Scribd Logo
Upload

Welcome to Scribd!

  • Drug Eruption

    Uploaded by

    oktarinadya
    27 views34 pages
    Drug eruptions can be caused by allergic reactions to systemic drugs taken through various routes of administration. There are four main types of immunologic drug reactions: type 1 (anaphylaxis), type 2 (cytotoxic), type 3 (immune complex), and type 4 (delayed hypersensitivity). Common skin manifestations of drug eruptions include urticaria, erythema, dermatitis, purpura, fixed drug eruptions, erythema nodosum, erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Diagnosis involves obtaining a drug history, examining acute or chronic skin lesions, and considering their distribution and appearance. Treatment involves stopping the

    Original Description:

    drug eruption

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Drug eruptions can be caused by allergic reactions to systemic drugs taken through various routes of administration. There are four main types of immunologic drug reactions: type 1 (anaphylaxis), type 2 (cytotoxic), type 3 (immune complex), and type 4 (delayed hypersensitivity). Common skin manifestations of drug eruptions include urticaria, erythema, dermatitis, purpura, fixed drug eruptions, erythema nodosum, erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Diagnosis involves obtaining a drug history, examining acute or chronic skin lesions, and considering their distribution and appearance. Treatment involves stopping the

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    27 views34 pages

    Drug Eruption

    Uploaded by

    oktarinadya
    Drug eruptions can be caused by allergic reactions to systemic drugs taken through various routes of administration. There are four main types of immunologic drug reactions: type 1 (anaphylaxis), type 2 (cytotoxic), type 3 (immune complex), and type 4 (delayed hypersensitivity). Common skin manifestations of drug eruptions include urticaria, erythema, dermatitis, purpura, fixed drug eruptions, erythema nodosum, erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Diagnosis involves obtaining a drug history, examining acute or chronic skin lesions, and considering their distribution and appearance. Treatment involves stopping the

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 34

    DRUG ERUPTION

    Definition
    Allergic

    drug reaction allergic reaction


    to systemic drug used that manifested on
    the skin & mucocutaneus

    Drugs

    route mouth, eye, nose, ear,


    rectum, vagina, injection/needle,
    mouthwash, topical drugs

    Drug

    substance used for diagnosis


    purpose, profilaction, and medication,
    including medicinal herbs

    Pathogenesis
    4

    type immunologic reaction of


    Coombs and Gell :

    type 1 (anaphylaxis reaction)


    type 2 (cytotoxic reaction)
    type 3 (immune complex)
    type 4 (delayed hypersensitivity)

    Type 1 (anaphylaxis reaction)

    Type 2 (cytotoxic reaction)

    Type 3 (immune complex)

    Type 4 (delayed hipersensitivity)

    Diagnosis
    Anamnesis
    Drugs

    consumption
    Acute or chronic of skin lesion
    Itch, burn, pain, fever

    Skin

    disorder

    Distribution

    : localized or generalized
    Varying manifestation of skin lesions

    Skin disorder figures


    Urticaria
    Erythem
    Dermatitis
    Purpura
    Fixed

    drug eruption
    Erythema nodosum
    Erythema multiforme
    Steven-Jhonson syndrome
    Lyell syndrome ( toxic epidermal necrolysis)

    Urticaria
    Skin

    reaction, characterized by pruritic red


    wheals
    Lesions vary in size, small point large
    area
    Individual lesion rarely last > 24 h
    Deep dermal & subcutaneus tissue
    angioedema mucous membrane life
    threatening

    Urticarial

    lesions along with pruritus and


    morbiliform (or macular & papular)
    eruptions >>

    Fixed drug eruption


    Characterized:
    Single

    or a few, sharply demarcated


    erythematous lesion
    Often: face & genitalia burning
    The lesions recurs in the same location

    Erythema multiforme
    Acute,

    self limited inflammatory disorder


    skin & mucous membranes
    Characterized:
    Distinctive

    iris / terget lesions


    Distributed acrally & over joint
    Sudden onset
    Association malaise & sore throat
    Serious SJS & TEN

    Stevens-Johnson syndrome (SJS)


    Episodic

    acute mucocutaneuos
    intolerance reactions drugs >>
    Macular rashes, atypical target lesions
    Involvement: the skin, > 1 mucosal site &
    eyes
    Constitutional symptoms & internal organ
    involvement occur severe
    Epidermolysis < 10 % body surface

    Skin:
    Erythema
    Vesicle

    / bullous
    Purpura
    Orificium
    Mouth

    mucous

    >> (100%)
    Nose (8%)
    Anorectum (4%)

    Eyes:
    Conjuctivitis
    Simblepharon
    Hemorrhagic
    Corneum

    ulcer

    Iritis
    Iridocyclitis

    Systemic

    sign

    Fever
    Fluid

    & electrolyte imbalance

    Toxic epidermal necrolysis


    Most

    cases of TEN are likely to develop


    from SJS
    The rash coalesence to widespread
    erythema, necrosis, and bullous
    detachment of the epidermis resembling
    scalding
    Epidermolysis > 30% body surface
    Death >>

    Epidermolisis 42.5%

    Treatment
    Ceased

    suspicious drug

    Topical:
    Wet

    dressing for madidans lesion


    Salicyl talk 2% for dry lesion
    Corticosteroid
    Systemic
    Corticosteroid
    Antihistamin

    Severe

    drug reaction (SJS or TEN)

    Intensive

    care unit or burn unit


    Rehidration
    Supportive medication

    You might also like