HIPERBILIRUBINEMIA

Definition
• Increased total bilirubin levels in the first week of
birth. Maximum normal levels are 12-13 mg%
(205-220 mmol/L).
• Elevated plasma levels of bilirubin 2 standard
deviation or more than expected levels based on
infant age or more than presentil 90.
• Bilirubin levels in the blood exceed 1 mg/dL
(17,1 umol/L)
 Etiology
• Excessive Production
• Disruption in uptake and conjugate hepatic
processes
• Transportation Interruption
• Erection disorder
 Clinical Manifestation
• Letargi
• Belly belly
• Seizures
• Enlargement of the liver
• Deaf, speech disorders,
• Feces are colored like
mental retardation
putty
• When the baby lives in old
• Vomiting, anorexia,
age with muscle spasms,
fatigue
convulsions, stenosis
• The color of urine is
accompanied by muscle
dark
tension
Pathophysiolgy
 Pathophysiology

•Bilirubin is the orange jelly crystalline pigment

which is the final form of heme cation breakdown
through the oxidation-reduction process.
•The first oxidation step is biliverdin which is
formed from heme with the help of heme
oxygenase enzyme.