute lower-respiratory infection in children. Lancet. 1998;351:404 408 10. Bordley WC, Viswanathan M, King VJ, et al. Diagnosis and testing in bronchiolitis: a systematic review. Arch Pediatr Adolesc Med. 2004;158: 119 126 12. Reijonen T, Korppi M, Pitkakangas S, Tenhola S, Remes K. The clinical efficacy of nebulized racemic epinephrine and albuterol in acute bronchiolitis. Arch Pediatr Adolesc Med. 1995;149:686 692 13. Patel H, Platt RW, Pekeles GS, Ducharme FM. A randomized, controlled trial of the effectiveness of nebulized therapy with epinephrine compared with albuterol and saline in infants hospitalized for acute viral bronchiolitis. J Pediatr. 2002;141:818 824 14. Menon K, Sutcliffe T, Klassen TP. A randomized trial comparing the efficacy of epinephrine with salbutamol in the treatment of acute bronchiolitis. J Pediatr. 1995;126:1004 1007 15. Bertrand P, Aranibar H, Castro E, Sanchez I. Efficacy of nebulized epinephrine versus salbutamol in hospitalized infants with bronchiolitis. Pediatr Pulmonol. 2001;31:284 288 16. Hartling L, Wiebe N, Russell K, Patel H, Klassen T. Epinephrine for bronchiolitis. Cochrane Database Syst Rev. 2004;1:CD003123 17. Patel H, Platt RW, Lozano JM, Wang EE. Glucocorticoids for acute viral bronchiolitis in hospitalized infants and young children. Cochrane Database Syst Rev. 2004;(3):CD004878 18. van Woensel JB, Wolfs TF, van Aalderen WM, Brand PL, Kimpen JL. Randomised double blind placebo controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis. Thorax. 1997;52:634 637 19. van Woensel JB, van Aalderen WM, de Weerd W, et al. Dexamethasone for treatment of patients mechanically ventilated for lower respiratory tract infection caused by respiratory syncytial virus. Thorax. 2003;58: 383387 20. Kajosaari M, Syvanen P, Forars M, Juntunen-Backman K. Inhaled corticosteroids during and after respiratory syncytial virus bronchiolitis may decrease subsequent asthma. Pediatr Allergy Immunol. 2000;11: 198 202 21. Cade A, Brownlee KG, Conway SP, et al. Randomised placebo controlled trial of nebulised corticosteroids in acute respiratory syncytial viral bronchiolitis. Arch Dis Child. 2000;82:126 130 22. Richter H, Seddon P. Early nebulized budesonide in the treatment of bronchiolitis and the prevention of postbronchiolitic wheezing. J Pediatr. 1998;132:849 853 23. Perlstein PH, Kotagal UR, Bolling C, et al. Evaluation of an evidence based guideline for bronchiolitis. Pediatrics. 1999;104:1334 1341 24. Wilson SD, Dahl BB, Wells RD. An evidence-based clinical pathway for bronchiolitis safely reduces antibiotic overuse. Am J Med Qual. 2002;17: 195199 25. Todd J, Bertoch D, Dolan S. Use of a large national database for comparative evaluation of the effect of a bronchiolitis/viral pneumonia clinical care guideline on

patient outcome and resource utilization. Arch Pediatr Adolesc Med. 2002;156:1086 1090 26. Newman K, Ponsky T, Kittle K, et al. Appendicitis 2000: variability in practice, outcomes, and resource utilization at thirty pediatric hospitals. J Pediatr Surg. 2003;38:372379; discussion 372379 27. Kittle K, Currier K, Dyk L, Newman K. Using a pediatric database to drive quality improvement. Semin Pediatr Surg. 2002;11:60 63 28. Gardner E. New analysis product employs ICCS (International Classification and Coding System). Mod Healthc. 22 1993;23:50 29. Averill RF, Goldfield NI, Muldoon J, Steinbeck BA, Grant TM. A closer look at all-patient refined DRGs. J AHIMA. 2002;73:46 50 30. Shen Y. Applying the 3M All Patient Refined Diagnosis Related Groups Grouper to measure inpatient severity in the VA. Med Care. 2003; 41(suppl):II103II110 31. Lumley T, Diehr P, Emerson S, Chen L. The importance of the normality assumption in large public health data sets. Annu Rev Public Health. 2002;23:151169 32. Donner A, Donald A. Analysis of data arising from a stratified design with the cluster as unit of randomization. Stat Med. 1987;6:4352 33. Neuhaus JM, Kalbfleisch JD, Hauck WW. A comparison of clusterspecific and population-averaged approaches for analyzing correlated binary data. Int Stat Rev. 1991;59:2535 1. Schofield D, Cotran RS. Enfermedades durante la lactancia y la niez. En: Cotran RS, Kumar V, Robbins SL. Patologa estructural y funcional. 5 Ed. Madrid: McGraw-Hill Interamericana; 1995: 479-517. 2. Rowe SM, Miller S, Sorscher EJ. Cystic fibrosis. N Engl J Med 2005; 352:19922001. 3. Knowles MR, Durie PR. What is cystic fibrosis? N Engl J Med 2002; 347(6):439442. 4. Ratjen F. Restoring airway surface liquid in cystic fibrosis.N Engl J Med. 2006; 354(3):291-3. 5. Robertson CF. How do we choose a therapeutic regimen in cystic fibrosis? Thorax 2002; 57(10):839-840. 6. Tarran R, Grubb BR, Gatzy JT, Davis CW, Boucher RC. The relative roles of pasive surface forces and active ion transport in the modulation of airway surface liquid volume and composition. J Gen Physiol 2001;118:223-36. 7. Matsui H, Davis CW, Tarran R, Boucher RC. Osmotic water permeabilities of cultured, well diferentited normal and cystic fibrosisairway epithelia. J Clin Invest 2000; 105:1419-27. 15.Robinson M, Hemming AL, Regnis JA, et al. Effects of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis. Thorax 1997;52:900-3. 16.Kastelik JA, Aziz I, Morice AH. Sputum induction in young cystic fibrosis patients. Eur Respir J 2001;17:832 21. Zhang L, et al. Nebulized hypertonic saline solution for acute bronchiolitis in infants (Review) Copyright 2008 The Cochrane Collaboration. Published by JohnWiley & 22. Wainwright C. Acute viral bronchiolitis in children, a very common condition with few therapeutic options. Ped Resp Rev 2010;11: 39-45.