Given the data in Table below, calculate elimination rate and excretion

rate after an IV Bolus dose of 400 mg. Find the equation of the
excretion profile. Assume a linear one compartment model.
Jumlah
Interval
duration Volume of Konsetrasi obat yang
Rate of
waktu
Midpoint
of interval
Urine
bat dalam di ekskresi
excretion,
sampel
time, t*
(jam)
Excreted, urine, Cu
dalam
dDu/dt
urine
(hr)
dt
Vu (ml)
(g/ml)
urine, Du
(mg/jam)
(jam)
(mg)
0-1

91

805

73,255

0,5

73,26

1-2

99

539

53,361

1,5

53,36

2-4

206

324

66,744

33,37

4-6

194

181

35,114

17,56

6-9

no sample

9-12

577

16

9,232

10,5

3,08

12-24

12

1127

5,635

18

0,47

7,5

0-1
1-2
2-4
4-6
6-9
9-12
12-24

0,5
1,5
3
5
7,5
10,5
18

73,26
53,36
33,37
17,56

Ke.DB0= 84
mg/jam

Ke.400 mg= 84
mg/jam
Ke = 84 mg/jam / 400
mg
Ke = 0,21 jam-1

0
30,
0
20,
0

t1/2 =(7,25 4,75)

jam
t1/2 = 2,5 jam

Laju ekskresi dDu/dt

(mg/jam)

Given the data in Table

below,
calculate
elimination
rate
and
excretion rate after an IV
Bolus dose of 400 mg.
Find the equation of the
excretion
profile.
Assume a linear one
compartment model.
Rate of
Time Midpoint
excretion,
Interval time, t*
dDu/dt
(hr)
(hr)
(mg/jam)

10,
90,
0
80,
0
70,
0
0
60,
0
50,
0
40,

K = 0,693/t1/2
K = 0,693/2,5
jam-1
K = 0,277 jam-1

10,
9,0
0
8,0
7,0
6,0
5,0
4,0

3,0

2,0

1,0
0,9
0,8
0,7
0,6

0,5
0,4
0,3

3,08
0,47

0,2

0,1
0

4,75

7,2
7

10

11

12

13

14

t
(jam)

15

16

17

f(x) = NaN exp( NaN x )

f(x) = NaN exp( NaN x )

12

10

10
8
Laju ekskresi urin, dDu/dt (mg/jam)

Laju ekskresi urin, dDu/dt (mg/jam)

4
2
0

1
0

10 20

Waktu, t (jam)

Plot
linier

Ke.DB0= 79,14
mg/jam

0 10 20
Waktu, t (jam)

Plot
semilogaritmik

Ke.400 mg= 79,14

mg/jam
Ke = 79,14 mg/jam / 400
mg
Ke = 0,198 jam-1

Given the data in Table below, calculate elimination rate and excretion
rate after an IV Bolus dose of 400 mg. Find the equation of the
excretion profile. Assume a linear one compartment model.

Time
Interval
(hr)

Amount of
Rate of
duration of
drug
Midpoint excretion,
interval Volume of Concentrat excreted in
time, t* (hr) dDu/dt
(hr)
urin, Du
Urine
ion in
(mg/jam)
(mg)
Excreted
Urine
(ml)
(g/ml)

0-1

65

480

31,20

0,5

31,20

1-2

64

390

24,96

1,5

24,96

2-4

121

315

38,12

19,06

4-6

130

205

26,65

13,33

6-9

no sample

9 - 12

175

75

13,13

10,5

4,38

12 - 24

12

750

25

18,75

18

1,56

7,5