Professional Documents
Culture Documents
Inf Dis
Inf Dis
Diseases
Dr. Wael H. Mansy, MD
Edited by; Willy Chou
Assistant Professor
College of Pharmacy
King Saud University
2009
Infectious Diseases
Study Objectives: to know
1. What is an infectious disease??
2. What is an infection??
3. Causes of re-emerging of the problem of the infectious diseases
4. Microbiological Classification of Infectious Diseases.
5. Means of Transmission of Infectious Diseases.
6. The action of pathogen in infectious process (pathogenicity)
7. What is infectivity ,virulence, Immunogenicity and incubation period .
8. Manifestations of infectious process (Infection spectrum).
9. The immune reaction of host in infectious process.
10. Common symptoms and signs.
Infectious Diseases
What is an infectious diseases??
Definition of infection
Complex process of interaction between pathogen
and human body
Infection is composed of three factors: pathogen,
host and environment
There are commensalisms and opportunistic
infection
Infectious Diseases
Causes of re-emerging of the problem of the infectious diseases:
1. Loss of Antibiotic Effectiveness.
Bacterial Gram-negative
Gram-positive
Viral DNA virus
RNA virus
Enveloped vs non-enveloped
Fungal Disseminated
Localized
Parasitic Protozoa
Helminths
Means of Transmission of Infectious
Diseases
Contact Requires direct or indirect contact (fomite,
blood, or body fluid)
Food or Ingestion of contaminated food or water
Water
Airborne Inhalation of contaminated air
Agent Environment
Infectivity Weather
Pathogenicity Housing
Virulence Geography
Immunogenicity Occupational setting
Antigenic stability Air quality
Survival Food
Age
Host Sex
Genotype
Behaviour
Nutritional status
Health status
Infectious Diseases
Factors Influencing Disease Transmission( Agent)
Pathogenicity
What does pathogenicity mean???
It means the ability of a microbiological agent to
induce disease
The pathogenicity of pathogen is related to :
1. Invasiveness
2. virulent
3. Number of pathogen
4. Mutation (variability)
Infectious Diseases
Factors Influencing Disease Transmission( Agent)
Infectivity:
Ability of agent to cause infection
Number of infectious particles required
In person-to-person transmission, secondary attack rate is
a measure of infectivity
Virulence :
Severity of the disease after infection occurs.
Measured by case fatality rate or proportion of clinical cases that
Immunogenicity
Ability of an organism to produce an immune response that
agent
Humoral
Immunity
Barrier Action
Immunoglobulin:
IgG, IgM, IgE, IgA, IgD
Ext. barriers:
Int. barriers: Cell mediated
skin , mucosa &
Placenta or BBB immunity
their Secretion
Phagocytosis
Humoral Action
Complement, Lysozyme,
Fibronectin, Cytokines
Infectious Diseases
Barriers for Defense Against Infection:
1. Skin:
Prevents entry of infectious organisms, unless injured.
Severe burn patients who die are usually killed by infections. So much skin is
damaged they are very vulnerable to infections.
2. Mucus membrane:
Mucous is usually rich in enzymes that will kill many pathogens
3. Cilia:
These are hair-like structures lining the respiratory tract. They work to sweep
foreign particles out of the respiratory tract.
Damaged by smoking, leaving smokers more vulnerable to infections.
4. Coughing:
Helps remove foreign material from respiratory tract.
5. Personal Hygiene
Helps reduce the number of pathogenic organisms on the skin and other
surfaces of the body.
Infectious Diseases
Infection and Immunity
Manifestations of infectious process (Infection spectrum):
1) Clearance of pathogen (no infection)
2) Covert infection (subclinical infection)
3) Overt infection (Clinical infection or apparent infection)
4) Carrier states
Health carrier after covert infection.
Convalescent carrier after overt infection.
Incubatory carrier before onset of disease.
According to carrier time : #acute (transient) carrier
#chronic carrier
5) Latent infection.
Infectious Diseases
Pathogenetic Mechanisms:
Direct tissue invasion: like smallpox
Immune suppression
Infectious Diseases
Transmission
Cases
Index the first case identified
Primary the case that brings the infection into a population
Secondary infected by a primary case
Tertiary infected by a secondary case
T
S
Susceptible P
S
Immune
S
T
Sub-clinical
Clinical
Infectious Diseases
Incubation
periodexposure and onset of symptoms or signs of
Time between
infection.
Tuberculosis
Scarlet Fever
tetanus
Gonorrhea
Diptheria
Streptococcal Infections
Pneumonia (can also be viral or fungal)
Pertussis
Bubonic Plague
There are many others.
Viral Diseases
*Common Cold
*Influenza
*AIDS/HIV
*Herpes (Simplex and Zoster)
*Hepatitis A,B,C, D, E, F and G.
*Measles, Mumps and Rubella.
*Poliomyelitis.
*Infectious mononucleosis.
Fungi
*Organisms, but without chlorophyll