KAWASAKI

DISEASE
DEFINITION ICD 10
M30.3
acute
self limited
multisystemic vasculitis
unknown origin (idiopathic)
mucutaneous lymph syndrome
EPIDEMIOLOGY
6 months - 5 y.o
: = 1.5:1
recurrence <2%
rare in siblings
person to person transmission is not
documented
mostly in winter & spring
RISK FACTOR
no treatment with IVIG
male gender < 1 y.o
long duration of fever (>10 days)
haemoglobin < 10 mg/dL
platelet count
albumin level
CLINICAL PRESENTATION
STRAWBERRY
TONGUE &
RASH
CLINICAL PRESENTATION
DIAGNOSIS
INCOMPLETE
KAWASAKI
DISEASE
DDx
Measles
Scarlet fever
Drug reactions
Steven-Johnson Syndrome
Other viral exanthema
Rocky Mountain spotted fever
Toxic shock syndrome
Bacterial cervical lymphadenitis
Juvenile rheumatoid artheitis
Leptospirosis
Imaging Studies
Echocardiography subclinical
pericardial effusion

USG abdominal gallbladder hydrops

 TREATMENTS
1. Non-pharmacologic therapy
2. Pharmacological
 Non-pharmacologic Therapy

Coronary Bypass Graft for Coronary Angioplasty

reversible ischemia caused not effective for
by coronary artery stenotic lesions
stenosis, if : effective for stent
the myocardium is viable placement
no distal stenoses are
present
Cornoary Angioplasty
 IVIG
2 g/kgBB over 12 hours

Metylprednisolone IV
if resistant to IVIG

Aspirin
80-100 mg / kgBB / day p.o.
Chronic treatment
Aspirin Echocardiogram Clopidogrel

3-5 mg/kgBB for at 2 - 8 weeks after KD if stable small

least 8 weeks for cardio evaluation aneurysm are seen
if no abnormalities
aspirin stop

Heparin followed tPA Varicella &

by warfarin Influenza Vaccine

for anticoagulation, for acute to patient taking aspirin

if giant aneurysm (>8 coronary for long term
mm) are seen occlusion
 Patient's Family
Education
basic cardiopulmonary
resuscitation
if syncope or acute exercise
intolerance develops
cardiologist
cardiac-healhty lifestyle
Thanks!
ANY QUESTIONS?