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  • Immune Response Immune Tolerance Allergy

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    Aka
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    This document summarizes key aspects of the immune response. It discusses pathogen associated molecular patterns that trigger toll-like receptors and initiate innate and adaptive immune responses involving inflammation. The innate response involves epithelial cells, neutrophils, and macrophages. The adaptive response involves T cells and B cells. T cells are activated by antigen presenting cells via MHC molecules and require costimulation. Activated T cells and B cells carry out effector functions, and B cells can differentiate into plasma cells or memory cells. The document also mentions immune tolerance, allergies, and features of immediate and late phase allergic responses.

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    respon immun

    Original Title

    3 Immune Response YT

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    This document summarizes key aspects of the immune response. It discusses pathogen associated molecular patterns that trigger toll-like receptors and initiate innate and adaptive immune responses involving inflammation. The innate response involves epithelial cells, neutrophils, and macrophages. The adaptive response involves T cells and B cells. T cells are activated by antigen presenting cells via MHC molecules and require costimulation. Activated T cells and B cells carry out effector functions, and B cells can differentiate into plasma cells or memory cells. The document also mentions immune tolerance, allergies, and features of immediate and late phase allergic responses.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
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    4 views35 pages

    Immune Response Immune Tolerance Allergy

    Uploaded by

    Aka
    This document summarizes key aspects of the immune response. It discusses pathogen associated molecular patterns that trigger toll-like receptors and initiate innate and adaptive immune responses involving inflammation. The innate response involves epithelial cells, neutrophils, and macrophages. The adaptive response involves T cells and B cells. T cells are activated by antigen presenting cells via MHC molecules and require costimulation. Activated T cells and B cells carry out effector functions, and B cells can differentiate into plasma cells or memory cells. The document also mentions immune tolerance, allergies, and features of immediate and late phase allergic responses.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 35

    Immune Response

    Immune Tolerance
    Allergy
    PAMP: Pathogen associated molecular
    patterns (Receptors-Ligands)
    TLR
    Immune Response: Inflammation
    Innate + Adaptive
    Immune Response: Inflammation (1)
    Immune Response: Inflammation (2)
    Innate Immune respons: Epithelia
    Innate immune response: PMN
    Recruitment and Phagocytosis
    Innate immune response: Macrophage
    Innate immune response: Macrophage
    Combination between Macrophage and Lymphocyte
    NK Cells
    DIRECT
    INDIRECT
    NK Cells response
    to IL-12.

    NK Cells secrete IFN


    Enhanced T-cells
    response by IFN-
    Adaptive response : Lymphocyte
    T-Cells activated by APC
    T-Cells activated by APC
    Costimulation
    of T-cells
    in MHC-I
    (CD8+)
    and
    MHC-II
    (CD4+)
    CTL (CD8+)-mediated lysis of
    target cells
    B-Cells
    B-cells: Plasma and memory
    B-cells switching mediated by:
    CD40, MHC-II and Cytokines
    Lymphocyte classes
    Sensitive tissue: Mucosal epithelium

    Large number of
    APC:
    Peyers patch
    Epitel
    Lamina Propria

    M-Cell
    (Membranous
    Cells)
    Delivering
    antigen to
    peyers patch
    Immune tolerance
    Central and Peripheral Tolerance
    T-Cells Anergy
    B-Cells Tolerance
    Summary: B-Cells and T-Cells
    tolerance
    ALLERGY
    Immediate and late phase
    hypersensitivity

    Immediate: Vasodilatation, Congestion, edema


    Late: Infiltration of immune cells (eosinophile, T-cells, PMN)
    Mast cells activation
    Bronchial Asma

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