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Vitamines
Vitamines
combustion of food.
Vitamins
century.
as precursors of provitamins.
Group characteristics of
vitamins
Characteristics
Water soluble
Lipid soluble
Names
Vitamins A, D, E and K
Solubility
In Water
Storage
Absorption
Directly
Freely
Deficiency
Fat mal-absorption
syndrome
(Steatorhea)
Unlikely to occur
Likely to occur
Functions
Forms thiamine pyrophosphate (TPP), a combination of two
fat.
Deficiency
causes Beriberi, which literally means I cant I
Types of Beribri
Wet beriberi- acute form, leads to heart failure
Somali
Prevention
Any one of the following meets thiamine requirements
of a country: Avoid over milling (over processing) of the
staple cereal
Fortify staple cereal with Vitamin B1
Avail adequate amounts of alternative foods rich in
thiamine
RDA: The requirement is therefore
0.5mg/1000Kcal. The therapeutic dose is
0-6 months 0.3mg
between 3-8 g daily.
6-12 months 0.4mg
1-3 years 0.7mg
4-6 years 0.9mg
Females
11-50 years 1.1mg
51+ years 1.0mg
Pregnant 1.5mg
Lactating 1.6mg
7-10 years 1.0mg
Males
11-14 years 1.3mg
15-50 years 1.5mg
51+ years 1.2mg
Food Sources
The best dietary sources of thiamine are whole-grain cereals
and meat however; it is found in all of the following foods.
Plant Source: Whole-grain products, Rice bran, Brewer's yeast , Chickpeas,
Beans, Soybeans, Sunflower seeds, Wheat germ, Flour, rye and whole-wheat
Animal Source
Salmon steak
Pork
Beef kidney
Beef liver
Function
Acts as component in two co-enzymes (FAD and FAMN) needed for
Deficiency
Cracks and sores in corners of mouth (angular Stomatistis/ Cheilitis)
Inflammation of tongue and lips
Eyes too sensitive to light and easily tired
Itching, burning and reddening ( Drunkards eye)
Itching and scaling of skin around nose,
mouth, scrotum, forehead, ears, scalp
Trembling
Dizziness
Insomnia
Slow learning
Food sources
RDA
Intake of 0.6 mg/1000
Kilocalorie is sufficient.
Males
11-14 years 1.5mg
15-18 years 1.8mg
19-50 years 1.7mg
51+ years 1.4mg
Females
11-50 years 1.3mg
51+ years 1.2mg
Pregnant 1.6mg
Lactating 1st 6 months 1.8mg
2nd 6 months 1.7 mg
Deficiency (a disease of 4 Ds: Diarrhea, Dematitis, Dementia & Death)
Early Symptoms:
Muscle weakness
General fatigue
Loss of appetite
Skin lesions, including rashes, dry scaly skin, wrinkles,
coarse skin texture
Nausea and vomiting
Dermatitis (affecting the sun exposed areas)
Casals Necklace
Diarrhea
Late consequences of severe deficiency called pellagra:
Dementia
Death
A pellagra epidemic in Kuito,
Angola
Age - RDA
0-6 months 5mg
6-12 months 6mg
1-3 years 9mg
4-6 years 12mg
7-10 years 13mg
Males
11-14 years 17mg
15-18 years 20mg
19-50 years 19mg
51+ years 15mg
Females
11-50 years 15mg
51+ years 13mg
Pregnant 17mg
Lactating 20mg
Food Sources
Plant
Brewer's yeast
Peanuts
Sunflower seeds
Animal
Salmon
Pork
Chicken, white meat
Beef liver
Tuna
Turkey
Veal
Pyridoxine (Vitamin B6)
Vitamin B-6 is a family of water-soluble compounds that includes pyridoxine,
pyridoxal, and pyridoxamine.
Functions
It is particularly indispensable to the action of amino acid neurotransmitters, like
Pyrodoxine deficiency
Peripheral neuropathy (pins and needles in the palms and feels)
Weakness, Mental confusion , Irritability, Nervousness, Insomnia
Poor coordination walking, Hyperactivity, Abnormal
electroencephalogram
Muscle twitching
Patients with carpal tunnel syndrome are often deficient in Vitamin B-
Drug interaction
Isoniazid (INH) increases excresion of B-6
Tobacco decreases absorption. Smokers may require
Food sources
Tuna, beaf, chicken,
Folic Acid (Vitamin B9)
Folic Acid (Vitamin B9)
Vitamin B-9, more commonly known as folic acid, functions
together with a group of related water-soluble compounds,
collectively called folacin, in many body processes
FUNCTIONS
It is critical to cellular division because it is necessary in DNA synthesis.
