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  • Lecture 1

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    Bariston Gkitz
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    This document provides an overview of basic embryology, covering topics such as fertilization and implantation, fetal landmarks, embryologic derivatives, teratogens, and important genes of embryogenesis. Key information includes that fertilization occurs at day 0, implantation at day 6, and organogenesis from weeks 3-8, when the embryo is most susceptible to teratogens. The major embryologic derivatives are from the surface ectoderm, neural crest, neuroectoderm, endoderm and mesoderm. Examples of important genes involved in embryogenesis include the sonic hedgehog, Wnt-7 and FGF genes which regulate limb development.

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    Basic embryology

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    This document provides an overview of basic embryology, covering topics such as fertilization and implantation, fetal landmarks, embryologic derivatives, teratogens, and important genes of embryogenesis. Key information includes that fertilization occurs at day 0, implantation at day 6, and organogenesis from weeks 3-8, when the embryo is most susceptible to teratogens. The major embryologic derivatives are from the surface ectoderm, neural crest, neuroectoderm, endoderm and mesoderm. Examples of important genes involved in embryogenesis include the sonic hedgehog, Wnt-7 and FGF genes which regulate limb development.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    4 views16 pages

    Lecture 1

    Uploaded by

    Bariston Gkitz
    This document provides an overview of basic embryology, covering topics such as fertilization and implantation, fetal landmarks, embryologic derivatives, teratogens, and important genes of embryogenesis. Key information includes that fertilization occurs at day 0, implantation at day 6, and organogenesis from weeks 3-8, when the embryo is most susceptible to teratogens. The major embryologic derivatives are from the surface ectoderm, neural crest, neuroectoderm, endoderm and mesoderm. Examples of important genes involved in embryogenesis include the sonic hedgehog, Wnt-7 and FGF genes which regulate limb development.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 16

    LECTURE 1

    Basic Embryology

    BASIC MEDICAL SCIECNE

    Topics

    Fertilization and implantation


    Fetal landmarks
    Embryologic derivatives
    Teratogen
    Important genes of embryogenesis

    Fertilization and
    Implantation

    Fetal Landmarks
    Day 0 = Fertilization
    Day 6 = Implantation hCG
    secretion
    Within week 2 Bilaminar disk
    Within week 3 Gastrulation,
    Primitive streak, notochord, and neur
    al plate formation
    Week 3-8 (Embryonic period)
    Neural tube, organogenesis, suscepti
    ble to teratogens

    Note

    Embryologic Derivatives
    Surface ectoderm

    Adenohypophysis Craniopharyngioma
    Lens of eye
    Epithelial lining oral cavity
    Sensory organs of ear
    Retina
    Olfactory epithelium
    Epidermis
    Gland

    Neural crest
    ANS + CN +
    Ganglion
    Melanocyte
    Chromaffin cells
    Parafollicular cells
    Schwann cells
    Pia and arachnoid
    Skull
    Odonblasts
    Aorticopulmonary
    septum

    Neuroectoderm
    CNS
    Retina

    Endoderm

    Gut tube epithelium

    Mesoderm

    Abnormality

    VACTERL

    Muscle Bone - CNT


    Vertebral
    Serous lining body cavities
    defect
    Spleen
    Anal atresia
    Cardiovascular structures Cardiac
    Lymphatics
    defect
    TE fistula
    Blood
    Renal defect
    Urogenital structures
    Limb defect
    Adrenal cortex

    Teratogen

    Vitamin A Alter HOX


    gene expression Synpol
    ydactyly
    Homeobox (HOX) gene
    codes for TF Segmental o
    rganization

    Note

    Important Genes for


    Embryogenesis
    Sonic hedgehog gene: produced at
    base of limbs in the zone of polarizin
    g activity Organization along anter
    ior-posterior axis
    Wnt-7 gene: produced at apical
    ectodermal ridge Organization alo
    ng dorsal-ventral axis
    FGF gene: produced at apical
    ectodermal ridge Limb lengthenin
    g

    Note

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