Professional Documents
Culture Documents
INTRODUCTION
Adhesion is binding of cells to surfaces such as ECM of another
cell
Important in maintaining multicellular structure
for instance, the lining of the small intestine, and sheets of
hepatocytes two cells thick make up much of the liver
Occur due to the action of Cell Adhesion Molecules(CAMs)
mediate homophilic (like-binds-like) adhesion between cells of a
single type and heterophilic adhesion between cells of different
types
Most CAMs are uniformly distributed along the regions of
plasma membranes
a) hydrostatic interactions
b) electrostatic interactions
i) Cadherins
iii) Integrins
iv) Selectins
v) Mucins
2 type adhesions based on Ca2+ ions
a) Ca Dependent ( i & iv )
1) Cell sorting
2) Contact inhibition
4) Cellular migration
1) Classical ( CDH1 )
2) Desmosomal ( DSG1 )
3) Protocadherins ( PCD H1 )
4) Ungrouped ( CDH9 )
Major Cadherin Molecules on Mammalian Cells
E-cadherin Preimplantation
embryos, non-neural
epithelial tissue
P-cadherin Trophoblast
Homophilic interaction
Eg:-
3) CD2
4) CD48 etc
Integrins
Cell- ECM adhesion
3) Immune patroling
3) Cell migration
4) Cell growth
5) Cell division
6) Cell survival
7) Apoptosis
8) Cell differentiation
9) Forms hemidesmosomes
Eg:-
1) VLA 1
1) E-selectin(inendothelialcells)
2) L-selectin(inleukocytes)
functions include
2) inhibitory role
component ofsaliva
Structure
Mature mucins are composed of two distinct regions:
acidsareserineorthreonine.