ANTIHYPERTENSIVE AGENT

CENTRALLY ACTING SYMPATHOPLE-

GIC DRUGS
-BLOCKERS
THIAZIDE DIURETICS
VASODILATORS
ADRENERGIC NEURONE-BLOCKING
AGENTS
GANGLION BLOCKING AGENT
 CENTRALLY ACTING
SYMPATHOPLEGIC DRUGS

METHYLDOPA
CLONIDINE
GUANABENZ
GUANFACINE
These drugs are agonist of alpha 2 adrenoceptor post synaptic
in the CNS (medulla) decrease sympathetic tone
decrease blood pressure.
 -BLOCKERS

PROPRANOLOL
NADOLOL
PINDOLOL
ATENOLOL
BISOPROLOL
METOPROLOL
LABETALOL
 THIAZIDE DIURETICS
HYDROCHLOROTHIAZIDE
CHLOROTHIAZIDE
BENDROFLUAZIDE
CHORTHALIDONE
INDAPAMIDE
 VASODILATORS
ACE INHIBITOR & ARB
CALCIUM ANTAGONIST
1BLOCKERS
K+CHANNEL ACTIVATOR
NO (NITRIC OXIDE)
HYDRALAZINE (UNKNOWN MECHA-
NISM)
 ANGIOTENSIN RECEPTOR BLOCKING
AGENT
(Angiotensin II ( AT1 ) Receptor Blocker)
-LOSARTAN
-VALSARTAN
-TELMISARTAN
-IRBESARTAN
-CANDESARTAN
-EPROSARTAN
 ADRENERGIC NEURON-
BLOCKING AGENTS

GUANETHIDINE
RESERPINE
These drugs lower blood pressure by preventing normal
physiologic release of norepinephrine from post ganglionic
sympathetic neurones.
GANGLIONIC BLOCKING AGENTS

They competitively block nicotinic choinoceptors on postgangli

onic neurons in both sympathetic and parasympathetic ganglia.

ADR: *Sympathoplegia ;orthostatic hypotension ,sexual dys-

function.

*Parasympathoplegia ; constipation,dry mouth,laucoma.

Example: MECAMYLAMINE
DARI MEDICAL PHARMACOLOGY AT A GLANCE ; NEAL M.J. 1995