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  • Post Translational Modification

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    CynCyntya Harlyana
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    The document summarizes key steps in post-translational modification: 1) After translation, proteins undergo folding and proteolytic cleavage to achieve their functional shape. 2) Amino acids in the protein are modified through processes like phosphorylation, glycosylation, and acetylation. 3) Multiple modified protein subunits may then aggregate together to form multi-subunit protein complexes.

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    modifikasi post translasi

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    The document summarizes key steps in post-translational modification: 1) After translation, proteins undergo folding and proteolytic cleavage to achieve their functional shape. 2) Amino acids in the protein are modified through processes like phosphorylation, glycosylation, and acetylation. 3) Multiple modified protein subunits may then aggregate together to form multi-subunit protein complexes.

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    9 views11 pages

    Post Translational Modification

    Uploaded by

    CynCyntya Harlyana
    The document summarizes key steps in post-translational modification: 1) After translation, proteins undergo folding and proteolytic cleavage to achieve their functional shape. 2) Amino acids in the protein are modified through processes like phosphorylation, glycosylation, and acetylation. 3) Multiple modified protein subunits may then aggregate together to form multi-subunit protein complexes.

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    © All Rights Reserved
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    POST TRANSLATIONAL CYNTYA HARLYANA

    MODIFICATION
    Process of post-translational modification

    Translated
    mRNA Protein
    Cytosol Ribosome

    P
    Endoplasmic P
    reticulum
    (ER) Protein folding
    & PTMs
    Removal of CH3 CH3
    certain N- and
    Cleaved protein
    C-terminal Protease
    residues Glc
    Glc

    Source: Modified from Biochemistry by A.L.Lehninger, 6th edition (ebook)


    POST TASLATIONAL PROCESS

    Protein folding

    Proteolytic clavage

    Modification of aminoacid

    Subunit agrregation
    PROTEIN FOLDING
    PROTEOLYTIC CLAVAGE
    MODIFIKASI ASAM AMINO

    Phosphorylation Glikosilasi Carboxylation Hydroxylation

    Acetylation Methylation ADP


    Ribosylation
    SUBUNIT AGGREGATION

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