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  • Pathophysiology of Systemic Lupus Erythematosus

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    Chairunisa Anggraini
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    presentasi mengenai patofisiologi sle

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    presentasi mengenai patofisiologi sle

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    647 views14 pages

    Pathophysiology of Systemic Lupus Erythematosus

    Uploaded by

    Chairunisa Anggraini
    presentasi mengenai patofisiologi sle

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 14

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    DEFINITION OF LUPUS

    PREVALENCE
    System(s) affected: Hemic/Lymphatic/Immunologic, Nervous, Renal/Urologic, Endocrine/Metabolic, Skin/Exocrine, Gastrointestinal, Musculoskeletal Genetics: Markers: HLA-B8; HLA-DR2; HLA-DR3 Predominant age: All ages, but 30-50 are most common Predominant sex: Female > Male (10:1)

    WHAT IS CAUSES LUPUS?


    Cause is unknown. Posible factors :

    ENVIRONMENTAL TRIGGERS

    WHAT HAPPENS?
    Loss of self-non-self recognition Diversification of antigen-driven responses Hyperactivity of T & B Cells
    Formation of immune complexes Type III hypersensitivity reaction

    PATHOGENESIS

    TIPE III HYPERSENSITIVITY


    1. Heaping Antibody in tissue 2. Immune complex reaction 3. Activating complement reaction 4. Necrosis

    REFERENCES
    1.http://www.med.uio.no/rh/immi/research/co mplementgroup/pics/complement_fig.gif 2.http://www.lupus.org/smusermanager/Memb ersonly/support/Lupus.ppt 3. Kumar. Robins. Buku ajar Patologi. Jakarta. EGC.2007

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