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Mutation:
any permanent heritable change in
sequence of genomic DNA
Mutation rate ( )
expressed as the n of mutation per locus
per gamete per generation
Type of mutations
Where occur:
* Germinal mutation
* Somatic mutation
How occur:
* Spontaneous mutation
* Induced mutation
Size of Material
Point mutation
* not visible under a microscope
* mechanism: - base substitution
- frame shift
Broad mutation
* microscopically visible aberration
* mechanism: deletion, insertion, etc
Germinal Mutation
Occurs in a cell that is
destined to become an egg or
sperm
Transmitted to future
generations
Somatic Mutation
Occurs in a body cell ( liver, bone
etc) not ancestral to gametes.