Pathophysiology

Disruption of skin barrier

Filaggrin mutation

captured by Langerhans cells

antigen exposure in
individuals with
atopic tendency Presenting to peripheral
lymph node
differentiation of naive T
cell
Cooperate with MHC II
Th 1 : IFN-, TNF, IL-2, IL-17
Th 2: IL-4, IL-5, IL-13

T cell mediated, delayed type

hypersensitivity
Disruption of skin
barrier
Filaggrin mutation

Captured by IgE on the

surface of mast cell
antigen exposure in
individuals with
atopic tendency
Cross-linking
between IgE and
FceR
Degranulation of mast cell
releasing histamine and
others chemotactic factors

IgE mediated, immediate

hypersensitivity reactions