CHEMICAL BIOLOGY

SEMESTER III and VII

2017-18

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 CHEMICAL BIOLOGY SCHEDULE, 2017-18

8:30 am 9:30 am 10:30 am 11:30 am Recess 1:30 pm 2:30 pm 3:30 pm 4:30 pm

UG-CS-3
MONDAY
CWRS-G4

UG-CS-3
TUESDAY
MB-1-31

UG-ME-7 UG-CS-3
WEDNESDAY
CWRS-T2 MB-1-2

UG-ME-7 UG-ME-7
THURSDAY CWRS-T2 CWRS-T2

FRIDAY

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 Course Content
CHEMICAL BIOLOGY 3-0-0-3

Unit 1: Introduction significance of biology in modern technology. (2 Lectures)

Unit 2: Biochemical evolution and cell - Molecular evolution of Life. Biochemical evolut
ion and the first cell. (4 Lectures)
Unit 3: Cell Structure and types. Different organelles and function. Cell division. DNA r
eplication and protein synthesis in cells. Cellular respiration. (8 Lectures)
Unit 4: Biomolecules and their importance carbohydrates, proteins, lipids, nucleic ac
ids, vitamins and hormones (14 Lectures)
Unit 5: Applications of Biology in 21st century: Recombinant DNA Technology and clo
ning. Concepts of Gene, Gene transfer and Gene therapy. Stem cell technology. DNA f
ingerprinting: application in Forensic Science (crime investigation & parental testing). E
nergy sources from biological system. Biomanufacturing biosensors and sophisticate
d surgical instruments. (14 Lectures)

Text Books:
Singh, B. D. Biotechnology, 1st Edition, 2005.
Bernum, S. R. Biotechnology: An Introduction, Wadsworth Pub. Co.
Lewin, B. Genes VII, 7th Ed. Oxford University Press. 3
What is chemical biology?

The application of synthetic chemical techniques

and tools to the study and manipulation of biologi
cal systems

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Why does it matter?

Drugs:
Modern Medicinal Chemistry (inhibitor design) is essentially chemical biology

Different Drugs
Antibody Therapeutics
Interference RNAs

Probes and Diagnostics

Tumor cell labeling
Enzymes and Metabolic tracking

21st century Medicine

Proteomics and Glycobiology

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How engineer play important role?

Have you heard the name of BIOSENOR

?
Definition: A sensor that integrates a biological element with a physioch
emical transducer to produce an electronic signal proportional to a sin
gle analyte which is then conveyed to a detector.

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The biosensor system

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Example of biosensors
Monitors the glucose level in the blood :for diabetes patients.

which uses the enzyme glucose oxidase to break blood glucose

1962 First description of a biosensor: an amperometric enzyme
electrodre for glucose (Clark)
1998 Blood glucose biosensor launch by LifeScan FastTake

down

Amperometric New Machine

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Example of biosensors
Infectous disease biosensor from RBS

Tuberculosis (TB) infection, a highly contagious disease spread through the air wh
en those who are infected cough, sneeze or spit.
8.8 million active cases of tuberculosis (TB) are diagnosed each year 25,000 ev
ery day.
Whilst developing new and better medicines are vital to combating the TB epidemi
c, effective diagnosis enables health workers to quickly identify the correct course
of treatment and so avoid wasting both time and valuable resources

TB Breathalyser: 9
Magnetic Resonance Imaging (MRI)

What is MRI?

Magnetic resonance imaging (MRI) is a spectroscopic imagin

g technique used in medical settings to produce images of t
he inside of the human body.

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How Does it Work?
MRI is based on the principles of nuclear magnetic resonance (NMR),
which is a spectroscopic technique used to obtain microscopic chemi
cal and physical data about molecules.

Magnetic nuclei are abundant in the human body (H, C, Na,P ,K) and spin randoml
y

Since most of the body is H2O, the Hydrogen nucleus is especially prevalent
patient is placed in a static magnetic field
Magnetized protons (spinning H nuclei) in the patient align in this field like compa
ss needles

In 1977 the first MRI exam was performed on a human being. It took 5
hours to produce one image.

At present : 30 minutes - 2 hours

depending on the type of study being done 11
Other Applications:

1. Vaccines
2. Pacemaker for heart
3. Sorting of blood for preservation in Blood banks.
4. Development of surgical instruments
5. Brain imaging studies
6. Developing programs for genome study.

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