DRUGS FOR THE

TREATMENT OF AIDS

Dwi Indria Anggraini

Medical School Lampung University

Introduction
Viruses
structures
Main types of
viruses
Antiviral
Target
therapeutic

Virus multiplication and modes of action of

antiviral agents

Chemical structure of virustatic

antimetabolites

Activation of acyclovir and inhibition of viral

DNA synthesis

Inhibitor of DNA polymerase

(Foscarnet)

Prophylaxis for viral flu

RNA Retroviruses

Drugs for the Treatment of AIDS

(ARV)

I. Inhibitors of Reverse
Transcriptase

IA. Nucleoside agents

IB. Non-nucleoside inhibitors

II. HIV protease inhibitors

IA. Nucleoside agents

Analogues of thymine
(azidothymidine, stavudine),
adenine (didanosine), cytosine
(lamivudine, zalcitabine), and
guanine (carbovir, a metabolite
of abacavir).
Undergo triphosphorylation,
giving rise to nucleotides that
both inhibit reverse transcriptase
and cause strand breakage
following incorporation into viral
DNA.

IB. Non-nucleoside inhibitors

HIV protease inhibitors

Combination Regimens

For the dual purpose of

increasing the
effectiveness of antiviral
therapy and preventing the
development of a therapylimiting viral resistance,
inhibitors of reverse
transcriptase are combined
with each other and/or with
protease inhibitors.

Combination regimens are

designed in accordance
with substance specific
development of resistance
and pharmacokinetic
parameters (CNS
penetrability,
neuroprotection, dosing
frequency).

CONCLUSIONS
I. Inhibitors of Reverse
Transcriptase
II. HIV protease
inhibitors