Maintains the cells genetic code and transfer inherited traits from one cell to
another
Promotes normal red blood cell formation.
Regulates embryonic and foetal development of nerve cells.
Deficiency
Megalobastic anemia
Folic acid deficiency during pregnancy has been linked to several birth
defects (Neural tube defect)
Due to the overwhelming evidence of folacins impact on preventing neural
tube defects, WHO recommends supplementation of high risk women with
folate 1 month before and the first 3 months after the onset of pregnancy
Low Risk woman400 (0.4 mg) g
High-risk women should consume 4000 (4 mg) g of folic acid per day
At greatest risk for a folate deficiency are the elderly, women taking birth
control pills, long-term antibiotic patients, and alcoholics.
Methylated Product
DNA Cycle
(Cell Replication)
The
folate
Trap
Age RDA
0-6 months 25mcg
6-12 months 35mcg
1-3 years 50mcg
4-6 years 75mcg
7-10 years 100mcg
Males
11-14 years 150mcg
15+ years 200mcg
Females
11-14 years 150mcg
15+ years 180mcg
Pregnant 400mcg
Lactating 1st 6 months 280mcg
2nd 6 months 260mcg
Food Sources
Barley
Beans
Brewer's yeast
Calves' liver
Fruits
Garbanzo beans (chickpeas)
Green, leafy vegetables
Lentils
Peas
Rice
Soybeans
Split peas
Sprouts
Wheat
Wheat germ
Orange juice
Oranges
Cyanocobalamin (Vitamin B12)
Parietal cells secrete a special digestive hormone
factor.
Unlike other water-soluble vitamins, this vitamin is
FUNCTION
Acts as co-enzyme for normal DNA synthesis.
Prevents folate deficiency
Prevents Vitamin B-12 deficiency in vegan vegetarians and persons with
absorption diseases.
Plays an important role in homocysteine and energy metabolism, and
immune function.
Promotes red blood-cell development, and DNA synthesis of covering to
Deficiency
Deficiency is not common
Pernicious anemia (megaloblastic anaemia)
Impaired brain and nervous system function; demylination of
Risk factors for B12 deficiency
A Vitamin B-12 deficiency can result from:
An inadequate diet as in the case of vegans (absolute vegetarians)
Disease like infection with fish tapeworm called Diphyllobothyrium latum
Lack of intrinsic factor in the small intestine as in the case of surgical
Age RDA
Food Sources
In 1753, Brish Naval Physician, James Lind recognized scurvys direct link to diet
when he noted lemons, limes and fresh green produce contained a mysterious
scurvy-preventing substance.
Unbeknownst to Lind, humans are one of a very few species that cannot
manufacture vitamin C and must depend on food for this vital nutrient.
Functions
Helps to form collagen in connective tissue (Converts proline and lysine in
to their hydroxilated forms in the collagen synthesis pathway) and tissue repair.
Increases iron absorption from intestines (converts non hem iron in to
hem iron).
It is antioxidant
Deficiency
Scurvy: muscle weakness, swollen gums, loss of teeth, tiredness,
Age RDA
11-14 years 50mg
15+ years 60mg
Pregnant 70mg
Lactating 1st 6 months 95mg
2nd 6 months 90mg
0-6 months 30mg
6-12 months 35mg
1-3 years 40 mg
4-6 years 45mg
7-10 years 45mg
1-10 years 45mg
Food Sources:
Oranges
Papayas
Potatoes
Spinach
Strawberries
Sweet and hot peppers
Cabbage
Grapefruit
Collards
Vitamin A (retinol)
Beta-carotene is a pro-vitamin A, fat-soluble
compound found in plants,
Beta-carotene has the greatest pro-vitamin A activity
The body converts beta-carotene to Vitamin A.
from animals.
One RE = 1 mcg retinol = 6 mcg beta-carotene.
Function
Combines with purple
pigment of retina (opsin) form rhodopsin, which is
necessary for sight in partial darkness.
