ECTOPIA LENTIS

1. Acquired
2. Isolated familial ectopia lentis
3. Associated with systemic syndromes
Marfan syndrome
Weill-Marchesani syndrome
Homocystinuria
4. Treatment options
 Acquired ectopia lentis
Trauma Stretched zonules

Buphthalmos
Megalocornea
Anterior uveal tumours Degenerate eye
 Isolated familial ectopia lentis
Autosomal recessive

Pupil may be normal Pupil may be displaced in opposite

direction (ectopia lentis et pupillae)
 Autosomal dominant
Systemic features of Marfan syndrome

Limb-trunk disproportion Arachnodactyly

Pectus excavatum Aortic dilatation, dissection

and regurgitation
High-arched palate Mitral valve prolapse
 Ocular features of Marfan syndrome
Lens Retinal detachment

Upward subluxation Lattice degeneration Axial myopia

Zonule usually intact

Angle anomaly and Cornea plana Blue sclera

glaucoma
 Autosomal recessive
Weill-Marchesani syndrome
Systemic features Ocular features

Short stature Microspherophakia

Usually anterior lens subluxation
Short stubby fingers (brachydactyly)
Mental handicap Angle anomaly and glaucoma
 Homocystinuria
Autosomal recessive
Defect in cystathio beta-synthase
Systemic features Ocular features

Malar flush and fine, fair hair Downward lens subluxation

Marfanoid habaitus Disintegration of zonule
Increased platelet stickiness
Mental handicap
 Treatment Options for Ectopia Lentis
1. Spectacle correction
For induced astigmatism
For aphakic portion

2. Nd:YAG laser zonulysis to displace lens out of visual axis

3. Surgical removal
Associated cataract
Lens-induced glaucoma
Endothelial touch
When other methods are inappropriate