CHRONIC

INFLAMMATION,
SYSTEMIC EFFECTS &
CONSEQUENCES
R. HUGO MARTÍNEZ LOZANO, M.D.

September 1st., 2006

 LEARNING OBJECTIVES:
KNOW & UNDERSTAND:
THE GENERAL FEATURES
CAUSES
MORPHOLOGY
CELLS
GRANULOMATOUS INFLAMMATION
-TYPES OF GRANULOMAS
SYSTEMIC EFFECTS
DEFECTS OR EXCESS (Consequences)
¡¡¡ CLINICAL SIGNIFICANCE !!!
Ref: pp. 78-85.
 GENERAL FEATURES
 DEFINITION:
-TIME.
-CHARACTERISTICS – ACTIVE
- T. DESTRUCTION
- REPAIR
-CLINICAL SIGNIFICANCE…
 CAUSES
 PERSISTENT INFECTION
 PROLONGED EXPOSURE
 AUTOIMMUNITY
Chlamydiae intracellular
inclusions. (Pap stained
smear).
 CAUSES
 PERSISTENT INFECTION
 PROLONGED EXPOSURE
 AUTOIMMUNITY
 CAUSES
 PERSISTENT INFECTION
 PROLONGED EXPOSURE
 AUTOIMMUNITY
LES
IDEM
CELLS
OTHER CELLS
GRANULOMATOUS
INFLAMMATION
IDEM
 TYPES OF GRANULOMA
FOREIGN BODY IMMUNE
TALC
 SYSTEMIC EFFECTS OF
INFLAMMATION
 FEVER: PYROGENS
- EXOGENOUS
 SYSTEMIC EFFECTS OF
INFLAMMATION

 FEVER: PYROGENS
- ENDOGENOUS
 SYSTEMIC EFFECTS OF
INFLAMMATION
 ACUTE-PHASE PROTEINS:
- CRP
- SAA
- FIBRINOGEN (ESR)
SYSTEMIC EFFECTS OF
INFLAMMATION
 DEFECTIVE INFLAMMATION
 DIABETIC
ULCER
 EXCESSIVE INFLAMMATION
BRONCHIAL ASTHMA
STATUS ASMATHICUS
QUESTIONS?