Necessary for growth of bone, testicular function,
ovarian function, embryonic development, regulation
of growth, differentiation of tissues
Forms Visual pigment :
mucous membranes
Functions
These forms include retinal, which is used in
Deficiency
WHO Classification of
Xerophthalmia
1N Night
blindness
2B Bitots spots
X3 Corneal
xerosis
X4 Corneal
ulcerations
-Keratomalaci
a
X5 Corneal
scars permanent
2B
X4
X3
X5
Bitots Spot
Keratomalacia
Age RDA
Age Retinol Equivalents International Units
0-6 months 375RE =2,100IU
6-12 months 375RE = 2,100IU
1-3 years 400RE = 2,000IU
4-6 years 500RE = 2,500IU
7-10 years 700RE = 3,300IU
Males
11+ years 1,000RE = 5,000IU
Females
11+ years 800RE = 4,000IU
Pregnant 800RE = 4,000IU
Lactating 1st 6 months +500RE = +2,500IU
2nd 6 months +500RE = + 2,500IU
Over dosage toxicity
Toxicity occurs if a person takes more than the mega
dose==10XRDA
Signs and symptoms
Bulging soft spot on head in babies (infants), sometimes
Food Sources
Plant sources: Vitamin A is generally found in deep
green leafy vegetables(GLV), yellow orange fruits in the form of Bcarotene[ Papaya, Mango, Asparagus , broccoli , Cantaloupe, Carrots, Kale,
fresh Apricots, Red palm oil, Mustard greens, Pumpkin, Spinach, Squash,
Orange fleshy Sweet potatoes, Watermelon)
Prevention of and control of Vitamin A deficiency
2.
potatoes
Vitamin D (1,25, Dihydroxychole
Calciferol)
The two most important are D-2 and D-3.
Vitamin D-2 (Ergocalciferol or its three forms) exists in fungi
and yeast and is the form generally added to milk, food, and
vitamin supplements.
Vitamin D-3 (Cholecalciferol) is found in fish oils, egg yolks, and milk.
The body produces Vitamin D-3 in the presence of ultraviolet
sunlight.
Many factors, including smoke, fog, clothes, and glass, can block
Skin is (7-dehyderocholestrol) + UV light=== >cholecalciferol, which is
vitamin
Functions
Regulates growth, hardening and repair of bone by controlling
Deficiency
Short term problems
Rickets (a childhood deficiency disease): malformations of joints or bones,
Long-term Problems
Chest deformity
Scoliosis
Genu valgum
Genu varum
Rachitic Deformities
Age RDA
0-6 months 7.5mcg
6-12 months 10mcg
1-10 years 10mcg
Males
11-18 years 10mcg
19-24 years 10mcg
25+ years 5mcg
Females
11-18 years 10mcg
19-24 years 10mcg
25+ years 5mcg
Pregnant 10mcg
Lactating 10mcg
Sources
Food
Butter
Cod-liver oil
Egg yolks
Salmon
Sardines
Vitamin D-fortified milk
UV light plus subcutaneous fat
Vitamin E (also called alpha-
tocopherol)
The term Vitamin E applies to a family of eight related
beta (), delta (), and gamma (), on the basis of the
chemical structure.
Alpha-tocopherol, commonly known as Vitamin E, is the
Function
As an antioxidant, it stabilizes membranes and
Involved in reproduction
Deficiency
Premature infants and children:
Hemolytic anemia
Adults
Apathy
Disinterest in physical activity
Decreased sexual performance/ Causes infertility
Age RDA
0-12 months 3-4mg
1-10 years 6-7mg
Males
11+ years 10mg
Females
11+ years 8mg
Pregnant 10mg
Lactating 1st 6 mos 12mg
2nd 6 mos 11mg
Note: Labels may be listed as mg or IU. 1 mg synthetic
= 1 IU. 1 mg natural = 1.3 IU.
Food Sources
All vegetable oils (Apricot oil, corn oil, cottonseed oil, peanut oil)
Wheat germ
Whole-wheat flour
Margarine
Almonds
Safflower nuts
Sunflower seeds
Walnuts
Vitamin K
forms.
One form, K1 or phylloquinone, is found in many plants and animals,
Functions
Promotes production of active prothrombin (factor II),
Deficiency
Infants:
Hemorrhagic disease of the newborn characterized by vomiting blood
and bleeding from intestine, umbilical cord, circumcision site. Symptoms
begin 2 or 3 days after birth.
Adults:
Abnormal blood clotting that can lead to nosebleeds, blood in urine,
stomach bleeding, bleeding from capillaries or skin causing spontaneous
black-and-blue marks.
Prolonged clotting time
Recommended Daily Allowance (RDA):
Adequate and safe range is 2-mcg/kg
body weights per day.
Age Estimated Safe Intake
0-6 months 5mcg
6-12 months 10mcg
1-3 years 15mcg
4-6 years 20mcg
7-10 years 30mcg
Females
11-14 years 45mcg
15-18 years 55mcg
19-24 years 60mcg
25+ years 65mcg
Pregnant 65mcg
Lactating 65mcg
Males
11-14 years
45mcg
15-18 years
65mcg
19-24 years
70mcg
25+ years 80mcg