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H.bonded arrangement
of backbone of the
Spatial arrangement of protein is possible due to
the atoms in the free rotation of bonds
polypeptide chain between:
-C and -N (phi )
-C and carboxyl
Formed and stabilized by carbon (psi )
hydrogen bond between
the amide proton and
carbonyl oxygen
SECONDARY STRUCTURE
Kinds of Secondary Structure
-Helix
-Pleated sheet
-bends or reverse bends
Random coil
Other helical structures
SECONDARY STRUCTURE: -Helix
Spiral structure
Stabilized by intramolecular
hydrogen bonds
Structural features:
C=O of each peptide bond is
hydrogen bonded to the N-H of the
fourth amino acid away; there are
3.6 aa/turn
Pitch: 5.4
H-bonds are parallel to helical axis
All R groups point outward from
helix
Coil of the helix either right-handed
(clockwise) or left-handed (counter-
clockwise)
SECONDARY STRUCTURE: -Helix