Teratogens in fetal period

ACEI renal failure, oligohydramnion

tyreostatics (carbimazol, thiamazol, propylthiouracil)
benzodiazepins - dependency
barbiturtes - dependency
beta-blockers (atenolol)
NSA constriction of ductus
tetracyclins disturbances of bone mass, teeth
warfarin intracranial hemorhagies
aspirin - bleeding
Cytostatica
phenytoin, carbamazepine, valproate
- neura tube defects (spina bifida)
lithium cardiac malformations
warfarin - bone deformation, chondrodysplasy, CNS defects
heparin (demineralization of
bone in mother switch to LMW)
retinoids-def. CNS, heart, limbs, liver
danazol
oncologic drugs (fluorouracil, metotrexat, cyclofosfamid, busulfan,)