IRWAN, S.

Si
G2L117010

Program Pasca Sarjana

Program Studi Kimia
Universitas Halu Oleo
2017
INTRODUCTION
PINEAL GLAND – ITS LOCATION

Pineal gland is a small organ, shaped

like a Pine cone.

is located at the midline of the

brain at the roof

Pineal body is present in human as

well as in animals

It secretes a hormone – the

Melatonin that informs the body
parts about environmental light
DEFINITION OF MELATONIN (Mell)

Melatonin has the molecular formula (C13H16N2O2), and it is has many chemical names such as
(N-Acetyl-5-methoxytryptamine, 73-31-4 Ciradian, 5-methoxy-n-acetyltryptamine) and the
IUPAC name melatonin is (N-[2-(5-methoxy-1H-indol-3-y)ethyl]acetamide)

2D structure 3D Conformer
FOODS HIGH IN MELATONIN
BIOSYNTHESIS OF MELATONIN
Melatonin synthesis – the pathway Melopsin
is a photosensive

step
Photo receptor cells of the retina perceives
the light status

Produce and send signals to the hypothalamic

nucleic which include

Sympathetic nerve fibers to the cells of

Pineal gland to ↑ Mell synthesis at night
Mell – the mechanism of action

Hipnotik
Cronobiotic

Mengatur ulang ritme

sikardium
MELATONIN SECRETION BY THE PINEAL GLAND
CICARDIUM RYTHM
MELL – BIOLOGICAL EFFECTS
THANK YOU