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Infective Endocarditis

Modifiable

Non-Modifiable
Age
Congenital heart disease
Gender
Preexisting heart conditions

IV drug use
Environment
Prosthetic valve surgery
(PVE)
Immunosuppressed

Damage/Inflammation to Endothelial lining


[referred to as nonbacterial
thrombotic endocarditis (NBTE)]

Platelet-firbrin thrombus

Bacteremia

Immune
system
activation

Bacterial
vegetation on
thrombus
Excretion of glycocalyx

Cytokine production

WBC

Fever/Chills

Bacterial
thrombus
development on
edges of heart
valves

Biofilm
Valvular dysfunction
/Regurgitation

30-40% of pts
develop CHF

Decreased
peripheral
perfusion

Cardiac valve
insufficiency

Heart murmurs

Increased O2 demand
Hypertension

Embolization of vegetation
Septic emboli lodges
into different parts of
the body
Non-immunologic
response

Antigen-Antibody
complex

Pulmonar
y Artery

Brain

Under
fingernail
s

Fingers,
toes,
noes,
earlobes

Pulmonary
Embolism

Stroke

Splinter
hemorrhages

Janewa
y
lesions

Hands, feet

Eyes

Kidneys

Oslers Nodes

Roth
spots

Glomurulonephritis

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